Isosorbide Dinitrate combined with Metoprolol Succinate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Transient Ischaemic Attack Hospitalization 2/24/2003 63 Male 150 lb 3/22/2006 Physician Germany
Primary
Concomitant
Tremor Other Serious 2/23/2002 46 Male 3/22/2006 Physician United States
Primary
Concomitant
Dehydration Hospitalization 4/26/2006 85 Male 200 lb 5/15/2006 Pharmacist United States
Primary
Concomitant
Middle Insomnia 85 Male 165 lb 7/12/2006 Consumer United States
Primary
Concomitant
Myalgia Other Serious 7/12/2006 58 Male 198 lb 8/15/2006 Other Health Professional United States
Primary
Concomitant
Cardiomegaly Other Serious 4/24/2006 Female 160 lb 12/14/2006 Consumer Canada
Primary
Concomitant
Renal Failure Required Intervention 5/16/2006 76 Female 12/13/2006 Pharmacist United States
Primary
Secondary
Concomitant
Shock Other Serious 9/15/2006 Male 172 lb 2/6/2007 Physician Germany
Primary
Concomitant
Thrombocytopenia Hospitalization 1/24/2007 60 Male 172 lb 2/12/2007 Pharmacist United States
Primary
Concomitant
Drug Ineffective 75 Male 3/7/2007 Consumer United States
Primary
Concomitant
Nightmare Hospitalization 84 Male 200 lb 8/21/2004 Other Health Professional United States
Primary
Secondary
Presyncope Hospitalization 2/8/2007 85 Male 2/28/2007 United States
Primary
Secondary
Soft Tissue Disorder Hospitalization 11/11/2006 56 Male 4/19/2007 Physician China
Primary
Concomitant
Neoplasm Hospitalization 11/11/2006 56 Male 5/15/2007 China
Primary
Concomitant
Lower Gastrointestinal Haemorrhage Hospitalization 9/5/2005 12/13/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 8/21/2000 Male 12/13/2006 Consumer United States
Primary
Concomitant
Somnolence 1/1/2007 82 Male 160 lb 4/12/2007 Consumer United States
Primary
Concomitant
Vision Blurred Other Serious 4/25/2007 Male 181 lb 6/7/2007 Physician United States
Primary
Concomitant
Skin Necrosis Other Serious 3/29/2007 72 Male 6/8/2007 Physician Puerto Rico
Primary
Secondary
Concomitant
Drug Ineffective 2/23/2007 67 Female 5/17/2007 United States
Primary
Concomitant
Infection Life Threatening 7/7/2006 Female 148 lb 6/12/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypersensitivity 5/1/2007 72 Male 185 lb 6/4/2007 Consumer United States
Primary
Secondary
Concomitant
Muscle Spasms Other Serious 1/1/2007 Male 364 lb 6/18/2007 Consumer United States
Primary
Concomitant
Toothache Other Serious 12/30/2006 Female 180 lb 6/22/2007 Consumer United States
Primary
Concomitant
Urine Output Decreased 10/27/2006 Male 6/26/2007 Physician United States
Primary
Concomitant
Haemoglobin Decreased 1/16/2007 Male 6/26/2007 Pharmacist United States
Primary
Concomitant
Sensory Loss Other Serious 12/1/2006 Male 266 lb 6/29/2007 Physician United States
Primary
Concomitant
Drug Ineffective Other Serious 5/5/2007 Male 190 lb 7/6/2007 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2007 Female 7/6/2007 Other Health Professional United States
Primary
Concomitant
Weight Increased Other Serious 4/25/2007 Male 181 lb 7/9/2007 Physician United States
Primary
Concomitant
Myocardial Infarction Life Threatening 7/18/2007 60 Male 179 lb 7/19/2007 Consumer United States
Primary
Concomitant
Nausea 5/1/2007 8/10/2007 Consumer United States
Primary
Concomitant
Unresponsive To Stimuli Life Threatening 4/18/2007 76 Female 6/5/2007 Pharmacist United States
Primary
Concomitant
Weight Increased Other Serious 5/5/2007 Male 190 lb 8/23/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased 1/1/2006 66 Female 294 lb 7/11/2007 Consumer United States
Primary
Concomitant
Pulmonary Embolism Required Intervention 4/15/2007 50 Male 220 lb 4/26/2007 Pharmacist United States
Primary
Concomitant
Hypotension Hospitalization 7/6/2007 50 Male 9/4/2007 Other Health Professional Philippines
Primary
Secondary
Concomitant
Gastritis Hospitalization 4/24/2007 68 Female 135 lb 9/5/2007 Consumer United States
Primary
Concomitant
Staphylococcal Infection Hospitalization 6/10/2007 Male 9/11/2007 Physician United States
Primary
Secondary
Concomitant
Pancreatitis Chronic Other Serious 1/5/2005 Male 128 lb 9/12/2007 Physician Mexico
Primary
Concomitant
Weight Increased Other Serious 1/1/2007 Female 9/14/2007 Other Health Professional United States
Primary
Concomitant
Nausea Other Serious 9/1/2007 54 Female 120 lb 9/20/2007 Consumer United States
Primary
Concomitant
Back Pain 8/24/2006 Female 161 lb 9/20/2007 Consumer United States
Primary
Concomitant
Back Pain 10/26/2006 62 Male 150 lb 9/20/2007 Other Health Professional United States
Primary
Concomitant
Tongue Oedema Other Serious 11/1/2007 Male 241 lb 12/19/2007 Consumer United States
Primary
Concomitant
Tachycardia Hospitalization 4/6/2007 78 Male 118 lb 12/3/2007 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Required Intervention 4/1/2008 73 Female 148 lb 6/10/2008 Physician United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 11/24/2007 76 Female 137 lb 6/17/2008 United States
Primary
Concomitant
Diarrhoea 4/1/2007 Female 7/2/2008 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 7/18/2008 67 Male 187 lb 7/21/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 4/3/2008 86 Female 7/17/2008 United States
Primary
Concomitant
Oedema Peripheral Hospitalization 7/2/2008 Female 8/14/2008 Consumer United States
Primary
Concomitant
Hyperkalaemia Hospitalization 11/30/2007 Male 198 lb 8/21/2008 Physician Germany
Primary
Secondary
Concomitant
Palpitations 1/1/2006 Female 167 lb 8/27/2008 Consumer United States
Primary
Concomitant
Renal Failure Other Serious 10/1/2007 Male 157 lb 10/30/2008 Other Health Professional Germany
Primary
Concomitant
Upper Respiratory Tract Infection 9/19/2008 Female 195 lb 12/12/2008 United States
Primary
Concomitant
Cardiac Failure Congestive Hospitalization 12/15/2008 55 Male 170 lb 12/29/2008 Other Health Professional United States
Primary
Concomitant
Vomiting Other Serious 2/9/2008 Male 1/19/2009 Lawyer United States
Primary
Concomitant
Paraesthesia Hospitalization 8/25/2008 45 Male 181 lb 1/20/2009 Physician Germany
Primary
Secondary
Concomitant
Interacting
Syncope Hospitalization 6/12/2008 84 Female 1/22/2009 Physician Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 2/9/2008 82 Male 2/19/2009 Lawyer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 4/19/2002 50 Male 211 lb 4/20/2009 United States
Primary
Concomitant
Urinary Incontinence Hospitalization 2/5/2009 Female 4/23/2009 Physician
Primary
Concomitant
Weight Increased Other Serious 1/1/2007 Female 5/22/2009 Other Health Professional United States
Primary
Concomitant
Wound Dehiscence Other Serious 7/10/2003 Male 6/25/2009 Physician Germany
Primary
Secondary
Concomitant
Coronary Artery Disease Hospitalization 9/22/2008 Male 7/1/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 11/1/2007 82 Male 7/16/2009 Physician United States
Primary
Concomitant
Renal Disorder Death 67 Male 7/14/2009 Lawyer United States
Primary
Concomitant
Haemoglobin Decreased 5/1/2008 Female 85 lb 7/23/2009 Consumer United States
Primary
Concomitant
White Blood Cell Count Decreased 4/1/2009 Male 7/24/2009 Other Health Professional United States
Primary
Concomitant
Fall Male 7/27/2009 Other Health Professional United States
Primary
Concomitant
Diabetic Foot Other Serious 1/1/2004 45 Male 200 lb 7/29/2009 Other Health Professional United States
Primary
Concomitant
Prothrombin Time Prolonged Other Serious 76 Male 7/31/2009 Other Health Professional United States
Primary
Concomitant
Overdose Hospitalization 76 Male 8/17/2009 Pharmacist United States
Primary
Concomitant
Insomnia Male 8/21/2009 United States
Primary
Concomitant
Pruritus Female 8/22/2009 United States
Primary
Concomitant
Flushing 8/1/2008 Male 265 lb 8/24/2009 United States
Primary
Concomitant
Hyperkalaemia Hospitalization 11/30/2007 Male 198 lb 11/30/2009 Physician Germany
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 1/12/2010 92 Female 175 lb 2/19/2010 Physician Germany
Primary
Concomitant
Rhinalgia 5/5/2009 Male 4/22/2010 Consumer United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 10/19/2009 79 Male 141 lb 6/2/2010 United States
Primary
Secondary
Concomitant
Coronary Artery Disease Hospitalization 6/28/2010 75 Male 192 lb 7/19/2010 Physician United States
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/19/2010 65 Male 7/23/2010 Physician
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 10/14/2002 41 Female 165 lb 7/26/2010 Lawyer United States
Primary
Secondary
Concomitant
Hepatitis Other Serious 6/3/2010 85 Female 119 lb 7/29/2010 Physician Germany
Primary
Concomitant
Cardiac Failure Life Threatening 6/18/2010 84 Female 10/22/2010 Physician Germany
Primary
Concomitant
Weight Decreased 4/1/2010 84 Male 130 lb 11/8/2010 Consumer United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2007 77 Male 159 lb 12/2/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sudden Death Other Serious 9/1/2010 59 Male 143 lb 12/23/2010 Other Health Professional United States
Primary
Concomitant
Interacting
Blood Bilirubin Increased Other Serious 6/3/2010 85 Female 119 lb 1/14/2011 Other Health Professional Germany
Primary
Concomitant
Tongue Pigmentation Other Serious 76 Female 3/14/2011 Physician United States
Primary
Concomitant
Atrial Flutter Hospitalization 11/12/2009 67 Female 273 lb 3/16/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Immobile 12/15/2010 84 Male 3/18/2011 Consumer United States
Primary
Concomitant
Application Site Pain 5/1/2010 68 Male 3/25/2011 Pharmacist United States
Primary
Concomitant
Sudden Death Other Serious 8/29/2010 59 Male 143 lb 3/21/2011 Other Health Professional United States
Primary
Concomitant
Interacting
Angina Unstable Life Threatening 8/29/2010 59 Male 143 lb 3/30/2011 Physician United States
Primary
Concomitant
Interacting
Sudden Death Hospitalization 8/29/2010 59 Male 143 lb 3/30/2011 Other Health Professional United States
Primary
Concomitant
Interacting
Pruritus Hospitalization 1/1/2007 79 Male 174 lb 4/11/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Unevaluable Event 11/27/2010 73 Male 163 lb 2/7/2011 Consumer United States
Primary
Concomitant
Akinesia Hospitalization 1/1/2011 86 Male 5/2/2011 Physician United States
Primary
Concomitant
Bronchospasm 10/1/2010 71 Male 5/3/2011 Physician United States
Primary
Concomitant
Blood Glucose Increased Male 5/10/2011 Consumer United States
Primary
Concomitant
Pain Hospitalization 1/9/2007 48 Male 209 lb 5/11/2011 Physician United States
Primary
Concomitant
Bronchitis Hospitalization 72 Female 215 lb 4/27/2011 Consumer United States
Primary
Concomitant
Increased Tendency To Bruise 12/15/2010 84 Male 5/12/2011 Consumer United States
Primary
Concomitant
Electrocardiogram T Wave Abnormal Other Serious 3/17/2009 66 Female 273 lb 5/16/2011 Consumer United States
Primary
Secondary
Concomitant
Cholecystitis Other Serious 7/5/2006 36 Female 160 lb 5/17/2011 Lawyer United States
Primary
Secondary
Concomitant
Injury Other Serious Female 172 lb 5/23/2011 Other Health Professional United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 4/24/2010 67 Male 249 lb 5/18/2011 Pharmacist United States
Primary
Secondary
Concomitant
Syncope Hospitalization 4/9/2011 77 Male 7/13/2011 Physician United States
Primary
Secondary
Concomitant
Mobility Decreased Other Serious 12/1/2006 79 Male 187 lb 7/14/2011 Lawyer United States
Primary
Concomitant
Nausea 5/17/2011 80 Male 7/15/2011 Physician Germany
Primary
Concomitant
Diverticulitis Hospitalization 5/20/2011 70 Male 7/27/2011 United States
Primary
Concomitant
Colitis Hospitalization 6/2/2011 85 Female 147 lb 8/2/2011 Physician United States
Primary
Concomitant
Colon Adenoma Disability 6/2/2011 85 Female 147 lb 8/15/2011 Physician United States
Primary
Concomitant
Haematochezia Hospitalization 11/22/2010 72 Female 124 lb 9/1/2011 Other Health Professional United States
Primary
Concomitant
Interacting
Thrombocytopenia Disability 6/2/2011 85 Female 147 lb 9/12/2011 Physician United States
Primary
Concomitant
Muscle Spasms Hospitalization 7/1/2011 55 Female 9/12/2011 Other Health Professional United States
Primary
Concomitant
Dizziness Exertional Other Serious 4/29/2008 73 Male 194 lb 9/13/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Colitis Disability 6/2/2011 85 Female 147 lb 9/26/2011 Physician United States
Primary
Concomitant
Pleural Effusion Hospitalization 11/22/2010 72 Female 124 lb 9/16/2011 Other Health Professional United States
Primary
Concomitant
Interacting
Haemorrhagic Stroke Disability 8/29/2010 59 Male 143 lb 9/28/2011 Other Health Professional United States
Primary
Concomitant
Interacting
Cardiac Failure Death 73 Female 11/1/2011 Consumer Germany
Primary
Secondary
Concomitant
Chest Discomfort Hospitalization 10/1/2011 84 Male 164 lb 11/14/2011 Other Health Professional United States
Primary
Concomitant
Calculus Bladder Male 11/15/2011 Consumer United States
Primary
Concomitant
Peripheral Sensory Neuropathy Hospitalization 11/1/2011 77 Male 225 lb 12/6/2011 Physician United States
Primary
Secondary
Concomitant
Peripheral Sensory Neuropathy Hospitalization 11/1/2011 77 Male 225 lb 12/12/2011 Physician United States
Primary
Secondary
Concomitant
Blindness Unilateral Hospitalization 1/1/2006 55 Female 223 lb 12/15/2011 Consumer Brazil
Primary
Concomitant
Death Hospitalization 11/10/2011 77 Male 225 lb 12/22/2011 Physician United States
Primary
Secondary
Concomitant
Drug Interaction Other Serious 91 Male 161 lb 12/30/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Coronary Artery Disease Hospitalization Female 222 lb 1/6/2012 Physician United States
Primary
Concomitant
Peripheral Sensory Neuropathy Death 11/10/2011 77 Male 225 lb 1/13/2012 Physician United States
Primary
Secondary
Concomitant
Neuropathy Peripheral Death 77 Male 2/2/2012 Consumer United States
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 11/3/2011 65 Female 144 lb 2/24/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Injection Site Pain Hospitalization 1/1/2010 75 Female 3/1/2012 Consumer United States
Primary
Concomitant
Dyspnoea Death 6/17/2011 51 Male 177 lb 3/2/2012 Physician Serbia
Primary
Concomitant
Concomitant Disease Progression Hospitalization 3/3/2010 71 Male 229 lb 3/5/2012 Physician Ireland
Primary
Secondary
Concomitant
Dyspnoea Life Threatening 8/23/2011 83 Female 115 lb 3/5/2012 Other Health Professional New Zealand
Primary
Concomitant
International Normalised Ratio Increased Other Serious 73 Male 3/2/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Anaemia Hospitalization 9/13/2010 78 Male 188 lb 3/6/2012 Physician United States
Primary
Secondary
Concomitant
Arteriosclerosis Other Serious 12/1/2011 Male 203 lb 3/8/2012 Consumer United States
Primary
Concomitant
Demyelination Death 11/10/2011 77 Male 225 lb 3/9/2012 Physician United States
Primary
Secondary
Concomitant
Blood Pressure Systolic Increased Hospitalization 5/11/2007 57 Male 200 lb 2/27/2012 Lawyer United States
Primary
Concomitant
Skin Irritation 8/1/2011 86 Female 3/9/2012 Consumer United States
Primary
Concomitant
Bronchospasm Hospitalization 11/3/2011 63 Male 176 lb 3/12/2012 Other Health Professional United Kingdom
Primary
Concomitant
Hypotension Other Serious 3/3/2010 71 Male 229 lb 3/13/2012 Physician Ireland
Primary
Secondary
Concomitant
Condition Aggravated Hospitalization 11/3/2011 65 Female 144 lb 3/20/2012 Physician United States
Primary
Secondary
Concomitant
Stent Malfunction Other Serious 2/1/2012 45 Male 220 lb 3/16/2012 Consumer United States
Primary
Concomitant
Fluid Intake Reduced Hospitalization Female 3/15/2012 Consumer United States
Primary
Concomitant
Emotional Distress Other Serious 12/1/2004 64 Male 135 lb 3/23/2012 Consumer United States
Primary
Concomitant

Drug Data