Isosorbide Dinitrate combined with Warfarin Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Liver Disorder Hospitalization 12/14/2004 72 Female 1/6/2006 Physician Japan
Primary
Concomitant
Weight Decreased Other Serious 64 Male 2/28/2006 Israel
Primary
Concomitant
Treatment Noncompliance Hospitalization 57 Female 3/17/2006 United States
Primary
Secondary
Concomitant
Subdural Haematoma Life Threatening 12/3/2004 69 Male 231 lb 3/30/2006 Pharmacist United States
Primary
Concomitant
Renal Impairment Hospitalization 3/9/2006 52 Female 4/6/2006 Physician Czech Republic
Primary
Concomitant
Pulmonary Oedema Required Intervention 57 Female 3/30/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Retroperitoneal Haemorrhage Other Serious 3/8/2006 Male 164 lb 4/24/2006 Physician Japan
Primary
Concomitant
Interacting
Varices Oesophageal Hospitalization 3/9/2006 52 Female 4/18/2006 Other Health Professional Czech Republic
Primary
Concomitant
Renal Disorder Hospitalization 76 Male 5/19/2006 Other Health Professional Japan
Primary
Concomitant
Interacting
Vomiting Hospitalization 1/1/1999 58 Male 5/19/2006 Consumer United States
Primary
Secondary
Concomitant
Varices Oesophageal Hospitalization 3/9/2006 52 Female 5/22/2006 Czech Republic
Primary
Concomitant
Spinal Osteoarthritis Hospitalization 8/28/2002 76 Male 5/26/2006 Physician Japan
Primary
Secondary
Concomitant
Stomach Discomfort Hospitalization 1/1/2005 87 Male 134 lb 5/31/2006 United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 4/24/2006 67 Male 7/5/2006 Pharmacist United States
Primary
Secondary
Concomitant
Medication Residue 75 Male 7/21/2006 Consumer United States
Primary
Concomitant
Loss Of Consciousness Hospitalization 6/3/2006 54 Male Pharmacist United States
Primary
Concomitant
Ventricular Tachycardia Death 6/1/2006 83 Male 7/21/2006 Other Health Professional Japan
Primary
Concomitant
White Blood Cells Urine Positive Life Threatening 7/7/2006 69 Female 148 lb 7/26/2006 Pharmacist United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Death 2/16/2006 70 Female 7/27/2006 Physician Japan
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 7/1/2006 Male 200 lb 8/25/2006 United States
Primary
Concomitant
White Blood Cells Urine Positive Life Threatening 7/7/2006 69 Female 148 lb 8/25/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 6/20/2006 70 Male 9/13/2006 Pharmacist United States
Primary
Secondary
Concomitant
Rash Other Serious 7/18/2006 74 Male 341 lb 7/18/2006 Pharmacist United States
Primary
Concomitant
Rectal Haemorrhage Hospitalization 4/19/2005 81 Male 247 lb 9/28/2006 Pharmacist United States
Primary
Secondary
Concomitant
Tricuspid Valve Incompetence Other Serious 78 Male 10/6/2006 Physician Czech Republic
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 1/2/2006 91 Female 86 lb 10/26/2006 Physician Japan
Primary
Concomitant
Visual Acuity Reduced Other Serious 62 Male 11/16/2006 Consumer Japan
Primary
Concomitant
Pulmonary Hypertension Hospitalization 4/20/2005 38 Female 101 lb 11/30/2006 Physician Japan
Primary
Concomitant
Renal Failure Required Intervention 5/16/2006 76 Female 12/13/2006 Pharmacist United States
Primary
Secondary
Concomitant
Xanthopsia Other Serious 62 Male 12/21/2006
Primary
Concomitant
Xanthopsia Other Serious 62 Male 12/14/2006 Physician Japan
Primary
Concomitant
Perianal Abscess Life Threatening 7/7/2006 69 Female 148 lb 12/18/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Liver Function Test Abnormal Hospitalization 9/1/2006 80 Male 12/28/2006 Consumer United States
Primary
Concomitant
Iron Deficiency Anaemia Hospitalization 10/20/2004 Female 12/28/2006 Physician Japan
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 9/23/2006 65 Male 247 lb 10/21/2006 Pharmacist United States
Primary
Concomitant
Prothrombin Time Prolonged Hospitalization 12/20/2006 Female 99 lb 2/12/2007 Physician Japan
Primary
Secondary
Concomitant
Protein Urine Required Intervention 70 Male 2/23/2006 United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 9/9/2006 Male 294 lb 1/22/2007 Pharmacist United States
Primary
Concomitant
Inadequate Diet Required Intervention 10/5/2005 73 Male 1/3/2007 Pharmacist United States
Primary
Concomitant
Angina Pectoris Life Threatening 3/1/2007 83 Female 5/7/2007 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Hospitalization 8/21/2000 Male 12/13/2006 Consumer United States
Primary
Concomitant
Infection Life Threatening 7/7/2006 Female 148 lb 6/12/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypersensitivity 5/1/2007 72 Male 185 lb 6/4/2007 Consumer United States
Primary
Secondary
Concomitant
Hypoglycaemic Unconsciousness Other Serious 1/26/2007 82 Female 4/26/2007 United States
Primary
Secondary
Concomitant
Hyperglycaemia Other Serious 9/1/2005 80 Male 4/26/2007 United States
Primary
Concomitant
Vomiting 5/14/2007 86 Female 8/3/2007 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 11/1/2006 67 Male 230 lb 8/24/2007 Consumer United States
Primary
Concomitant
Pulmonary Oedema Hospitalization 9/4/2007 78 Female 9/14/2007 Consumer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 9/2/2007 Female 218 lb 9/24/2007 Consumer United States
Primary
Concomitant
Headache Other Serious 9/6/2007 64 Female 170 lb 10/11/2007 Consumer United States
Primary
Secondary
Concomitant
Skin Discolouration Other Serious 8/15/2007 87 Male 190 lb 10/22/2007 Consumer United States
Primary
Concomitant
Interacting
Restlessness 7/25/2007 51 Female 10/5/2007 Consumer United States
Primary
Concomitant
Nausea 8/23/2007 65 Male 203 lb 10/5/2007 Consumer United States
Primary
Concomitant
Muscular Weakness 3/1/2006 76 Female 10/25/2007 Consumer United States
Primary
Concomitant
Lipase Increased Hospitalization 6/1/2007 Male 10/29/2007 Physician United States
Primary
Concomitant
Vision Blurred Male 11/12/2007 Consumer United States
Primary
Secondary
Concomitant
Drug Ineffective 6/1/2007 84 Male 11/14/2007 Consumer United States
Primary
Secondary
Concomitant
Flatulence 9/18/2007 87 Male 11/16/2007 Consumer United States
Primary
Concomitant
Drug Ineffective 1/1/2007 Male 12/3/2007 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 11/23/2006 66 Male 230 lb 11/30/2007 Other Health Professional United States
Primary
Concomitant
Pancreatitis Hospitalization 1/1/2007 Male 12/17/2007 Physician United States
Primary
Concomitant
Dysphagia 8/1/2007 84 Male 12/20/2007 Consumer United States
Primary
Concomitant
Breast Tenderness 5/1/2007 84 Male 12/20/2007 Consumer United States
Primary
Concomitant
Subdural Haematoma Life Threatening 12/8/2007 73 Female 12/26/2007 Pharmacist United States
Primary
Concomitant
Drug Ineffective 1/1/2007 Male 1/4/2008 Consumer United States
Primary
Concomitant
Rhabdomyolysis Other Serious 10/20/2007 Male 206 lb 1/8/2008 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 9/11/2003 47 Female 261 lb 1/18/2008 Physician United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 12/3/2007 66 Male 185 lb 12/6/2007 Pharmacist United States
Primary
Concomitant
Xanthopsia Other Serious 62 Male 1/28/2008 Physician Japan
Primary
Concomitant
Ventricular Tachycardia Life Threatening 1/1/2007 64 Male 1/21/2008 Other Health Professional United Kingdom
Primary
Concomitant
Ventricular Tachycardia Life Threatening 1/1/2007 64 Male 1/30/2008 Other Health Professional United Kingdom
Primary
Concomitant
Flatulence 9/18/2007 87 Male 163 lb 2/13/2008 Consumer United States
Primary
Concomitant
Convulsion Other Serious 1/1/2008 87 Female 2/22/2008 Consumer United States
Primary
Concomitant
Pancreatitis Hospitalization 1/24/2008 78 Female 108 lb 3/3/2008 Consumer United States
Primary
Concomitant
Pancreatitis Hospitalization 1/1/2007 Male 3/3/2008 Physician United States
Primary
Concomitant
Renal Failure Acute Hospitalization 6/1/2006 Male 3/7/2008 Physician Australia
Primary
Secondary
Concomitant
Sinusitis Hospitalization 6/6/2006 Male 3/10/2008 Physician United States
Primary
Secondary
Concomitant
Wound Complication Other Serious 1/1/2000 Female 3/7/2008 Consumer United States
Primary
Concomitant
Pancreatitis Hospitalization 6/29/2007 Male 3/13/2008 Physician United States
Primary
Concomitant
Oxygen Saturation Abnormal Hospitalization 7/8/2007 Female 313 lb 3/19/2008 Physician United States
Primary
Concomitant
Ventricular Tachycardia Life Threatening 1/1/2007 64 Male 3/17/2008 United Kingdom
Primary
Concomitant
Sinusitis Hospitalization 5/22/2006 Male 3/26/2008 Consumer France
Primary
Secondary
Concomitant
Pneumonia Death 9/13/2004 77 Female 220 lb 3/28/2008 United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/2006 Female 3/31/2008 Pharmacist United States
Primary
Concomitant
Sinusitis Hospitalization 5/22/2006 Male 4/15/2008 Consumer France
Primary
Secondary
Concomitant
Tremor Other Serious 12/1/2007 87 Female 4/14/2008 Consumer United States
Primary
Concomitant
Death Death 5/10/1998 Female 155 lb 4/22/2008 Physician United States
Primary
Concomitant
Wound Complication Other Serious 1/1/2000 Female 4/16/2008 Physician United States
Primary
Concomitant
Hunger 1/1/2008 Male 224 lb 3/14/2008 Consumer United States
Primary
Concomitant
Weight Increased 1/1/2008 Male 224 lb 3/14/2008 Consumer United States
Primary
Concomitant
Wheezing Other Serious 5/7/2008 84 Female 5/14/2008 Consumer United States
Primary
Concomitant
Unresponsive To Stimuli Other Serious 1/1/2008 85 Female 5/13/2008 Pharmacist United States
Primary
Concomitant
Epistaxis Hospitalization 4/1/2008 Male 5/27/2008 Other Health Professional Japan
Primary
Concomitant
Interacting
Loss Of Consciousness Other Serious 4/1/2008 79 Male 180 lb 5/28/2008 United States
Primary
Concomitant
Presyncope Hospitalization 5/5/2008 Male 6/9/2008 Physician Italy
Primary
Secondary
Concomitant
Drug Ineffective 5/17/2007 75 Male 6/11/2008 Consumer United States
Primary
Concomitant
Vomiting Death 4/2/2008 55 Male 170 lb 6/3/2008 United States
Primary
Concomitant
Urethritis Hospitalization 1/30/2008 63 Male 6/5/2008 Norway
Primary
Concomitant
Weight Decreased Other Serious 75 Male 205 lb 6/12/2008 United States
Primary
Concomitant
Gait Disturbance Hospitalization 76 Male 1/4/2008 Other Health Professional United States
Primary
Concomitant
Skin Tightness Male 162 lb 7/25/2008 Consumer United States
Primary
Concomitant
International Normalised Ratio Decreased 7/27/2007 65 Male 201 lb 7/29/2008 Other Health Professional United States
Primary
Concomitant
Orthostatic Hypotension Other Serious 9/1/2006 80 Female 8/14/2008 Physician Canada
Primary
Secondary
Concomitant
Heart Rate Decreased Other Serious 80 Female 8/26/2008 Pharmacist Denmark
Primary
Concomitant
Metabolic Disorder Hospitalization 80 Female 8/21/2008 Consumer Canada
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 4/25/2007 77 Female 11/24/2008 Physician Japan
Primary
Concomitant
Fall Other Serious 9/1/2006 80 Female 12/1/2008
Primary
Secondary
Red Blood Cell Count Decreased Required Intervention 9/1/2007 Female 9/17/2008 Consumer United States
Primary
Concomitant
Heart Rate Decreased Hospitalization 80 Female 3/4/2009 Canada
Primary
Concomitant
Hyponatraemia Other Serious 77 Female 4/13/2009 Canada
Primary
Concomitant
Potentiating Drug Interaction Other Serious 1/1/2009 64 Female 5/22/2009 Consumer United States
Primary
Concomitant
Mouth Haemorrhage Hospitalization 4/15/2009 Female 119 lb 6/17/2009 Physician Japan
Primary
Concomitant
Interacting
Renal Disorder Death 67 Male 7/14/2009 Lawyer United States
Primary
Concomitant
Pneumonia Hospitalization 1/1/2007 84 Female 7/15/2009 United States
Primary
Concomitant
Injury Death 72 Female 7/14/2009 United States
Primary
Concomitant
Vomiting Death 86 Female 7/20/2009 United States
Primary
Concomitant
Renal Failure Other Serious 7/1/1998 41 Female 233 lb 7/27/2009 United States
Primary
Concomitant
Prothrombin Time Prolonged Other Serious 76 Male 7/31/2009 Other Health Professional United States
Primary
Concomitant
Overdose Hospitalization 76 Male 8/17/2009 Pharmacist United States
Primary
Concomitant
Dizziness 5/1/2008 Male 8/21/2009 United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 3/25/2009 65 Male 180 lb 8/24/2009 Physician United States
Primary
Concomitant
Wheezing Other Serious 1/1/2007 74 Male 209 lb 9/3/2009 Consumer United States
Primary
Concomitant
Pulmonary Haemorrhage Other Serious 55 Male 10/9/2009 Japan
Primary
Concomitant
Thrombosis In Device Other Serious 55 Female 115 lb 10/22/2009 Physician Japan
Primary
Secondary
Concomitant
Tremor Hospitalization 11/1/2001 27 Female 11/3/2009 Other Health Professional United States
Primary
Concomitant
Presyncope Life Threatening 10/31/2008 78 Female 172 lb 11/17/2009 Physician Czech Republic
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 11/27/2009 56 Female 200 lb 12/17/2009 Pharmacist United States
Primary
Concomitant
Coronary Artery Occlusion Other Serious 1/1/2008 78 Female 135 lb 2/22/2010 Consumer United States
Primary
Concomitant
Vomiting Other Serious 10/1/2007 57 Male 2/25/2010 Lawyer United States
Primary
Concomitant
Tenodesis Hospitalization 64 Female 3/5/2010 Lawyer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 90 Female 90 lb 3/17/2010 Consumer United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 73 Female 3/25/2010 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 58 Male 4/6/2010 Lawyer United States
Primary
Concomitant
Embolism Other Serious 12/8/2009 75 Female 5/27/2010 Physician Japan
Primary
Concomitant
Acute Respiratory Distress Syndrome Hospitalization 3/26/2009 65 Male 181 lb 6/25/2010 Other Health Professional United States
Primary
Concomitant
Vomiting Other Serious 12/1/2007 61 Male 7/15/2010 Other Health Professional United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 7/1/1998 41 Female 218 lb 8/6/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 49 Male 8/10/2010 United States
Primary
Concomitant
Off Label Use Other Serious Male 211 lb 9/2/2010 Physician United States
Primary
Concomitant
Gastritis Haemorrhagic Hospitalization 7/23/2005 70 Female 10/20/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Incorrect Drug Administration Duration Male 10/13/2010 Consumer United States
Primary
Concomitant
Ventricular Arrhythmia Other Serious 3/1/2008 81 Male 12/1/2010 Lawyer United States
Primary
Concomitant
Anxiety 78 Male 190 lb 12/14/2010 Consumer United States
Primary
Concomitant
Vomiting Other Serious 12/1/2007 61 Male 256 lb 12/28/2010 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Death 1/1/2008 82 Female 198 lb 1/6/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Peripheral Arterial Occlusive Disease Other Serious 72 Female 1/13/2011 Consumer United States
Primary
Concomitant
Toxicity To Various Agents Hospitalization 1/14/2011 70 Female 2/1/2011 Consumer United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Life Threatening 1/14/2011 70 Female 2/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Blood Potassium Increased Hospitalization 7/14/2010 56 Male 272 lb 2/21/2011 Physician United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Life Threatening 1/14/2011 70 Female 3/3/2011 Other Health Professional United States
Primary
Secondary
Concomitant

Drug Data