Isosorbide Mononitrate combined with Metformin Hcl

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pneumonia Hospitalization 6/6/2002 89 Female 141 lb 1/26/2006 United Kingdom
Primary
Concomitant
Muscular Weakness Other Serious 10/18/2005 Male 160 lb 12/14/2005 Pharmacist United States
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 2/23/2006 United States
Primary
Concomitant
Eye Operation Other Serious 1/6/2006 51 Female 2/20/2006 Pharmacist United Kingdom
Primary
Concomitant
Tachycardia Life Threatening 70 Male 170 lb 8/7/2006 Pharmacist Greece
Primary
Secondary
Spinal Osteoarthritis Required Intervention 70 Male 170 lb 8/28/2006 Consumer Greece
Primary
Secondary
Concomitant
Somnolence Life Threatening 70 Male 8/23/2006 Germany
Primary
Secondary
Concomitant
Urine Output Decreased Required Intervention 70 Male 170 lb 8/29/2006 Greece
Primary
Secondary
Concomitant
Somnolence Required Intervention 70 Male 170 lb 8/29/2006 Consumer Greece
Primary
Secondary
Concomitant
Angina Pectoris Life Threatening 5/1/2003 63 Male 9/5/2006 United Kingdom
Primary
Concomitant
Syncope Hospitalization 7/26/2006 64 Male 205 lb 9/6/2006 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2005 Male 9/11/2006 Brazil
Primary
Secondary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2005 Male 10/11/2006 Brazil
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2005 70 Male 10/20/2006 Brazil
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 8/11/2006 64 Male 11/2/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Asthma Other Serious 1/21/2007 42 Male 1/31/2007 Consumer United Kingdom
Primary
Concomitant
Asthma Other Serious 1/21/2007 42 Male 2/2/2007 Consumer United Kingdom
Primary
Concomitant
Loss Of Consciousness Other Serious 12/14/2005 Female 201 lb 2/9/2007 Physician United Kingdom
Primary
Concomitant
Tremor Hospitalization 11/1/2006 70 Male 3/8/2007 Consumer United States
Primary
Concomitant
Loss Of Consciousness Other Serious 12/14/2005 Female 201 lb 3/14/2007 Physician United Kingdom
Primary
Concomitant
Urticaria Other Serious 1/20/2007 63 Male 337 lb 1/25/2007 Pharmacist United States
Primary
Concomitant
Weight Increased Hospitalization 1/21/2007 42 Male 4/9/2007 Physician United Kingdom
Primary
Concomitant
Tremor Hospitalization 11/1/2006 70 Male 4/27/2007 Consumer United States
Primary
Concomitant
Dyspnoea Hospitalization 4/24/2007 72 Male 152 lb 5/11/2007 Consumer United States
Primary
Secondary
Concomitant
Wheezing Other Serious 1/1/2007 Male 254 lb 5/17/2007 Physician United Kingdom
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 3/17/2007 Male 225 lb 5/10/2007 Pharmacist United States
Primary
Concomitant
Dyspnoea Other Serious 1/24/2007 69 Female 5/18/2007 Consumer United Kingdom
Primary
Concomitant
Diverticulum Intestinal Haemorrhagic Hospitalization 2/28/2006 80 Male 12/13/2006 Physician United States
Primary
Concomitant
Pain In Extremity Other Serious 85 Female 5/22/2007 United Kingdom
Primary
Secondary
Concomitant
Spinal Osteoarthritis Hospitalization 70 Male 170 lb 5/24/2007 Physician United States
Primary
Concomitant
Rash Generalised Other Serious 4/18/2007 Female 161 lb 6/18/2007 Consumer United Kingdom
Primary
Concomitant
Tearfulness Other Serious 3/26/2007 69 Female 116 lb 6/18/2007 Other Health Professional United Kingdom
Primary
Concomitant
Rash Generalised Other Serious 4/18/2007 Female 161 lb 6/22/2007 Consumer United Kingdom
Primary
Concomitant
Nephrolithiasis Hospitalization 6/14/2007 46 Male 210 lb 6/27/2007 Consumer United Kingdom
Primary
Concomitant
Rash Required Intervention 7/9/2007 47 Female 188 lb 7/18/2007 Pharmacist United States
Primary
Concomitant
Orthostatic Hypotension Hospitalization 6/7/2007 89 Female 7/26/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/21/2007 42 Male 7/27/2007 Physician United Kingdom
Primary
Concomitant
Orthostatic Hypotension Hospitalization 6/7/2007 89 Female 7/24/2007 Other Health Professional United Kingdom
Primary
Concomitant
Orthostatic Hypotension Hospitalization 6/7/2007 89 Female 7/27/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Orthostatic Hypotension Hospitalization 89 Female 7/30/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Orthostatic Hypotension Hospitalization 6/7/2007 89 Female 7/18/2007 United Kingdom
Primary
Secondary
Concomitant
Normochromic Normocytic Anaemia Other Serious 75 8/8/2007 Physician United Kingdom
Primary
Concomitant
Drug Interaction Other Serious 66 Male 8/16/2007 Sweden
Primary
Concomitant
Interacting
Weight Increased Other Serious 1/1/2006 53 Female 297 lb 8/13/2007 Consumer United States
Primary
Concomitant
Normochromic Normocytic Anaemia Other Serious 7/26/2007 75 Female 119 lb 8/23/2007 Physician United Kingdom
Primary
Concomitant
Vision Blurred Required Intervention 8/15/2007 68 Male 9/7/2007 United Kingdom
Primary
Concomitant
Blood Glucose Fluctuation Other Serious 8/28/2007 60 Male 220 lb 10/16/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pain In Extremity Other Serious 5/1/2007 68 Male 198 lb 10/22/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Somnolence Other Serious 11/8/2007 Female 263 lb 11/29/2007 Other Health Professional United Kingdom
Primary
Concomitant
Tachycardia Hospitalization Female 12/5/2007 Brazil
Primary
Concomitant
Dyspnoea Hospitalization 4/24/2007 72 Male 152 lb 12/13/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Wheezing Other Serious 1/1/2007 Male 254 lb 12/17/2007 Physician United Kingdom
Primary
Concomitant
International Normalised Ratio Decreased Other Serious 11/1/2007 Female 295 lb 1/29/2008 Physician United States
Primary
Concomitant
Interacting
Renal Failure Acute Life Threatening 7/15/2003 Male 267 lb 2/21/2008 Australia
Primary
Secondary
Concomitant
Intermittent Claudication Other Serious Male 3/17/2008 Consumer United Kingdom
Primary
Concomitant
Constipation Hospitalization 3/23/2008 70 Male 4/10/2008 Physician Sweden
Primary
Concomitant
Rash Generalised Other Serious 4/18/2007 Female 161 lb 4/18/2008 Consumer United Kingdom
Primary
Concomitant
Constipation Hospitalization 3/23/2008 70 Male 4/18/2008 Physician Sweden
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 4/18/2008 United States
Primary
Concomitant
Myocardial Ischaemia Life Threatening 8/30/2005 Male 139 lb 4/22/2008 United States
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 4/30/2008 United States
Primary
Concomitant
Bradycardia Hospitalization 11/29/2007 Female 196 lb 5/8/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 5/9/2008 United States
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 5/15/2008 United States
Primary
Concomitant
Haemoglobin Decreased Hospitalization 3/23/2008 70 Male 5/20/2008 Physician Sweden
Primary
Concomitant
Constipation Hospitalization 3/23/2008 70 Male 5/23/2008 Physician Sweden
Primary
Concomitant
Urinary Tract Infection Hospitalization 2/28/2008 89 Male 5/23/2008 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Hospitalization 2/28/2008 89 Male 5/20/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Bradycardia Hospitalization 11/29/2007 Female 196 lb 6/4/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 2/28/2008 89 Male 6/10/2008
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 8/30/2005 Male 139 lb 6/27/2008 United States
Primary
Concomitant
Constipation Hospitalization 3/1/2008 70 Male 7/21/2008 Physician Sweden
Primary
Concomitant
Oedema Peripheral 7/2/2008 69 Male 8/4/2008 Consumer United States
Primary
Concomitant
Tenderness 12/1/2007 55 Female 205 lb 7/7/2008 Consumer United States
Primary
Concomitant
Jaundice Cholestatic Hospitalization 3/23/2008 47 Male 328 lb 8/13/2008 Pharmacist United States
Primary
Concomitant
Flushing 4/19/2008 Male 200 lb 8/27/2008 Consumer United States
Primary
Concomitant
Ulcer 1/1/2008 71 Female 8/15/2008 United States
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 6/2/2008 55 Male 194 lb 7/30/2008 Pharmacist United States
Primary
Concomitant
Speech Disorder Other Serious 7/19/2008 60 Female 9/1/2008 Portugal
Primary
Concomitant
Jaundice Cholestatic Other Serious 2/1/2008 Male 9/12/2008 Physician United Kingdom
Primary
Concomitant
Psoriasis 6/1/2008 Male 240 lb 9/12/2008 Physician United States
Primary
Concomitant
Syncope Other Serious 9/11/2008 Male 154 lb 9/17/2008 Physician Brazil
Primary
Concomitant
Hypoglycaemic Unconsciousness Other Serious 12/14/2005 Female 201 lb 9/30/2008 Physician United Kingdom
Primary
Concomitant
Renal Failure Death 9/12/2008 Female 154 lb 10/8/2008 Physician Netherlands
Primary
Secondary
Concomitant
Muscle Atrophy Other Serious 6/1/2008 Male 301 lb 10/24/2008 Consumer United Kingdom
Primary
Concomitant
Jaundice Cholestatic Other Serious 2/1/2008 Male 11/6/2008 Physician United Kingdom
Primary
Concomitant
Drug Ineffective 8/4/2008 69 Male 11/14/2008 United States
Primary
Concomitant
Hypoglycaemic Unconsciousness Other Serious 12/14/2005 Female 201 lb 11/25/2008 Physician United Kingdom
Primary
Concomitant
Tendon Rupture Hospitalization 3/1/2008 75 Male 165 lb 12/4/2008 Pharmacist China
Primary
Concomitant
Product Quality Issue Hospitalization 11/1/2008 78 Male 175 lb 12/8/2008 Consumer United States
Primary
Concomitant
Tendon Rupture Hospitalization 3/1/2008 75 Male 165 lb 12/17/2008 Pharmacist China
Primary
Concomitant
Product Quality Issue Death 11/21/2008 86 Male 180 lb 12/15/2008 Consumer United States
Primary
Concomitant
Wheezing Other Serious 5/1/2008 88 Female 191 lb 12/16/2008 Consumer United States
Primary
Concomitant
Splenomegaly Other Serious 1/20/2008 12/22/2008 Other Health Professional Singapore
Primary
Secondary
Concomitant
Syncope Hospitalization 11/1/2008 75 Female 12/17/2008 Consumer United States
Primary
Concomitant
Renal Function Test Abnormal Other Serious 10/5/2008 55 Male 12/19/2008 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 1/1/2008 Male 188 lb 12/24/2008 Consumer United States
Primary
Concomitant
Vascular Graft Hospitalization 10/24/2008 72 Male 227 lb 12/30/2008 Consumer United States
Primary
Concomitant
Sleep Apnoea Syndrome Other Serious 4/1/2008 56 Female 1/15/2009 Consumer United States
Primary
Concomitant
Hypertension Death 71 Male 1/21/2009 Consumer United States
Primary
Concomitant
Renal Failure Acute Other Serious 1/20/2008 1/30/2009 Other Health Professional Singapore
Primary
Secondary
Concomitant
Stent Placement Other Serious 1/1/2000 Male 2/4/2009 Other Health Professional United States
Primary
Concomitant
Product Quality Issue Death 9/11/2008 67 Male 2/23/2009 Consumer United States
Primary
Concomitant
Thrombosis Other Serious 5/1/2008 67 Female 141 lb 3/13/2009 Consumer Brazil
Primary
Concomitant
Hypomagnesaemia Hospitalization Female 3/16/2009 United Kingdom
Primary
Concomitant
Hypomagnesaemia Hospitalization Female 3/18/2009 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 3/9/2009 60 Male 4/1/2009 Physician United Kingdom
Primary
Concomitant
Constipation Hospitalization 3/1/2008 Male 4/22/2009 Physician Sweden
Primary
Secondary
Concomitant
Nephropathy Other Serious 66 Male 4/23/2009 Physician United Kingdom
Primary
Concomitant
Normochromic Normocytic Anaemia Other Serious 66 Male 6/30/2009 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Congestion Other Serious 65 Male 157 lb 6/25/2009 Physician Portugal
Primary
Concomitant
Hyperglycaemia Other Serious 67 Female 7/13/2009
Primary
Concomitant
Hand Deformity Other Serious 4/1/2009 76 Male 8/6/2009 United Kingdom
Primary
Concomitant
Dyspnoea Other Serious 6/10/2009 59 Male 8/5/2009 Other Health Professional Denmark
Primary
Concomitant
Tinnitus Death 80 Female 8/21/2009 Lawyer United States
Primary
Concomitant
Toxic Skin Eruption Other Serious 6/1/2009 Male 8/28/2009 Portugal
Primary
Concomitant
Weight Decreased Other Serious 76 Male 9/1/2009 Lawyer United States
Primary
Concomitant
Renal Impairment Other Serious 6/23/2009 70 Male 165 lb 9/10/2009 Physician United States
Primary
Secondary
Concomitant
Interacting
Vitamin D Deficiency Death 80 Female 9/4/2009 Lawyer United States
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 3/10/1998 54 Male 209 lb 9/23/2009 United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/1999 53 Male 9/23/2009 United States
Primary
Concomitant
Stress Ulcer Hospitalization 7/14/2009 53 Male 9/28/2009 Physician China
Primary
Secondary
Concomitant
Weight Decreased Other Serious 76 Male 10/26/2009 United States
Primary
Concomitant
Dyspnoea Other Serious 6/10/2009 59 Male 11/4/2009 Other Health Professional Denmark
Primary
Concomitant
Sleep Apnoea Syndrome Hospitalization 4/28/2009 55 Female 11/5/2009 United Kingdom
Primary
Concomitant
Stress Ulcer Hospitalization 7/14/2009 53 Male 11/10/2009 China
Primary
Secondary
Concomitant
Stress Ulcer Hospitalization 7/14/2009 53 Male 11/10/2009 China
Primary
Secondary
Concomitant
Visual Acuity Reduced Other Serious 64 Male 11/18/2009 United States
Primary
Concomitant
Temporal Arteritis Other Serious 1/1/2009 Female 102 lb 12/1/2009 Consumer United States
Primary
Concomitant
Visual Acuity Reduced Other Serious 64 Male 12/1/2009 Lawyer United States
Primary
Concomitant
Visual Acuity Reduced Other Serious 64 Male 1/8/2010 United States
Primary
Concomitant
Weight Decreased Hospitalization 2/1/2007 74 Female 144 lb 1/20/2010 Lawyer United States
Primary
Concomitant
Pain In Extremity Hospitalization 11/17/2008 69 Male 263 lb 1/20/2010 Other Health Professional United States
Primary
Concomitant
Paraesthesia Hospitalization 57 Male 2/2/2010 Physician Norway
Primary
Concomitant
Paraesthesia Hospitalization 57 Male 2/2/2010 Physician Norway
Primary
Concomitant
Sopor Hospitalization 12/29/2009 80 Female 2/18/2010 Pharmacist Italy
Primary
Secondary
Concomitant
Rib Fracture Hospitalization 7/18/2007 76 Female 238 lb 2/25/2010 Physician United Kingdom
Primary
Concomitant
Hypoglycaemic Unconsciousness Other Serious 1/1/2010 73 Female 3/2/2010 Consumer United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/14/2008 77 Female 3/3/2010 Consumer United States
Primary
Concomitant
Syncope Hospitalization 11/17/2008 69 Male 263 lb 3/3/2010 Other Health Professional United States
Primary
Concomitant
Weight Decreased Hospitalization 2/1/2007 74 Female 144 lb 3/3/2010 Lawyer United States
Primary
Concomitant
Hypomagnesaemia Hospitalization 57 Male 3/17/2010 Other Health Professional Norway
Primary
Concomitant
Sopor Hospitalization 12/29/2009 80 Female 3/30/2010 Pharmacist Italy
Primary
Secondary
Concomitant
Hypomagnesaemia Other Serious 57 Male 4/2/2010 Other Health Professional Germany
Primary
Concomitant
Malaise Life Threatening Male 4/15/2010 Consumer United States
Primary
Secondary
Concomitant
Arthralgia 1/1/2010 74 Male 223 lb 4/19/2010 Consumer United States
Primary
Concomitant
Hypomagnesaemia Hospitalization 3/1/2008 57 Male 4/20/2010 Other Health Professional Norway
Primary
Concomitant

Drug Data