Isoniazid combined with Rifampin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Metabolic Acidosis Hospitalization 2 Female 2/3/2006 Other Health Professional United States
Primary
Concomitant
Interacting
Ischaemic Cerebral Infarction Hospitalization 5/10/2003 69 Male 2/27/2006 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 4/21/2005 57 Female 2/28/2006 Physician United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 2/1/2006 Male 3/3/2006 Other Health Professional United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2003 52 Female 150 lb 3/10/2006 Lawyer United States
Primary
Concomitant
Sinus Bradycardia Hospitalization 5/10/2003 69 Male 3/13/2006 Lawyer United States
Primary
Concomitant
Tuberculosis Hospitalization 10/3/2001 69 Male 157 lb 3/15/2006 Lawyer United States
Primary
Concomitant
Thrombocytopenia Hospitalization 10/3/2003 88 Female 3/21/2006 Other Health Professional France
Primary
Concomitant
Ventricular Hypertrophy Hospitalization 10/3/2001 69 Male 157 lb 3/24/2006 Physician United States
Primary
Concomitant
Hyponatraemia Hospitalization 32 Male 3/30/2006 Physician Switzerland
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 4/21/2005 57 Female 4/11/2006 Physician United States
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 32 Male 4/14/2006 Physician Switzerland
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 1/1/2003 52 Female 150 lb 4/18/2006 Physician United States
Primary
Concomitant
Renal Failure Hospitalization 39 Male 5/11/2006
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 4/21/2005 57 Female 7/11/2006 Physician United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 39 Male 5/11/2006 Other Health Professional Spain
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization 40 Male 7/31/2006 Consumer United States
Primary
Secondary
Serum Ferritin Increased 6/17/2005 52 Male 12/29/2005 Physician United States
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization 40 Male 8/16/2006 Consumer United States
Primary
Secondary
International Normalised Ratio Increased Required Intervention 8/6/2006 78 Male 119 lb 8/15/2006 Pharmacist United States
Primary
Concomitant
Lethargy Life Threatening 6/2/2006 56 Female 128 lb 10/25/2006 United States
Primary
Secondary
Toxic Epidermal Necrolysis Hospitalization 7/31/2004 59 Male 11/17/2006 Consumer Taiwan, Province Of China
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 7/31/2004 59 Male 11/27/2006 Consumer Taiwan, Province Of China
Primary
Secondary
Concomitant
Blood Bilirubin Increased Hospitalization 12/12/2006 Male 70 lb 12/14/2006 Pharmacist United States
Primary
Concomitant
Vomiting Hospitalization 11/14/2004 41 Female 128 lb 2/16/2007 United States
Primary
Concomitant
Tuberculosis Other Serious 1/1/2007 Female 104 lb 3/2/2007 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 12/17/2006 58 Male 207 lb 3/3/2007 Pharmacist United States
Primary
Secondary
Hepatitis Hospitalization 7/30/2006 Male 127 lb 2/13/2007 Pharmacist United States
Primary
Secondary
Concomitant
Uveitis Other Serious 40 Male 6/22/2007 India
Primary
Secondary
Tendon Disorder Other Serious 6/22/2007 35 Male 209 lb 7/6/2007 Other Health Professional United States
Primary
Concomitant
Uveitis Other Serious 40 Male 8/2/2007
Primary
Secondary
Vomiting Other Serious 7/31/2007 Male 115 lb 9/7/2007 Other Health Professional United States
Primary
Secondary
Septic Shock Other Serious 42 Male 10/16/2007 Other Health Professional United States
Primary
Concomitant
Sepsis Hospitalization 18 Male 10/23/2007
Primary
Secondary
Concomitant
Visual Disturbance Required Intervention 10/7/2007 20 Male 10/22/2007 Pharmacist United States
Primary
Secondary
Uveitis Other Serious 58 Female 10/31/2007
Primary
Secondary
Concomitant
Stridor Hospitalization 44 Female 11/19/2007 Physician France
Primary
Secondary
Concomitant
Kaposi's Sarcoma Hospitalization 33 Female 11/19/2007 Physician France
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 12/27/2007 40 Male 1/28/2008 Pharmacist Japan
Primary
Concomitant
Vision Blurred Other Serious 2/21/2008 48 Female 3/19/2008 Pharmacist United States
Primary
Secondary
Staphylococcal Sepsis Hospitalization 4/29/2007 Female 97 lb 4/7/2008 Physician Japan
Primary
Secondary
Concomitant
Tuberculosis Life Threatening 3/6/2008 23 Male 144 lb 4/10/2008 Pharmacist United States
Primary
Secondary
Staphylococcal Sepsis Hospitalization 4/29/2007 Female 97 lb 4/18/2008 Physician Japan
Primary
Secondary
Concomitant
Grand Mal Convulsion Life Threatening 4/8/2008 50 Male 110 lb 5/5/2008 Consumer United Kingdom
Primary
Concomitant
Tuberculoid Leprosy Other Serious 37 Male 5/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Grand Mal Convulsion Life Threatening 4/8/2008 50 Male 110 lb 5/16/2008 Consumer United Kingdom
Primary
Concomitant
Hepatitis Required Intervention 2/11/2008 43 Female 4/22/2008 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Life Threatening 4/28/2008 Female 83 lb 5/6/2008 Pharmacist United States
Primary
Secondary
Concomitant
Hepatitis Required Intervention 5/14/2008 Female 107 lb 6/6/2008 Other Health Professional United States
Primary
Secondary
Tuberculosis Death 10/1/2007 Female 146 lb 6/16/2008 Physician United States
Primary
Secondary
Concomitant
Hepatotoxicity Life Threatening 6/17/2008 37 Male 7/1/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Hospitalization 1/1/2007 17 Male 7/24/2008 Physician United States
Primary
Secondary
Vomiting Other Serious 81 Female 8/14/2008 Italy
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 4/28/2004 29 Female 8/29/2008 Korea, Republic Of
Primary
Secondary
Lung Adenocarcinoma Metastatic Hospitalization 50 Female 9/8/2008 Physician United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 2/1/2008 Male 132 lb 9/18/2008 Physician Korea, Republic Of
Primary
Concomitant
Interacting
Weight Decreased Hospitalization 2/1/2008 Male 132 lb 10/2/2008 Physician Korea, Republic Of
Primary
Concomitant
Interacting
Vomiting Hospitalization 42 Male 10/31/2008 Consumer Korea, Republic Of
Primary
Secondary
Concomitant
Lactic Acidosis Hospitalization 1/1/2008 81 Female 11/13/2008 Other Health Professional Italy
Primary
Secondary
Encephalitis Hospitalization 1/27/2008 Male 211 lb 11/18/2008 Physician United States
Primary
Concomitant
Pyrexia Other Serious 2/6/2008 Male 112 lb 11/20/2008 Physician United States
Primary
Concomitant
Neuroleptic Malignant Syndrome Hospitalization 1/1/2008 42 Male 11/26/2008 Other Health Professional Korea, Democratic People's Republic Of
Primary
Secondary
Concomitant
Pyrexia Other Serious 2/6/2008 Male 112 lb 12/1/2008 Physician United States
Primary
Concomitant
Protein Urine Present Hospitalization 12/3/2008 28 Male 12/12/2008 Physician United States
Primary
Concomitant
Neuroleptic Malignant Syndrome Hospitalization 42 Male 12/15/2008
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Hospitalization 12/3/2008 28 Male 12/20/2008 Physician United States
Primary
Concomitant
Hepatic Enzyme Increased Hospitalization 12/3/2008 28 Male 12/23/2008 Physician United States
Primary
Concomitant
Hepatic Enzyme Increased Hospitalization 11/19/2008 28 Male 1/5/2009 Physician United States
Primary
Concomitant
Renal Failure Death 12/13/2008 29 Male 96 lb 1/8/2009 Physician United States
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 12/27/2008 47 Female 1/21/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 12/27/2008 47 Female 1/27/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Paradoxical Drug Reaction Hospitalization 1/1/2009 19 Female 1/28/2009 Other Health Professional Korea, Democratic People's Republic Of
Primary
Secondary
Renal Impairment Life Threatening 12/27/2008 47 Female 2/2/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Death 12/13/2008 29 Male 96 lb 2/2/2009 United States
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 12/27/2008 47 Female 2/9/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 12/27/2008 47 Female 2/25/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Rash Death 45 Female 2/27/2009
Primary
Concomitant
Hepatotoxicity Death 27 Female 2/27/2009
Primary
Concomitant
Hyperuricaemia Other Serious 2/5/2009 Male 112 lb 2/13/2009 Physician Taiwan, Province Of China
Primary
Concomitant
Hepatotoxicity Death Female 3/13/2009
Primary
Secondary
Hepatotoxicity Death Female 3/13/2009
Primary
Secondary
Death Death 0 Male 4/16/2009 Germany
Primary
Concomitant
Weight Decreased Death 0 Male 4/16/2009 Germany
Primary
Concomitant
Weight Decreased Death 0 Female 4/16/2009 Germany
Primary
Concomitant
Pruritus Other Serious 10/7/2008 Female 154 lb 4/23/2009 Physician United States
Primary
Secondary
Concomitant
Paradoxical Drug Reaction Other Serious 1/1/2008 11 Male 121 lb 4/23/2009 Other Health Professional China
Primary
Secondary
Wrong Drug Administered 1/27/2009 51 Female 142 lb 4/28/2009 Pharmacist United States
Primary
Secondary
Weight Decreased Hospitalization 2/1/2003 51 Male 5/21/2009 Other Health Professional Japan
Primary
Concomitant
Respiratory Failure Life Threatening 6/12/2008 73 5/29/2009 Other Health Professional Taiwan, Province Of China
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/29/2009 47 Male 123 lb 6/5/2009 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 42 Male 6/10/2009 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Pneumonia Bacterial Hospitalization 4/29/2009 47 Male 123 lb 6/18/2009 United States
Primary
Secondary
Concomitant
Vomiting Death 5/23/2009 43 Male 119 lb 6/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Death 5/23/2009 43 Male 119 lb 7/9/2009 United States
Primary
Secondary
Concomitant
Tuberculosis Other Serious 43 Female 7/20/2009
Primary
Secondary
Concomitant
Lupus Nephritis Hospitalization 29 Male 7/21/2009 Physician Romania
Primary
Secondary
Concomitant
Lupus Nephritis Hospitalization 29 Male 7/24/2009 Physician Romania
Primary
Secondary
Concomitant
Lupus Nephritis Hospitalization 29 Male 8/3/2009 Physician Romania
Primary
Secondary
Concomitant
Cerebral Haemorrhage Death 6/16/2009 34 Female 8/18/2009 Botswana
Primary
Secondary
Concomitant
Hepatitis Fulminant Life Threatening 5/16/2009 36 Female 8/28/2009 Other Health Professional France
Primary
Secondary
Concomitant
Hepatitis Fulminant Disability 3/4/2009 25 Male 9/15/2009 Pharmacist United States
Primary
Secondary
Tachypnoea Hospitalization 19 Female 9/17/2009 Korea, Republic Of
Primary
Concomitant
Tubulointerstitial Nephritis Hospitalization 6/1/2006 26 Male 118 lb 9/21/2009 Japan
Primary
Concomitant
Systemic Inflammatory Response Syndrome Hospitalization 7/17/2009 86 Male 9/29/2009 Physician United States
Primary
Secondary
Hypophosphataemia Life Threatening 7/21/2009 36 Male 183 lb 10/16/2009 Consumer United States
Primary
Secondary
Concomitant
Hypophosphataemia Life Threatening 7/21/2009 36 Male 183 lb 10/26/2009 Consumer United States
Primary
Secondary
Concomitant
Ulcer Required Intervention 11 Male 121 lb 11/2/2009 China
Primary
Concomitant
Maternal Drugs Affecting Foetus Hospitalization Female 11/10/2009 Physician Germany
Primary
Concomitant
Neutropenia Life Threatening 11/2/2009 32 Male 11/17/2009 Physician United States
Primary
Secondary
Concomitant
Skin Exfoliation Hospitalization 8/14/2009 33 Female 11/25/2009 Other Health Professional France
Primary
Secondary
Concomitant
Neutropenia Life Threatening 11/2/2009 32 Male 12/29/2009 Physician United States
Primary
Secondary
Concomitant
Neutropenia Life Threatening 11/2/2009 32 Male 12/31/2009 Physician United States
Primary
Secondary
Concomitant
Systemic Inflammatory Response Syndrome Hospitalization Male United States
Primary
Secondary
Concomitant
Rectal Cancer Hospitalization 66 Female 12/23/2009 Korea, Democratic People's Republic Of
Primary
Concomitant
Septic Shock Other Serious 12/24/2009 Male 140 lb 1/15/2010 Mexico
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2 Male 2/2/2010
Primary
Secondary
Concomitant
Rash Hospitalization 8/20/1998 22 Male 115 lb 1/15/2010 Other Health Professional United States
Primary
Secondary
Hepatitis Fulminant Life Threatening 5/16/2009 36 Female 2/19/2010 Other Health Professional France
Primary
Secondary
Concomitant
Septic Shock Life Threatening 12/28/2009 Male 140 lb 2/19/2010 Mexico
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 50 Female 2/5/2010 Other Health Professional United Kingdom
Primary
Concomitant
Rash Life Threatening 9/23/2003 35 Female 183 lb 1/13/2010 Other Health Professional United States
Primary
Secondary
Tuberculoma Of Central Nervous System Other Serious 1/1/2009 7 Male 3/19/2010 Other Health Professional India
Primary
Secondary
Liver Transplant 7/28/2008 66 Female 10/8/2008 Physician United States
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Other Serious 1/1/2009 70 Male 4/2/2010 Physician United States
Primary
Secondary
Hyperglycaemia Hospitalization 3/17/1994 41 Female 4/21/2010 Physician Japan
Primary
Secondary
Concomitant
Hepatitis Cholestatic Hospitalization 1/12/2010 38 Female 150 lb 5/10/2010 Other Health Professional France
Primary
Secondary
Concomitant
Tremor Other Serious 28 Female 5/17/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pyrexia Other Serious 11/1/2008 73 Female 5/24/2010 Physician Japan
Primary
Secondary
Pyrexia Other Serious 11/1/2008 73 Female 5/28/2010 Physician Japan
Primary
Secondary
Splenic Abscess Other Serious 1/1/2010 6/4/2010 Other Health Professional India
Primary
Secondary
Sinus Tachycardia Hospitalization 6/1/2009 87 Female 6/30/2010 Physician Japan
Primary
Secondary
Concomitant
Sinus Tachycardia Hospitalization 6/1/2009 87 Female 7/2/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Death 12/13/2008 29 Male 96 lb 7/16/2010 United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 11/1/2008 73 Female 7/27/2010 Physician Japan
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 7/4/2010 55 Female 99 lb 8/6/2010 Physician Korea, Republic Of
Primary
Secondary
Syncope Hospitalization 50 Female 8/6/2010 Other Health Professional Italy
Primary
Concomitant
Tuberculosis Hospitalization 7/4/2010 55 Female 99 lb 8/16/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 7/21/2010 21 Male 106 lb 8/17/2010 Brazil
Primary
Secondary
Concomitant
Hemiparesis Other Serious 1/1/2007 5 Female 8/17/2010 Germany
Primary
Concomitant
Vascular Pseudoaneurysm Other Serious 75 Male 8/20/2010
Primary
Secondary
Leukopenia Other Serious 7/26/2010 54 Male 117 lb 8/25/2010 Brazil
Primary
Secondary
Concomitant
Leukopenia Other Serious 7/26/2010 54 Male 8/20/2010 France
Primary
Secondary
Concomitant
Leukopenia Other Serious 7/26/2010 54 Male 8/23/2010 France
Primary
Secondary
Concomitant
Neutropenia Other Serious 4/17/2010 54 Male 8/26/2010 France
Primary
Secondary
Concomitant
Paradoxical Drug Reaction Hospitalization 1/1/2010 44 Male 9/2/2010 Other Health Professional Spain
Primary
Secondary
Vomiting Death 27 Female 99 lb 9/24/2010
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 45 Female 121 lb 9/24/2010
Primary
Secondary
Tuberculosis Hospitalization 7/4/2010 55 Female 99 lb 9/28/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Other Serious 44 Female 9/29/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Hepatitis Fulminant Life Threatening 9/18/2010 55 Female 9/27/2010 France
Primary
Concomitant

Drug Data