Isoniazid combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Ventricular Fibrillation Life Threatening 6/30/2005 Female 99 lb 1/6/2006 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/30/2005 65 Male 137 lb 2/1/2006 Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/30/2005 65 Male 137 lb 2/8/2006 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 10/1/2005 Female 2/24/2006 Other Health Professional United Kingdom
Primary
Concomitant
Ovarian Cancer Metastatic Life Threatening 3/15/2004 Female 143 lb 3/2/2006 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/30/2005 65 Male 137 lb 2/27/2006 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/30/2005 65 Male 137 lb 3/2/2006 Physician Japan
Primary
Concomitant
Hepatic Enzyme Increased Hospitalization 2/16/2006 Male 154 lb 4/6/2006 Physician Austria
Primary
Interacting
Anaphylactoid Reaction Other Serious 8/26/2005 Female 88 lb 4/11/2006 Physician Japan
Primary
Concomitant
Haemoptysis Hospitalization 3/27/2006 Male 148 lb 4/14/2006 Norway
Primary
Concomitant
Weight Decreased Hospitalization 3/29/2006 Male 119 lb 4/18/2006 Other Health Professional Canada
Primary
Concomitant
Sepsis Death 3/25/2006 47 Female 4/13/2006 Physician Indonesia
Primary
Concomitant
Pleural Effusion Hospitalization 2/1/2006 Female 4/25/2006 Other Health Professional United Kingdom
Primary
Concomitant
Haemoptysis Hospitalization 3/27/2006 Male 148 lb 4/28/2006 Norway
Primary
Concomitant
Weight Decreased Hospitalization 3/29/2006 Male 119 lb 4/28/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 3/29/2006 Male 119 lb 4/28/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
B-cell Lymphoma Hospitalization 4/1/2006 Female 106 lb 5/2/2006 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 1/19/2006 42 Male 5/8/2006 Physician Germany
Primary
Concomitant
B-cell Lymphoma Other Serious 8/15/2005 Male 130 lb 5/16/2006 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 3/30/2006 Male 119 lb 5/18/2006 Other Health Professional United States
Primary
Secondary
Concomitant
B-cell Lymphoma Stage Iv Life Threatening 3/1/2006 Female 90 lb 5/23/2006 Physician Japan
Primary
Secondary
Concomitant
Unevaluable Event Death 3/25/2006 47 Female 5/24/2006 Physician Indonesia
Primary
Concomitant
Ovarian Cancer Metastatic Life Threatening 3/15/2004 Female 143 lb 5/31/2006 Physician United Kingdom
Primary
Concomitant
Pleural Effusion Hospitalization 2/1/2006 Female 5/31/2006 Other Health Professional United Kingdom
Primary
Concomitant
Metastases To Spleen Life Threatening 1/1/2006 Male 183 lb 6/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 3/29/2006 Male 115 lb 6/2/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 3/29/2006 Male 115 lb 6/2/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 9/1/2005 71 Male 6/19/2006 Other Health Professional Sweden
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Other Serious 23 Male 6/22/2006 Other Health Professional Greece
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2006 Male 119 lb 6/28/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2006 Male 119 lb 6/28/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Therapy Non-responder Hospitalization 3/27/2006 Male 148 lb 7/7/2006 Norway
Primary
Concomitant
Haemoptysis Hospitalization 3/27/2006 Male 148 lb 7/7/2006 Norway
Primary
Concomitant
Pruritus Hospitalization 50 Female 7/14/2006 Physician Brazil
Primary
Concomitant
Lung Neoplasm Malignant Life Threatening 1/1/2006 Male 183 lb 7/19/2006 Other Health Professional United Kingdom
Primary
Concomitant
Pruritus Other Serious 50 Female 7/19/2006 Physician Brazil
Primary
Concomitant
Tuberculosis Skin Test Positive Hospitalization 7/19/2006 50 Female 187 lb 7/28/2006 Physician Greece
Primary
Concomitant
Angina Pectoris Hospitalization Female 143 lb 8/24/2006 Physician Netherlands
Primary
Concomitant
Pruritus Other Serious 50 Female 9/1/2006 Physician Brazil
Primary
Secondary
Concomitant
Angina Pectoris Hospitalization 7/6/2006 Female 143 lb 9/8/2006 Physician Netherlands
Primary
Secondary
Concomitant
Traumatic Amputation Other Serious 4/1/2006 Male 9/14/2006 Physician Canada
Primary
Concomitant
Paraesthesia Other Serious 8/1/2006 Female 11/4/2006 Physician South Africa
Primary
Concomitant
Blindness Unilateral Other Serious Male 11/22/2006 Physician Germany
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Other Serious 10/1/2006 60 Male 11/30/2006 Physician Greece
Primary
Secondary
Atypical Mycobacterial Infection Hospitalization 3/22/2006 Female 117 lb 12/6/2006 Physician Japan
Primary
Concomitant
Angina Pectoris Hospitalization 7/6/2006 Female 143 lb 12/22/2006 Physician Netherlands
Primary
Secondary
Concomitant
Carcinoid Tumour Hospitalization 2/1/2006 21 Male 1/17/2007 Other Health Professional Turkey
Primary
Concomitant
Atypical Mycobacterial Infection Hospitalization 3/22/2006 Female 117 lb 2/20/2007 Physician Japan
Primary
Concomitant
Stomatitis Hospitalization 11/10/2006 Female 107 lb 2/27/2007 Other Health Professional France
Primary
Secondary
Concomitant
Insomnia Disability 1/15/2007 Female 128 lb 3/6/2007 Physician Colombia
Primary
Concomitant
Rectal Prolapse Other Serious 11/17/2005 Female 150 lb 3/7/2007 Consumer United Kingdom
Primary
Concomitant
Gait Disturbance Hospitalization 6/28/2005 Male 154 lb 3/7/2007 Consumer United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2006 Male 119 lb 3/20/2007 Other Health Professional Canada
Primary
Secondary
Concomitant
Pyrexia Other Serious 9/26/2000 57 Female 4/5/2007 Other Health Professional Spain
Primary
Secondary
Concomitant
Rectal Haemorrhage Hospitalization 1/31/2007 Female 164 lb 4/12/2007 Canada
Primary
Concomitant
Pulmonary Tuberculosis Other Serious 48 Female 4/17/2007 Other Health Professional Portugal
Primary
Concomitant
Rectal Haemorrhage Hospitalization 1/31/2007 Female 164 lb 4/20/2007 Canada
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 3/14/2007 Female 150 lb 4/25/2007 Physician United States
Primary
Concomitant
Hepatitis Acute Hospitalization 1/1/2006 Female 150 lb 4/27/2007 Physician Japan
Primary
Concomitant
Pneumonitis Other Serious 4/12/2007 Male 4/30/2007 Physician Norway
Primary
Concomitant
Pleural Effusion Other Serious 12/1/2003 Female 121 lb 5/29/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/22/2004 Male 121 lb 6/5/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Lymphocytic Leukaemia Hospitalization 3/1/2007 Male 96 lb 6/17/2007 Physician Brazil
Primary
Concomitant
Vomiting Hospitalization 7/22/2004 Male 121 lb 7/6/2007 Physician Japan
Primary
Secondary
Concomitant
Duodenal Ulcer Hospitalization 10/20/2006 Female 150 lb 7/10/2007 Physician Japan
Primary
Concomitant
Tongue Neoplasm Malignant Stage Unspecified Life Threatening 7/1/2007 Male 132 lb 8/3/2007 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 7/9/2007 Female 132 lb 8/7/2007 Physician Japan
Primary
Concomitant
Renal Impairment Death 5/31/2007 Male 8/10/2007 Other Health Professional Italy
Primary
Concomitant
Renal Impairment Death 5/31/2007 Male 8/15/2007 Other Health Professional Italy
Primary
Concomitant
Tuberculosis Life Threatening 9/1/2005 Male 8/16/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 2/10/2007 Female 110 lb 9/12/2007 Italy
Primary
Concomitant
Vomiting Hospitalization 7/9/2007 Female 132 lb 9/18/2007 Physician Japan
Primary
Concomitant
Wound Drainage Hospitalization 9/10/2007 Male 160 lb 9/20/2007 Canada
Primary
Concomitant
Pancytopenia Hospitalization 6/8/2005 Female 95 lb 9/21/2007 Physician Japan
Primary
Secondary
Concomitant
Wound Drainage Hospitalization 9/10/2007 Male 160 lb 9/26/2007 Canada
Primary
Concomitant
Ectopic Acth Syndrome Other Serious 2/1/2006 21 Male 10/9/2007
Primary
Secondary
Wound Drainage Hospitalization 9/10/2007 Male 160 lb 10/11/2007 Canada
Primary
Concomitant
Suffocation Feeling Other Serious 7/1/2007 55 Female 141 lb 10/19/2007 Physician Tunisia
Primary
Secondary
Concomitant
Uveitis Other Serious 58 Female 10/31/2007
Primary
Secondary
Concomitant
Tongue Neoplasm Malignant Stage Unspecified Life Threatening 7/1/2006 Male 132 lb 11/15/2007 Physician Japan
Primary
Concomitant
Multiple Fractures Hospitalization 3/5/2004 Female 146 lb 12/7/2007 United Kingdom
Primary
Concomitant
Diplopia 9/18/2006 Female 12/13/2007 Physician United States
Primary
Concomitant
Rash 10/3/2007 Female 140 lb 12/14/2007 United States
Primary
Concomitant
Cervical Dysplasia Other Serious 3/30/2006 Female 115 lb 12/26/2007 Other Health Professional United Kingdom
Primary
Concomitant
Diarrhoea Hospitalization 2/10/2007 Female 110 lb 12/28/2007 Italy
Primary
Concomitant
Post Procedural Complication Hospitalization 2/19/2007 Female 150 lb 1/8/2008 Consumer United Kingdom
Primary
Concomitant
Vomiting Hospitalization 12/27/2004 Male 121 lb 1/17/2008 Physician Japan
Primary
Secondary
Concomitant
Oxygen Saturation Decreased Hospitalization 9/20/2007 Female 132 lb 1/17/2008 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Legionella Hospitalization 1/8/2008 69 Male 181 lb 1/29/2008 Physician Italy
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/21/2008 Female 2/1/2008 Physician Belgium
Primary
Secondary
Concomitant
Pneumonia Legionella Hospitalization 1/8/2008 69 Male 181 lb 2/8/2008 Physician Italy
Primary
Secondary
Concomitant
Encephalitis Hospitalization 45 Female 2/8/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Tuberculosis Other Serious 7/19/2004 Female 163 lb 3/5/2008 United Kingdom
Primary
Concomitant
Petechiae Hospitalization 8/9/2007 Male 159 lb 3/7/2008 Japan
Primary
Secondary
Concomitant
Thymoma Malignant Other Serious 3/1/2006 Male 3/14/2008 Other Health Professional Turkey
Primary
Concomitant
Insomnia 12/10/2007 Female 130 lb 3/14/2008 United States
Primary
Concomitant
Injection Site Pain 12/9/2007 Female 135 lb 3/15/2008 United States
Primary
Concomitant
Headache 1/1/2008 Female 130 lb 3/15/2008 United States
Primary
Concomitant
Vomiting Hospitalization 12/20/2004 Male 121 lb 3/21/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Disorder Other Serious 5/1/2005 Female 153 lb 3/26/2008 Physician United States
Primary
Secondary
Concomitant
Swelling Face Hospitalization 2/1/2008 67 Female 187 lb 4/4/2008 Physician Turkey
Primary
Concomitant
Lupus-like Syndrome Other Serious 11/7/2003 Female 4/11/2008 Physician United States
Primary
Concomitant
Alveolitis Allergic Other Serious 3/26/2008 Male 161 lb 4/21/2008 Argentina
Primary
Secondary
Concomitant
Tuberculosis Other Serious 2/20/2002 Male 5/9/2008 Physician Germany
Primary
Secondary
Concomitant
Bronchopneumonia Death 4/6/2008 Male 220 lb 5/16/2008 Czech Republic
Primary
Secondary
Concomitant
Atypical Mycobacterial Infection Hospitalization 3/22/2006 Female 117 lb 5/23/2008 Physician Japan
Primary
Concomitant
Bronchopneumonia Death 4/6/2008 Male 220 lb 5/23/2008 Czech Republic
Primary
Secondary
Concomitant
Occult Blood Positive Hospitalization 2/10/2007 Female 110 lb 5/29/2008 Italy
Primary
Concomitant
Bronchopneumonia Hospitalization 4/6/2008 Male 220 lb 6/2/2008 Czech Republic
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 42 Male 6/4/2008 Other Health Professional Spain
Primary
Secondary
Venoocclusive Disease Other Serious 42 Male 6/9/2008 Other Health Professional Spain
Primary
Secondary
Tongue Neoplasm Malignant Stage Unspecified Life Threatening 7/1/2006 Male 132 lb 6/12/2008 Physician Japan
Primary
Concomitant
Musculoskeletal Stiffness 5/10/2008 Female 6/13/2008 United States
Primary
Concomitant
Sneezing 5/22/2008 Female 130 lb 6/13/2008 United States
Primary
Concomitant
Pancytopenia Hospitalization 6/8/2005 Female 95 lb 6/13/2008 Physician Japan
Primary
Secondary
Concomitant
Right Ventricular Failure Hospitalization 4/6/2008 Male 220 lb 6/16/2008 Czech Republic
Primary
Secondary
Concomitant
Tuberculosis Death 10/1/2007 Female 146 lb 6/16/2008 Physician United States
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 70 Male 6/25/2008
Primary
Concomitant
Pneumonia Hospitalization Female 105 lb 6/25/2008 Canada
Primary
Concomitant
Haemoptysis Other Serious 8/1/2007 60 Male 161 lb 7/2/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/18/2006 Female 154 lb 7/2/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Malaise Other Serious 42 Female 130 lb 7/3/2008 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization Female 104 lb 7/16/2008 Canada
Primary
Concomitant
Tuberculosis Other Serious 7/3/2002 Female 7/17/2008 Other Health Professional United States
Primary
Concomitant
Pulmonary Mass Other Serious 7/8/2008 Male 7/18/2008 China
Primary
Concomitant
Pneumonia Mycoplasmal Hospitalization 5/15/2008 Female 93 lb 7/21/2008 Physician Japan
Primary
Secondary
Concomitant
Tuberculous Pleurisy Hospitalization 5/9/2008 65 Female 7/29/2008 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Mass Other Serious 7/8/2008 Male 8/1/2008 China
Primary
Concomitant
Alveolitis Allergic Other Serious 3/26/2008 Male 161 lb 8/7/2008 Argentina
Primary
Secondary
Concomitant
Myocardial Ischaemia Death 3/28/2008 Female 163 lb 8/13/2008 United Kingdom
Primary
Concomitant
Pulmonary Mass Other Serious 7/8/2008 Male 9/8/2008 China
Primary
Concomitant
Weight Decreased Hospitalization 42 Male 9/3/2008 Spain
Primary
Secondary
Injection Site Pain 1/1/2008 Female 191 lb 9/12/2008 Consumer United States
Primary
Concomitant
Weight Increased Other Serious 4/11/2008 Female 197 lb 9/15/2008 Physician United States
Primary
Concomitant
Alveolitis Allergic Other Serious 3/26/2008 Male 161 lb 9/19/2008 Argentina
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 7/19/2007 Female 121 lb 9/21/2008 Physician Japan
Primary
Secondary
Concomitant
Optic Neuritis Hospitalization 9/5/2008 Female 9/30/2008 Other Health Professional Italy
Primary
Secondary
Concomitant
Weight Increased Other Serious 4/11/2008 Female 197 lb 10/2/2008 Physician United States
Primary
Concomitant
Vomiting Hospitalization 7/9/2007 Female 132 lb 11/5/2008 Physician Japan
Primary
Concomitant
Latent Tuberculosis Death Female 11/17/2008 Other Health Professional United States
Primary
Concomitant
Alveolitis Allergic Other Serious 3/26/2008 Male 161 lb 11/21/2008 Argentina
Primary
Secondary
Concomitant
Renal Cyst Hospitalization 10/30/2008 Male 101 lb 11/21/2008 Japan
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 12/1/2003 Female 143 lb 11/26/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Death Hospitalization 11/10/2008 Female 115 lb 12/1/2008 Belgium
Primary
Secondary
Concomitant
Pleural Effusion Death 1/1/2003 47 Female 12/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Nasopharyngitis 2/18/2008 Male 135 lb 12/8/2008 Physician United States
Primary
Concomitant
Rash Life Threatening 47 Female 121 lb 12/3/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Injection Site Irritation 4/3/2008 Female 130 lb 12/11/2008 Consumer United States
Primary
Concomitant
Systemic Candida Hospitalization 11/10/2008 Female 115 lb 12/12/2008 Belgium
Primary
Secondary
Concomitant
Sepsis Other Serious 8/22/2008 Female 12/16/2008 Japan
Primary
Concomitant

Drug Data