Isosorbide Mononitrate combined with Spironolactone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Stent Occlusion Hospitalization 7/25/2005 64 Male 183 lb 1/12/2006 Poland
Primary
Secondary
Concomitant
Pancreatitis Acute Other Serious 1/7/2006 74 Male 1/18/2006 Other Health Professional United States
Primary
Concomitant
Weight Decreased Required Intervention 10/24/2005 Male 198 lb Pharmacist United States
Primary
Secondary
Weight Increased Life Threatening 3/1/2005 71 Female 2/21/2006 Other Health Professional Germany
Primary
Concomitant
Myocardial Ischaemia Death 62 Male 2/22/2006 Physician United Kingdom
Primary
Concomitant
Odynophagia Hospitalization 1/15/2006 71 Male 3/10/2006 Physician Japan
Primary
Secondary
Angioneurotic Oedema Hospitalization 1/15/2006 71 Male 3/17/2006 Physician Japan
Primary
Secondary
Tinnitus Hospitalization 8/1/2001 78 Female 3/31/2006 Lawyer Poland
Primary
Concomitant
Tinnitus Hospitalization 8/1/2001 78 Female 4/7/2006 Physician Poland
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 1/15/2006 71 Male 4/3/2006 Physician Japan
Primary
Secondary
Urinary Tract Infection Other Serious 6/22/2005 45 Female 150 lb 4/25/2006 Pharmacist United States
Primary
Concomitant
Chest Pain Hospitalization 10/31/2004 89 Female 6/8/2006 Other Health Professional Sweden
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 5/23/2006 92 Male 7/7/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Gallbladder Cancer Hospitalization 3/14/2006 Male 7/14/2006 Physician Japan
Primary
Concomitant
Pancytopenia Hospitalization 1/10/2006 90 Male 8/11/2006 Other Health Professional Sweden
Primary
Secondary
Concomitant
Blood Amylase Increased Other Serious 5/1/2005 78 Male 9/5/2006 United Kingdom
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 5/11/2006 79 Female 154 lb 10/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 79 Female 154 lb 9/29/2006 United Kingdom
Primary
Concomitant
Ill-defined Disorder Hospitalization 7/7/2006 82 Male 192 lb 10/4/2006 Pharmacist United States
Primary
Concomitant
Nodal Rhythm Hospitalization 9/25/2006 80 Female 10/16/2006 Physician Poland
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 9/14/2006 Male 10/23/2006 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/2/2006 91 Female 86 lb 10/26/2006 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 10/5/2006 91 Female 11/3/2006 Sweden
Primary
Secondary
Concomitant
Neutropenia Hospitalization 12/4/2006 Female 176 lb 12/5/2006 Pharmacist United States
Primary
Concomitant
Pallor Hospitalization 10/15/2006 84 Female 12/19/2006 United Kingdom
Primary
Secondary
Concomitant
Visual Disturbance Hospitalization Female 1/4/2007 Consumer United States
Primary
Concomitant
Myocardial Ischaemia Hospitalization 9/28/2006 68 Female 115 lb 1/4/2007 Other Health Professional Poland
Primary
Secondary
Concomitant
Pain In Extremity 1/1/2006 66 Female 162 lb 10/24/2006 Pharmacist United States
Primary
Concomitant
Renal Impairment Other Serious 12/1/2006 79 Male 1/18/2007 Physician China
Primary
Concomitant
Ventricular Tachycardia Life Threatening 12/8/2005 73 Male 1/30/2007 United Kingdom
Primary
Concomitant
Nausea Hospitalization 9/25/2006 80 Female 2/12/2007 Poland
Primary
Secondary
Concomitant
Renal Injury Disability 9/1/2006 83 Female 3/1/2007
Primary
Concomitant
Renal Failure Disability 9/1/2006 83 Female 2/26/2007 United Kingdom
Primary
Concomitant
Renal Impairment Other Serious 12/1/2006 79 Male 3/6/2007 Physician China
Primary
Concomitant
Urticaria Other Serious 1/20/2007 63 Male 337 lb 1/25/2007 Pharmacist United States
Primary
Concomitant
Pulmonary Embolism Other Serious 3/7/2007 72 Male 4/4/2007 Physician United Kingdom
Primary
Concomitant
Myocardial Ischaemia Hospitalization 9/28/2006 Female 115 lb 4/11/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Death 1/1/2007 77 Female 4/13/2007 Other Health Professional United Kingdom
Primary
Concomitant
Loss Of Consciousness Hospitalization 3/23/2007 72 Male 4/10/2007 Physician United Kingdom
Primary
Concomitant
Loss Of Consciousness Hospitalization 3/23/2007 72 Male 4/16/2007 United Kingdom
Primary
Concomitant
Pulmonary Embolism Other Serious 3/7/2007 72 Male 5/11/2007 Physician United Kingdom
Primary
Concomitant
Pallor Hospitalization 5/11/2006 79 Female 154 lb 5/18/2007 Other Health Professional United Kingdom
Primary
Concomitant
Rash Hospitalization 4/28/2007 77 Male 5/22/2007 Other Health Professional United Kingdom
Primary
Concomitant
Diverticulum Intestinal Haemorrhagic Hospitalization 2/28/2006 80 Male 12/13/2006 Physician United States
Primary
Concomitant
Ventricular Tachycardia Life Threatening 78 Male 6/4/2007 Physician Switzerland
Primary
Concomitant
Rash Hospitalization 4/28/2007 77 Male 183 lb 6/5/2007 Other Health Professional United Kingdom
Primary
Concomitant
Ventricular Tachycardia Hospitalization 5/23/2007 72 Male 6/4/2007 United Kingdom
Primary
Concomitant
Platelet Count Decreased Other Serious 11/1/2005 75 Female 7/17/2007 Other Health Professional China
Primary
Concomitant
Interacting
Lipids Abnormal Other Serious 6/1/2007 70 Female 121 lb 7/19/2007 Pharmacist United Kingdom
Primary
Concomitant
Hypotension Hospitalization 7/6/2007 50 Male 9/4/2007 Other Health Professional Philippines
Primary
Secondary
Concomitant
Pain In Jaw Other Serious 7/1/2006 66 Female 162 lb 9/12/2007 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 8/30/2006 60 Female 11/10/2007 Pharmacist United States
Primary
Concomitant
Hyponatraemia Hospitalization 11/6/2007 12/18/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Other Serious 11/30/2007 76 Female 154 lb 12/21/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Malaise Hospitalization 9/8/2007 75 Female 12/17/2007 United Kingdom
Primary
Concomitant
Syncope Other Serious 11/30/2007 76 Female 154 lb 12/28/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cardiac Failure Death 12/7/2007 65 Male 1/10/2008 Other Health Professional Korea, Republic Of
Primary
Concomitant
Oesophagitis Life Threatening 12/19/2007 86 Female 1/9/2008 United Kingdom
Primary
Secondary
Concomitant
Oesophagitis Life Threatening 12/19/2007 86 Female 1/22/2008 United Kingdom
Primary
Secondary
Concomitant
Urethritis Hospitalization 1/30/2008 63 Male 2/4/2008 Norway
Primary
Concomitant
Tremor Hospitalization 1/1/2007 81 Male 2/12/2008 Other Health Professional France
Primary
Concomitant
Polymyositis Hospitalization 12/1/2006 77 Male 2/18/2008 Other Health Professional Norway
Primary
Concomitant
Syncope Vasovagal Hospitalization 9/8/2007 75 Female 3/7/2008 United Kingdom
Primary
Concomitant
Mass 1/1/2008 Female 114 lb 3/15/2008 Consumer United States
Primary
Concomitant
Peritonitis Hospitalization 3/15/2008 71 Male 201 lb 4/10/2008 Physician United States
Primary
Concomitant
Hypotension Other Serious 7/6/2007 Male 4/21/2008 Philippines
Primary
Secondary
Concomitant
Renal Failure Hospitalization 3/31/2008 80 Male 4/17/2008 United Kingdom
Primary
Concomitant
Myocardial Ischaemia Hospitalization 3/6/2008 80 Male 5/20/2008 United Kingdom
Primary
Concomitant
Left Ventricular Dysfunction Hospitalization 1/1/2004 80 Male 5/23/2008 United Kingdom
Primary
Concomitant
Cardiac Failure Congestive Other Serious 9/5/2007 81 Male 6/11/2008 Japan
Primary
Secondary
Concomitant
Urethritis Hospitalization 1/30/2008 63 Male 6/5/2008 Norway
Primary
Concomitant
Cardiomegaly Other Serious 9/11/2007 81 Male 6/27/2008 Japan
Primary
Secondary
Concomitant
Acute Coronary Syndrome Hospitalization 4/22/2008 Male 6/27/2008 Netherlands
Primary
Concomitant
Therapeutic Response Unexpected 1/1/2008 72 Male 5/6/2008 United States
Primary
Concomitant
Cardiomegaly Other Serious 9/11/2007 81 Male 7/17/2008 Japan
Primary
Secondary
Concomitant
Cardiomegaly Other Serious 9/11/2007 81 Male 8/6/2008 Japan
Primary
Secondary
Concomitant
Pericarditis Hospitalization 7/29/2008 Female 8/14/2008 Pharmacist United States
Primary
Concomitant
Henoch-schonlein Purpura Hospitalization 4/27/2008 Male 8/27/2008 United States
Primary
Secondary
Concomitant
Tremor Hospitalization 1/1/2007 81 Male 9/23/2008 Other Health Professional France
Primary
Concomitant
Tremor Other Serious 9/15/2007 81 Male 124 lb 9/22/2008 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Hospitalization 7/1/2008 Female 11/25/2008 Consumer United States
Primary
Concomitant
Syncope Hospitalization 6/1/2008 87 135 lb 11/25/2008 Consumer United States
Primary
Concomitant
Renal Failure Acute Death 11/1/2006 86 Female 12/15/2008 Consumer United States
Primary
Concomitant
Product Quality Issue Death 5/1/2008 65 Male 225 lb 12/15/2008 Consumer United States
Primary
Concomitant
Hodgkin's Disease Hospitalization 9/23/2005 Male 144 lb 12/19/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Product Quality Issue Hospitalization 3/1/2008 60 Female 130 lb 12/17/2008 Consumer United States
Primary
Concomitant
Product Quality Issue Death 4/7/2007 72 Male 170 lb 12/19/2008 Consumer United States
Primary
Concomitant
Wrist Fracture Hospitalization 11/7/2008 90 Female 130 lb 12/23/2008 Consumer United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2008 44 Male 362 lb 2/13/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 44 Male 2/19/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 1/1/2004 77 Female 241 lb 2/23/2009 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 362 lb 3/2/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 3/2/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 5/1/2008 43 Female 362 lb 3/5/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 362 lb 3/5/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Lower Gastrointestinal Haemorrhage Life Threatening 3/6/2008 77 Male 176 lb 3/5/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 3/6/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sudden Death Death 1/6/2009 Male 220 lb 3/6/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 3/9/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 5/1/2007 43 Female 362 lb 3/9/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 3/9/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 3/2/2009 Other Health Professional United Kingdom
Primary
Concomitant
Gastrointestinal Haemorrhage Life Threatening 3/6/2008 77 Male 176 lb 3/6/2009 Pharmacist Germany
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 3/13/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 5/1/2007 43 Female 3/13/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Dyspepsia Hospitalization 10/10/2008 3/12/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2008 44 Male 360 lb 3/12/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2008 44 Male 360 lb 3/13/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 3/10/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2008 43 Female 362 lb 3/16/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 5/1/2007 43 Female 360 lb 3/18/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 5/1/2007 43 Female 360 lb 3/20/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 10/13/2008 44 Male 3/16/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 3/20/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Ocular Toxicity 12/26/2005 73 Male 3/25/2009 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 3/25/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 3/26/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 3/25/2009 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 3/9/2009 60 Male 4/1/2009 Physician United Kingdom
Primary
Concomitant
Acute Myocardial Infarction Death 74 Male 4/7/2009 Physician Greece
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 1/1/2008 86 Female 4/20/2009 Physician Finland
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 1/1/2008 86 Female 5/1/2009 Physician Finland
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 1/1/2008 86 Female 5/13/2009 Physician Finland
Primary
Secondary
Concomitant
Product Quality Issue Death 5/1/2008 65 Male 225 lb 5/11/2009 Consumer United States
Primary
Concomitant
Reflux Oesophagitis Hospitalization 2/1/2009 93 Female 6/18/2009 Other Health Professional Sweden
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2008 43 Female 362 lb 6/29/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 362 lb 7/6/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 7/2/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 7/7/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 5/1/2007 43 Female 360 lb 7/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 360 lb 7/13/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 360 lb 7/16/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 7/17/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 362 lb 7/23/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 362 lb 7/27/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxic Skin Eruption Other Serious 6/1/2009 Male 8/12/2009 Portugal
Primary
Concomitant
Toxic Skin Eruption Other Serious 6/1/2009 Male 8/28/2009 Portugal
Primary
Concomitant
Weight Decreased Other Serious 76 Male 9/1/2009 Lawyer United States
Primary
Concomitant
Pancreatitis Acute Other Serious 6/27/2009 69 Male 9/8/2009 Physician United States
Primary
Concomitant
Incorrect Dose Administered 4/2/2007 Female 115 lb 9/11/2009 Consumer United States
Primary
Concomitant
Hyperkalaemia Other Serious 9/1/2009 78 Male 9/25/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Other Serious 9/1/2009 78 9/25/2009 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Pancreatitis Acute Other Serious 6/27/2009 69 Male 9/28/2009 Physician United States
Primary
Concomitant
Peritonitis Bacterial Life Threatening 8/20/2009 78 Male 9/29/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Life Threatening 9/1/2009 78 Male 9/22/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Other Serious 9/1/2009 78 Male 9/24/2009 United Kingdom
Primary
Concomitant
Hyperkalaemia Other Serious 9/1/2009 78 Male 9/25/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 72 10/5/2009 Physician Brazil
Primary
Concomitant
Acute Coronary Syndrome Hospitalization 4/22/2008 55 10/8/2009 Physician Netherlands
Primary
Concomitant
Weight Increased Other Serious 1/1/2008 43 Female 362 lb 10/22/2009 Consumer United Kingdom
Primary
Secondary
Concomitant

Drug Data