Isosorbide Dinitrate combined with Metformin Hcl

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Therapeutic Agent Toxicity Hospitalization 72 Male 1/5/2006 Physician United States
Primary
Secondary
Drug Ineffective 2/7/2006 69 Female 181 lb 9/6/2006 Consumer United States
Primary
Concomitant
Hypotension Other Serious 8/29/2006 81 Male 117 lb 8/29/2006 Pharmacist United States
Primary
Concomitant
Sepsis Other Serious 9/15/2006 75 Male 172 lb 11/3/2006 Physician Germany
Primary
Concomitant
Weight Decreased Other Serious 8/9/2006 76 Female 12/14/2006 Other Health Professional France
Primary
Secondary
Concomitant
Weight Decreased Other Serious 8/9/2006 76 Female 12/19/2006 France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/6/2006 71 Male 1/16/2007 Pharmacist United States
Primary
Concomitant
Shock Other Serious 9/15/2006 Male 172 lb 2/6/2007 Physician Germany
Primary
Concomitant
Protein Urine Required Intervention 70 Male 2/23/2006 United States
Primary
Concomitant
Nasopharyngitis 9/1/2006 74 Female 1/12/2007 Consumer United States
Primary
Concomitant
Pneumonia Other Serious 6/4/2007 Female 200 lb 6/12/2007 United States
Primary
Concomitant
Myocardial Infarction Hospitalization 92 Male 6/12/2007 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 4/5/2007 Male 6/13/2007 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 5/1/2007 Male 6/21/2007 Consumer United States
Primary
Concomitant
Malaise Other Serious 3/1/2006 45 Male 4/26/2007 Physician United States
Primary
Concomitant
Subdural Haematoma Other Serious 1/1/2007 83 Female 7/19/2007 Consumer United States
Primary
Concomitant
Subdural Haematoma Other Serious 1/1/2007 83 Female 142 lb 7/26/2007 Consumer United States
Primary
Concomitant
Nausea 5/1/2007 8/10/2007 Consumer United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2006 62 Male 183 lb 8/10/2007 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 4/1/2007 Male 195 lb 8/21/2007 Consumer United States
Primary
Concomitant
Stent Placement Hospitalization Male 8/24/2007 Consumer United States
Primary
Concomitant
Myocardial Infarction Hospitalization 1/1/2006 Female 8/27/2007 Consumer United States
Primary
Concomitant
Weight Increased Life Threatening 6/1/2007 70 Male 8/31/2007 Germany
Primary
Concomitant
Thrombosis Other Serious 6/9/2007 59 Female 238 lb 9/10/2007 Consumer United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Other Serious 4/1/2007 Female 220 lb 9/11/2007 Physician United States
Primary
Concomitant
Haematochezia Other Serious 4/1/2007 Female 9/11/2007 Consumer United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2007 67 Male 217 lb 9/11/2007 Consumer United States
Primary
Concomitant
Pancreatitis Chronic Other Serious 1/5/2005 Male 128 lb 9/12/2007 Physician Mexico
Primary
Concomitant
Gastrointestinal Haemorrhage Other Serious 3/1/2007 Female 229 lb 10/4/2007 Consumer United States
Primary
Concomitant
Gastrointestinal Pain Hospitalization 4/1/2007 Female 203 lb 10/12/2007 Consumer United States
Primary
Concomitant
Limb Injury Other Serious 7/23/2007 Male 225 lb 11/26/2007 Physician United States
Primary
Concomitant
Anorexia 7/9/2007 80 Male 11/16/2007 United States
Primary
Concomitant
Shock Other Serious 69 Male 12/4/2007 Other Health Professional Germany
Primary
Secondary
Blood Glucose Increased 9/14/2007 68 Male 11/16/2007 United States
Primary
Concomitant
Gastrointestinal Haemorrhage Other Serious 3/1/2007 Female 229 lb 12/11/2007 Consumer United States
Primary
Concomitant
Shock Other Serious 69 Male 12/14/2007 Other Health Professional Germany
Primary
Secondary
Vision Blurred Other Serious 4/26/2000 Male 301 lb 1/25/2008 Other Health Professional United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 12/15/2007 58 Male 203 lb 1/28/2008 Pharmacist United Kingdom
Primary
Concomitant
Heart Rate Decreased Hospitalization 11/1/2007 71 Female 196 lb 1/30/2008 Consumer United Kingdom
Primary
Concomitant
Ventricular Tachycardia Life Threatening 1/1/2007 64 Male 1/21/2008 Other Health Professional United Kingdom
Primary
Concomitant
Ventricular Tachycardia Life Threatening 1/1/2007 64 Male 1/30/2008 Other Health Professional United Kingdom
Primary
Concomitant
Swollen Tongue Other Serious 1/1/2008 Male 186 lb 2/13/2008 United States
Primary
Concomitant
Headache Death 5/17/2007 77 Male 3/5/2008 Consumer United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2006 Male 245 lb 3/11/2008 Other Health Professional United States
Primary
Concomitant
Urticaria 67 Male 240 lb 3/19/2008 Physician United States
Primary
Concomitant
Ventricular Tachycardia Life Threatening 1/1/2007 64 Male 3/17/2008 United Kingdom
Primary
Concomitant
Respiratory Failure Life Threatening 2/21/2008 Female 143 lb 4/4/2008 Physician Taiwan, Province Of China
Primary
Concomitant
Blood Glucose Increased Other Serious 3/24/2008 Female 144 lb 4/8/2008 United States
Primary
Concomitant
Suicidal Ideation Other Serious 3/24/2008 Female 145 lb 4/21/2008 United States
Primary
Concomitant
Unevaluable Event Hospitalization 3/1/2007 Male 170 lb 4/25/2008 Consumer United States
Primary
Concomitant
Renal Impairment 82 Male 4/22/2008 Germany
Primary
Concomitant
Chest Pain Other Serious 2/29/2008 Male 197 lb 4/30/2008 Physician Netherlands
Primary
Concomitant
Unevaluable Event Hospitalization 3/1/2007 Male 170 lb 5/1/2008 Consumer United States
Primary
Concomitant
Insomnia Death 5/17/2007 77 Male 4/29/2008 Consumer United States
Primary
Secondary
Concomitant
Unevaluable Event Hospitalization 3/1/2007 Male 172 lb 5/7/2008 Consumer United States
Primary
Concomitant
Bradycardia Hospitalization 11/29/2007 Female 196 lb 5/8/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2006 Male 245 lb 5/16/2008 Other Health Professional United States
Primary
Concomitant
Treatment Noncompliance Other Serious 1/1/2006 74 Male 5/17/2008 Consumer
Primary
Concomitant
Vomiting Hospitalization 1/1/2007 Female 159 lb 5/23/2008 Physician United States
Primary
Secondary
Concomitant
Vascular Bypass Dysfunction Other Serious 9/1/2004 Female 5/30/2008 United States
Primary
Secondary
Bradycardia Hospitalization 11/29/2007 Female 196 lb 6/4/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Impairment 7/20/2007 82 Male 5/30/2008 Physician Germany
Primary
Concomitant
Vascular Bypass Dysfunction Other Serious 9/1/2004 Female 6/12/2008 United States
Primary
Concomitant
Pneumonia Hospitalization 11/24/2007 76 Female 137 lb 6/17/2008 United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2007 Female 202 lb 6/23/2008 Consumer United States
Primary
Concomitant
Hyperglycaemia Other Serious 7/20/2007 52 Female 4/30/2008 United States
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 4/1/2008 Male 6/30/2008 Consumer United States
Primary
Concomitant
Coronary Artery Occlusion Hospitalization Female 164 lb 7/18/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased 1/1/2007 Female 202 lb 7/19/2008 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 7/18/2008 67 Male 187 lb 7/21/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Rash 8/18/2007 Female 204 lb 8/27/2008 Physician United States
Primary
Concomitant
Pruritus 7/1/2008 Female 210 lb 8/29/2008 United States
Primary
Concomitant
Back Pain Other Serious 7/5/2008 10/13/2008 Canada
Primary
Concomitant
Shock Other Serious 69 Male 10/22/2008 Other Health Professional Germany
Primary
Secondary
Flushing Male 11/26/2008 United States
Primary
Concomitant
Nausea Hospitalization 11/7/2008 55 Female 200 lb 12/4/2008 Consumer United States
Primary
Concomitant
Upper Respiratory Tract Infection 9/19/2008 Female 195 lb 12/12/2008 United States
Primary
Concomitant
Visual Acuity Reduced Other Serious 10/1/2007 Female 162 lb 12/23/2008 Consumer United States
Primary
Concomitant
Thyroid Function Test Abnormal Hospitalization Female 179 lb 1/9/2009 Consumer United States
Primary
Concomitant
Thyroid Function Test Abnormal Hospitalization 12/24/2008 Female 179 lb 1/21/2009 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2008 65 Male 198 lb 1/22/2009 Consumer Austria
Primary
Concomitant
Syncope Life Threatening 5/26/2008 66 Male 1/16/2009 Germany
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 55 Male 226 lb 2/9/2009 Other Health Professional United States
Primary
Concomitant
Surgery Other Serious 7/1/2007 Female 2/11/2009 Consumer Mexico
Primary
Concomitant
Hyperkalaemia Hospitalization 3/1/2006 76 Male 2/12/2009 Other Health Professional Japan
Primary
Concomitant
Interacting
Pyrexia Other Serious 11/30/2008 77 Male 2/4/2009 Physician Japan
Primary
Secondary
Concomitant
Syncope Other Serious 2/1/2009 77 Female 2/16/2009 Consumer Brazil
Primary
Concomitant
Wheezing Hospitalization 12/1/2008 85 Female 3/19/2009 Physician United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 4/19/2002 50 Male 211 lb 4/20/2009 United States
Primary
Concomitant
Weight Decreased Other Serious 3/1/2004 75 Female 7/2/2009
Primary
Secondary
Concomitant
Renal Disorder Death 67 Male 7/14/2009 Lawyer United States
Primary
Concomitant
Vision Blurred Hospitalization 59 Female 7/13/2009 Lawyer United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 72 Male 7/17/2009 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 76 Male 7/15/2009 Lawyer United States
Primary
Concomitant
Vomiting Life Threatening 3/4/2009 54 Female 7/16/2009 United Kingdom
Primary
Concomitant
Diabetes Mellitus Female 189 lb 7/22/2009 United States
Primary
Concomitant
Pyrexia Other Serious 11/30/2008 77 Male 7/30/2009 Physician Japan
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Death 68 Male 8/12/2009 Consumer United States
Primary
Concomitant
Varices Oesophageal Hospitalization 11/23/2007 67 Male 8/12/2009 Consumer United States
Primary
Concomitant
Vision Blurred Other Serious 4/23/2007 54 Female 258 lb 8/12/2009 United States
Primary
Concomitant
Vomiting Hospitalization 7/1/2007 48 Male 8/12/2009 United States
Primary
Concomitant
Flushing Male 8/22/2009 United States
Primary
Concomitant
Skin Burning Sensation 2/1/2008 Female 140 lb 8/22/2009 Physician United States
Primary
Concomitant
Pruritus 6/2/2009 240 lb 8/22/2009 United States
Primary
Concomitant
Rash 12/1/2008 Male 8/22/2009 United States
Primary
Concomitant
Skin Burning Sensation 7/16/2009 Male 225 lb 8/23/2009 United States
Primary
Concomitant
Vomiting Hospitalization 2/20/2008 65 Female 180 lb 8/21/2009 Lawyer United States
Primary
Concomitant
Weight Increased Other Serious Female 8/28/2009 Consumer United States
Primary
Concomitant
Wheezing Hospitalization 45 Male 8/25/2009 United States
Primary
Concomitant
Death Death Female 9/3/2009 Lawyer United States
Primary
Concomitant
Thrombocytopenia Hospitalization 69 Male 10/27/2009 Portugal
Primary
Concomitant
Retinopathy Disability 10/21/2009 Male 203 lb 11/20/2009 Physician Germany
Primary
Secondary
Concomitant
Somnolence Other Serious 9/6/2009 84 Female 165 lb 11/30/2009 Pharmacist Germany
Primary
Secondary
Concomitant
Shock Haemorrhagic Life Threatening 8/26/2009 80 Male 183 lb 12/3/2009 Physician Russian Federation
Primary
Concomitant
Hyperkalaemia Hospitalization 3/22/2006 76 Male 12/4/2009 Japan
Primary
Secondary
Concomitant
Interacting
Hypoglycaemia Life Threatening 8/13/2008 81 Male 128 lb 2/15/2010 Other Health Professional Germany
Primary
Concomitant
Interacting
Hypoglycaemia Life Threatening 8/13/2008 81 Male 128 lb 2/15/2010 Other Health Professional Germany
Primary
Concomitant
Interacting
Personality Change Life Threatening 8/13/2008 81 Male 128 lb 2/16/2010
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 10/1/2009 60 Female 4/13/2010 Consumer United States
Primary
Secondary
Somnolence Other Serious 9/6/2009 84 Female 165 lb 4/21/2010 Pharmacist Germany
Primary
Secondary
Concomitant
Rhinalgia 5/5/2009 Male 4/22/2010 Consumer United States
Primary
Concomitant
Pain In Extremity Other Serious 10/1/2009 60 Female 4/26/2010 Consumer France
Primary
Secondary
Syncope Hospitalization 5/26/2008 66 Male 234 lb 5/4/2010 Pharmacist Germany
Primary
Secondary
Concomitant
Interacting
Syncope Life Threatening 5/26/2008 66 Male 8/20/2010 Other Health Professional Germany
Primary
Concomitant
Interacting
Syncope Life Threatening 5/26/2008 66 Male 8/20/2010 Other Health Professional Germany
Primary
Concomitant
Interacting
Syncope Life Threatening 5/26/2008 66 Male 8/20/2010 Other Health Professional Germany
Primary
Concomitant
Interacting
Osteitis Other Serious 48 Male 8/23/2010 Consumer Germany
Primary
Secondary
Concomitant
Hypoglycaemia Life Threatening 8/13/2008 81 Male 128 lb 9/24/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 7/26/2010 75 Male 10/28/2010 France
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Other Serious 8/4/2010 72 Male 192 lb 10/12/2010 Netherlands
Primary
Concomitant
Tricuspid Valve Incompetence Required Intervention 12/2/2008 48 Male 12/9/2010 Mexico
Primary
Concomitant
Fatigue Other Serious 10/1/2007 Female 263 lb 1/5/2011 Consumer Switzerland
Primary
Concomitant
Renal Impairment Other Serious 12/3/2008 62 Male 1/6/2011 Other Health Professional Japan
Primary
Concomitant
Peripheral Arterial Occlusive Disease Other Serious 72 Female 1/13/2011 Consumer United States
Primary
Concomitant
Cough 10/1/2010 71 Male 1/14/2011 Consumer
Primary
Concomitant
Toxicity To Various Agents Hospitalization 1/14/2011 70 Female 2/1/2011 Consumer United States
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 50 Male 211 lb 2/4/2011 Pharmacist United States
Primary
Concomitant
Abdominal Pain Male 294 lb 2/16/2011 Consumer United States
Primary
Concomitant
Blood Glucose Increased 9/1/2010 65 Male 2/25/2011 Pharmacist United States
Primary
Concomitant
Oedema Peripheral Other Serious 12/15/2009 68 Male 168 lb 2/25/2011 Other Health Professional United States
Primary
Concomitant
Haematoma Hospitalization 88 Female 3/4/2011 Physician United States
Primary
Concomitant
Skin Burning Sensation Other Serious 1/1/2010 48 Male 265 lb 3/16/2011 Consumer United States
Primary
Concomitant
Hypotension Hospitalization 2/22/2011 76 Male 205 lb 3/11/2011 Pharmacist United States
Primary
Secondary
Concomitant
Jaw Fracture Other Serious 4/1/2010 61 Female 4/12/2011 Consumer United States
Primary
Concomitant
Coronary Artery Occlusion Hospitalization 3/1/2011 75 Male 190 lb 4/19/2011 Consumer United States
Primary
Concomitant
Pain Hospitalization 1/9/2007 48 Male 209 lb 5/11/2011 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 4/7/2011 76 Male 5/11/2011 Pharmacist Japan
Primary
Concomitant
Gastric Haemorrhage Hospitalization 11/21/2010 67 Male 132 lb 5/19/2011 Physician United States
Primary
Secondary
Concomitant
Chest Pain Other Serious 12/28/2010 63 Female 132 lb 5/23/2011 Physician Japan
Primary
Concomitant
Burning Sensation Female 5/24/2011 Consumer United States
Primary
Concomitant

Drug Data