Isosorbide Mononitrate combined with Metformin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Visual Acuity Reduced Other Serious 79 Male 1/12/2006 Consumer United States
Primary
Secondary
Concomitant
Ulnar Nerve Injury Hospitalization 8/4/1999 56 Male 300 lb 1/17/2006 Physician United States
Primary
Concomitant
Ischaemic Stroke Hospitalization 9/1/2004 77 Female 190 lb 2/16/2006 Physician United States
Primary
Concomitant
Pharmaceutical Product Complaint Hospitalization 1/6/2006 51 Female 2/10/2006 United Kingdom
Primary
Concomitant
Lethargy Hospitalization 5/21/2005 Female 137 lb 3/10/2006 Other Health Professional United Kingdom
Primary
Concomitant
Ventricular Hypertrophy Hospitalization 6/1/2000 66 Female 157 lb 3/31/2006 Physician United States
Primary
Concomitant
Rectal Haemorrhage Other Serious 3/11/2006 72 Male 4/12/2006 Consumer United States
Primary
Concomitant
Tumour Invasion Hospitalization 1/1/2002 63 Female 4/4/2006 Consumer Hungary
Primary
Concomitant
Tumour Invasion Hospitalization 1/1/2002 63 Female 4/6/2006 Consumer Hungary
Primary
Secondary
Concomitant
Ulnar Nerve Injury Hospitalization 8/4/1999 56 Male 300 lb 4/24/2006 Physician United States
Primary
Concomitant
Weight Increased 9/14/2005 63 Female 225 lb 4/14/2006 Physician United States
Primary
Concomitant
Urinary Tract Infection Death 1/25/2006 72 Female 150 lb 5/1/2006 Other Health Professional Czech Republic
Primary
Secondary
Concomitant
Syncope Other Serious 4/1/2006 67 Female 5/11/2006 Consumer United States
Primary
Concomitant
Arthralgia Other Serious 4/3/2006 49 Female 181 lb 5/11/2006 Consumer United Kingdom
Primary
Concomitant
Ulnar Nerve Injury Hospitalization 8/4/1999 56 Male 300 lb 5/15/2006 Physician United States
Primary
Concomitant
Anosmia Other Serious 1/29/2006 50 Male 35 lb 5/17/2006 Consumer United Kingdom
Primary
Concomitant
Pulmonary Oedema Life Threatening 10/20/2004 72 Male 187 lb 5/11/2006 Physician India
Primary
Concomitant
Tumour Invasion Hospitalization 1/1/2002 63 Female 5/22/2006 Consumer Hungary
Primary
Secondary
Concomitant
Hepatitis Acute Other Serious 6/5/2006 71 Male 6/29/2006 Other Health Professional Italy
Primary
Concomitant
Urticaria Generalised Other Serious 6/21/2006 62 Female 7/14/2006 Consumer United States
Primary
Concomitant
Lethargy Other Serious 5/17/2005 Female 137 lb 8/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Hospitalization 7/26/2006 64 Male 205 lb 8/17/2006 Consumer United States
Primary
Secondary
Concomitant
Vomiting Life Threatening 7/4/2006 73 Female 8/16/2006 United Kingdom
Primary
Secondary
Concomitant
Vomiting Life Threatening 7/4/2006 73 Female 8/23/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Somnolence Required Intervention 70 Male 170 lb 8/29/2006 Greece
Primary
Secondary
Concomitant
Rash Erythematous Other Serious 10/6/2006 62 Female 198 lb 11/14/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rash Erythematous Disability 10/6/2006 62 Female 198 lb 11/17/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Injection Site Pain 5/1/2006 Female 12/20/2006 Pharmacist United States
Primary
Concomitant
Low Density Lipoprotein Decreased Other Serious 62 Male 11/28/2006 United States
Primary
Concomitant
Pain In Extremity Other Serious 85 Female 5/15/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Nasopharyngitis Other Serious 1/1/2004 61 Male 10/1/2007 Lawyer Brazil
Primary
Secondary
Concomitant
Tendon Rupture Hospitalization 3/1/2008 75 Male 165 lb 6/17/2008 Pharmacist China
Primary
Concomitant
Tendon Rupture Hospitalization 3/1/2008 75 Male 165 lb 6/23/2008 Pharmacist China
Primary
Concomitant
Urinary Tract Infection Hospitalization 2/28/2008 89 Male 6/10/2008
Primary
Secondary
Concomitant
Chest Pain Hospitalization 1/1/2008 Female 9/8/2008 Consumer United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 6/1/2003 73 Female 3/16/2009 United States
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 6/1/2003 73 Female 3/20/2009 United States
Primary
Secondary
Concomitant
Renal Failure Acute Death 2/23/2009 Female 3/26/2009 Physician Norway
Primary
Concomitant
Interacting
Myocardial Infarction Other Serious 75 Female 5/27/2009 Consumer United States
Primary
Concomitant
Temporal Arteritis Other Serious 1/1/2009 Female 102 lb 5/30/2009 Consumer United States
Primary
Concomitant
Pulmonary Congestion Other Serious 65 Male 154 lb 6/17/2009 Portugal
Primary
Concomitant
Hand Deformity Other Serious 4/1/2009 Male 7/30/2009 Other Health Professional United Kingdom
Primary
Concomitant
Social Problem Death 82 Female 7/22/2009 Lawyer United States
Primary
Concomitant
Toxic Skin Eruption Other Serious 6/1/2009 Male 8/12/2009 Portugal
Primary
Concomitant
Feeling Abnormal 7/27/2008 Female 8/21/2009 United States
Primary
Concomitant
Pneumonia Hospitalization 10/11/2008 Male 10/1/2009 Consumer United Kingdom
Primary
Concomitant
Muscle Rupture Hospitalization 69 Male 10/8/2009 Other Health Professional Netherlands
Primary
Concomitant
Interacting
Muscle Rupture Hospitalization 69 Male 11/16/2009 Other Health Professional Netherlands
Primary
Concomitant
Interacting
Sleep Apnoea Syndrome Hospitalization 4/28/2009 55 Female 11/25/2009 United Kingdom
Primary
Concomitant
Stress Ulcer Hospitalization 7/14/2008 53 Male 12/4/2009 China
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 7/14/2008 53 Male 1/4/2010 China
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 7/13/2008 53 Male 1/7/2010 China
Primary
Secondary
Concomitant
Paraesthesia Oral Hospitalization 57 Male 1/26/2010 Norway
Primary
Concomitant
Cardiogenic Shock Death 5/10/2009 66 Male 170 lb 1/29/2010 Physician Brazil
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/16/2010 75 Female 2/12/2010 Physician Denmark
Primary
Concomitant
Urinary Tract Obstruction Hospitalization 76 Male 2/19/2010 United States
Primary
Concomitant
Epilepsy Other Serious 2/23/2010 88 Male 3/25/2010 Other Health Professional United Kingdom
Primary
Concomitant
Epilepsy Other Serious 2/23/2010 88 Male 3/26/2010 Other Health Professional United Kingdom
Primary
Concomitant
Sopor Hospitalization 12/29/2009 80 Female 4/8/2010 Pharmacist Italy
Primary
Secondary
Concomitant
Pancreatic Neoplasm Hospitalization 7/31/2008 70 Male 164 lb 6/3/2010 Physician United States
Primary
Secondary
Concomitant
Sinus Bradycardia Life Threatening 4/13/2010 63 Male 154 lb 6/17/2010 Other Health Professional United Kingdom
Primary
Concomitant
Tongue Discolouration Hospitalization 5/3/2010 74 Female 121 lb 6/30/2010 Consumer United States
Primary
Concomitant
Impaired Gastric Emptying Hospitalization 3/17/2010 41 Male 273 lb 7/21/2010 Physician Denmark
Primary
Concomitant
Pruritus Generalised 5/19/2010 82 Male 183 lb 8/16/2010 Consumer United States
Primary
Concomitant
Death Death 7/15/2010 64 Male 218 lb 8/17/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Medication Residue 1/1/2010 60 Male 293 lb 8/20/2010 Consumer United States
Primary
Concomitant
Ventricular Arrhythmia Death 7/15/2010 64 Male 218 lb 8/27/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Flushing 10/22/2009 65 Male 210 lb 8/28/2010 United States
Primary
Concomitant
Paraesthesia Other Serious 1/1/2010 75 Female 8/29/2010 Consumer United States
Primary
Concomitant
Pancreatic Neoplasm Hospitalization 7/31/2008 70 Male 164 lb 9/2/2010 Physician United States
Primary
Secondary
Concomitant
Pancreatitis Acute Other Serious 7/13/2010 52 Male 298 lb 9/7/2010 Physician United States
Primary
Concomitant
Renal Impairment Other Serious 6/23/2009 70 Male 165 lb 9/13/2010 Physician United States
Primary
Concomitant
Interacting
Renal Impairment Hospitalization 6/23/2009 70 Male 165 lb 9/13/2010 Consumer United States
Primary
Secondary
Concomitant
Schizophrenia Other Serious 8/1/2010 52 Male 229 lb 9/15/2010 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 12/7/1999 53 Male 9/17/2010 United States
Primary
Concomitant
Diarrhoea 11/17/2009 76 Male 9/18/2010 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/1999 53 Male 400 lb 9/21/2010 United States
Primary
Concomitant
Proteus Infection Hospitalization 7/31/2008 70 Male 164 lb 9/21/2010 Physician United States
Primary
Secondary
Concomitant
Renal Impairment Other Serious 6/23/2009 70 Male 165 lb 9/22/2010 Physician United States
Primary
Secondary
Concomitant
Interacting
Palpitations Other Serious 7/23/2010 74 Male 163 lb 9/22/2010 Other Health Professional United Kingdom
Primary
Concomitant
Renal Impairment Hospitalization 6/23/2009 70 Male 165 lb 9/23/2010 Consumer United States
Primary
Secondary
Concomitant
Sinus Bradycardia Life Threatening 4/13/2010 63 Male 154 lb 9/30/2010 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Chronic Hospitalization 9/29/2010 55 Female 10/5/2010 Other Health Professional Italy
Primary
Concomitant
Proteus Infection Hospitalization 7/31/2008 70 Male 164 lb 10/6/2010 Physician United States
Primary
Concomitant
Drug Administration Error Death 2/10/2010 76 Female 203 lb 10/7/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ventricular Tachycardia Other Serious 11/1/2007 58 Male 137 lb 10/7/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Intentional Overdose Death 2/10/2010 76 Female 203 lb 10/7/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Intentional Overdose Death 2/10/2010 76 Female 203 lb 10/7/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Schizophrenia Other Serious 1/1/2010 51 Male 242 lb 10/7/2010 Consumer United States
Primary
Concomitant
Sudden Cardiac Death Death 2/10/2010 76 Female 203 lb 10/6/2010 Other Health Professional
Primary
Secondary
Concomitant
Renal Failure Chronic Hospitalization 9/29/2010 55 Female 10/15/2010 Other Health Professional Italy
Primary
Concomitant
Renal Impairment Other Serious 6/23/2009 70 Male 165 lb 10/19/2010 Physician Netherlands
Primary
Secondary
Concomitant
Interacting
Proteus Infection Hospitalization 7/31/2008 70 Male 164 lb 10/21/2010 Physician United States
Primary
Concomitant
Renal Impairment Other Serious 6/23/2009 70 Male 165 lb 11/10/2010 Physician Netherlands
Primary
Secondary
Concomitant
Interacting
Flushing 10/1/2010 67 Male 280 lb 11/16/2010 Consumer United States
Primary
Concomitant
Wound Infection Other Serious 10/1/2010 65 Male 220 lb 11/29/2010 Consumer United States
Primary
Concomitant
Weight Increased 8/29/2010 11/30/2010 Consumer United States
Primary
Concomitant
Renal Failure Acute Other Serious 12/15/2006 66 Male 219 lb 12/16/2010 Other Health Professional United Kingdom
Primary
Concomitant
Jaundice Hospitalization 11/29/2010 71 Female 1/6/2011 Other Health Professional
Primary
Secondary
Concomitant
Myopathy Hospitalization 2/3/2011 69 Male 2/22/2011 Other Health Professional United Kingdom
Primary
Concomitant
Diarrhoea Hospitalization 1/11/2011 76 Male 2/28/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Chest Discomfort Life Threatening 1/11/2011 76 Male 2/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Troponin T Increased Hospitalization 1/11/2011 76 Male 2/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/11/2011 76 Male 3/9/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Acute Myocardial Infarction Hospitalization 1/11/2011 76 Male 2/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cardiac Disorder Hospitalization 64 Female 193 lb 3/11/2011 Physician United States
Primary
Concomitant
Myalgia Disability 5/1/2010 68 Female 251 lb 3/21/2011 Physician United Kingdom
Primary
Concomitant
Liver Function Test Abnormal Other Serious 11/12/2010 67 Male 3/28/2011 Consumer United Kingdom
Primary
Concomitant
Diarrhoea Life Threatening 1/11/2011 76 Male 3/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Diarrhoea Life Threatening 1/11/2011 76 Male 3/30/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/11/2011 76 Male 3/30/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Haemorrhage Hospitalization 87 Male 4/7/2011 United States
Primary
Concomitant
Acute Myocardial Infarction Life Threatening 1/11/2011 76 Male 3/29/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Muscle Spasms Hospitalization 1/29/2011 45 Female 175 lb 4/4/2011 Consumer United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/13/2011 76 Male 4/4/2011 Other Health Professional Denmark
Primary
Secondary
Concomitant
Malaise Hospitalization 6/23/2009 70 Male 165 lb 4/15/2011 Physician Netherlands
Primary
Secondary
Concomitant
Confusional State Other Serious 11/1/2007 58 Male 137 lb 4/18/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 1/11/2011 76 Male 4/18/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Malaise Hospitalization 6/23/2009 70 Male 165 lb 4/19/2011 Physician Netherlands
Primary
Secondary
Concomitant
Acute Myocardial Infarction Life Threatening 1/11/2011 76 Male 4/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Headache Other Serious 81 Female 4/25/2011 United States
Primary
Secondary
Concomitant
Circulatory Collapse Other Serious 3/30/2011 81 Male 256 lb 5/5/2011 Other Health Professional Netherlands
Primary
Concomitant
Guillain-barre Syndrome Hospitalization 2/26/2008 55 Male 197 lb 5/23/2011 Other Health Professional United States
Primary
Concomitant
Muscle Spasms Death 2/11/2011 49 Female 238 lb 6/1/2011 Other Health Professional United Kingdom
Primary
Concomitant
Malaise Hospitalization 6/23/2009 70 Male 165 lb 6/22/2011 Physician Netherlands
Primary
Secondary
Concomitant
Peripheral Coldness Life Threatening 2/11/2011 49 Female 238 lb 9/7/2011 Other Health Professional United Kingdom
Primary
Concomitant
Diarrhoea Other Serious 8/19/2011 84 Male 176 lb 9/12/2011 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 10/30/2011 78 Male 11/23/2011 United Kingdom
Primary
Concomitant
Proteus Infection Hospitalization 7/31/2008 70 Male 164 lb 11/25/2011 United States
Primary
Concomitant
Treatment Noncompliance Hospitalization 11/1/2011 70 Female 195 lb 12/15/2011 Pharmacist United States
Primary
Secondary
Concomitant
Pruritus Generalised Other Serious Female 12/27/2011 Consumer United States
Primary
Secondary
Concomitant
Pruritus Generalised Other Serious Female 12/27/2011 Physician United States
Primary
Secondary
Concomitant
Erythema Hospitalization Male 3/14/2012 Consumer United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 10/30/2011 78 Male 5/8/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Pancreatic Carcinoma Other Serious 10/1/2011 85 Female 6/27/2012 Physician United States
Primary
Concomitant
Cerebrovascular Accident Hospitalization 10/30/2011 78 Male 8/23/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Breast Disorder Male Other Serious 87 Male 9/28/2012 Other Health Professional It
Primary
Concomitant
Hypoglycaemia Hospitalization 5/23/2012 60 Male 12/27/2012 Consumer Us
Primary
Secondary
Concomitant
Pulmonary Congestion Hospitalization 6/27/2012 64 Female 9/17/2012 Physician Cn
Primary
Concomitant
Drug Dispensing Error Hospitalization 7/4/2011 74 Female 111 lb 9/19/2012 Physician Hk
Primary
Secondary
Concomitant
Neoplasm Malignant Other Serious 2007 60 Female 236 lb 9/24/2012 Consumer Us
Primary
Secondary
Concomitant
Pain Other Serious 2010 65 Female 160 lb 12/2/2012 Consumer Us
Primary
Secondary
Concomitant
Incorrect Dose Administered 49 Male 324 lb 10/2/2012 Consumer Us
Primary
Concomitant
Fungal Infection 65 Male 227 lb 11/15/2012 Consumer Us
Primary
Secondary
Concomitant
Angina Pectoris Hospitalization 5/27/2012 74 Male 245 lb 11/19/2012 Physician Gb
Primary
Concomitant
Colitis Microscopic Other Serious 70 Female 159 lb 11/21/2012 Physician Gb
Primary
Secondary
Death Other Serious 11/6/2012 77 Female 12/14/2012 Consumer Country Not Specified
Primary
Concomitant
Colitis Microscopic Other Serious 70 Female 159 lb 12/31/2012 Physician Gb
Primary
Secondary
Colitis Microscopic Other Serious 70 Female 159 lb 12/20/2012 Physician Gb
Primary
Secondary
Colitis Microscopic Other Serious 70 Female 159 lb 12/11/2012 Consumer Gb
Primary
Secondary

Drug Data