Isosorbide Mononitrate combined with Metoprolol Succinate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Ventricular Hypertrophy Other Serious 9/5/2005 Male 185 lb 1/27/2006 United States
Primary
Concomitant
Dizziness Postural Hospitalization 10/19/2005 Male 207 lb 12/2/2005 Pharmacist United States
Primary
Secondary
Concomitant
Contusion Hospitalization 3/17/2004 53 Female 190 lb 12/27/2005 Consumer United States
Primary
Concomitant
Nausea Other Serious 9/1/2005 76 Male 173 lb 12/27/2005 Consumer United States
Primary
Secondary
Concomitant
Xeroderma Hospitalization 1/1/2005 75 Male 155 lb 4/3/2006 Physician United States
Primary
Concomitant
Urinary Tract Infection Other Serious 6/22/2005 45 Female 150 lb 4/25/2006 Pharmacist United States
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 5/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Wound Infection Bacterial Other Serious 4/13/2006 69 Female 165 lb 5/5/2006 United States
Primary
Secondary
Concomitant
Renal Failure Required Intervention 1/11/2006 76 Male 118 lb 5/24/2006 Pharmacist United States
Primary
Concomitant
Ventricular Extrasystoles Other Serious 10/8/2002 67 Female 6/21/2006 United States
Primary
Concomitant
Respiratory Arrest Other Serious 9/5/2005 Male 185 lb 6/30/2006 United States
Primary
Concomitant
Pneumonia Hospitalization 2/25/2006 79 Female 8/29/2006 Denmark
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2005 Male 9/11/2006 Brazil
Primary
Secondary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2005 Male 10/11/2006 Brazil
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2005 70 Male 10/20/2006 Brazil
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/5/2006 91 Female 11/3/2006 Sweden
Primary
Secondary
Concomitant
Drug Toxicity Death 82 11/10/2006 Physician United States
Primary
Secondary
Upper Gastrointestinal Haemorrhage Hospitalization 8/10/2006 75 Male 231 lb 11/21/2006 Pharmacist United States
Primary
Secondary
Concomitant
Death Death 10/17/2006 71 Male 11/17/2006 Other Health Professional United States
Primary
Concomitant
Melaena Other Serious 3/15/1999 72 Male 169 lb 11/17/2006 Consumer United States
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Life Threatening 1/1/2003 76 Male 12/21/2006
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 11/24/2006 69 Male 154 lb 12/22/2006 United States
Primary
Secondary
Concomitant
Syncope Vasovagal Life Threatening 1/1/2003 76 Male 12/29/2006 United States
Primary
Secondary
Concomitant
Splenectomy Hospitalization 11/24/2006 69 Female 154 lb 1/4/2007 Romania
Primary
Secondary
Concomitant
Heparin-induced Thrombocytopenia Required Intervention 8/15/2006 Male 243 lb 8/15/2006 Pharmacist United States
Primary
Secondary
Concomitant
Haemolytic Anaemia Hospitalization 9/21/2006 Male 150 lb 10/19/2006 Pharmacist United States
Primary
Concomitant
Renal Failure Acute Hospitalization 4/9/2002 65 Male 254 lb 3/3/2005 United States
Primary
Concomitant
Diverticular Perforation Hospitalization 10/17/2006 66 Female 1/23/2007 Physician Sweden
Primary
Concomitant
Reiter's Syndrome Hospitalization 4/5/2006 66 Male 1/26/2007 Sweden
Primary
Concomitant
Rash Generalised Hospitalization 11/27/2006 Male 216 lb 12/22/2006 Pharmacist United States
Primary
Secondary
Concomitant
Vascular Dementia Hospitalization 7/6/2006 Male 170 lb 2/15/2007 Netherlands
Primary
Concomitant
Platelet Count Increased Hospitalization 11/24/2006 69 Male 154 lb 2/12/2007 Romania
Primary
Secondary
Concomitant
Hypertension Hospitalization 1/25/2007 Male 173 lb 3/1/2007 Physician Germany
Primary
Concomitant
Vitreous Haemorrhage Other Serious 83 Male 3/5/2007 United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 10/15/2006 66 Female 3/12/2007 Physician Sweden
Primary
Concomitant
Implantable Defibrillator Insertion Hospitalization 1/25/2007 Male 173 lb 3/27/2007 Physician Germany
Primary
Concomitant
Renal Failure Chronic Other Serious 3/12/2007 Male 190 lb 3/27/2007 Consumer United States
Primary
Concomitant
Urticaria Other Serious 1/20/2007 63 Male 337 lb 1/25/2007 Pharmacist United States
Primary
Concomitant
Condition Aggravated Hospitalization 2/26/2007 57 Male 184 lb 3/28/2007 Pharmacist United States
Primary
Secondary
Concomitant
Dyspepsia Hospitalization 3/26/2007 Female 198 lb 4/5/2007 United States
Primary
Secondary
Concomitant
Myocardial Ischaemia Hospitalization 9/28/2006 Female 115 lb 4/11/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Required Intervention 3/6/2007 62 4/17/2007 Pharmacist United States
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 8/28/2006 72 Male 2/21/2007 United States
Primary
Concomitant
Drug Ineffective Hospitalization 3/4/2006 56 Female 120 lb 12/13/2006 Pharmacist United States
Primary
Concomitant
Syncope Hospitalization 5/1/2006 82 Male 140 lb 12/13/2006 United States
Primary
Concomitant
Contusion Hospitalization 8/7/2006 89 Female 123 lb 12/13/2006 Consumer United States
Primary
Concomitant
Urticaria Other Serious 10/1/2006 77 Female 134 lb 4/30/2007 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Hospitalization 78 Male 4/30/2007 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Life Threatening 2/1/2007 Female 6/15/2007 Physician Norway
Primary
Concomitant
Rash Required Intervention 7/9/2007 47 Female 188 lb 7/18/2007 Pharmacist United States
Primary
Concomitant
Hypotension Hospitalization 7/6/2007 50 Male 8/16/2007 Physician Philippines
Primary
Secondary
Concomitant
Drug Interaction Other Serious 66 Male 8/16/2007 Sweden
Primary
Concomitant
Interacting
Blood Glucose Increased Hospitalization 7/17/2007 83 Male 8/17/2007 Consumer United States
Primary
Concomitant
Death Hospitalization 7/30/2007 Male 8/24/2007 Physician United States
Primary
Concomitant
Rhabdomyolysis Other Serious 72 Male 159 lb 8/31/2007 Other Health Professional France
Primary
Concomitant
Interacting
Hypotension Hospitalization 7/6/2007 50 Male 9/4/2007 Other Health Professional Philippines
Primary
Secondary
Concomitant
Chest Pain Hospitalization 6/15/2007 79 Female 9/5/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Orthostatic Hypotension Hospitalization 5/1/2007 90 Female 9/6/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Muscle Spasticity Other Serious 1/1/2007 Female 177 lb 9/10/2007 United States
Primary
Secondary
Concomitant
Drug Ineffective Hospitalization 1/22/2005 76 Male 185 lb 9/7/2007 United States
Primary
Concomitant
Muscle Spasms Hospitalization 3/1/2007 Male 192 lb 9/15/2007 Pharmacist Netherlands
Primary
Secondary
Concomitant
Sepsis Hospitalization 2/6/2006 Male 128 lb 9/21/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hypotension Life Threatening 7/18/2007 47 Female 126 lb 10/5/2007 Physician United States
Primary
Secondary
Concomitant
Breath Odour 7/1/2007 Male 8/6/2007 Pharmacist United States
Primary
Concomitant
Ventricular Extrasystoles Life Threatening 7/18/2007 47 Female 126 lb 10/26/2007 Physician United States
Primary
Secondary
Concomitant
Nausea Life Threatening 7/18/2007 47 Female 11/6/2007 United States
Primary
Secondary
Concomitant
Erythema Hospitalization 1/1/2007 87 Female 126 lb 1/2/2008 Other Health Professional Finland
Primary
Concomitant
Weight Decreased Life Threatening 2/14/2007 Female 2/1/2008 Physician Norway
Primary
Concomitant
Hypotension Life Threatening 7/18/2007 47 Female 126 lb 2/6/2008 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 11/28/2007 61 Female 2/8/2008 Sweden
Primary
Concomitant
Small Intestinal Haemorrhage Other Serious 10/1/2006 83 Male 11/29/2007 Consumer United States
Primary
Concomitant
Troponin Increased Hospitalization 2/20/2008 62 Female 3/6/2008 Sweden
Primary
Concomitant
Vomiting 1/30/2008 66 Female 170 lb 3/11/2008 Physician United States
Primary
Concomitant
Troponin Increased Hospitalization 2/20/2008 62 Female 3/19/2008 Sweden
Primary
Concomitant
Rhabdomyolysis Other Serious 8/9/2006 72 Male 158 lb 2/21/2008 Pharmacist United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 11/28/2007 61 Female 3/28/2008 Sweden
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 5/7/2008 62 Female 6/6/2008 Sweden
Primary
Concomitant
Oral Intake Reduced Hospitalization 86 Male 6/2/2008 Other Health Professional United States
Primary
Secondary
Polyneuropathy Other Serious 60 Male 5/30/2008 Physician Sweden
Primary
Concomitant
Nausea Hospitalization 86 Male 6/16/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 1/1/2004 Male 6/27/2008 Consumer
Primary
Concomitant
Transaminases Increased Other Serious 6/3/2008 79 Female 7/7/2008 Consumer Italy
Primary
Concomitant
Retinal Detachment Hospitalization Male 7/21/2008 Consumer United States
Primary
Secondary
Concomitant
Flushing 4/19/2008 Male 200 lb 8/27/2008 Consumer United States
Primary
Concomitant
Wound Infection Staphylococcal Hospitalization 5/22/2008 48 Male 133 lb 9/9/2008 Sweden
Primary
Concomitant
Psoriasis 6/1/2008 Male 240 lb 9/12/2008 Physician United States
Primary
Concomitant
Troponin Increased Hospitalization 2/20/2008 62 Female 9/23/2008 Sweden
Primary
Concomitant
Febrile Neutropenia Hospitalization 9/25/2008 Female 10/10/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Sciatica Other Serious 8/7/2007 74 Female 198 lb 10/10/2008 Physician Australia
Primary
Concomitant
Febrile Neutropenia Hospitalization 9/25/2008 Female 10/24/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 9/25/2008 Female 11/26/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 11/12/2008 Female 11/26/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Medication Residue 11/1/2007 Female 12/4/2008 Pharmacist United States
Primary
Concomitant
Pneumonia 1/1/2006 Female 125 lb 12/12/2008 United States
Primary
Concomitant
Product Quality Issue 9/17/2008 Male 225 lb 12/12/2008 United States
Primary
Concomitant
Haemoglobin Decreased 9/1/2008 Female 250 lb 12/12/2008 United States
Primary
Secondary
Concomitant
Product Quality Issue Hospitalization 8/1/2008 73 Male 150 lb 12/22/2008 Consumer United States
Primary
Concomitant
Rash Other Serious 1/21/2009 51 Female 150 lb 2/4/2009 Physician Romania
Primary
Concomitant
Syncope Hospitalization 3/3/2008 58 Male 3/30/2009 Consumer United States
Primary
Secondary
Concomitant
Dry Mouth 2/1/2009 Male 4/22/2009 Consumer
Primary
Concomitant
Febrile Neutropenia Hospitalization 11/12/2008 Female 4/22/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Syncope Required Intervention 89 Female 5/7/2009 United States
Primary
Concomitant
Myocardial Infarction Hospitalization 8/19/2008 Female 213 lb 5/23/2009 Other Health Professional United States
Primary
Concomitant
International Normalised Ratio Increased 4/14/2009 73 Male 167 lb 5/14/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Percutaneous Coronary Intervention Hospitalization 3/23/2009 Male 6/2/2009 Consumer United States
Primary
Secondary
Concomitant
Hypotension Hospitalization 5/19/2009 Male 6/2/2009 Other Health Professional Australia
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 75 Female 5/27/2009 Consumer United States
Primary
Concomitant
Percutaneous Coronary Intervention Hospitalization 3/23/2009 Male 6/9/2009 Consumer United States
Primary
Secondary
Concomitant
Temporal Arteritis Other Serious 1/1/2009 Female 102 lb 5/30/2009 Consumer United States
Primary
Concomitant
Myocardial Infarction Hospitalization 3/23/2009 Male 6/16/2009 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 8/3/2003 Male 139 lb 6/23/2009 Physician Sweden
Primary
Secondary
Concomitant
Ureteric Obstruction Hospitalization 12/3/2003 Female 6/30/2009 Physician Sweden
Primary
Secondary
Concomitant
Myocardial Ischaemia Other Serious 9/1/2005 70 Female 204 lb 7/2/2009 Physician United States
Primary
Concomitant
Vomiting Hospitalization 47 Female 163 lb 7/7/2009 Lawyer United States
Primary
Concomitant
Transplant Rejection Other Serious 10/1/2008 53 Male 247 lb 7/24/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Suicide Attempt Hospitalization 7/13/2009 82 Female 143 lb 8/5/2009 Germany
Primary
Secondary
Suicide Attempt Other Serious 62 Male 8/21/2009 Other Health Professional Netherlands
Primary
Concomitant
Suicide Attempt Other Serious 62 Male 8/26/2009 Other Health Professional Netherlands
Primary
Concomitant
Accidental Needle Stick 7/17/2007 Female 170 lb 9/11/2009 Consumer United States
Primary
Concomitant
Drug Withdrawal Syndrome Life Threatening 8/10/2009 76 Male 198 lb 9/21/2009 Other Health Professional Netherlands
Primary
Concomitant
Drug Withdrawal Syndrome Life Threatening 8/10/2009 76 Male 198 lb 9/22/2009 Physician Netherlands
Primary
Concomitant
Musculoskeletal Discomfort Life Threatening 8/10/2009 76 Male 198 lb 9/28/2009 Physician Netherlands
Primary
Concomitant
Stress Ulcer Hospitalization 7/14/2009 53 Male 9/28/2009 Physician China
Primary
Secondary
Concomitant
Muscle Rupture Hospitalization 69 Male 10/8/2009 Other Health Professional Netherlands
Primary
Concomitant
Interacting
Osteoporosis Other Serious 11/1/2008 Male 159 lb 11/2/2009 Brazil
Primary
Concomitant
Muscle Rupture Hospitalization 69 Male 11/16/2009 Other Health Professional Netherlands
Primary
Concomitant
Interacting
Temporal Arteritis Other Serious 1/1/2009 Female 102 lb 12/1/2009 Consumer United States
Primary
Concomitant
Renal Failure Chronic Other Serious Male 159 lb 5/6/2010 Physician United States
Primary
Concomitant
Respiratory Failure Hospitalization 70 Female 204 lb 5/14/2010 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 4/17/2010 54 Female 5/21/2010 Consumer Netherlands
Primary
Concomitant
Hyperglycaemia Hospitalization 5/1/2010 80 Male 6/4/2010 Physician Germany
Primary
Concomitant
Paraesthesia Other Serious 1/1/2008 54 Female 179 lb 6/16/2010 Lawyer United States
Primary
Concomitant
Hyperglycaemia Other Serious 5/1/2010 80 Female 176 lb 6/23/2010 Physician Germany
Primary
Concomitant
Protein Urine Present Other Serious 5/1/2010 80 Female 176 lb 6/25/2010 Physician Germany
Primary
Concomitant
Vision Blurred Other Serious 1/4/2008 72 Male 7/13/2010 Lawyer United States
Primary
Secondary
Concomitant
Myalgia Other Serious 70 Female 7/22/2010 Pharmacist United States
Primary
Secondary
Urinary Tract Infection 1/1/2008 43 Male 240 lb 7/23/2010 Consumer United States
Primary
Concomitant
Skin Discolouration Other Serious 1/1/2008 51 Male 247 lb 7/27/2010 Lawyer United States
Primary
Concomitant
Myocardial Infarction Hospitalization 10/14/2002 41 Female 165 lb 7/26/2010 Lawyer United States
Primary
Secondary
Concomitant
Vascular Dementia Hospitalization 3/18/2007 77 Female 214 lb 8/4/2010 Physician United States
Primary
Concomitant
Paraesthesia Other Serious 7/1/2008 54 Female 179 lb 8/12/2010 Physician United States
Primary
Concomitant
Visual Impairment Other Serious 1/1/2010 64 Male 300 lb 8/16/2010 Consumer United States
Primary
Concomitant
Vascular Dementia Hospitalization 3/18/2007 77 Female 214 lb 8/25/2010 Physician United States
Primary
Concomitant
Loss Of Consciousness Life Threatening 3/29/2010 71 Male 9/8/2010 Other Health Professional Japan
Primary
Concomitant
Vision Blurred Other Serious 1/1/2008 72 Male 214 lb 9/13/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Drug Interaction Other Serious 64 Female 11/2/2010 United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2008 72 Male 214 lb 11/8/2010 Lawyer United States
Primary
Secondary
Concomitant

Drug Data