Isosorbide Dinitrate combined with Levothyroxine Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Weight Decreased Hospitalization 10/27/2005 87 Male 127 lb 12/1/2005 Pharmacist United States
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 57 Female 3/17/2006 United States
Primary
Secondary
Concomitant
Pulmonary Oedema Required Intervention 57 Female 3/30/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Toxicity Required Intervention 4/26/2005 72 Male 175 lb 4/20/2006 Pharmacist United States
Primary
Concomitant
Rhabdomyolysis Life Threatening 11/2/2005 71 Male 216 lb 6/27/2006 Other Health Professional Germany
Primary
Concomitant
Vomiting Life Threatening 4/1/2006 80 Female 6/23/2006 Physician Germany
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 4/24/2006 67 Male 7/5/2006 Pharmacist United States
Primary
Secondary
Concomitant
Rash Pruritic Hospitalization 3/1/2006 81 Male 6/29/2006 Physician Japan
Primary
Concomitant
Rash Hospitalization 3/1/2006 81 Male 7/7/2006 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 4/12/2006 79 Male Pharmacist United States
Primary
Concomitant
Shunt Occlusion Hospitalization 7/18/2006 Female 8/10/2006 Consumer Canada
Primary
Concomitant
Photophobia Hospitalization 1/1/2001 69 Male 8/15/2006 Other Health Professional United States
Primary
Concomitant
Shunt Occlusion Hospitalization 7/18/2006 Female 9/8/2006 Consumer Canada
Primary
Concomitant
Pruritus Other Serious 8/10/2006 52 Female 115 lb 9/6/2006 Germany
Primary
Concomitant
Shunt Occlusion Hospitalization 7/18/2006 Female 11/7/2006 Consumer Canada
Primary
Concomitant
Visual Acuity Reduced Other Serious 62 Male 11/16/2006 Consumer Japan
Primary
Concomitant
Cardiac Murmur Hospitalization 4/24/2006 Female 160 lb 11/16/2006 Consumer Canada
Primary
Concomitant
Cerebrovascular Accident Hospitalization 78 Male 168 lb 12/1/2006 Physician Germany
Primary
Concomitant
Cardiomegaly Other Serious 4/24/2006 Female 160 lb 12/14/2006 Consumer Canada
Primary
Concomitant
Cerebrovascular Accident Hospitalization 78 Male 168 lb 12/14/2006 Physician Germany
Primary
Concomitant
Renal Failure Required Intervention 5/16/2006 76 Female 12/13/2006 Pharmacist United States
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 78 Male 168 lb 12/21/2006 Physician Germany
Primary
Concomitant
Xanthopsia Other Serious 62 Male 12/21/2006
Primary
Concomitant
Xanthopsia Other Serious 62 Male 12/14/2006 Physician Japan
Primary
Concomitant
Treatment Noncompliance Hospitalization 10/10/2006 Male 215 lb 12/19/2006 Pharmacist United States
Primary
Secondary
Concomitant
Somnolence Other Serious 12/14/2005 65 Female 190 lb 2/12/2007 Physician Poland
Primary
Concomitant
Somnolence Other Serious 5/1/2005 65 Female 190 lb 2/19/2007 Physician Poland
Primary
Concomitant
Somnolence Other Serious 5/1/2005 65 Female 190 lb 2/21/2007 Physician Poland
Primary
Concomitant
Protein Urine Required Intervention 70 Male 2/23/2006 United States
Primary
Concomitant
Liver Disorder Other Serious 1/5/2007 55 Male 4/12/2007 Japan
Primary
Concomitant
Somnolence Other Serious 5/1/2005 65 Female 190 lb 5/14/2007 Physician Poland
Primary
Concomitant
Syncope Other Serious 1/1/2005 65 Female 190 lb 5/16/2007 Physician Poland
Primary
Concomitant
Rhabdomyolysis Other Serious 4/16/2007 67 Male 5/22/2007 Physician United States
Primary
Secondary
Concomitant
Lower Gastrointestinal Haemorrhage Hospitalization 9/5/2005 12/13/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 2/15/2007 78 Female 6/5/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2002 78 Female 121 lb 6/1/2007 Other Health Professional United States
Primary
Secondary
Cholelithiasis Hospitalization 2/22/2007 78 Female 122 lb 6/12/2007 United States
Primary
Secondary
Cholelithiasis Hospitalization 2/22/2007 78 Female 122 lb 6/18/2007 United States
Primary
Concomitant
Increased Upper Airway Secretion Hospitalization 4/1/2007 77 Female 6/29/2007 United States
Primary
Concomitant
Drug Ineffective Other Serious 5/5/2007 Male 190 lb 7/6/2007 Consumer United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/22/2007 78 Female 122 lb 7/13/2007 United States
Primary
Concomitant
Vomiting Hospitalization 2/22/2007 78 Female 122 lb 7/12/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased 8/1/2006 Female 7/26/2007 Physician United States
Primary
Concomitant
Muscle Haemorrhage Hospitalization 12/30/2006 Male 214 lb 5/1/2007 Pharmacist United States
Primary
Concomitant
Weight Increased Other Serious 5/5/2007 Male 190 lb 8/23/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombosis Other Serious 6/9/2007 59 Female 238 lb 9/10/2007 Consumer United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 9/9/2007 77 Female 134 lb 9/11/2007 Pharmacist United States
Primary
Concomitant
Pyuria Death 2/10/2006 Male 10/4/2007 Other Health Professional Japan
Primary
Concomitant
Stomatitis 7/4/2007 86 Female 10/26/2007 Consumer United States
Primary
Concomitant
Pyuria Death 2/10/2006 Male 11/7/2007 Other Health Professional Japan
Primary
Concomitant
Nocturnal Dyspnoea 8/22/2007 69 Male 11/14/2007 Consumer United States
Primary
Concomitant
Somnolence Other Serious 9/17/2007 61 269 lb 11/30/2007 Other Health Professional United Kingdom
Primary
Concomitant
Dyspnoea Hospitalization 9/12/2007 Female 175 lb 12/14/2007 Physician United States
Primary
Concomitant
Underdose 1/1/2004 Male 241 lb 12/15/2007 Consumer United States
Primary
Concomitant
Syncope Other Serious 8/1/2004 65 Female 190 lb 1/9/2008 Physician Poland
Primary
Concomitant
Vision Blurred Other Serious 4/26/2000 Male 301 lb 1/25/2008 Other Health Professional United States
Primary
Concomitant
Heart Rate Decreased Hospitalization 11/1/2007 71 Female 196 lb 1/30/2008 Consumer United Kingdom
Primary
Concomitant
Xanthopsia Other Serious 62 Male 1/28/2008 Physician Japan
Primary
Concomitant
Subdural Haematoma Life Threatening 85 Female 2/14/2008 Other Health Professional Switzerland
Primary
Concomitant
Pain In Extremity Other Serious 11/1/2007 Female 160 lb 2/22/2008 Canada
Primary
Concomitant
Pain Other Serious 9/20/2007 82 Male 3/4/2008 Pharmacist United States
Primary
Concomitant
Wound Complication Other Serious 1/1/2000 Female 3/7/2008 Consumer United States
Primary
Concomitant
Accidental Exposure 1/27/2008 Female 110 lb 3/15/2008 Consumer United States
Primary
Concomitant
Urticaria 67 Male 240 lb 3/19/2008 Physician United States
Primary
Concomitant
Visual Acuity Reduced Other Serious 1/14/2008 Female 140 lb 3/12/2008 Other Health Professional United States
Primary
Concomitant
Visual Disturbance Other Serious 1/14/2008 Female 140 lb 4/15/2008 Other Health Professional United States
Primary
Concomitant
Wound Complication Other Serious 1/1/2000 Female 4/16/2008 Physician United States
Primary
Concomitant
Rash 8/26/2007 Female 185 lb 4/28/2008 Physician United States
Primary
Concomitant
Renal Disorder Hospitalization 12/1/2007 73 Female 4/30/2008 Consumer United Kingdom
Primary
Concomitant
Bradycardia Hospitalization 11/29/2007 Female 196 lb 5/8/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Insomnia 2/22/2008 49 Female 3/14/2008 Consumer United States
Primary
Concomitant
Medication Error Other Serious 1/1/2008 Female 164 lb 5/16/2008 Consumer United States
Primary
Concomitant
Ventricular Hypokinesia Life Threatening 9/10/2004 76 Male 141 lb 5/21/2008 Germany
Primary
Secondary
Concomitant
Bradycardia Hospitalization 11/29/2007 Female 196 lb 6/4/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Wound Complication Other Serious 1/1/2000 Female 6/4/2008 Physician United States
Primary
Concomitant
Incontinence Hospitalization 5/1/2008 82 Female 176 lb 6/9/2008 United States
Primary
Concomitant
Therapeutic Response Decreased Other Serious 4/1/2008 Female 6/23/2008 Other Health Professional
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 86 Female 6/20/2008 Physician United States
Primary
Concomitant
Pain In Extremity Other Serious 6/1/2008 Female 160 lb 6/27/2008 Canada
Primary
Concomitant
Syncope Other Serious 8/1/2004 65 Female 190 lb 7/7/2008 Physician Poland
Primary
Concomitant
Therapeutic Response Decreased Other Serious 4/1/2008 Female 7/16/2008 Other Health Professional
Primary
Concomitant
Renal Disorder Hospitalization 12/1/2007 73 Female 7/29/2008 Consumer United Kingdom
Primary
Concomitant
Therapeutic Response Decreased Other Serious 4/1/2008 Female 77 lb 7/29/2008 Other Health Professional
Primary
Concomitant
Lung Neoplasm Malignant Other Serious 6/16/2008 75 Male 8/6/2008 Other Health Professional Croatia (Local Name: Hrvatska)
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 6/1/2008 Female 160 lb 11/20/2008 Canada
Primary
Concomitant
Visual Impairment Other Serious Male 140 lb 11/22/2008 Consumer United States
Primary
Concomitant
Coronary Artery Disease Hospitalization 9/15/2004 Male 12/2/2008 Physician Germany
Primary
Secondary
Concomitant
Tachycardia Hospitalization 11/1/2008 93 Female 11/20/2008 Germany
Primary
Secondary
Product Quality Issue Death 10/19/2008 65 Male 12/8/2008 Consumer United States
Primary
Concomitant
Visual Acuity Reduced Other Serious 10/1/2007 Female 162 lb 12/23/2008 Consumer United States
Primary
Concomitant
Vomiting Other Serious 10/1/2007 Female 162 lb 12/24/2008 Consumer United States
Primary
Concomitant
Skin Burning Sensation 1/1/2004 Female 192 lb 1/15/2009 Physician United States
Primary
Concomitant
Wheezing Hospitalization 12/1/2008 85 Female 3/19/2009 Physician United States
Primary
Concomitant
Suicidal Ideation Other Serious 3/22/2009 4/28/2009 Other Health Professional United Kingdom
Primary
Concomitant
Potentiating Drug Interaction Other Serious 1/1/2009 64 Female 5/22/2009 Consumer United States
Primary
Concomitant
Paraesthesia Hospitalization 6/11/2009 Female 187 lb 7/16/2009 Physician Switzerland
Primary
Concomitant
Paraesthesia Hospitalization 6/11/2009 Female 187 lb 7/21/2009 Physician Switzerland
Primary
Concomitant
Vomiting Death 86 Female 7/20/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 78 Female 7/23/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Death 68 Male 8/12/2009 Consumer United States
Primary
Concomitant
Paraesthesia 10/14/2008 Female 8/22/2009 United States
Primary
Concomitant
Pruritus 11/7/2008 Female 8/22/2009 United States
Primary
Concomitant
Vomiting Hospitalization 2/20/2008 65 Female 180 lb 8/21/2009 Lawyer United States
Primary
Concomitant
Laboratory Test Abnormal Other Serious 75 Female 9/28/2009 Other Health Professional France
Primary
Secondary
Concomitant
Tardive Dyskinesia Other Serious 12/29/2006 59 Male 303 lb 10/8/2009 United States
Primary
Secondary
Concomitant
Muscle Spasms Other Serious 9/20/2009 Male 300 lb 10/20/2009 Consumer United States
Primary
Concomitant
Suicidal Ideation Other Serious 3/22/2009 56 Female 11/13/2009 Other Health Professional United Kingdom
Primary
Concomitant
Osteonecrosis Disability 12/1/2007 57 Female 11/25/2009 United States
Primary
Concomitant
Pain In Extremity Other Serious 11/27/2009 56 Female 200 lb 12/17/2009 Pharmacist United States
Primary
Concomitant
Hepatic Steatosis Other Serious 77 Female 132 lb 12/24/2009 Other Health Professional France
Primary
Concomitant
Paraesthesia Other Serious Male 178 lb 1/8/2010 Physician United States
Primary
Secondary
Concomitant
Vascular Resistance Systemic Increased Other Serious 77 Female 132 lb 1/4/2010 Other Health Professional United States
Primary
Concomitant
Hepatic Steatosis Hospitalization 77 Female 132 lb 2/2/2010 Physician United States
Primary
Concomitant
Hypoglycaemia Hospitalization 12/29/2009 80 Female 2/15/2010 Other Health Professional Italy
Primary
Secondary
Concomitant
Hypoglycaemia Hospitalization 12/29/2009 80 Female 2/17/2010 Other Health Professional Italy
Primary
Secondary
Concomitant
Hypoglycaemia Hospitalization 12/29/2009 80 Female 2/22/2010 Other Health Professional Italy
Primary
Secondary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 90 Female 90 lb 3/17/2010 Consumer United States
Primary
Secondary
Concomitant
Vomiting Life Threatening 2/11/2010 Female 3/26/2010 Physician Argentina
Primary
Concomitant
Hypoglycaemia Hospitalization 12/29/2009 80 Female 3/29/2010 Other Health Professional Italy
Primary
Secondary
Concomitant
Vomiting Life Threatening 2/11/2010 Female 3/29/2010 Physician Argentina
Primary
Concomitant
Alopecia Other Serious 1/27/2010 70 Female 192 lb 3/31/2010 Physician United Kingdom
Primary
Concomitant
Somnolence Hospitalization 12/29/2009 80 Female 4/5/2010 Other Health Professional Italy
Primary
Secondary
Concomitant
Vomiting Life Threatening 2/11/2010 81 Female 4/9/2010 Physician Argentina
Primary
Concomitant
Cardiac Arrest Death 86 Male 313 lb 4/13/2010 Other Health Professional United States
Primary
Concomitant
Vascular Occlusion Hospitalization Male 191 lb 4/26/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Wrong Technique In Drug Usage Process Life Threatening 5/27/2010 59 Female 7/15/2010 Other Health Professional United States
Primary
Concomitant
Hepatitis Other Serious 6/3/2010 85 Female 119 lb 7/29/2010 Physician Germany
Primary
Concomitant
Venous Thrombosis Hospitalization 1/1/2010 66 Female 154 lb 9/3/2010 Physician Germany
Primary
Concomitant
Tooth Disorder Hospitalization 1/1/2007 57 Female 9/8/2010 Other Health Professional United States
Primary
Concomitant
Tooth Disorder Hospitalization 1/1/2007 57 Female 9/30/2010 Other Health Professional United States
Primary
Concomitant
Heparin-induced Thrombocytopenia Other Serious 6/13/2010 81 Female 10/7/2010 Other Health Professional Italy
Primary
Secondary
Concomitant
Tooth Infection Other Serious 1/1/2007 57 Female 10/14/2010 Other Health Professional United States
Primary
Concomitant
Venous Thrombosis Hospitalization 5/7/2010 66 Female 154 lb 10/19/2010 Physician Germany
Primary
Concomitant
Weight Increased Other Serious 7/31/2004 57 Female 181 lb 11/15/2010 Other Health Professional United States
Primary
Concomitant
Venous Thrombosis Hospitalization 5/7/2010 66 Female 154 lb 11/16/2010 Physician Germany
Primary
Concomitant
Renal Failure Hospitalization 9/29/2010 11/23/2010 Physician Belgium
Primary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/2010 78 Female 107 lb 11/24/2010 Consumer United States
Primary
Concomitant
Visual Acuity Reduced Other Serious Female 12/8/2010 Consumer United States
Primary
Concomitant
Psoriasis 11/1/2009 12/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Blood Bilirubin Increased Other Serious 6/3/2010 85 Female 119 lb 1/14/2011 Other Health Professional Germany
Primary
Concomitant
Oral Herpes 6/10/2010 62 Female 1/29/2011 Consumer United States
Primary
Concomitant
Venous Thrombosis Hospitalization 4/7/2010 66 Female 154 lb 2/16/2011 Physician Germany
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Other Serious 1/1/2005 57 Female 181 lb 3/10/2011 Other Health Professional United States
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Other Serious 1/1/2005 57 Female 181 lb 3/14/2011 Other Health Professional United States
Primary
Concomitant
Blood Glucose Increased 2/20/2011 75 Male 3/25/2011 Consumer United States
Primary
Concomitant
Rhabdomyolysis Other Serious 3/30/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cardiomyopathy Hospitalization 2/20/2008 48 Female 180 lb 3/17/2011 United States
Primary
Concomitant
Sepsis Hospitalization 11/12/2009 67 Female 273 lb 4/25/2011 Physician United States
Primary
Secondary
Concomitant
Oliguria Hospitalization 11/12/2009 67 Female 273 lb 4/25/2011 Physician United States
Primary
Secondary
Concomitant
Rash Maculo-papular Other Serious 8/1/2007 64 Female 160 lb 4/7/2011 Consumer United States
Primary
Secondary
Concomitant

Drug Data