Isosorbide combined with Metoprolol

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Myocardial Infarction Other Serious 3/3/2001 69 Male 192 lb 1/3/2006 Physician United States
Primary
Concomitant
Cardiac Arrest Death 12/19/2005 83 Male 1/5/2006 Physician
Primary
Concomitant
Eosinophilia 10/7/2005 65 207 lb 1/6/2006 Pharmacist United States
Primary
Concomitant
Ventricular Hypokinesia Hospitalization 3/4/2003 66 Female 238 lb 1/17/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 6/6/2001 68 Male 1/27/2006 Physician United States
Primary
Concomitant
Ventricular Hypertrophy Other Serious 12/19/2005 83 Male 2/1/2006 Physician
Primary
Concomitant
Hypotension Hospitalization 10/28/2005 72 Male Pharmacist United States
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 12/13/2005 79 Male Pharmacist United States
Primary
Concomitant
Road Traffic Accident Other Serious 9/15/2003 64 Male 185 lb 2/14/2006 Lawyer United States
Primary
Concomitant
Middle Insomnia 8/6/2005 84 Male 1/5/2006 Consumer United States
Primary
Concomitant
Ventricular Hypokinesia Hospitalization 3/4/2003 66 Female 238 lb 2/21/2006 Physician United States
Primary
Concomitant
Myocardial Infarction Hospitalization 1/1/2000 37 Male 351 lb 3/3/2006 Lawyer United States
Primary
Concomitant
Urinary Incontinence Other Serious 5/17/2001 64 Male 185 lb 3/3/2006 Physician United States
Primary
Concomitant
Urine Output Decreased Hospitalization 64 Male 3/7/2006 Physician Canada
Primary
Concomitant
Sepsis Hospitalization 64 Male 3/7/2006 Consumer United States
Primary
Concomitant
Urine Output Decreased Hospitalization 64 Male 3/7/2006 Physician Canada
Primary
Concomitant
Sepsis Hospitalization 64 Male 3/7/2006 Consumer United States
Primary
Concomitant
Chills Life Threatening 83 Male 3/13/2006 Other Health Professional United Kingdom
Primary
Concomitant
Ulcer Hospitalization 1/1/1999 58 Female 170 lb 3/15/2006 Lawyer United States
Primary
Concomitant
Stress Hospitalization 9/7/2000 75 Female 170 lb 3/16/2006 Lawyer Puerto Rico
Primary
Concomitant
Intestinal Haemorrhage Other Serious 1/1/2002 89 Female 120 lb 12/29/2005 Consumer United States
Primary
Concomitant
Ventricular Hypokinesia Hospitalization 3/4/2003 66 Female 238 lb 3/22/2006 Physician United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 2/21/2001 62 Male 212 lb 3/28/2006 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Other Serious 5/28/2001 81 Female 146 lb 3/29/2006 Lawyer United States
Primary
Concomitant
Myocardial Infarction Hospitalization 1/1/2002 63 Male 176 lb 3/29/2006 Lawyer United States
Primary
Concomitant
Ventricular Hypokinesia Hospitalization 3/4/2003 66 Female 238 lb 3/29/2006 Physician United States
Primary
Concomitant
Pharmaceutical Product Complaint 7/4/2005 76 Female 190 lb 3/29/2006 Consumer United States
Primary
Concomitant
Death Death 2/16/2006 Female 3/30/2006 Consumer
Primary
Concomitant
Rheumatoid Arthritis Other Serious 5/28/2001 81 Female 146 lb 4/4/2006 Physician United States
Primary
Concomitant
Ventricular Hypokinesia Hospitalization 7/30/2003 66 Female 238 lb 4/13/2006 Physician United States
Primary
Concomitant
Syncope Hospitalization 12/1/1999 Male 280 lb 4/17/2006 Lawyer United States
Primary
Concomitant
Stress Hospitalization 9/7/2000 75 Female 170 lb 4/19/2006 Physician Puerto Rico
Primary
Concomitant
White Blood Cell Count Increased Other Serious 6/6/2001 68 Male 4/21/2006 Physician United States
Primary
Concomitant
Ureteric Injury Hospitalization 6/6/2001 67 Male 231 lb 5/1/2006 Physician United States
Primary
Concomitant
Syncope Hospitalization 6/23/2004 67 Male 5/1/2006 Physician United States
Primary
Concomitant
Blood Glucose Decreased Hospitalization 4/14/2006 85 Male 194 lb 4/27/2006 Pharmacist United States
Primary
Concomitant
Uterine Prolapse Other Serious 9/5/2001 77 Female 150 lb 5/3/2006 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 11/3/2001 64 Male 181 lb 5/3/2006 Physician United States
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 2/7/2003 72 Female 132 lb 5/12/2006 Lawyer United States
Primary
Concomitant
Confusional State Hospitalization 2/2/2006 64 Male 174 lb 4/18/2006 Pharmacist United States
Primary
Concomitant
Nausea 8/6/2005 62 Male 7/21/2006 Consumer United States
Primary
Concomitant
Fluid Retention Male 7/21/2006 Consumer United States
Primary
Concomitant
Thrombosis Life Threatening 6/28/2006 78 Male 230 lb 8/25/2006 Pharmacist United States
Primary
Concomitant
Myocardial Infarction Death 2/16/2006 Female 10/24/2006 Consumer
Primary
Concomitant
Heart Rate Increased Hospitalization 3/1/2007 87 Male 5/8/2008 Consumer United States
Primary
Concomitant
Hip Surgery Hospitalization 6/27/2008 Female 172 lb 8/11/2008 Physician United States
Primary
Secondary
Hip Surgery Hospitalization 6/27/2008 Female 172 lb 8/11/2008 Physician United States
Primary
Secondary
Contusion Other Serious Female 240 lb 9/4/2008 Consumer United States
Primary
Concomitant
Myositis Hospitalization 10/3/2006 70 Male 9/16/2008 Physician United States
Primary
Concomitant
Retinopathy Hospitalization Female 9/8/2008 Physician United States
Primary
Concomitant
Malaise Hospitalization 1/1/2008 72 Female 132 lb 9/26/2008 Consumer United States
Primary
Concomitant
Pharmaceutical Product Complaint Hospitalization 1/27/2008 Female 9/29/2008 Consumer
Primary
Concomitant
Myocardial Infarction Hospitalization 55 Male 226 lb 11/24/2008 Lawyer United States
Primary
Concomitant
Rheumatoid Arthritis 10/21/2008 Female 130 lb 12/12/2008 Consumer United States
Primary
Concomitant
Contusion Other Serious Female 240 lb 12/18/2008 Consumer United States
Primary
Concomitant
Myocardial Infarction Hospitalization 7/1/2008 57 Female 12/18/2008 Consumer United States
Primary
Secondary
Concomitant
Pain Other Serious 1/1/2006 Male 241 lb 12/22/2008 Consumer United States
Primary
Concomitant
Rash 8/1/2008 Female 183 lb 12/22/2008 Physician United States
Primary
Concomitant
Myocardial Infarction Hospitalization 7/1/2008 57 Female 1/13/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 7/1/2008 57 Female 2/3/2009 Physician United States
Primary
Secondary
Concomitant
Visual Impairment Death 11/12/2008 Male 200 lb 2/11/2009 Consumer United States
Primary
Secondary
Concomitant
Pruritus Male 2/24/2009 United States
Primary
Concomitant
Pain Hospitalization 57 Male 256 lb 3/9/2009 Consumer United States
Primary
Concomitant
Tendon Disorder Other Serious 1/1/2005 72 Female 139 lb 3/9/2009 Physician United States
Primary
Concomitant
Multiple Injuries Death 67 Male 3/12/2009 United States
Primary
Concomitant
Tubulointerstitial Nephritis Other Serious 11/29/2005 72 Male 130 lb 3/20/2009 Lawyer United States
Primary
Concomitant
Loss Of Consciousness Other Serious 1/1/2008 Male 167 lb 3/30/2009 Consumer United States
Primary
Concomitant
Tendon Disorder Other Serious 1/1/2005 72 Female 139 lb 3/31/2009 Physician United States
Primary
Concomitant
Urinary Incontinence Hospitalization 2/5/2009 Female 4/1/2009 Consumer
Primary
Concomitant
Type 2 Diabetes Mellitus Death 1/1/1996 45 Male 4/2/2009 United States
Primary
Concomitant
Treatment Noncompliance Other Serious 2/1/2009 Male 4/8/2009 Consumer Mexico
Primary
Concomitant
Rectal Haemorrhage Hospitalization 4/19/2006 67 Male 180 lb 5/1/2009 United States
Primary
Concomitant
Wrong Drug Administered Other Serious 1/1/2009 84 Female 5/6/2009 Consumer United States
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 55 Male 226 lb 5/18/2009 Other Health Professional United States
Primary
Concomitant
Weight Increased 3/1/2009 Female 5/27/2009 United States
Primary
Concomitant
Blood Glucose Increased 3/1/2008 70 Male 4/25/2008 Other Health Professional United States
Primary
Concomitant
Myocardial Ischaemia Hospitalization 6/30/2003 63 Female 7/7/2009 Physician United States
Primary
Secondary
Concomitant
Renal Function Test Abnormal Disability 1/1/2006 Male 7/6/2009 Consumer United States
Primary
Concomitant
Pain In Extremity Hospitalization 54 Female 7/22/2009 Lawyer United States
Primary
Concomitant
Renal Disorder Death 67 Male 8/3/2009 Lawyer United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 8/4/2009 Lawyer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 4/11/2005 54 Male 280 lb 8/13/2009 United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2005 Male 242 lb 8/12/2009 Consumer United States
Primary
Concomitant
Unevaluable Event Hospitalization 77 Male 8/25/2009 Lawyer United States
Primary
Concomitant
Troponin Increased Hospitalization 54 Female 8/26/2009 United States
Primary
Concomitant
Oedema Peripheral 7/7/2009 82 Female 9/8/2009 Consumer
Primary
Concomitant
Vomiting Other Serious 82 Female 9/10/2009 United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 76 Male 9/15/2009 United States
Primary
Concomitant
Vitreous Haemorrhage Hospitalization 2/20/2008 65 Female 180 lb 9/15/2009 United States
Primary
Concomitant
Back Pain Other Serious 9/13/2009 91 Female 172 lb 9/13/2009 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization Female 9/16/2009 United States
Primary
Concomitant
Lethargy Hospitalization 11/10/2008 56 Female 208 lb 11/11/2008 Pharmacist United States
Primary
Concomitant
Surgery Hospitalization 78 Female 9/17/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 48 Male 456 lb 9/17/2009 Consumer United States
Primary
Concomitant
Wheezing Hospitalization 78 Male 9/21/2009 United States
Primary
Concomitant
In-stent Coronary Artery Restenosis Hospitalization 7/1/2009 Male 260 lb 10/2/2009 Physician United States
Primary
Concomitant
Vomiting Death 86 Female 9/23/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 48 Male 456 lb 9/23/2009 United States
Primary
Concomitant
Spinal Column Stenosis Hospitalization 9/7/2008 53 Male 9/28/2009 United States
Primary
Concomitant
Vomiting Hospitalization 2/20/2008 62 Female 180 lb 9/28/2009 United States
Primary
Concomitant
Unemployment Hospitalization 1/20/2006 73 Male 163 lb 9/22/2009 United States
Primary
Concomitant
Platelet Count Decreased Other Serious 1/1/2009 Female 185 lb 10/7/2009 Consumer United States
Primary
Concomitant
Pain Hospitalization 57 Male 256 lb 10/13/2009 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 64 Female 10/10/2009 United States
Primary
Concomitant
Vision Blurred Hospitalization 59 Female 10/10/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 48 Male 456 lb 10/10/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 9/7/2008 53 Male 243 lb 10/9/2009 United States
Primary
Concomitant
Surgery Hospitalization 78 Female 10/18/2009 United States
Primary
Concomitant
Ventricular Dysfunction Hospitalization 54 Female 10/22/2009 United States
Primary
Concomitant
Platelet Count Decreased Other Serious 1/1/2009 Female 185 lb 10/29/2009 Consumer United States
Primary
Concomitant
Vision Blurred Other Serious 59 Female 10/26/2009 United States
Primary
Concomitant
Skin Ulcer Hospitalization 7/1/2009 60 Male 11/2/2009 Other Health Professional United States
Primary
Concomitant
Unresponsive To Stimuli Hospitalization 78 Female 10/26/2009 United States
Primary
Concomitant
Prothrombin Time Prolonged Death 68 Male 10/26/2009 United States
Primary
Concomitant
Vomiting Other Serious 78 Female 10/27/2009 Lawyer United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 59 Female 11/2/2009 United States
Primary
Concomitant
Thrombocytopenia Other Serious 10/2/2009 Male 170 lb 11/11/2009 Physician United States
Primary
Concomitant
Weight Decreased Death 73 Female 11/5/2009 United States
Primary
Concomitant
Weight Decreased Other Serious Male 11/9/2009 United States
Primary
Concomitant
Drug Ineffective 10/1/2008 67 Male 11/11/2009 Consumer United States
Primary
Concomitant
Weight Increased 1/1/2007 Female 175 lb 11/24/2009 Consumer United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 56 Female 11/18/2009 United States
Primary
Concomitant
Unresponsive To Stimuli Hospitalization 78 Female 11/16/2009 United States
Primary
Concomitant
Ulcer Hospitalization 67 Male 11/20/2009 United States
Primary
Concomitant
Weight Decreased Other Serious 73 Male 11/17/2009 United States
Primary
Concomitant
Vitreous Haemorrhage Hospitalization 2/20/2008 62 Female 180 lb 11/17/2009 United States
Primary
Concomitant
Throat Tightness Hospitalization 1/1/2009 52 Female 330 lb 11/13/2009 Physician United States
Primary
Concomitant
Thrombocytopenia Other Serious 3/6/2009 Male 170 lb 12/1/2009 Physician United States
Primary
Concomitant
Pain Death 68 Male 11/24/2009 United States
Primary
Concomitant
Renal Failure Other Serious Male 11/30/2009 Lawyer United States
Primary
Concomitant
Wound Complication Other Serious 1/1/2000 Female 12/1/2009 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2005 Female 185 lb 12/1/2009 Physician United States
Primary
Concomitant
Retinopathy Hospitalization Female 12/1/2009 Physician United States
Primary
Concomitant
Pollakiuria 11/13/2009 Male 12/8/2009 Consumer
Primary
Concomitant
Skin Lesion 5/15/2008 Male 235 lb 12/11/2009 Consumer United States
Primary
Concomitant
Transplant Failure Hospitalization Female 12/11/2009 Physician United States
Primary
Secondary
Concomitant
Peritonitis Bacterial Other Serious 3/15/2009 66 Male 11/3/2009 Other Health Professional United States
Primary
Concomitant
Peritonitis Other Serious 3/31/2009 62 Female 11/3/2009 Other Health Professional United States
Primary
Concomitant
Occult Blood Positive Other Serious 12/22/2009 73 Female 1/11/2010 Consumer United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 3/6/2009 Male 170 lb 1/12/2010 Physician United States
Primary
Concomitant
Respiratory Failure Other Serious 8/17/2009 Female 146 lb 1/14/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Skin Ulcer Other Serious 9/1/2006 79 Male 152 lb 1/21/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Hospitalization 78 Female 1/11/2010 United States
Primary
Concomitant
Skin Ulcer Other Serious 9/1/2006 79 Male 152 lb 1/22/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 3/6/2009 Male 170 lb 1/26/2010 Physician United States
Primary
Concomitant
Occult Blood Positive Other Serious 12/22/2009 73 Female 1/27/2010 Consumer United States
Primary
Secondary
Concomitant
Occult Blood Positive Other Serious 12/22/2009 73 Female 178 lb 1/29/2010 Physician United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization Male 2/5/2010 Lawyer United States
Primary
Concomitant
Myocardial Infarction Hospitalization 6/18/2009 65 Female 2/12/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 67 Male 3/5/2010 Consumer United States
Primary
Concomitant

Drug Data