Isosorbide Dinitrate combined with Metoprolol Tartrate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Hepatic Enzyme Increased 1/31/2001 47 Male 1/5/2006 Consumer United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 11/3/2005 60 Male 185 lb 11/4/2005 Pharmacist United States
Primary
Secondary
Concomitant
Syncope Hospitalization 11/3/2005 60 Male 188 lb 11/4/2005 Pharmacist United States
Primary
Concomitant
Haematocrit Decreased Hospitalization 8/1/2004 70 Male 12/21/2005 Physician United States
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 2/25/2004 71 Male 201 lb 5/15/2006 Lawyer United States
Primary
Concomitant
Arthralgia Other Serious 5/10/2006 40 Male 192 lb 6/21/2006 Physician Slovakia (Slovak Republic)
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 4/24/2006 67 Male 7/5/2006 Pharmacist United States
Primary
Secondary
Concomitant
Dizziness Hospitalization 4/8/2006 87 Male Pharmacist United States
Primary
Secondary
Concomitant
Hypokalaemia Hospitalization 4/24/2006 55 Male Pharmacist United States
Primary
Concomitant
Bradycardia Hospitalization 6/5/2006 71 Male Pharmacist United States
Primary
Concomitant
Loss Of Consciousness Hospitalization 6/3/2006 54 Male Pharmacist United States
Primary
Concomitant
Unevaluable Event Hospitalization 5/31/2006 65 Male Pharmacist United States
Primary
Concomitant
Syncope Hospitalization 5/10/2006 80 Male Pharmacist United States
Primary
Concomitant
Pneumonia Other Serious 9/1/2004 Female 145 lb 7/26/2006 Other Health Professional Canada
Primary
Concomitant
White Blood Cells Urine Positive Life Threatening 7/7/2006 69 Female 148 lb 7/26/2006 Pharmacist United States
Primary
Secondary
Concomitant
Shunt Occlusion Hospitalization 7/18/2006 Female 8/10/2006 Consumer Canada
Primary
Concomitant
Ventricular Fibrillation Life Threatening 5/8/2006 78 Male 176 lb 8/15/2006 Bulgaria
Primary
Secondary
Concomitant
Renal Tubular Necrosis Other Serious 5/21/2006 65 Male 185 lb 8/23/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cells Urine Positive Life Threatening 7/7/2006 69 Female 148 lb 8/25/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Thirst 63 Male 355 lb 7/24/2006 Other Health Professional United States
Primary
Concomitant
Shunt Occlusion Hospitalization 7/18/2006 Female 9/8/2006 Consumer Canada
Primary
Concomitant
Arthralgia Other Serious 5/10/2006 40 Male 192 lb 9/29/2006 Physician Slovakia (Slovak Republic)
Primary
Concomitant
Somnolence Hospitalization 4/3/2005 85 Male 150 lb 9/28/2006 Pharmacist United States
Primary
Concomitant
Macular Degeneration Other Serious 1/1/2004 89 Male 10/17/2006 Consumer Canada
Primary
Concomitant
Nervous System Disorder Disability 1/1/1996 41 Male 10/18/2006 Norway
Primary
Secondary
Concomitant
Sepsis Other Serious 9/15/2006 75 Male 172 lb 10/26/2006 Physician Germany
Primary
Concomitant
Bronchopneumonia Life Threatening 2/4/2006 57 Female 11/2/2006 Physician Germany
Primary
Concomitant
Sepsis Other Serious 9/15/2006 75 Male 172 lb 11/3/2006 Physician Germany
Primary
Concomitant
Shunt Occlusion Hospitalization 7/18/2006 Female 11/7/2006 Consumer Canada
Primary
Concomitant
Cardiac Murmur Hospitalization 4/24/2006 Female 160 lb 11/16/2006 Consumer Canada
Primary
Concomitant
Speech Disorder Hospitalization 66 Male 12/14/2006 Physician Switzerland
Primary
Concomitant
Perianal Abscess Life Threatening 7/7/2006 69 Female 148 lb 12/18/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pseudarthrosis Other Serious 3/1/2005 83 Female 1/12/2007 Other Health Professional Germany
Primary
Concomitant
Gastroenteritis Hospitalization 2/24/2005 78 Female 163 lb 11/6/2006 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/6/2006 71 Male 1/16/2007 Pharmacist United States
Primary
Concomitant
Pulmonary Hypertension Life Threatening 8/30/2006 70 Female 150 lb 1/18/2007 Pharmacist United States
Primary
Concomitant
Somnolence Hospitalization 66 Male 2/15/2007 Other Health Professional Switzerland
Primary
Concomitant
Angioedema Disability 1/1/2007 47 Male 3/28/2007 Pharmacist United States
Primary
Concomitant
Syncope Hospitalization 1/1/2005 86 Male 160 lb 12/13/2006 Consumer United States
Primary
Concomitant
Ventricular Fibrillation Life Threatening 5/8/2006 78 Male 176 lb 6/25/2007 Bulgaria
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 3/1/2007 Male 214 lb 7/18/2007 Other Health Professional Poland
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 3/1/2007 Male 214 lb 7/23/2007 Other Health Professional Poland
Primary
Secondary
Concomitant
Weight Increased Life Threatening 6/1/2007 70 Male 8/31/2007 Germany
Primary
Concomitant
Chest Pain Life Threatening 9/7/2007 54 Male 252 lb 10/5/2007 Physician Russian Federation
Primary
Concomitant
Hepatitis Hospitalization 3/1/2005 61 Male 10/24/2007 Physician Netherlands
Primary
Secondary
Concomitant
Rectal Haemorrhage Other Serious 10/30/2007 79 Female 108 lb 11/13/2007 Consumer United States
Primary
Concomitant
Pulmonary Vasculitis Other Serious 66 Male 12/10/2007 Physician Canada
Primary
Concomitant
Pulmonary Oedema Death 12/3/2007 Male 12/27/2007 Physician Italy
Primary
Secondary
Concomitant
Hypotension 5/24/2007 84 Male 1/16/2008 Pharmacist United States
Primary
Secondary
Eosinophilia Death 1/24/2008 United States
Primary
Concomitant
Scleritis Other Serious 11/15/2006 Female 2/4/2008 Physician United States
Primary
Concomitant
Retinopathy Hospitalization 1/1/2006 58 Male 11/29/2007 Consumer United States
Primary
Concomitant
Myocardial Infarction Hospitalization 3/9/2007 74 Female 11/30/2007 Consumer United States
Primary
Concomitant
Swollen Tongue Other Serious 1/1/2008 Male 186 lb 2/13/2008 United States
Primary
Concomitant
Hypotension Other Serious 7/6/2007 50 Male 2/15/2008 Physician Philippines
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 11/1/2007 Female 160 lb 2/22/2008 Canada
Primary
Concomitant
Scratch Hospitalization 3/6/2007 Male 220 lb 6/27/2007 Pharmacist United States
Primary
Concomitant
Scleritis Other Serious 11/15/2006 Female 2/29/2008 Physician United States
Primary
Concomitant
Pain Other Serious 9/20/2007 82 Male 3/4/2008 Pharmacist United States
Primary
Concomitant
Sensory Loss Other Serious 1/1/2004 Male 330 lb 3/7/2008 Physician United States
Primary
Concomitant
Swelling 11/1/2007 69 Male 234 lb 3/11/2008 Consumer United States
Primary
Concomitant
Wound Complication Other Serious 1/1/2000 Female 3/7/2008 Consumer United States
Primary
Concomitant
Syncope Hospitalization Female 143 lb 3/11/2008 United States
Primary
Concomitant
Bronchitis 1/5/2008 Female 185 lb 3/15/2008 United States
Primary
Concomitant
Visual Acuity Reduced Other Serious 1/14/2008 Female 140 lb 3/12/2008 Other Health Professional United States
Primary
Concomitant
Haemorrhage Life Threatening 56 Male 289 lb 5/24/2006 United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2005 Female 185 lb 4/9/2008 Consumer United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 3/27/2008 Female 4/14/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/1/2008 71 Female 128 lb 4/16/2008 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 1/1/2008 71 Female 128 lb 4/18/2008 Other Health Professional United States
Primary
Concomitant
Hypotension Other Serious 7/6/2007 Male 4/21/2008 Philippines
Primary
Secondary
Concomitant
Visual Disturbance Other Serious 1/14/2008 Female 140 lb 4/15/2008 Other Health Professional United States
Primary
Concomitant
Wound Complication Other Serious 1/1/2000 Female 4/16/2008 Physician United States
Primary
Concomitant
Unevaluable Event Hospitalization 3/1/2007 Male 170 lb 4/25/2008 Consumer United States
Primary
Concomitant
Tendon Disorder Other Serious Male 225 lb 4/25/2008 Consumer United States
Primary
Concomitant
Unevaluable Event Hospitalization 3/1/2007 Male 170 lb 5/1/2008 Consumer United States
Primary
Concomitant
Unevaluable Event Hospitalization 3/1/2007 Male 172 lb 5/7/2008 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2005 Female 185 lb 5/13/2008 Consumer United States
Primary
Concomitant
Urine Abnormality Other Serious 4/7/2008 Male 225 lb 5/16/2008 Consumer United States
Primary
Concomitant
Syncope Hospitalization 2/29/2008 Female 143 lb 5/19/2008 United States
Primary
Concomitant
Hypotension Hospitalization 2/23/2006 85 Male 5/27/2008 Pharmacist United States
Primary
Secondary
Concomitant
Chest Pain Hospitalization 1/13/2008 55 Male 174 lb 5/21/2008 United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2005 Female 185 lb 6/2/2008 Physician United States
Primary
Concomitant
Gait Disturbance Hospitalization 76 Male 1/4/2008 Other Health Professional United States
Primary
Concomitant
Pruritus Generalised 12/6/2007 Male 219 lb 8/27/2008 Consumer United States
Primary
Concomitant
Renal Failure Life Threatening 5/23/2008 87 Male 134 lb 8/29/2008 Physician Netherlands
Primary
Concomitant
Renal Failure Acute Life Threatening 9/15/2008 9/30/2008 Consumer United States
Primary
Concomitant
Angina Pectoris Other Serious Male 11/17/2008 Russian Federation
Primary
Secondary
Angina Pectoris Other Serious Male 11/17/2008 Russian Federation
Primary
Secondary
Angina Pectoris Other Serious Male 11/17/2008 Russian Federation
Primary
Secondary
Angina Pectoris Other Serious Male 11/17/2008 Russian Federation
Primary
Secondary
Angina Pectoris Other Serious Male 11/17/2008 Russian Federation
Primary
Secondary
Angina Pectoris Other Serious Male 11/17/2008 Russian Federation
Primary
Secondary
Angina Pectoris Other Serious Male 11/17/2008 Russian Federation
Primary
Secondary
Angina Pectoris Other Serious Male 11/17/2008 Russian Federation
Primary
Secondary
Toxic Skin Eruption Other Serious Male 11/17/2008 Russian Federation
Primary
Secondary
Angina Pectoris Other Serious Male 11/17/2008 Russian Federation
Primary
Secondary
Angina Pectoris Other Serious Male 11/17/2008 Russian Federation
Primary
Secondary
Angina Pectoris Other Serious Male 11/17/2008 Russian Federation
Primary
Secondary
Angina Pectoris Other Serious Male 11/17/2008 Russian Federation
Primary
Secondary
Angina Pectoris Other Serious Male 11/17/2008 Russian Federation
Primary
Secondary
Myocardial Infarction Death Male 11/17/2008 Russian Federation
Primary
Secondary
Rash Other Serious 7/6/2008 Male 174 lb 11/17/2008 Other Health Professional United States
Primary
Concomitant
Heparin-induced Thrombocytopenia Hospitalization 6/22/2008 63 Male 177 lb 10/25/2008 United States
Primary
Concomitant
Pain In Extremity Other Serious 6/1/2008 Female 160 lb 11/20/2008 Canada
Primary
Concomitant
Visual Impairment Other Serious Male 140 lb 11/22/2008 Consumer United States
Primary
Concomitant
Flushing Male 11/26/2008 United States
Primary
Concomitant
Helicobacter Gastritis 63 Female 135 lb 12/17/2008 United States
Primary
Concomitant
Palpitations Hospitalization Male 12/31/2008 Pharmacist Netherlands
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 9/15/2008 65 Male 1/15/2009 Physician United States
Primary
Concomitant
Skin Burning Sensation 1/1/2004 Female 192 lb 1/15/2009 Physician United States
Primary
Concomitant
Haematochezia Other Serious 1/1/2008 67 Male 218 lb 1/21/2009 Consumer United States
Primary
Concomitant
Haematochezia Other Serious 1/1/2008 67 Male 218 lb 1/23/2009 Consumer United States
Primary
Concomitant
Tricuspid Valve Incompetence Hospitalization 12/25/2004 75 Female 155 lb 1/23/2009 Consumer United States
Primary
Concomitant
Tricuspid Valve Incompetence Hospitalization 57 Male 256 lb 1/26/2009 Consumer United States
Primary
Concomitant
Haematochezia Other Serious 1/1/2008 67 Male 218 lb 1/27/2009 Consumer United States
Primary
Concomitant
Vision Blurred Other Serious 84 Female 1/24/2009 United States
Primary
Concomitant
Myocardial Infarction Hospitalization 55 Male 226 lb 2/9/2009 Other Health Professional United States
Primary
Concomitant
Vision Blurred Hospitalization 84 Female 2/27/2009 Consumer United States
Primary
Concomitant
Tricuspid Valve Incompetence Hospitalization 12/25/2004 75 Female 155 lb 3/12/2009 Consumer United States
Primary
Concomitant
Wheezing Hospitalization 12/1/2008 85 Female 3/19/2009 Physician United States
Primary
Concomitant
Vision Blurred Hospitalization 84 Female 4/22/2009 United States
Primary
Concomitant
Urticaria 4/1/2008 71 Female 4/30/2009 Consumer United States
Primary
Concomitant
Shock Other Serious 5/1/2009 71 5/28/2009 Physician China
Primary
Secondary
Concomitant
Nausea Other Serious 3/26/2009 Female 238 lb 5/29/2009 Consumer United States
Primary
Concomitant
Nausea Other Serious 3/26/2009 Female 238 lb 6/9/2009 Consumer United States
Primary
Concomitant
Staphylococcal Infection Hospitalization 3/23/2005 Male 7/7/2009 Consumer Germany
Primary
Secondary
Concomitant
Vomiting Death 86 Female 7/20/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 78 Female 7/23/2009 United States
Primary
Concomitant
Diabetic Neuropathy Other Serious 7/23/2003 49 Female 191 lb 7/30/2009 United States
Primary
Concomitant
Temperature Difference Of Extremities Hospitalization 54 Female 8/5/2009 United States
Primary
Concomitant
Wheezing Hospitalization 45 Male 8/25/2009 United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 6/6/2000 51 Male 175 lb 10/5/2009 United States
Primary
Concomitant
Tremor Hospitalization 11/1/2001 27 Female 11/3/2009 Other Health Professional United States
Primary
Concomitant
Respiratory Failure Hospitalization 9/22/2009 77 Male 154 lb 12/21/2009 Physician United States
Primary
Concomitant
Respiratory Failure Hospitalization 9/22/2009 77 Male 154 lb 12/31/2009 Physician United States
Primary
Concomitant
Respiratory Failure Hospitalization 9/22/2009 77 Male 154 lb 1/5/2010 Physician United States
Primary
Concomitant
Pneumonia Hospitalization 12/1/2009 82 Male 1/14/2010 Consumer China
Primary
Concomitant
Pancreatic Carcinoma Other Serious 8/9/2009 Male 190 lb 1/25/2010 Other Health Professional United States
Primary
Concomitant
Chest Pain Hospitalization 11/30/2009 Male 112 lb 2/1/2010 Physician Hong Kong
Primary
Concomitant
Drug Withdrawal Syndrome Hospitalization 1/19/2010 Male 2/10/2010 Physician
Primary
Secondary
Concomitant
Drug Withdrawal Syndrome Hospitalization 1/19/2010 Male 2/18/2010 Physician
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/19/2010 Male 2/22/2010 Physician
Primary
Secondary
Concomitant
Skin Ulcer Other Serious 10/23/2007 63 Female 141 lb 2/23/2010 Physician United States
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 9/22/2008 Male 150 lb 2/26/2010 Physician China
Primary
Secondary
Concomitant
Hypomagnesaemia Hospitalization 3/1/2008 57 Male 3/3/2010 Other Health Professional Norway
Primary
Concomitant
Hypomagnesaemia Hospitalization 3/1/2008 57 Male 3/3/2010 Other Health Professional Norway
Primary
Concomitant
Wheelchair User Hospitalization 1/1/2009 61 Male 3/4/2010 Other Health Professional United States
Primary
Concomitant
Therapeutic Response Decreased Other Serious 9/9/2009 69 Male 293 lb 4/1/2010 Physician United States
Primary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/19/2010 65 Male 4/6/2010 Physician
Primary
Secondary
Concomitant

Drug Data