Isosorbide Mononitrate combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tachycardia Death 11/17/2005 77 Female 1/3/2006 Other Health Professional Netherlands
Primary
Concomitant
Skin Ulcer Hospitalization 2/13/2002 Female 1/4/2006 France
Primary
Concomitant
Renal Failure Life Threatening 9/2/2003 Male 1/4/2006 Finland
Primary
Concomitant
Coronary Ostial Stenosis Hospitalization 11/21/2005 71 Male 192 lb 1/4/2006 United States
Primary
Secondary
Concomitant
Sinus Bradycardia Hospitalization 12/6/2005 81 Male 154 lb 1/4/2006 United States
Primary
Secondary
Concomitant
Coronary Artery Surgery Hospitalization 4/12/2005 46 Male 192 lb 1/4/2006 United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Death 11/19/2005 Male 1/13/2006 Italy
Primary
Secondary
Concomitant
Stent Occlusion Hospitalization 7/25/2005 64 Male 183 lb 1/12/2006 Poland
Primary
Secondary
Concomitant
Rhabdomyolysis Death 11/19/2005 Male 1/19/2006 Italy
Primary
Secondary
Concomitant
Skin Oedema Other Serious 1/1/2005 79 Male 1/13/2006 United Kingdom
Primary
Secondary
Concomitant
Coronary Artery Thrombosis Other Serious 8/10/2004 50 Male 1/25/2006 Physician Brazil
Primary
Concomitant
Pericardial Effusion Hospitalization 9/5/2005 58 Female 1/18/2006 Physician United Kingdom
Primary
Concomitant
Sensory Loss Hospitalization 11/2/2005 Male 1/26/2006 Italy
Primary
Secondary
Concomitant
Myocardial Infarction Life Threatening 9/23/2005 72 Male 176 lb 1/30/2006 Physician
Primary
Concomitant
Pneumonitis Death 6/1/2005 69 Male 1/30/2006 United Kingdom
Primary
Concomitant
Treatment Noncompliance Hospitalization 11/30/2005 Male 153 lb 1/3/2006 Other Health Professional United States
Primary
Concomitant
Urine Output Decreased Hospitalization 11/19/2005 Male 208 lb 1/3/2006 Pharmacist United States
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 2/9/2006 United States
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 2/9/2006 United States
Primary
Concomitant
Pneumonitis Death 6/1/2005 69 Male 2/6/2006 United Kingdom
Primary
Concomitant
Skin Oedema Other Serious 1/1/2005 79 Male 2/7/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Dizziness Postural Hospitalization 10/12/2005 Male 144 lb 10/13/2005 Pharmacist United States
Primary
Secondary
Concomitant
Pain Other Serious 1/13/2006 44 Male 2/8/2006 Other Health Professional United Kingdom
Primary
Concomitant
Subcutaneous Haematoma Hospitalization 6/15/2005 66 Male 198 lb 2/9/2006 Poland
Primary
Concomitant
Interacting
Myocardial Infarction Other Serious 5/15/2003 76 Female 77 lb 2/21/2006 Lawyer United Kingdom
Primary
Concomitant
Procedural Site Reaction Hospitalization 11/21/2005 Male 2/15/2006 Pharmacist United States
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 2/23/2006 United States
Primary
Concomitant
Sinus Bradycardia Hospitalization 12/6/2005 81 Male 154 lb 2/15/2006 Poland
Primary
Secondary
Concomitant
Pneumonia Hospitalization 12/19/2005 77 Female 115 lb 2/16/2006 Poland
Primary
Secondary
Concomitant
Vomiting Other Serious 8/1/2001 76 Female 99 lb 2/24/2006 Physician United Kingdom
Primary
Concomitant
Ischaemic Stroke Hospitalization 5/9/2005 77 Male 220 lb 2/21/2006 Other Health Professional Poland
Primary
Secondary
Concomitant
Myocardial Ischaemia Death 62 Male 2/22/2006 Physician United Kingdom
Primary
Concomitant
Vomiting Other Serious 8/1/2001 76 Female 99 lb 3/2/2006 Physician United Kingdom
Primary
Concomitant
Pneumonia Hospitalization 12/19/2005 77 Female 115 lb 2/28/2006 Poland
Primary
Secondary
Concomitant
Troponin Increased Hospitalization 5/9/2005 77 Male 220 lb 2/28/2006 Poland
Primary
Secondary
Concomitant
Hypertension Other Serious 2/15/2006 59 Male 220 lb 3/7/2006 United Kingdom
Primary
Concomitant
Sepsis Hospitalization 10/26/2004 79 Male 175 lb 12/29/2005 Consumer United States
Primary
Secondary
Concomitant
Factor V Leiden Mutation Hospitalization 2/17/2006 85 Male 187 lb 3/14/2006 Pharmacist United States
Primary
Concomitant
Rectal Haemorrhage Hospitalization 7/1/2004 80 Male 190 lb 12/21/2005 Physician United States
Primary
Concomitant
Skin Cancer Life Threatening 5/9/2005 77 Male 220 lb 3/10/2006 Poland
Primary
Secondary
Concomitant
Hypertension Other Serious 2/15/2006 59 Male 220 lb 3/17/2006 Other Health Professional United Kingdom
Primary
Concomitant
Tachycardia Hospitalization 1/1/2002 47 Male 3/31/2006 Physician Poland
Primary
Concomitant
Coronary Artery Disease Hospitalization 1/22/2005 76 Male 185 lb 4/6/2006 Czech Republic
Primary
Secondary
Concomitant
Myalgia Other Serious 7/22/2005 51 Male 227 lb 4/13/2006 Pharmacist United States
Primary
Concomitant
Vitreous Haemorrhage Other Serious 2/9/2003 84 Male 4/20/2006 United Kingdom
Primary
Secondary
Concomitant
Hypoglycaemia Hospitalization 3/17/2006 46 Female 4/13/2006 Other Health Professional Netherlands
Primary
Concomitant
Gastrointestinal Haemorrhage Required Intervention 4/18/2006 77 Male 134 lb 4/18/2006 Pharmacist United States
Primary
Concomitant
Acute Coronary Syndrome Hospitalization 3/24/2006 79 Female 4/17/2006 United Kingdom
Primary
Concomitant
Hypoglycaemia Hospitalization 3/17/2006 46 Female 4/17/2006 Other Health Professional Netherlands
Primary
Concomitant
Hallucination, Visual Hospitalization 10/28/2005 79 Male 148 lb 4/18/2006 Physician Canada
Primary
Concomitant
Urinary Tract Infection Other Serious 6/22/2005 45 Female 150 lb 4/25/2006 Pharmacist United States
Primary
Concomitant
Skin Burning Sensation Hospitalization 11/1/2005 77 Female 134 lb 5/3/2006 Physician United Kingdom
Primary
Concomitant
Treatment Noncompliance Hospitalization 2/26/2006 Male 258 lb 5/2/2006 Pharmacist United States
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 2/27/2006 Male 258 lb 5/2/2006 Pharmacist United States
Primary
Secondary
Concomitant
Myopathy Hospitalization 1/19/2006 79 Female 5/10/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sensory Loss Hospitalization 11/2/2005 Male 5/17/2006 Other Health Professional Italy
Primary
Secondary
Concomitant
Tardive Dyskinesia Other Serious 2/1/2006 53 Male 154 lb 6/2/2006 Consumer United Kingdom
Primary
Concomitant
Renal Failure Required Intervention 1/11/2006 76 Male 118 lb 5/24/2006 Pharmacist United States
Primary
Concomitant
Hepatic Function Abnormal Other Serious 2/21/2005 68 Male 154 lb 5/25/2006 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Retention Hospitalization 11/19/2005 78 Male 196 lb 6/13/2006 United Kingdom
Primary
Secondary
Concomitant
Bradycardia Hospitalization 3/10/2006 75 Male 219 lb 6/1/2006 Pharmacist United States
Primary
Concomitant
Sinus Headache Disability 5/4/2006 79 Male 212 lb 6/19/2006 Other Health Professional United Kingdom
Primary
Concomitant
Skin Burning Sensation Hospitalization 11/1/2005 77 Female 134 lb 6/22/2006 Physician United Kingdom
Primary
Concomitant
Cardiac Failure Death 3/9/2006 Male 6/20/2006 Physician Netherlands
Primary
Concomitant
Renal Failure Acute Hospitalization 6/9/2006 56 Male 205 lb 6/23/2006 Physician Brazil
Primary
Concomitant
Chest Pain Hospitalization 4/10/2004 69 Female 7/6/2006 Consumer Italy
Primary
Concomitant
Weight Increased Hospitalization 4/13/2006 67 Male 6/29/2006 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 6/9/2006 56 Male 205 lb 7/5/2006 Physician Brazil
Primary
Concomitant
Tardive Dyskinesia Other Serious 2/1/2006 53 Male 154 lb 7/17/2006 Other Health Professional Japan
Primary
Concomitant
Bronchitis Hospitalization 10/22/2005 64 Male 7/14/2006 United States
Primary
Secondary
Concomitant
Tardive Dyskinesia Other Serious 2/1/2006 53 Male 154 lb 7/26/2006 Other Health Professional Japan
Primary
Concomitant
Heart Rate Irregular Hospitalization 5/21/2006 64 Male 224 lb 5/23/2006 Pharmacist United States
Primary
Concomitant
Urine Abnormality Hospitalization 72 Female 7/20/2006 Spain
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 5/5/2001 77 Male 7/21/2006 United States
Primary
Concomitant
Hypertension Other Serious 1/1/2000 73 Male 217 lb 7/19/2006 Consumer United Kingdom
Primary
Concomitant
Vitreous Haemorrhage Required Intervention 2/9/2003 84 Male 8/8/2006 Denmark
Primary
Concomitant
Sepsis Hospitalization 7/20/2006 56 Male 203 lb 8/10/2006 Physician Brazil
Primary
Concomitant
Metastasis Other Serious 6/20/2006 75 Female 8/17/2006 Other Health Professional United Kingdom
Primary
Concomitant
Retroperitoneal Haemorrhage Other Serious 9/17/2004 74 Female 141 lb 8/28/2006 Australia
Primary
Secondary
Concomitant
Sepsis Hospitalization 7/20/2006 56 Male 203 lb 8/22/2006 Physician Brazil
Primary
Concomitant
Epistaxis Other Serious 2/8/2006 45 Male 8/28/2006 United Kingdom
Primary
Secondary
Concomitant
Pancreatitis Other Serious 5/29/2006 69 Male 195 lb 8/29/2006 Physician United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 2/25/2006 79 Female 8/29/2006 Denmark
Primary
Secondary
Concomitant
Sepsis Hospitalization 7/18/2006 56 Male 203 lb 9/1/2006 Brazil
Primary
Concomitant
Sepsis Hospitalization 7/18/2006 56 Male 203 lb 9/1/2006 Brazil
Primary
Concomitant
Haematoma Hospitalization 1/25/2006 Male 9/11/2006 Pharmacist United States
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/20/2006 Male 9/11/2006 Pharmacist United States
Primary
Secondary
Concomitant
Sensory Loss Hospitalization 11/2/2005 Male 9/14/2006 Other Health Professional Italy
Primary
Secondary
Concomitant
Rhinorrhoea Hospitalization 8/8/2006 60 Male 234 lb 9/12/2006 Other Health Professional Poland
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 7/18/2006 56 Male 203 lb 9/18/2006 Other Health Professional Brazil
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Myalgia Other Serious 5/9/2006 79 Male 182 lb 9/19/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Skin Oedema Hospitalization 76 Male 9/21/2006 Physician United Kingdom
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 5/11/2006 79 Female 154 lb 10/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 7/18/2006 56 Male 203 lb 9/27/2006 Other Health Professional Brazil
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 79 Female 154 lb 9/29/2006 United Kingdom
Primary
Concomitant
Ill-defined Disorder Hospitalization 7/7/2006 82 Male 192 lb 10/4/2006 Pharmacist United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/13/2006 77 Male 311 lb 10/4/2006 Pharmacist United States
Primary
Concomitant
Pancreatitis Other Serious 5/29/2006 69 Male 195 lb 10/5/2006 Physician United States
Primary
Secondary
Concomitant
Panic Attack Hospitalization 9/3/2006 63 Male 258 lb 10/5/2006 Germany
Primary
Concomitant
Panic Attack Hospitalization 8/15/2006 63 Male 258 lb 10/5/2006 Other Health Professional Germany
Primary
Concomitant
Thrombocytopenia Other Serious 7/18/2006 56 Male 203 lb 10/10/2006 Other Health Professional Brazil
Primary
Concomitant
Vomiting Required Intervention 8/7/2006 88 Male 169 lb 9/20/2006 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Required Intervention 8/23/2006 85 Male 160 lb 10/10/2006 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 9/27/2006 Male 10/23/2006 Pharmacist United States
Primary
Concomitant
Dizziness Hospitalization 7/5/2006 88 Male 135 lb 7/6/2006 Pharmacist United States
Primary
Secondary
Concomitant
Hypotension Hospitalization 7/12/2006 76 Male 118 lb 8/8/2006 Pharmacist United States
Primary
Secondary
Concomitant
Pancreatitis Other Serious 5/29/2006 69 Male 195 lb 10/20/2006 Physician United States
Primary
Secondary
Concomitant
Hyperkalaemia Life Threatening 8/18/2006 Male 187 lb 11/2/2006 United Kingdom
Primary
Secondary
Concomitant
Somnolence Hospitalization 1/1/2000 65 Male 10/31/2006 India
Primary
Secondary
Concomitant
Hyperkalaemia Life Threatening 8/18/2006 Male 187 lb 11/7/2006 United Kingdom
Primary
Secondary
Concomitant
Haematoma Other Serious 68 Male 164 lb 11/10/2006 Other Health Professional New Zealand
Primary
Concomitant
Rash Erythematous Other Serious 10/6/2006 62 Female 198 lb 11/14/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rash Erythematous Disability 10/6/2006 62 Female 198 lb 11/17/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Skin Reaction Other Serious 10/6/2006 62 Female 198 lb 11/27/2006 United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 10/21/2006 85 Female 12/6/2006 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Other Serious 10/21/2006 85 Female 12/11/2006 Other Health Professional United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 7/18/2006 56 Male 203 lb 12/13/2006 Other Health Professional Brazil
Primary
Concomitant
Skin Oedema Hospitalization 76 Male 12/14/2006 Other Health Professional United States
Primary
Concomitant
Swelling 12/1/2005 77 Male 12/28/2006 Consumer United States
Primary
Concomitant
Lip Swelling Other Serious 11/14/2006 77 Male 1/3/2007 United Kingdom
Primary
Concomitant
Haemolytic Anaemia Hospitalization 9/21/2006 Male 150 lb 10/19/2006 Pharmacist United States
Primary
Concomitant
Feeling Hot Other Serious 12/6/2006 81 Female 1/10/2007 United Kingdom
Primary
Concomitant
Urinary Hesitation Other Serious 10/30/2006 57 Male 1/15/2007 Consumer United Kingdom
Primary
Concomitant
Gastritis Hospitalization 12/1/2006 52 Male 1/11/2007 Physician United Kingdom
Primary
Concomitant
Orthostatic Hypotension Other Serious 81 Female 1/16/2007 Other Health Professional United Kingdom
Primary
Concomitant
Gastritis Hospitalization 12/1/2006 52 Male 1/18/2007 United Kingdom
Primary
Secondary
Concomitant
Rash Other Serious 8/23/2006 52 Male 329 lb 10/13/2006 Pharmacist United States
Primary
Concomitant
Renal Impairment Hospitalization 12/15/2006 1/26/2007 Consumer United Kingdom
Primary
Concomitant
Liver Function Test Abnormal Hospitalization 12/11/2006 Female 2/1/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 12/14/2005 Female 201 lb 2/9/2007 Physician United Kingdom
Primary
Concomitant
Hip Fracture Hospitalization 4/8/2006 Female 146 lb 2/9/2007 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 87 Male 2/7/2007 Physician Spain
Primary
Secondary
Concomitant
Hypertension Hospitalization 1/25/2007 Male 173 lb 3/1/2007 Physician Germany
Primary
Concomitant
Femur Fracture Other Serious 10/15/2005 Female 3/2/2007 Other Health Professional Sweden
Primary
Concomitant
Vomiting Life Threatening 1/18/2007 86 Female 3/2/2007 Consumer Germany
Primary
Concomitant
Vomiting Life Threatening 1/18/2007 87 Female 2/23/2007 Portugal
Primary
Concomitant
Vitreous Haemorrhage Other Serious 83 Male 3/5/2007 United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 87 Male 3/13/2007
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 12/14/2005 Female 201 lb 3/14/2007 Physician United Kingdom
Primary
Concomitant
Anaemia Required Intervention 3/12/2007 81 Male 158 lb 3/12/2007 Pharmacist United States
Primary
Concomitant
Hypotension Hospitalization 2/13/2007 84 Male 3/23/2007 Other Health Professional United Kingdom
Primary
Concomitant
Hypotension Hospitalization 2/13/2007 84 Male 3/19/2007 United Kingdom
Primary
Concomitant
Implantable Defibrillator Insertion Hospitalization 1/25/2007 Male 173 lb 3/27/2007 Physician Germany
Primary
Concomitant
Renal Failure Acute Hospitalization 6/8/2006 Male 205 lb 3/30/2007 Brazil
Primary
Concomitant
Thrombocytopenia Other Serious 7/21/2006 Male 203 lb 4/2/2007 Brazil
Primary
Concomitant
Pulmonary Embolism Other Serious 3/7/2007 72 Male 4/4/2007 Physician United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Death 11/17/2006 Female 106 lb 4/12/2007 Other Health Professional United Kingdom
Primary
Concomitant

Drug Data