Isoniazid combined with Rifampicin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Haemoptysis Death 9/7/2005 75 Male 12/30/2005 Japan
Primary
Concomitant
Vomiting Hospitalization 9/19/2003 40 Female 1/9/2006 Physician Uganda
Primary
Secondary
Concomitant
Skin Hyperpigmentation Hospitalization 54 Male 12/30/2005 Physician New Zealand
Primary
Concomitant
Vomiting Other Serious 46 2/1/2005 Other Health Professional United States
Primary
Secondary
Concomitant
Hepatitis Other Serious 56 Male 2/1/2005 Other Health Professional United States
Primary
Secondary
Concomitant
Hepatitis Other Serious 63 Female 2/1/2005 Other Health Professional United States
Primary
Secondary
Concomitant
Drug Ineffective Other Serious Male 5/27/2005 Other Health Professional United States
Primary
Secondary
Drug Ineffective Other Serious Male 5/27/2005 Other Health Professional United States
Primary
Secondary
Drug Ineffective Other Serious Male 4/28/2005 Other Health Professional United States
Primary
Secondary
Drug Ineffective Other Serious Male 4/28/2005 Other Health Professional United States
Primary
Secondary
Blindness Other Serious Male 5/17/2005 Other Health Professional United States
Primary
Secondary
Concomitant
Optic Neuritis Other Serious Female 9/20/2005 Other Health Professional United States
Primary
Concomitant
Transaminases Increased Other Serious 2 Female 1/20/2006 Germany
Primary
Secondary
Somnolence Hospitalization 2 Female 1/17/2006 United States
Primary
Secondary
Pancreatitis Hospitalization 12/14/2005 47 Female 1/26/2006 Physician Netherlands
Primary
Secondary
Transaminases Increased Other Serious 2 Female 2/9/2006 Germany
Primary
Secondary
Sleep Disorder Other Serious 42 Male 104 lb 2/10/2006 Other Health Professional Spain
Primary
Secondary
Concomitant
Vomiting Other Serious 11/1/2003 29 Female 90 lb 2/10/2006 Other Health Professional Spain
Primary
Secondary
Concomitant
Myopathy Disability 6/29/2005 Female 2/17/2006 United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 5/31/2005 37 Female 106 lb 2/13/2006 Physician Poland
Primary
Secondary
Concomitant
Skin Exfoliation Other Serious 11/7/2005 64 Male 95 lb 2/22/2006 Japan
Primary
Concomitant
Drug Level Increased Other Serious 40 Female 3/2/2006 Other Health Professional United Kingdom
Primary
Concomitant
Shoulder Pain Disability 6/29/2005 28 Female 2/17/2006 United Kingdom
Primary
Secondary
Concomitant
Visual Field Defect Other Serious 11/1/2000 74 Female 2/24/2006 Physician Japan
Primary
Secondary
Visual Field Defect Other Serious 6/1/2000 63 Female 2/24/2006 Physician Japan
Primary
Secondary
Pain Other Serious 61 Male 2/24/2006 Pharmacist Japan
Primary
Secondary
Convulsion Life Threatening 2/17/2006 85 Male 2/27/2006 Japan
Primary
Concomitant
Hepatorenal Syndrome Death 1/9/2006 82 Female 3/2/2006 Physician Norway
Primary
Secondary
Concomitant
Renal Failure Hospitalization 2/1/2006 49 Male 3/3/2006 Physician United States
Primary
Concomitant
Multi-organ Failure Life Threatening 2/17/2006 85 Male 3/9/2006 Japan
Primary
Concomitant
Shock Other Serious 6/1/2003 70 Male 3/15/2006 Physician Japan
Primary
Concomitant
Wound Secretion Hospitalization 1/1/2004 48 Male 154 lb 3/27/2006 Physician Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/1/2001 56 Female 117 lb 3/27/2006 Physician Germany
Primary
Secondary
Concomitant
Tuberculous Pleurisy Other Serious 7/28/2004 68 Male 3/28/2006 Physician Japan
Primary
Secondary
Concomitant
Tuberculous Pleurisy Other Serious 7/28/2004 68 Male 3/29/2006 Physician Japan
Primary
Secondary
Concomitant
Sepsis Death 3/25/2006 47 Female 4/13/2006 Physician Indonesia
Primary
Concomitant
Melaena Death 9/7/2005 75 Male 4/25/2006 Japan
Primary
Concomitant
Respiratory Tract Infection Hospitalization 1 Female 4/27/2006 Physician New Zealand
Primary
Secondary
Rash Other Serious 80 Male 4/21/2006 Physician Japan
Primary
Concomitant
Dermatitis Exfoliative Other Serious 90 Male 4/27/2006 Physician Japan
Primary
Secondary
Concomitant
Rash Other Serious 80 Male 4/27/2006 Physician Japan
Primary
Secondary
Pneumonia Other Serious 2/1/2003 66 Male 4/27/2006 Physician Japan
Primary
Concomitant
Hepatitis B Surface Antigen Positive Other Serious 3/30/2006 55 Male 148 lb 5/5/2006 Physician Philippines
Primary
Interacting
Drug Interaction Other Serious 3/30/2006 55 Male 148 lb 5/5/2006 Physician Philippines
Primary
Interacting
Dermatitis Exfoliative Other Serious 90 Male 4/27/2006 Physician Japan
Primary
Secondary
Weight Decreased Hospitalization 2/25/2004 Female 82 lb 5/8/2006 Physician Germany
Primary
Concomitant
Wound Dehiscence Death 8/18/2003 72 Female 5/22/2006 Other Health Professional Czech Republic
Primary
Concomitant
Headache Other Serious 42 Female 5/18/2006 Physician Tunisia
Primary
Concomitant
Vomiting Hospitalization 31 Male 99 lb 5/20/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Unevaluable Event Death 3/25/2006 47 Female 5/24/2006 Physician Indonesia
Primary
Concomitant
Skin Hyperpigmentation Hospitalization 2/25/1998 31 Female 5/19/2006 Physician Tunisia
Primary
Concomitant
Tubulointerstitial Nephritis Hospitalization 73 Male 5/23/2006 Physician Taiwan, Province Of China
Primary
Concomitant
Optic Neuritis Other Serious 5/13/2003 38 Female 5/23/2006 Other Health Professional France
Primary
Secondary
Skin Hyperpigmentation Hospitalization 2/25/1998 31 Female 5/19/2006 Other Health Professional Tunisia
Primary
Concomitant
Urinary Tract Infection Hospitalization 1/10/2006 27 Male 6/9/2006 Other Health Professional Hungary
Primary
Concomitant
Skin Lesion Hospitalization 2/25/1998 31 Female 6/2/2006 Other Health Professional Tunisia
Primary
Concomitant
Headache Other Serious 42 Female 6/2/2006 Physician Tunisia
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 6/1/2004 61 Female 119 lb 6/2/2006 Physician Japan
Primary
Secondary
Concomitant
Visual Field Defect Other Serious 5/13/2003 38 Female 6/8/2006 Other Health Professional France
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Life Threatening Unknown 6/12/2006 Physician Benin
Primary
Secondary
Concomitant
Pyrexia Other Serious 52 Male 6/23/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Cardiac Arrest Death 6/13/2006 51 Female 6/26/2006 Germany
Primary
Concomitant
Cardiac Tamponade Hospitalization 40 Female 6/21/2006 Physician Japan
Primary
Concomitant
Hepatotoxicity Hospitalization 5/4/2006 36 Male 7/3/2006 Consumer South Africa
Primary
Secondary
Concomitant
Pyrexia Hospitalization 40 Female 6/27/2006 Physician Japan
Primary
Secondary
Pulmonary Tuberculosis Life Threatening 5/31/2005 37 Female 106 lb 6/28/2006 Physician Poland
Primary
Secondary
Concomitant
Liver Disorder Death 67 Female 6/28/2006 Other Health Professional Japan
Primary
Concomitant
Liver Disorder Death 67 Female 7/6/2006 Other Health Professional Japan
Primary
Secondary
Dialysis Other Serious 72 Female 7/5/2006 Other Health Professional Japan
Primary
Secondary
Pyrexia Hospitalization 61 Male 110 lb 7/6/2006 Physician Japan
Primary
Concomitant
Hepatitis Fulminant Death 52 Male 7/11/2006 Physician Philippines
Primary
Concomitant
Vomiting Death 1/9/2006 82 Female 7/24/2006 Physician Norway
Primary
Secondary
Concomitant
Neutropenic Sepsis Hospitalization 12/31/2004 34 Male 8/1/2006 Physician Zimbabwe
Primary
Secondary
Concomitant
Lymph Node Tuberculosis Hospitalization 31 Male 7/27/2006 Japan
Primary
Secondary
Hepatic Enzyme Increased Hospitalization 7/17/2005 34 Male 88 lb 8/7/2006 Consumer Australia
Primary
Secondary
Concomitant
Hepatotoxicity Death 1/9/2006 82 Female 8/1/2006 Physician Norway
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Life Threatening 5/31/2005 37 Female 106 lb 8/4/2006 Physician Poland
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Hospitalization 7/28/2005 34 Male 88 lb 8/17/2006 Consumer Australia
Primary
Secondary
Concomitant
Toxoplasmosis Other Serious 1/4/2005 44 Female 8/25/2006 Physician Uganda
Primary
Secondary
Concomitant
Toxoplasmosis Other Serious 1/4/2005 44 Female 8/25/2006 Physician Uganda
Primary
Secondary
Concomitant
Pyrexia Other Serious 52 Male 8/28/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 24 Female 8/22/2006 Togo
Primary
Secondary
Tuberculosis Life Threatening 1/1/2003 39 Male 8/22/2006 Spain
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Life Threatening 44 Male 8/22/2006 Togo
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 39 Male 8/22/2006 Togo
Primary
Secondary
Toxic Epidermal Necrolysis Hospitalization 20 Male 8/22/2006 Togo
Primary
Secondary
Stevens-johnson Syndrome Hospitalization 24 Female 8/22/2006 Togo
Primary
Secondary
Toxic Epidermal Necrolysis Hospitalization 28 Male 8/22/2006 Togo
Primary
Secondary
Stevens-johnson Syndrome Life Threatening 35 Male 8/22/2006 Togo
Primary
Secondary
Hepatitis Other Serious 6/29/2006 30 Male 8/30/2006 Physician Viet Nam
Primary
Secondary
Concomitant
Osteoarthritis Disability 6/29/2005 Female 8/30/2006 United Kingdom
Primary
Secondary
Concomitant
Pyrexia Other Serious 52 Male 8/30/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Death 55 Male 8/21/2006 Japan
Primary
Concomitant
Pulmonary Tuberculosis Death 55 Male 8/28/2006 Japan
Primary
Secondary
Rash Macular Hospitalization 6/23/2006 Male 9/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Acute Generalised Exanthematous Pustulosis Other Serious 79 Male 9/14/2006 Pharmacist Japan
Primary
Concomitant
Tubulointerstitial Nephritis Other Serious 57 Male 9/28/2006 Physician Japan
Primary
Secondary
Tubulointerstitial Nephritis Other Serious 12/26/2003 38 Male 9/28/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Tubulointerstitial Nephritis Other Serious 63 Male 9/27/2006 Other Health Professional Japan
Primary
Secondary
Urine Abnormality Hospitalization 1/10/2006 27 Male 10/6/2006 Other Health Professional Hungary
Primary
Concomitant
Unresponsive To Stimuli Other Serious 19 Female 10/6/2006 Turkey
Primary
Secondary
Unresponsive To Stimuli Life Threatening 19 Female 9/29/2006 Physician Turkey
Primary
Secondary
Concomitant
Weight Decreased Other Serious 9 Female 10/6/2006
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Death 9/22/2006 29 Female 10/13/2006 United States
Primary
Secondary
Concomitant
Lymph Node Tuberculosis Other Serious 12 Male 10/6/2006 India
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 10/2/2006 65 Female 10/18/2006 Physician India
Primary
Concomitant
Serum Ferritin Increased Hospitalization 5/21/2006 25 Female 10/20/2006 Physician Japan
Primary
Secondary
Pyrexia Hospitalization 5/2/2006 84 Male 10/30/2006 Other Health Professional Japan
Primary
Concomitant
Lactic Acidosis Hospitalization 35 Male 10/20/2006 Other Health Professional United Kingdom
Primary
Concomitant
Rhinovirus Infection Life Threatening 0 NotSpecified 10/20/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Lactic Acidosis Hospitalization 35 Female 10/24/2006 United Kingdom
Primary
Concomitant
Oesophageal Candidiasis Hospitalization 12/6/2005 32 Female 11/8/2006 Other Health Professional France
Primary
Secondary
Concomitant
Drug Level Increased Other Serious 12/1/2004 40 Female 11/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Drug Level Increased Other Serious 40 Female 11/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Tuberculosis Death 9/22/2006 29 Female 11/10/2006 United States
Primary
Secondary
Concomitant
Prothrombin Time Prolonged Other Serious 10/2/2006 65 Female 11/7/2006 Physician India
Primary
Concomitant
Subcutaneous Abscess Other Serious 31 Female 11/3/2006 France
Primary
Secondary
Concomitant
Oesophageal Candidiasis Hospitalization 12/6/2005 32 Female 11/17/2006 Other Health Professional France
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 1/10/2006 27 Male 11/20/2006 Other Health Professional Hungary
Primary
Concomitant
Hepatic Encephalopathy Hospitalization 10/26/2006 31 Male 132 lb 11/22/2006 United States
Primary
Secondary
Concomitant
Tuberculosis Gastrointestinal Hospitalization 67 Male 11/16/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Sputum Culture Positive Life Threatening 10/26/2006 31 Male 132 lb 11/28/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Life Threatening 15 Female 11/15/2006 Physician Spain
Primary
Secondary
Vasculitis Other Serious 3/20/2006 25 Female 134 lb 12/7/2006 Physician Uganda
Primary
Concomitant
Pneumonia Other Serious 1/1/2006 31 Male 132 lb 12/7/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Therapy Non-responder Hospitalization 10/26/2006 31 Male 132 lb 12/8/2006 United States
Primary
Secondary
Concomitant
Systemic Lupus Erythematosus Life Threatening 5/6/2006 33 Female 12/5/2006 Physician Japan
Primary
Secondary
Concomitant
Hepatitis Other Serious 6/29/2006 30 Male 12/18/2006 Physician Viet Nam
Primary
Secondary
Concomitant
Vomiting Other Serious 9/25/2006 11 Female 1/19/2007 Consumer South Africa
Primary
Secondary
Concomitant
Gout Other Serious 76 Female 1/23/2007 United Kingdom
Primary
Secondary
Vomiting Hospitalization 55 Female 110 lb 1/17/2007 Physician Germany
Primary
Concomitant
Vomiting Other Serious 25 Female 1/17/2007 Other Health Professional Netherlands
Primary
Secondary
Somnolence Hospitalization 54 Male 1/17/2007 Other Health Professional Netherlands
Primary
Secondary
Hepatitis Other Serious 2/1/2006 54 Male 1/23/2007 Physician Japan
Primary
Secondary
Vomiting Hospitalization 55 Female 110 lb 1/26/2007 Physician Germany
Primary
Concomitant
Jaundice Other Serious 11/16/2006 27 Male 2/1/2007 Physician Viet Nam
Primary
Secondary
Electrocardiogram Qt Prolonged Other Serious 1/9/2007 24 Female 90 lb 2/9/2007 Pharmacist United Kingdom
Primary
Concomitant
Jaundice Other Serious 11/16/2006 27 Male 2/15/2007 Physician Viet Nam
Primary
Secondary
Pneumocystis Jiroveci Pneumonia Other Serious 11/1/2006 11 Female 2/16/2007 Consumer Botswana
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 11/1/2005 48 Female 2/16/2007 Physician Japan
Primary
Concomitant
Stomatitis Hospitalization 11/10/2006 Female 107 lb 2/27/2007 Other Health Professional France
Primary
Secondary
Concomitant
Vomiting Hospitalization 31 Female 3/6/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Splenomegaly Other Serious 51 Male 3/13/2007 France
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 64 Male 3/28/2007 Other Health Professional Japan
Primary
Concomitant
Interacting
Progressive Multifocal Leukoencephalopathy Hospitalization 1/1/2006 74 Female 3/29/2007 Other Health Professional Japan
Primary
Concomitant
Psoriasis Hospitalization 2/6/2007 73 Male 3/22/2007 Physician Japan
Primary
Concomitant
Hepatic Necrosis Hospitalization 2 Male 3/22/2007 Physician Germany
Primary
Secondary
Concomitant
Tuberculoma Of Central Nervous System Other Serious 21 Male 4/4/2007 India
Primary
Secondary
Pyrexia Other Serious 9/26/2000 57 Female 4/5/2007 Other Health Professional Spain
Primary
Secondary
Concomitant
Nephritis Interstitial Other Serious 51 Male 4/12/2007 France
Primary
Secondary
Concomitant

Drug Data