Isosorbide Dinitrate combined with Spironolactone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Muscular Weakness Life Threatening 11/10/2005 85 Female 110 lb 2/23/2006 Other Health Professional Japan
Primary
Concomitant
Weight Decreased Other Serious 64 Male 2/28/2006 Israel
Primary
Concomitant
Catheter Related Complication Death 4/5/2004 83 Female 130 lb 3/14/2006 Consumer France
Primary
Concomitant
Tricuspid Valve Incompetence Hospitalization 63 Male 3/16/2006
Primary
Secondary
Concomitant
Syncope Hospitalization 12/8/2004 48 Male 269 lb 11/21/2005 Physician United States
Primary
Secondary
Concomitant
Tricuspid Valve Incompetence Hospitalization 63 Male 3/21/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tremor Other Serious 2/23/2002 46 Male 3/22/2006 Physician United States
Primary
Concomitant
Treatment Noncompliance Hospitalization 57 Female 3/17/2006 United States
Primary
Secondary
Concomitant
Tricuspid Valve Incompetence Hospitalization 63 Male 3/28/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Toxicity Required Intervention 4/26/2005 72 Male 175 lb 4/20/2006 Pharmacist United States
Primary
Concomitant
Vision Blurred Hospitalization 4/28/2006 59 Male 7/6/2006 Pharmacist United States
Primary
Secondary
Concomitant
Gallbladder Cancer Hospitalization 3/14/2006 Male 7/14/2006 Physician Japan
Primary
Concomitant
Hypokalaemia Hospitalization 4/24/2006 55 Male Pharmacist United States
Primary
Concomitant
Pain In Extremity Hospitalization 6/23/2006 45 Male 7/17/2006 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Hospitalization 5/24/2006 70 Male Pharmacist United States
Primary
Secondary
Concomitant
Weight Decreased 6/1/2005 Male 215 lb 8/8/2006 Consumer United States
Primary
Concomitant
Thirst 63 Male 355 lb 7/24/2006 Other Health Professional United States
Primary
Concomitant
Pneumonia Hospitalization 8/19/2006 28 Female 137 lb 9/15/2006 Consumer United States
Primary
Concomitant
Hepatic Enzyme Increased Hospitalization 6/23/2006 46 Male 9/8/2006 Other Health Professional United States
Primary
Concomitant
Hyperkalaemia Hospitalization 6/20/2006 70 Male 9/13/2006 Pharmacist United States
Primary
Secondary
Concomitant
Coronary Artery Stenosis Hospitalization 6/22/2006 47 Male 203 lb 9/13/2006 United States
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 8/19/2006 28 Female 137 lb 9/22/2006 Consumer United States
Primary
Concomitant
Pneumonia Hospitalization 8/19/2006 28 Female 115 lb 9/25/2006 Consumer United States
Primary
Concomitant
Cardiac Failure Acute Hospitalization 8/11/2006 75 Female 133 lb 10/6/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 1/2/2006 91 Female 86 lb 10/26/2006 Physician Japan
Primary
Concomitant
Liver Function Test Abnormal Hospitalization 9/1/2006 80 Male 12/28/2006 Consumer United States
Primary
Concomitant
Treatment Noncompliance Hospitalization 10/10/2006 Male 215 lb 12/19/2006 Pharmacist United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 8/19/2006 28 Female 115 lb 3/5/2007 Consumer United States
Primary
Concomitant
Drug Ineffective 75 Male 3/7/2007 Consumer United States
Primary
Concomitant
Visual Acuity Reduced 2/9/2007 92 Female 141 lb 5/17/2007 Other Health Professional United States
Primary
Concomitant
Hypoglycaemic Unconsciousness Other Serious 1/26/2007 82 Female 4/26/2007 United States
Primary
Secondary
Concomitant
Pain In Extremity 1/1/2007 55 Male 228 lb 6/7/2007 Consumer United States
Primary
Concomitant
Pain 78 Female 8/3/2007 Consumer United States
Primary
Concomitant
Hypotension Hospitalization 7/6/2007 50 Male 9/4/2007 Other Health Professional Philippines
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2007 67 Male 217 lb 9/11/2007 Consumer United States
Primary
Concomitant
Visual Acuity Reduced 2/9/2007 92 Female 141 lb 8/16/2007 Other Health Professional United States
Primary
Concomitant
Vision Blurred 8/7/2007 78 Female 170 lb 10/12/2007 Physician United States
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 10/1/2007 69 Female 11/9/2007 Consumer United Kingdom
Primary
Concomitant
Nocturnal Dyspnoea 8/22/2007 69 Male 11/14/2007 Consumer United States
Primary
Concomitant
Cardiovascular Disorder Hospitalization 10/15/2007 66 Female 11/21/2007 Physician Russian Federation
Primary
Concomitant
Electrolyte Imbalance Life Threatening 11/29/2007 Other Health Professional Switzerland
Primary
Concomitant
Pain Other Serious 1/1/2007 56 Female 137 lb 12/3/2007 Consumer United States
Primary
Concomitant
Interacting
Vasoplegia Syndrome Death 7/21/2004 48 Male 217 lb 11/1/2007 Physician United States
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 73 Male 12/18/2007 Physician Switzerland
Primary
Secondary
Concomitant
Lung Disorder Other Serious 9/1/2007 Male 235 lb 12/18/2007 Other Health Professional United States
Primary
Concomitant
Urine Odour Abnormal Other Serious 11/1/2007 Female 153 lb 12/19/2007 Consumer United States
Primary
Concomitant
Breast Pain 2/1/2007 64 Male 12/20/2007 Consumer United States
Primary
Concomitant
Malaise Hospitalization 9/8/2007 75 Female 12/17/2007 United Kingdom
Primary
Concomitant
Subdural Haematoma Life Threatening 12/8/2007 73 Female 12/26/2007 Pharmacist United States
Primary
Concomitant
Ventricular Tachycardia Life Threatening 1/1/2007 64 Male 1/21/2008 Other Health Professional United Kingdom
Primary
Concomitant
Intervertebral Disc Protrusion Hospitalization 12/1/2006 Female 1/29/2008 Consumer United States
Primary
Concomitant
Ventricular Tachycardia Life Threatening 1/1/2007 64 Male 1/30/2008 Other Health Professional United Kingdom
Primary
Concomitant
Ascites Other Serious 63 Female 180 lb 2/22/2008 United States
Primary
Concomitant
Swelling 11/1/2007 69 Male 234 lb 3/11/2008 Consumer United States
Primary
Concomitant
Syncope Vasovagal Hospitalization 9/8/2007 75 Female 3/7/2008 United Kingdom
Primary
Concomitant
Ascites Other Serious 9/1/2007 63 Female 233 lb 3/20/2008 Physician United States
Primary
Concomitant
Ventricular Tachycardia Life Threatening 1/1/2007 64 Male 3/17/2008 United Kingdom
Primary
Concomitant
Shock Other Serious 2/1/2008 Male 4/8/2008 Physician Japan
Primary
Concomitant
Hypotension Other Serious 7/6/2007 Male 4/21/2008 Philippines
Primary
Secondary
Concomitant
Shock Other Serious 2/1/2008 Male 4/22/2008 Physician Japan
Primary
Concomitant
Renal Impairment 82 Male 4/22/2008 Germany
Primary
Concomitant
Shock Other Serious 2/1/2008 Male 5/1/2008 Physician Japan
Primary
Concomitant
Hunger 1/1/2008 Male 224 lb 3/14/2008 Consumer United States
Primary
Concomitant
Renal Failure Death 1/1/1990 Female 103 lb 5/8/2008 United States
Primary
Concomitant
Renal Failure Death 1/1/1990 Female 103 lb 5/15/2008 United States
Primary
Concomitant
Renal Failure Death 1/1/1990 Female 103 lb 5/30/2008 United States
Primary
Concomitant
Swollen Tongue Other Serious 5/12/2008 57 Male 197 lb 5/28/2008 United States
Primary
Concomitant
Renal Impairment 7/20/2007 82 Male 5/30/2008 Physician Germany
Primary
Concomitant
Vomiting Death 4/2/2008 55 Male 170 lb 6/3/2008 United States
Primary
Concomitant
Urethritis Hospitalization 1/30/2008 63 Male 6/5/2008 Norway
Primary
Concomitant
Pharmaceutical Product Complaint Hospitalization 12/24/2007 80 Female 6/5/2008 United States
Primary
Concomitant
White Blood Cell Count Decreased Required Intervention 4/1/2008 73 Female 148 lb 6/10/2008 Physician United States
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 4/1/2008 Male 6/30/2008 Consumer United States
Primary
Concomitant
Shock Other Serious 2/1/2008 Male 7/3/2008 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 1/1/2006 59 Female 150 lb 6/27/2008 United States
Primary
Concomitant
Weight Increased Hospitalization 1/1/2004 63 Male 7/14/2008 Consumer United States
Primary
Concomitant
Renal Failure Death 1/1/1990 Female 103 lb 7/15/2008 United States
Primary
Concomitant
Idiopathic Thrombocytopenic Purpura Other Serious 4/8/2008 Male 137 lb 7/17/2008 Physician France
Primary
Secondary
Concomitant
Cardiac Failure Death 2/26/2007 88 Male 7/21/2008 Japan
Primary
Concomitant
Cardiac Failure Death 2/26/2007 88 Male 97 lb 7/29/2008 Japan
Primary
Concomitant
Weight Increased Hospitalization 1/1/2004 63 Male 8/12/2008 Consumer United States
Primary
Concomitant
Glomerular Filtration Rate Decreased Other Serious 80 Female 8/19/2008 Canada
Primary
Secondary
Concomitant
Cardiac Failure Other Serious 61 Male 8/27/2008 United States
Primary
Concomitant
Pneumonia Death 2/26/2007 88 Male 97 lb 10/8/2008 Japan
Primary
Concomitant
Weight Decreased Other Serious 7/17/2008 58 Male 210 lb 11/7/2008 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 1/1/2004 63 Male 11/13/2008 Consumer United States
Primary
Concomitant
Ventricular Dysfunction Other Serious 61 Male 11/21/2008 Italy
Primary
Concomitant
Product Quality Issue Death 10/19/2008 65 Male 12/8/2008 Consumer United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 6/13/2008 80 Female 215 lb 11/19/2008 Pharmacist United States
Primary
Concomitant
Pneumonia Death 8/1/2008 Female 201 lb 12/24/2008 Physician United States
Primary
Concomitant
Thyroid Function Test Abnormal Hospitalization Female 179 lb 1/9/2009 Consumer United States
Primary
Concomitant
Product Quality Issue Hospitalization 1/1/2005 Male 280 lb 1/16/2009 Consumer United States
Primary
Concomitant
Thyroid Function Test Abnormal Hospitalization 12/24/2008 Female 179 lb 1/21/2009 Physician United States
Primary
Concomitant
Nausea Other Serious 1/1/2007 Male 232 lb 1/29/2009 Consumer United States
Primary
Concomitant
Hyperkalaemia Hospitalization 3/1/2006 76 Male 2/12/2009 Other Health Professional Japan
Primary
Concomitant
Interacting
Ventricular Dysfunction Other Serious 2/23/2009 Other Health Professional Italy
Primary
Concomitant
Ventricular Dysfunction Other Serious 61 Male 2/24/2009 Physician United States
Primary
Concomitant
Shock Other Serious 5/1/2009 71 5/28/2009 Physician China
Primary
Secondary
Concomitant
Renal Failure Chronic Life Threatening 8/20/2008 71 Female 6/10/2009 Physician Germany
Primary
Secondary
Concomitant
Weight Decreased Other Serious 76 Male 7/15/2009 Lawyer United States
Primary
Concomitant
Vision Blurred Hospitalization 10/25/2007 73 Female 229 lb 7/17/2009 United States
Primary
Concomitant
Vomiting Death 86 Female 7/20/2009 United States
Primary
Concomitant
Oedema Hospitalization 63 Female 7/21/2009 Lawyer United States
Primary
Concomitant
Renal Failure Other Serious 7/1/1998 41 Female 233 lb 7/27/2009 United States
Primary
Concomitant
Respiratory Failure Hospitalization 80 Female 8/13/2009 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 7/1/2007 48 Male 8/12/2009 United States
Primary
Concomitant
Hot Flush 4/28/2009 Female 8/22/2009 United States
Primary
Concomitant
Weight Increased Other Serious Female 8/28/2009 Consumer United States
Primary
Concomitant
Wheezing Hospitalization 45 Male 8/25/2009 United States
Primary
Concomitant
Hyperkalaemia Hospitalization 3/22/2006 76 Male 12/4/2009 Japan
Primary
Secondary
Concomitant
Interacting
Hepatic Steatosis Other Serious 77 Female 132 lb 12/24/2009 Other Health Professional France
Primary
Concomitant
Vascular Resistance Systemic Increased Other Serious 77 Female 132 lb 1/4/2010 Other Health Professional United States
Primary
Concomitant
Weight Increased Hospitalization 58 Male 292 lb 1/15/2010 United States
Primary
Concomitant
Hepatic Steatosis Hospitalization 77 Female 132 lb 2/2/2010 Physician United States
Primary
Concomitant
Personality Change Life Threatening 8/13/2008 81 Male 128 lb 2/16/2010
Primary
Secondary
Concomitant
Hepatic Cirrhosis Other Serious 2/22/2010 68 Male 4/9/2010 Consumer
Primary
Concomitant
Weight Increased Hospitalization 58 Male 292 lb 4/13/2010 Consumer United States
Primary
Concomitant
Cardiomyopathy Hospitalization 7/3/2008 41 Male 163 lb 4/20/2010 Consumer Ecuador
Primary
Secondary
Concomitant
Renal Failure Chronic Other Serious 11/19/2007 64 Male 5/24/2010 Lawyer United States
Primary
Concomitant
Paraesthesia Other Serious 7/5/2010 67 Male 285 lb 7/5/2010 Consumer United States
Primary
Concomitant
Myocardial Infarction Hospitalization 10/14/2002 41 Female 165 lb 7/26/2010 Lawyer United States
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Other Serious 7/1/1998 41 Female 218 lb 8/6/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 49 Male 8/10/2010 United States
Primary
Concomitant
Off Label Use Other Serious Male 211 lb 9/2/2010 Physician United States
Primary
Concomitant
Intentional Drug Misuse Other Serious 1/1/1998 Female 9/27/2010 Consumer United States
Primary
Secondary
Concomitant
Alopecia 1/1/2009 61 Female 115 lb 10/26/2010 Consumer United States
Primary
Concomitant
Respiratory Failure Other Serious 9/11/2010 55 Female 295 lb 11/16/2010 Physician United States
Primary
Concomitant
Respiratory Failure Other Serious 9/11/2010 55 Female 295 lb 11/22/2010 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/2010 78 Female 107 lb 11/24/2010 Consumer United States
Primary
Concomitant
Thirst Death 12/15/2006 12/6/2010 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 62 Male 11/17/2010 United States
Primary
Concomitant
Vision Blurred Hospitalization 1/1/2009 81 Female 12/9/2010 Consumer
Primary
Concomitant
Vertebral Artery Occlusion Other Serious 66 Male 12/3/2010 United States
Primary
Concomitant
Pneumonia Other Serious Male 268 lb 12/23/2010 Consumer United States
Primary
Concomitant
Jaundice Cholestatic Other Serious 9/1/2010 56 Male 212 lb 12/29/2010 Other Health Professional Russian Federation
Primary
Secondary
Concomitant
Urinary Tract Infection Fungal Hospitalization 7/26/2010 51 Male 198 lb 1/3/2011 Physician Japan
Primary
Secondary
Concomitant
Gastritis Erosive Other Serious 9/1/2010 56 Male 212 lb 1/4/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 9/1/2010 56 Male 212 lb 1/5/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Cardiac Tamponade Life Threatening 9/7/2010 55 Female 295 lb 1/12/2011 Physician United States
Primary
Concomitant
Rash Macular Hospitalization 11/6/2010 64 Female 1/17/2011 Physician France
Primary
Secondary
Concomitant
Palpitations Other Serious 3/1/2008 50 Male 328 lb 1/20/2011 Physician United States
Primary
Concomitant
Jaundice Cholestatic Other Serious 9/1/2010 56 Male 212 lb 1/24/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 9/1/2010 56 Male 212 lb 1/25/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Blood Disorder Other Serious 11/19/2007 64 Male 1/27/2011 Other Health Professional United States
Primary
Concomitant
Jaundice Cholestatic Other Serious 9/1/2010 56 Male 212 lb 2/7/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Ventricular Fibrillation Hospitalization 80 Male 1/28/2011 United States
Primary
Concomitant
Blood Potassium Increased Hospitalization 7/14/2010 56 Male 272 lb 2/21/2011 Physician United States
Primary
Secondary
Concomitant
Blood Ketone Body Increased Other Serious 45 Male 2/7/2011 Pharmacist United States
Primary
Concomitant
Bile Duct Cancer Death 70 Male 266 lb 3/17/2011 Other Health Professional United States
Primary
Concomitant
Supraventricular Extrasystoles Hospitalization 56 Male 3/9/2011 Consumer United States
Primary
Concomitant

Drug Data