Isosorbide Mononitrate combined with Warfarin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Stevens-johnson Syndrome Hospitalization 12/1/2005 70 Female 126 lb 1/19/2006 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious Male 1/17/2006 United States
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Life Threatening 1/3/2006 81 Male 176 lb 1/24/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2000 83 Female 99 lb 1/25/2006 United Kingdom
Primary
Concomitant
Myocardial Infarction Life Threatening 12/1/2005 70 Female 126 lb 1/30/2006 Physician Japan
Primary
Secondary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 3/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Memory Impairment Disability 2/25/2006 68 Female 99 lb 4/5/2006 Physician Japan
Primary
Concomitant
Rectal Haemorrhage Hospitalization 12/9/2005 76 Female 183 lb 4/6/2006 Other Health Professional United Kingdom
Primary
Concomitant
Skin Inflammation Death 4/15/2005 83 Male 3/17/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 4/13/2006 Other Health Professional United Kingdom
Primary
Concomitant
Memory Impairment Disability 2/25/2006 68 Female 99 lb 4/14/2006 Physician Japan
Primary
Concomitant
Transient Ischaemic Attack Other Serious 1/7/2004 86 Male 123 lb 4/20/2006 Physician United States
Primary
Concomitant
Renal Disorder Hospitalization 11/6/2000 53 Female 104 lb 8/21/2006 Pharmacist Japan
Primary
Secondary
Concomitant
Renal Disorder Hospitalization 11/6/2000 53 Female 104 lb 8/29/2006 Pharmacist Japan
Primary
Secondary
Concomitant
Nervous System Disorder Hospitalization 7/9/2006 62 Male 126 lb 9/5/2006 Physician Japan
Primary
Concomitant
Renal Disorder Hospitalization 11/6/2000 53 Female 104 lb 9/11/2006 Pharmacist Japan
Primary
Secondary
Concomitant
Vomiting Required Intervention 3/6/2007 62 4/17/2007 Pharmacist United States
Primary
Secondary
Concomitant
Drug Interaction Death 82 Female 8/16/2007 Sweden
Primary
Concomitant
Interacting
Drug Interaction Death 77 Female 8/16/2007 Sweden
Primary
Concomitant
Interacting
Drug Interaction Other Serious 66 Male 8/16/2007 Sweden
Primary
Concomitant
Interacting
Head Injury Hospitalization 6/17/2007 Female 120 lb 10/22/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Toxic Skin Eruption Other Serious 11/14/2008 67 Male 12/12/2008 Japan
Primary
Concomitant
Sudden Death Death 12/7/2008 72 Male 1/6/2009 Physician United Kingdom
Primary
Concomitant
Flushing 11/19/2008 Female 2/24/2009 United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 79 Female 3/16/2009 New Zealand
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 79 Female 3/20/2009 New Zealand
Primary
Secondary
Concomitant
Swelling Face 1/1/2007 5/4/2009 United States
Primary
Concomitant
Syncope Death 1/6/2009 79 Female 5/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Palpitations Hospitalization 5/26/2009 69 6/16/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Toxic Skin Eruption Other Serious 6/1/2009 Male 8/12/2009 Portugal
Primary
Concomitant
Vitreous Haemorrhage Other Serious 6/20/2009 Male 8/26/2009 Physician Switzerland
Primary
Secondary
Concomitant
Toxic Skin Eruption Other Serious 6/1/2009 Male 8/28/2009 Portugal
Primary
Concomitant
Liver Function Test Abnormal 5/12/2009 Male 220 lb 8/29/2009 Consumer United States
Primary
Concomitant
Retroperitoneal Haematoma Life Threatening 85 Female 9/16/2009 Other Health Professional United Kingdom
Primary
Concomitant
Sudden Death Death 12/7/2008 Male 245 lb 1/26/2010 Physician United Kingdom
Primary
Concomitant
Vasculitis Other Serious 1/31/2010 66 Male 325 lb 2/8/2010 Pharmacist United States
Primary
Secondary
Concomitant
Hallucination Other Serious 3/7/2010 88 Female 4/12/2010 Pharmacist Japan
Primary
Concomitant
Renal Failure Other Serious 2/6/2008 51 Male 163 lb 4/16/2010 Other Health Professional United States
Primary
Concomitant
Thrombosis Other Serious 12/1/2007 54 Male 163 lb 6/3/2010 Other Health Professional United States
Primary
Concomitant
Stent Placement Other Serious 12/14/2007 82 Male 130 lb 6/14/2010 Physician Japan
Primary
Concomitant
Sepsis Death 8/19/2009 84 Female 6/22/2010 Physician Switzerland
Primary
Concomitant
Haemorrhage Urinary Tract Other Serious 8/1/2006 84 Female 7/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vascular Graft Occlusion Other Serious 2/1/2008 53 Male 203 lb 8/12/2010 Lawyer United States
Primary
Secondary
Concomitant
Hypertension Other Serious 8/21/2010 90 Male 192 lb 8/30/2010 Consumer United States
Primary
Concomitant
Tetany Other Serious 5/1/2010 46 Female 304 lb 9/23/2010 Other Health Professional United Kingdom
Primary
Concomitant
Eyelid Oedema Other Serious 78 Female 10/25/2010 Pharmacist Canada
Primary
Concomitant
Thrombosis Other Serious 12/1/2007 54 Male 163 lb 11/2/2010 Lawyer United States
Primary
Secondary
Concomitant
Renal Failure Chronic Other Serious 1/1/2008 90 Male 11/22/2010 Lawyer United States
Primary
Concomitant
Vision Blurred Other Serious 9/1/2010 78 Female 236 lb 11/23/2010 Pharmacist Canada
Primary
Concomitant
Haemoptysis Hospitalization 1/31/2010 66 Male 325 lb 10/28/2010 Pharmacist
Primary
Concomitant
Fall Other Serious 12/3/2010 59 Male 289 lb 12/9/2010 Consumer United States
Primary
Concomitant
Ventricular Fibrillation Other Serious 45 Male 11/25/2010 United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 8/31/2000 80 Male 12/27/2010 Physician United Kingdom
Primary
Concomitant
Interacting
International Normalised Ratio Increased Hospitalization 8/31/2000 80 Male 12/29/2010 Physician United Kingdom
Primary
Concomitant
Interacting
Vascular Graft Occlusion Other Serious 2/1/2008 53 Male 203 lb 12/29/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 9/1/2010 78 Female 236 lb 12/30/2010 Pharmacist Canada
Primary
Concomitant
Diarrhoea 62 Male 1/7/2011 Consumer United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 8/31/2000 80 Male 1/17/2011 Physician United Kingdom
Primary
Concomitant
Interacting
Rhabdomyolysis Hospitalization 45 Male 1/18/2011 Pharmacist United States
Primary
Concomitant
Left Ventricular Dysfunction Hospitalization 45 Male 1/19/2011 Other Health Professional United States
Primary
Concomitant
Drug Interaction Life Threatening 8/31/2000 80 Male 1/21/2011 Physician United Kingdom
Primary
Concomitant
Interacting
Liver Function Test Abnormal Other Serious Male 1/24/2011 Physician Switzerland
Primary
Concomitant
Dizziness Hospitalization 9/10/2010 89 Male 1/25/2011 Consumer United States
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 8/31/2000 80 Male 1/27/2011 Physician United Kingdom
Primary
Concomitant
Interacting
Dyspnoea Life Threatening 12/20/2010 77 Male 2/7/2011 Other Health Professional United Kingdom
Primary
Concomitant
Gastrointestinal Perforation Hospitalization 7/14/2010 73 Male 249 lb 2/15/2011 Other Health Professional United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Other Serious 80 Male 2/23/2011 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Blood Potassium Decreased Other Serious 3/1/2008 81 Male 207 lb 2/28/2011 Other Health Professional United States
Primary
Concomitant
Off Label Use Other Serious 2/11/2011 76 Male 3/15/2011 Other Health Professional United Kingdom
Primary
Concomitant
Porencephaly Hospitalization 3/16/2011 Physician United Kingdom
Primary
Secondary
Complex Partial Seizures Hospitalization 3/17/2011 Other Health Professional United Kingdom
Primary
Secondary
Convulsion Other Serious 3/22/2011 Other Health Professional United Kingdom
Primary
Secondary
Porencephaly Hospitalization 3/23/2011 Other Health Professional United Kingdom
Primary
Secondary
Grand Mal Convulsion Hospitalization 3/23/2011 Other Health Professional United Kingdom
Primary
Secondary
Dizziness Hospitalization 9/10/2010 89 Male 3/25/2011 Consumer United States
Primary
Secondary
Concomitant
Complex Partial Seizures Hospitalization 3/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Complex Partial Seizures Hospitalization 3/29/2011 Other Health Professional United Kingdom
Primary
Secondary
Renal Failure Death 10/1/2006 70 Male 290 lb 3/29/2011 Other Health Professional United States
Primary
Concomitant
Anxiety Death 10/1/2006 70 Male 290 lb 3/29/2011 Consumer United States
Primary
Concomitant
Grand Mal Convulsion Other Serious 3/31/2011 Other Health Professional United Kingdom
Primary
Secondary
Complex Partial Seizures Hospitalization 3/21/2011 United Kingdom
Primary
Secondary
Periodontal Disease Other Serious 2/8/2005 65 Male 258 lb 4/13/2011 Physician United States
Primary
Secondary
Concomitant
Arrhythmia Other Serious 12/1/2007 54 Male 163 lb 4/18/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious 3/22/2011 79 Male 5/6/2011 Other Health Professional United Kingdom
Primary
Concomitant
Multiple Fractures Other Serious 80 Male 5/10/2011 Finland
Primary
Secondary
Concomitant
Palpitations Other Serious 59 Male 7/7/2011 United States
Primary
Concomitant
Mental Status Changes Hospitalization 4/9/2011 92 Female 218 lb 7/28/2011 Pharmacist United States
Primary
Concomitant
Infection Other Serious 6/28/2011 78 Female 99 lb 8/30/2011 Physician Japan
Primary
Secondary
Concomitant
Rash Other Serious 10/6/2010 61 Male 240 lb 9/13/2011 Consumer United Kingdom
Primary
Concomitant
Low Cardiac Output Syndrome Death 4/27/2011 68 Male 161 lb 9/16/2011 Physician Japan
Primary
Concomitant
Rash Other Serious 10/6/2010 61 Male 240 lb 9/19/2011 Other Health Professional United Kingdom
Primary
Concomitant
Cardiac Failure Congestive Death 4/27/2011 68 Male 161 lb 9/19/2011 Physician Japan
Primary
Concomitant
Infection Other Serious 6/28/2011 78 Female 99 lb 9/20/2011 Physician Japan
Primary
Secondary
Concomitant
Rash Death 57 Female 126 lb 9/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 62 Female 9/28/2011 Other Health Professional Croatia (Local Name: Hrvatska)
Primary
Concomitant
Pneumonia Death 4/27/2011 68 Male 161 lb 10/24/2011 Physician Japan
Primary
Concomitant
Coma Other Serious 1/1/2011 58 Female 77 lb 12/20/2011 Physician Japan
Primary
Concomitant
Drug Dose Omission Other Serious 72 Female 160 lb 1/5/2012 United States
Primary
Secondary
Concomitant
Hypoglycaemia Life Threatening 11/22/2011 58 Female 77 lb 2/2/2012 Physician Japan
Primary
Concomitant
Heart Rate Decreased Hospitalization 9/8/2011 81 Female 2/17/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
International Normalised Ratio Increased Other Serious 2/4/2012 73 Female 216 lb 2/28/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Constipation Other Serious 1/24/2012 66 Male 3/8/2012 Other Health Professional United Kingdom
Primary
Concomitant
Hypothyroidism Other Serious 1/18/2012 58 Male 157 lb 3/14/2012 Pharmacist Japan
Primary
Concomitant
Spinal Osteoarthritis Other Serious 12/14/2011 58 Male 157 lb 3/22/2012 Pharmacist Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 12/20/2011 31 Male 4/18/2012 Pharmacist Japan
Primary
Concomitant
Hepatic Enzyme Increased Other Serious 12/14/2011 58 Male 157 lb 4/18/2012 Pharmacist Japan
Primary
Concomitant
Renal Failure Acute Other Serious 5/30/2012 79 Female 6/4/2012 Physician Japan
Primary
Secondary
Concomitant
Quality Of Life Decreased Disability 79 Male 150 lb 6/4/2012 Lawyer United States
Primary
Concomitant
Pleural Effusion Other Serious 5/6/2012 73 Female 112 lb 6/14/2012 Physician Japan
Primary
Concomitant
Coagulation Time Prolonged Hospitalization 4/10/2011 81 Male 6/25/2012 Physician Japan
Primary
Concomitant
Renal Failure Acute Other Serious 5/30/2012 79 Female 128 lb 7/10/2012 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 12/20/2011 81 Male 110 lb 7/26/2012 Pharmacist Japan
Primary
Concomitant
Confusional State Hospitalization 58 Male 7/13/2012 Pharmacist United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 5/30/2012 79 Female 128 lb 7/27/2012 Physician Japan
Primary
Secondary
Concomitant
Drug Interaction Other Serious 8/19/2012 65 Male 8/22/2012 Physician China
Primary
Concomitant
Coagulation Time Prolonged Hospitalization 4/10/2011 81 Male 8/27/2012 Physician Japan
Primary
Concomitant
Rhabdomyolysis Hospitalization 45 Male 3/5/2013 Other Health Professional Us
Primary
Concomitant
Nasopharyngitis Other Serious 8/19/2012 65 Male 9/4/2012 Physician Cn
Primary
Concomitant
Vascular Graft Occlusion Hospitalization 61 Male 280 lb 9/3/2012 Consumer Us
Primary
Secondary
Concomitant
Rectal Haemorrhage Hospitalization 9/15/2012 86 Male 11/5/2012 Physician Us
Primary
Concomitant
Coronary Artery Disease Hospitalization 9/12/2012 66 Female 188 lb 10/8/2012 Physician Ru
Primary
Secondary
Concomitant
Platelet Function Test Abnormal Hospitalization 74 Male 10/15/2012 Physician Us
Primary
Concomitant
Urine Output Decreased Hospitalization 11/18/2009 79 Male 146 lb 11/2/2012 Physician Tw
Primary
Concomitant
Thrombocytopenia Death 9/14/2012 67 Male 11/1/2012 Pharmacist Gb
Primary
Concomitant
Rhabdomyolysis Hospitalization 9/20/2012 66 Male 6/11/2013 Physician Cn
Primary
Concomitant
Oral Candidiasis Other Serious 9/2012 Male 295 lb 11/16/2012 Consumer Country Not Specified
Primary
Concomitant
Urosepsis Other Serious 3/20/2012 Female 101 lb 11/28/2012 Physician Gb
Primary
Concomitant
Presyncope Hospitalization 2/8/2011 54 Male 205 lb 11/29/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Joint Warmth Other Serious 2009 83 Male 161 lb 12/17/2012 Consumer Us
Primary
Secondary
Concomitant
Cerebrovascular Accident Death 70 Male 209 lb 12/18/2012 Other Health Professional Ca
Primary
Concomitant
Mobility Decreased Other Serious 11/14/2012 44 Male 205 lb 12/20/2012 Pharmacist Gb
Primary
Concomitant
Mobility Decreased Other Serious 11/14/2012 44 Male 205 lb 12/27/2012 Other Health Professional Gb
Primary
Concomitant
Epilepsy Other Serious 70 12/28/2012 Pharmacist Gb
Primary
Concomitant
Mobility Decreased Other Serious 11/14/2012 44 Male 205 lb 12/28/2012 Other Health Professional Gb
Primary
Concomitant
Mobility Decreased Other Serious 11/14/2012 44 Male 12/27/2012 Other Health Professional Dk
Primary
Concomitant
Renal Impairment Hospitalization 11/22/2012 81 Female 1/18/2013 Pharmacist Gb
Primary
Concomitant
Renal Impairment Hospitalization 11/22/2012 81 Female 1/24/2013 Other Health Professional Gb
Primary
Concomitant
Basal Cell Carcinoma Other Serious 11/12/2012 75 Male 213 lb 6/4/2013 Physician Us
Primary
Secondary
Concomitant
Fatigue 11/6/2012 69 Male 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Cardiac Failure Death 1/4/2013 58 Male 119 lb 2/19/2013 Consumer Gb
Primary
Secondary
Concomitant
Malaise Death 1/24/2013 86 Male 216 lb 6/26/2013 Consumer Us
Primary
Concomitant
Pneumonia Other Serious 12/2012 83 Female 135 lb 2/11/2013 Consumer Us
Primary
Concomitant
Pneumonia Hospitalization 1/2013 83 Female 134 lb 2/8/2013 Consumer Us
Primary
Concomitant
Breast Pain Male 3/4/2013 Consumer Country Not Specified
Primary
Concomitant
Drug Ineffective 12/17/2012 76 Male 6/10/2013 Consumer Us
Primary
Concomitant
International Normalised Ratio Decreased Hospitalization 77 Male 3/15/2013 Pharmacist Gb
Primary
Concomitant
Interacting
Pneumonia Hospitalization 12/2012 Male 3/16/2013 Consumer Us
Primary
Concomitant
Pulmonary Embolism Hospitalization 77 Male 3/28/2013 Pharmacist Gb
Primary
Secondary
Concomitant
Interacting
Pneumonia Hospitalization 1/2013 83 Female 132 lb 4/18/2013 Consumer Us
Primary
Secondary
Concomitant
Vomiting Hospitalization 64 Male 265 lb 1/16/2013 Pharmacist Us
Primary
Secondary
Concomitant

Drug Data