Isosorbide Dinitrate combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Wrong Technique In Drug Usage Process Death 12/11/2005 67 Male 1/18/2006 China
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 12/2/2005 71 Male 2/6/2006 Pharmacist United States
Primary
Concomitant
Weight Decreased Hospitalization 10/27/2005 87 Male 127 lb 12/1/2005 Pharmacist United States
Primary
Secondary
Concomitant
Tricuspid Valve Incompetence Hospitalization 1/28/2006 75 Female 2/13/2006 Japan
Primary
Concomitant
Pneumonia Hospitalization 1/1/2004 84 Male 130 lb 4/11/2005 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 64 Male 2/28/2006 Israel
Primary
Concomitant
Subdural Haematoma Life Threatening 12/3/2004 69 Male 231 lb 3/30/2006 Pharmacist United States
Primary
Concomitant
Pulmonary Toxicity Required Intervention 4/26/2005 72 Male 175 lb 4/20/2006 Pharmacist United States
Primary
Concomitant
Renal Disorder Hospitalization 76 Male 5/19/2006 Other Health Professional Japan
Primary
Concomitant
Interacting
Dry Mouth Other Serious 4/3/2006 62 Male 207 lb 4/7/2006 Pharmacist United States
Primary
Concomitant
Syncope Hospitalization 3/1/2006 80 Male 6/5/2006 Other Health Professional
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 3/1/2006 80 Male 6/8/2006 Other Health Professional
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization 4/24/2006 67 Male 7/5/2006 Pharmacist United States
Primary
Secondary
Concomitant
Ventricular Arrhythmia Death 76 Male 161 lb 7/11/2006 Other Health Professional Netherlands
Primary
Concomitant
Sepsis Required Intervention 8/13/2005 58 Male 194 lb 7/8/2006 Pharmacist United States
Primary
Concomitant
Bradycardia Hospitalization 6/5/2006 71 Male Pharmacist United States
Primary
Concomitant
Loss Of Consciousness Hospitalization 6/15/2006 88 Male 198 lb 7/6/2006 Pharmacist United States
Primary
Concomitant
Weight Decreased 6/1/2005 Male 215 lb 8/8/2006 Consumer United States
Primary
Concomitant
Syncope Hospitalization 6/21/2006 70 Male 189 lb 7/17/2006 Pharmacist United States
Primary
Concomitant
Hyperkalaemia Hospitalization 6/20/2006 70 Male 9/13/2006 Pharmacist United States
Primary
Secondary
Concomitant
Delirium Hospitalization 66 Male 9/26/2006 Physician Switzerland
Primary
Concomitant
Rash Other Serious 7/18/2006 74 Male 341 lb 7/18/2006 Pharmacist United States
Primary
Concomitant
Myalgia Other Serious 7/12/2006 58 Male 198 lb 8/15/2006 Other Health Professional United States
Primary
Concomitant
Renal Failure Chronic Hospitalization 4/26/2005 78 Female 154 lb 12/11/2006 Pharmacist United States
Primary
Concomitant
Speech Disorder Hospitalization 66 Male 12/14/2006 Physician Switzerland
Primary
Concomitant
Scotoma Other Serious 1/1/2005 68 Male 12/15/2006 United Kingdom
Primary
Concomitant
Skin Cancer Other Serious 72 Male 250 lb 1/8/2007 Consumer United States
Primary
Concomitant
Pseudarthrosis Other Serious 3/1/2005 83 Female 1/12/2007 Other Health Professional Germany
Primary
Concomitant
Neurological Symptom Other Serious 72 Male 250 lb 1/9/2007 Consumer United States
Primary
Concomitant
Pulmonary Hypertension Life Threatening 8/30/2006 70 Female 150 lb 1/18/2007 Pharmacist United States
Primary
Concomitant
Pneumonia Life Threatening 5/10/2005 79 Male 165 lb 2/5/2007 Pharmacist United States
Primary
Secondary
Concomitant
Somnolence Other Serious 12/14/2005 65 Female 190 lb 2/12/2007 Physician Poland
Primary
Concomitant
Thrombocytopenia Hospitalization 1/24/2007 60 Male 172 lb 2/12/2007 Pharmacist United States
Primary
Concomitant
Somnolence Other Serious 5/1/2005 65 Female 190 lb 2/19/2007 Physician Poland
Primary
Concomitant
Somnolence Other Serious 5/1/2005 65 Female 190 lb 2/21/2007 Physician Poland
Primary
Concomitant
Somnolence Hospitalization 66 Male 2/15/2007 Other Health Professional Switzerland
Primary
Concomitant
Drug Ineffective 75 Male 3/7/2007 Consumer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process Hospitalization 11/23/2006 69 Male 251 lb 11/30/2006 Pharmacist United States
Primary
Concomitant
Somnolence Other Serious 5/1/2005 65 Female 190 lb 5/14/2007 Physician Poland
Primary
Concomitant
Syncope Other Serious 1/1/2005 65 Female 190 lb 5/16/2007 Physician Poland
Primary
Concomitant
Syncope Hospitalization 1/1/2005 86 Male 160 lb 12/13/2006 Consumer United States
Primary
Concomitant
Memory Impairment Other Serious 1/1/2007 Male 150 lb 5/30/2007 Consumer United States
Primary
Concomitant
Syncope Hospitalization 6/16/2004 82 Male 3/7/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Skin Necrosis Other Serious 3/29/2007 72 Male 6/8/2007 Physician Puerto Rico
Primary
Secondary
Concomitant
Renal Failure Hospitalization 4/5/2007 Male 6/13/2007 Consumer United States
Primary
Concomitant
Muscle Spasms Other Serious 1/1/2007 Male 364 lb 6/18/2007 Consumer United States
Primary
Concomitant
Memory Impairment Other Serious 1/1/2007 Male 150 lb 6/20/2007 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 5/1/2007 Male 6/21/2007 Consumer United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 3/1/2007 Male 214 lb 7/18/2007 Other Health Professional Poland
Primary
Secondary
Concomitant
Pain Hospitalization 7/10/2006 47 Male 154 lb 7/23/2007 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 3/1/2007 Male 214 lb 7/23/2007 Other Health Professional Poland
Primary
Secondary
Concomitant
Nausea 9/1/2006 Female 7/26/2007 Consumer United States
Primary
Concomitant
Unresponsive To Stimuli Life Threatening 4/18/2007 76 Female 6/5/2007 Pharmacist United States
Primary
Concomitant
Renal Failure Hospitalization 4/1/2007 Male 195 lb 8/21/2007 Consumer United States
Primary
Concomitant
Cholelithiasis Hospitalization 5/28/2007 71 Female 8/6/2007 Other Health Professional United States
Primary
Concomitant
Stent Placement Hospitalization Male 8/24/2007 Consumer United States
Primary
Concomitant
Urticaria 8/16/2007 81 Female 9/4/2007 Consumer United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 4/1/2007 Female 220 lb 9/11/2007 Physician United States
Primary
Concomitant
Haematochezia Other Serious 4/1/2007 Female 9/11/2007 Consumer United States
Primary
Concomitant
Urticaria 8/16/2007 81 Female 9/18/2007 Consumer United States
Primary
Concomitant
Nausea Other Serious 9/1/2007 54 Female 120 lb 9/20/2007 Consumer United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2007 Female 220 lb 9/21/2007 Physician United States
Primary
Concomitant
Gastrointestinal Haemorrhage Other Serious 3/1/2007 Female 229 lb 10/4/2007 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 1/1/2007 77 Male 10/25/2007 United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 44 Male 11/8/2007 Pharmacist Korea, Republic Of
Primary
Concomitant
Weight Increased 83 Female 11/14/2007 Consumer United States
Primary
Concomitant
Myocardial Infarction Hospitalization 8/17/2007 53 Male 270 lb 11/26/2007 Consumer United Kingdom
Primary
Concomitant
Gastrointestinal Haemorrhage Other Serious 3/1/2007 Female 229 lb 12/11/2007 Consumer United States
Primary
Concomitant
Uveitis Other Serious 11/16/2007 Female 12/17/2007 Physician United Kingdom
Primary
Concomitant
Myoclonus Required Intervention 1/29/2006 65 Male 12/11/2007 Pharmacist United States
Primary
Secondary
Concomitant
Myoclonus Hospitalization 1/29/2006 65 Male 12/18/2007 Other Health Professional France
Primary
Concomitant
Interacting
Gastric Ulcer Hospitalization 69 Female 12/13/2007 Korea, Republic Of
Primary
Secondary
Concomitant
Malaise Hospitalization 9/8/2007 75 Female 12/17/2007 United Kingdom
Primary
Concomitant
Myocardial Infarction Hospitalization 8/17/2007 53 Male 270 lb 1/2/2008 Consumer United Kingdom
Primary
Concomitant
Syncope Other Serious 8/1/2004 65 Female 190 lb 1/9/2008 Physician Poland
Primary
Concomitant
Weight Decreased Other Serious 9/11/2003 47 Female 261 lb 1/18/2008 Physician United States
Primary
Concomitant
Tachycardia Hospitalization 1/8/2008 Male 1/18/2008 United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 12/3/2007 66 Male 185 lb 12/6/2007 Pharmacist United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 12/15/2007 58 Male 203 lb 1/28/2008 Pharmacist United Kingdom
Primary
Concomitant
Heart Rate Decreased Hospitalization 11/1/2007 71 Female 196 lb 1/30/2008 Consumer United Kingdom
Primary
Concomitant
Tachycardia Hospitalization 1/8/2008 Male 2/4/2008 United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 12/27/2007 81 Female 1/28/2008 Portugal
Primary
Concomitant
Retinopathy Hospitalization 1/1/2006 58 Male 11/29/2007 Consumer United States
Primary
Concomitant
Upper Respiratory Tract Infection Death 2/3/2008 69 Male 2/4/2008 Other Health Professional United States
Primary
Concomitant
Rhinorrhoea Male 2/17/2008 United States
Primary
Concomitant
Rhinorrhoea Male 2/27/2008 Other Health Professional United States
Primary
Concomitant
Tachycardia Hospitalization 1/8/2008 Male 2/27/2008 Other Health Professional United States
Primary
Concomitant
Dyspnoea 2/11/2008 71 Male 262 lb 2/27/2008 Other Health Professional United States
Primary
Concomitant
Upper Respiratory Tract Infection Death 2/3/2008 69 Male 2/21/2008 Other Health Professional United States
Primary
Concomitant
Pancreatitis Hospitalization 1/24/2008 78 Female 108 lb 3/3/2008 Consumer United States
Primary
Concomitant
Swelling 10/1/2007 Female 145 lb 3/14/2008 Consumer United States
Primary
Concomitant
Medication Error Other Serious 12/27/2007 81 Female 3/5/2008 Portugal
Primary
Concomitant
Blood Glucose Increased Other Serious 3/24/2008 Female 144 lb 4/8/2008 United States
Primary
Concomitant
Haemorrhage Life Threatening 56 Male 289 lb 5/24/2006 United States
Primary
Concomitant
Suicidal Ideation Other Serious 3/24/2008 Female 145 lb 4/21/2008 United States
Primary
Concomitant
Unevaluable Event Hospitalization 3/1/2007 Male 170 lb 4/25/2008 Consumer United States
Primary
Concomitant
Unevaluable Event Hospitalization 3/1/2007 Male 170 lb 5/1/2008 Consumer United States
Primary
Concomitant
Unevaluable Event Hospitalization 3/1/2007 Male 172 lb 5/7/2008 Consumer United States
Primary
Concomitant
Bradycardia Hospitalization 11/29/2007 Female 196 lb 5/8/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Bradycardia Hospitalization 11/29/2007 Female 196 lb 6/4/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Nausea Hospitalization 86 Male 6/12/2008
Primary
Secondary
Concomitant
Nausea Hospitalization 86 Male 6/17/2008
Primary
Secondary
Concomitant
Diarrhoea Other Serious 4/3/2008 65 Female 134 lb 6/18/2008 Consumer United States
Primary
Concomitant
Hot Flush Other Serious 6/18/2008 83 Male 161 lb 6/26/2008 Pharmacist United States
Primary
Concomitant
Angina Unstable Other Serious 6/1/2005 68 Male 7/1/2008 Other Health Professional Argentina
Primary
Secondary
Concomitant
Somnolence Other Serious 10/2/2007 87 Male 4/30/2008 United States
Primary
Secondary
Concomitant
Muscle Spasms Other Serious Female 155 lb 7/2/2008 Consumer United States
Primary
Concomitant
Syncope Other Serious 8/1/2004 65 Female 190 lb 7/7/2008 Physician Poland
Primary
Concomitant
Myositis Other Serious 6/11/2008 78 Male 7/10/2008 Physician United Kingdom
Primary
Concomitant
Interacting
Cardiac Failure Congestive Other Serious 5/1/2008 90 Male 161 lb 7/14/2008 Other Health Professional United States
Primary
Concomitant
Gait Disturbance Hospitalization 76 Male 1/4/2008 Other Health Professional United States
Primary
Concomitant
Wheezing Hospitalization 11/13/2002 Male 7/21/2008 Other Health Professional United States
Primary
Concomitant
Pneumonia Hospitalization 7/15/2008 67 Male 161 lb 7/29/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 4/3/2008 86 Female 7/17/2008 United States
Primary
Concomitant
Sepsis Death Female 198 lb 8/12/2008 United Kingdom
Primary
Concomitant
Angina Pectoris Hospitalization 6/4/2008 Female 8/13/2008 Other Health Professional United States
Primary
Concomitant
Orthostatic Hypotension Other Serious 9/1/2006 80 Female 8/14/2008 Physician Canada
Primary
Secondary
Concomitant
Glomerular Filtration Rate Decreased Other Serious 80 Female 8/19/2008 Canada
Primary
Secondary
Concomitant
Fall Hospitalization 1/1/2006 Female 8/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Flushing 6/1/2008 Male 223 lb 8/27/2008 United States
Primary
Concomitant
Heart Rate Decreased Other Serious 80 Female 8/26/2008 Pharmacist Denmark
Primary
Concomitant
Renal Failure Life Threatening 5/23/2008 87 Male 134 lb 8/29/2008 Physician Netherlands
Primary
Concomitant
Metabolic Disorder Hospitalization 80 Female 8/21/2008 Consumer Canada
Primary
Secondary
Concomitant
Leukocytoclastic Vasculitis Other Serious 69 Female 132 lb 10/31/2008 Physician Germany
Primary
Concomitant
Fall Hospitalization 80 Female 11/11/2008 Canada
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 4/1/2008 64 Female 11/19/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Fall Other Serious 9/1/2006 80 Female 12/1/2008
Primary
Secondary
Fall Hospitalization 1/1/2006 80 Female 11/26/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Pulmonary Hypertension Death 2/3/2008 Female 12/9/2008 Germany
Primary
Concomitant
Tubulointerstitial Nephritis Hospitalization 67 Male 12/12/2008 Other Health Professional Spain
Primary
Concomitant
Vomiting Other Serious 10/25/2006 56 Female 132 lb 12/16/2008 Physician Germany
Primary
Concomitant
Vomiting Other Serious 10/25/2006 56 Female 132 lb 12/18/2008 Physician Germany
Primary
Concomitant
Orthostatic Hypotension Other Serious Male 12/19/2008 France
Primary
Secondary
Concomitant
Vomiting Other Serious 10/25/2006 56 Female 132 lb 12/26/2008 Physician Germany
Primary
Concomitant
Palpitations Hospitalization Male 12/31/2008 Pharmacist Netherlands
Primary
Secondary
Concomitant
Orthostatic Hypotension Other Serious Male 1/16/2009 France
Primary
Secondary
Concomitant
Paraesthesia Hospitalization 8/25/2008 45 Male 181 lb 1/20/2009 Physician Germany
Primary
Secondary
Concomitant
Interacting
Dizziness Hospitalization 5/24/2008 75 Male 1/21/2009 Consumer Germany
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2008 65 Male 198 lb 1/22/2009 Consumer Austria
Primary
Concomitant
Syncope Life Threatening 5/26/2008 66 Male 1/16/2009 Germany
Primary
Secondary
Concomitant
No Therapeutic Response Hospitalization 80 Female 1/20/2009 Canada
Primary
Concomitant
Syncope Hospitalization 6/12/2008 84 Female 1/22/2009 Physician Germany
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 8/4/2006 65 Male 261 lb 2/2/2009 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2008 65 Male 198 lb 1/30/2009 Physician Austria
Primary
Concomitant
Chest Discomfort Life Threatening 1/5/2009 2/9/2009 Other Health Professional Singapore
Primary
Concomitant
Glaucoma Other Serious Male 2/12/2009 Suriname
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 2/19/2009 74 Male 196 lb 2/25/2009 Other Health Professional United States
Primary
Concomitant
Heart Rate Decreased Hospitalization 80 Female 3/4/2009 Canada
Primary
Concomitant
Sinus Bradycardia Other Serious 80 Female 4/7/2009 Consumer Denmark
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 4/19/2002 50 Male 211 lb 4/20/2009 United States
Primary
Concomitant

Drug Data