Iscotin combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pneumocystis Jiroveci Pneumonia Hospitalization 12/17/2005 Female 101 lb 2/17/2006 Physician Japan
Primary
Secondary
Concomitant
Pseudomonas Infection Other Serious 8/4/2005 Female 97 lb 2/17/2006 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 12/17/2005 Female 101 lb 2/28/2006 Physician Japan
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 7/21/2005 Male 3/10/2006 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Other Serious 7/29/2005 Female 3/24/2006 Physician Japan
Primary
Secondary
Concomitant
Henoch-schonlein Purpura Other Serious 5/10/2005 Female 79 lb 4/11/2006 Physician Japan
Primary
Concomitant
Urticaria Other Serious 11/27/2003 Female 95 lb 4/20/2006 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Infection Other Serious 3/14/2005 Male 121 lb 5/26/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 6/22/2005 Female 121 lb 7/7/2006 Physician Japan
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 3/13/2006 47 Female 104 lb 7/26/2006 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 6/23/2006 Female 82 lb 8/28/2006 Physician Japan
Primary
Secondary
Concomitant
Lymphoma Hospitalization 2/14/2005 Female 99 lb 9/11/2006 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 4/12/2006 Male 121 lb 9/18/2006 Physician Japan
Primary
Secondary
Concomitant
Sepsis Hospitalization 6/23/2006 Female 82 lb 9/27/2006 Physician Japan
Primary
Secondary
Concomitant
Alveolitis Allergic Hospitalization 2/13/2006 Female 88 lb 10/11/2006 Physician Japan
Primary
Secondary
Pneumonia Hospitalization 2/13/2006 Female 88 lb 11/6/2006 Physician Japan
Primary
Secondary
Pneumocystis Jiroveci Pneumonia Hospitalization 6/22/2005 Female 121 lb 1/4/2007 Physician Japan
Primary
Secondary
Concomitant
Haematochezia Hospitalization 6/19/2006 Female 104 lb 1/22/2007 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 10/18/2006 Female 154 lb 1/31/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/16/2007 Female 90 lb 2/5/2007 Physician Japan
Primary
Secondary
Concomitant
Pseudomonas Infection Other Serious 8/4/2005 Female 97 lb 2/9/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/16/2007 Female 90 lb 2/27/2007 Physician Japan
Primary
Secondary
Concomitant
Hepatorenal Syndrome Hospitalization 2/1/2007 Female 132 lb 4/5/2007 Physician Japan
Primary
Secondary
Concomitant
Death Death Female 101 lb 4/11/2007 Physician Japan
Primary
Concomitant
Hepatorenal Syndrome Hospitalization 2/1/2007 Female 132 lb 4/12/2007 Physician Japan
Primary
Secondary
Concomitant
Hepatorenal Syndrome Hospitalization 2/1/2007 Female 132 lb 4/18/2007 Physician Japan
Primary
Secondary
Concomitant
Reflux Oesophagitis Hospitalization 3/4/2007 Female 146 lb 4/25/2007 Physician Japan
Primary
Secondary
Concomitant
Reflux Oesophagitis Hospitalization 3/4/2007 Female 146 lb 4/30/2007 Physician Japan
Primary
Secondary
Concomitant
Reflux Oesophagitis Hospitalization 3/4/2007 Female 146 lb 5/1/2007 Physician Japan
Primary
Secondary
Concomitant
Hepatorenal Syndrome Hospitalization 1/1/2007 Female 132 lb 5/7/2007 Physician Japan
Primary
Secondary
Concomitant
Hepatorenal Syndrome Hospitalization 1/1/2007 Female 132 lb 5/14/2007 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Other Serious 10/22/2003 Male 110 lb 5/25/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 3/4/2007 Female 146 lb 6/11/2007 Physician Japan
Primary
Secondary
Concomitant
Hepatorenal Syndrome Hospitalization 2/1/2007 Female 132 lb 6/18/2007 Physician Japan
Primary
Secondary
Concomitant
Somnolence Hospitalization 2/5/2004 Female 121 lb 6/21/2007 Physician Japan
Primary
Secondary
Concomitant
Hepatorenal Syndrome Hospitalization 2/1/2007 Female 132 lb 6/21/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/3/2007 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/3/2007 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/12/2007 Japan
Primary
Secondary
Concomitant
Hepatorenal Syndrome Hospitalization 2/1/2007 Female 132 lb 7/30/2007 Physician Japan
Primary
Secondary
Concomitant
Hepatorenal Syndrome Hospitalization 2/1/2007 Female 132 lb 8/1/2007 Physician Japan
Primary
Secondary
Concomitant
Aortic Dissection Death 5/11/2006 Female 110 lb 8/6/2007 Physician Japan
Primary
Concomitant
Pulmonary Fibrosis Other Serious 9/20/2006 Female 88 lb 8/30/2007 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 12/20/2006 Female 84 lb 8/31/2007 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 12/20/2006 Female 84 lb 9/27/2007 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Bacterial Hospitalization 6/1/2006 Female 126 lb 10/4/2007 Physician Japan
Primary
Secondary
Concomitant
Haematochezia Hospitalization 6/19/2006 Female 110 lb 10/17/2007 Physician Japan
Primary
Concomitant
Large Intestine Carcinoma Life Threatening 1/11/2007 Male 150 lb 10/22/2007 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Other Serious 3/11/2005 Female 110 lb 10/25/2007 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 10/15/2007 Female 112 lb 11/12/2007 Physician Japan
Primary
Secondary
Concomitant
Oesophageal Carcinoma Other Serious 4/3/2007 Male 148 lb 11/13/2007 Physician Japan
Primary
Concomitant
Haematochezia Hospitalization 6/19/2006 Female 110 lb 11/15/2007 Physician Japan
Primary
Concomitant
Large Intestine Carcinoma Life Threatening 1/11/2007 Male 150 lb 11/15/2007 Physician Japan
Primary
Concomitant
Eczema Other Serious 7/29/2007 Male 159 lb 12/7/2007 Physician Japan
Primary
Secondary
Concomitant
Peritoneal Perforation Hospitalization 7/29/2007 Male 159 lb 12/21/2007 Physician Japan
Primary
Secondary
Concomitant
Aortic Dissection Death 5/11/2006 Female 110 lb 12/26/2007 Physician Japan
Primary
Concomitant
Large Intestine Carcinoma Life Threatening 1/11/2007 Male 150 lb 12/27/2007 Physician Japan
Primary
Concomitant
Petechiae Hospitalization 8/9/2007 Male 159 lb 1/7/2008 Physician Japan
Primary
Secondary
Concomitant
Diffuse Large B-cell Lymphoma Life Threatening 7/20/2007 Female 1/25/2008 Physician Japan
Primary
Secondary
Concomitant
Nausea Other Serious 9/26/2007 59 Male 121 lb 2/6/2008 Physician Japan
Primary
Secondary
Concomitant
Petechiae Hospitalization 1/1/2007 Male 159 lb 2/15/2008 Physician Japan
Primary
Secondary
Concomitant
Petechiae Hospitalization 3/1/2007 Male 159 lb 3/4/2008 Physician Japan
Primary
Secondary
Concomitant
Extranodal Marginal Zone B-cell Lymphoma (Malt Type) Hospitalization 4/14/2005 Female 99 lb 3/7/2008 Physician Japan
Primary
Concomitant
Diffuse Large B-cell Lymphoma Life Threatening 7/20/2007 Female 3/17/2008 Physician Japan
Primary
Secondary
Concomitant
Peritonitis Hospitalization 3/1/2007 Male 159 lb 3/21/2008 Physician Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Hospitalization 7/30/2007 Male 141 lb 4/3/2008 Physician Japan
Primary
Secondary
Concomitant
Hodgkin's Disease Hospitalization 8/12/2004 Male 123 lb 4/10/2008 Physician Japan
Primary
Concomitant
Cardiac Failure Congestive Disability 4/16/2007 46 Female 108 lb 4/17/2008 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Congestive Disability 4/16/2007 46 Female 108 lb 4/22/2008 Physician Japan
Primary
Concomitant
Bronchiectasis Hospitalization 2/7/2008 Male 110 lb 5/19/2008 Physician Japan
Primary
Concomitant
Death Death Female 101 lb 5/23/2008 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 10/11/2007 Female 88 lb 5/30/2008 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Life Threatening 4/12/2008 Female 101 lb 6/3/2008 Physician Japan
Primary
Secondary
Concomitant
Aortic Dissection Death 5/11/2006 Female 110 lb 6/12/2008 Physician Japan
Primary
Concomitant
Diffuse Large B-cell Lymphoma Life Threatening 7/20/2007 Female 6/12/2008 Physician Japan
Primary
Secondary
Concomitant
Aortic Dissection Death 5/11/2006 Female 110 lb 7/1/2008 Physician Japan
Primary
Concomitant
Hodgkin's Disease Hospitalization 8/12/2004 Male 123 lb 7/8/2008 Physician Japan
Primary
Secondary
Concomitant
Cardiomegaly Disability 4/16/2007 46 Female 108 lb 7/15/2008 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 6/15/2008 Male 8/26/2008 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 8/18/2008 Female 95 lb 9/18/2008 Physician Japan
Primary
Secondary
Concomitant
Cardiomegaly Disability 4/16/2007 46 Female 108 lb 9/19/2008 Physician Japan
Primary
Secondary
Concomitant
Aortic Dissection Death 5/11/2006 Female 110 lb 10/24/2008 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 8/18/2008 Female 95 lb 11/5/2008 Physician Japan
Primary
Secondary
Concomitant
Reflux Oesophagitis Hospitalization 3/4/2007 Female 146 lb 11/7/2008 Physician Japan
Primary
Secondary
Concomitant
Large Intestine Carcinoma Other Serious 2/1/2008 Female 86 lb 2/26/2009 Physician Japan
Primary
Concomitant
Large Intestine Carcinoma Other Serious 2/1/2008 Female 86 lb 3/27/2009 Physician Japan
Primary
Secondary
Concomitant
Urethritis Life Threatening 3/4/2009 58 Female 4/16/2009 Physician Japan
Primary
Concomitant
Systemic Lupus Erythematosus Other Serious 3/9/2009 Female 88 lb 4/17/2009 Physician Japan
Primary
Concomitant
Systemic Lupus Erythematosus Other Serious 3/9/2009 Female 88 lb 5/1/2009 Physician Japan
Primary
Concomitant
Tuberculosis Of Genitourinary System Life Threatening 3/3/2009 Female 5/5/2009 Physician Japan
Primary
Secondary
Concomitant
Large Intestine Carcinoma Other Serious 3/31/2008 Female 86 lb 5/19/2009 Physician Japan
Primary
Secondary
Concomitant
Diffuse Large B-cell Lymphoma Hospitalization 8/26/2008 Female 119 lb 5/22/2009 Physician Japan
Primary
Secondary
Concomitant
Systemic Lupus Erythematosus Other Serious 3/9/2009 Female 88 lb 5/27/2009 Physician Japan
Primary
Concomitant
Tuberculosis Of Genitourinary System Other Serious 3/3/2009 Female 5/28/2009 Physician Japan
Primary
Secondary
Concomitant
Systemic Lupus Erythematosus Other Serious 3/9/2009 Female 88 lb 5/29/2009 Physician Japan
Primary
Concomitant
Diffuse Large B-cell Lymphoma Hospitalization 8/26/2008 Female 119 lb 6/4/2009 Physician Japan
Primary
Secondary
Concomitant
Sudden Death Death 6/2/2009 Female 77 lb 6/16/2009 Physician Japan
Primary
Concomitant
Systemic Lupus Erythematosus Other Serious 3/9/2009 Female 88 lb 6/23/2009 Physician Japan
Primary
Concomitant
Sudden Death Death 6/2/2009 Female 77 lb 7/2/2009 Physician Japan
Primary
Concomitant
Sudden Death Death 6/2/2009 Female 77 lb 7/14/2009 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Hospitalization 4/3/2009 Female 126 lb 8/13/2009 Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 4/3/2009 Female 126 lb 9/4/2009 Japan
Primary
Secondary
Concomitant
B-cell Lymphoma Hospitalization 1/30/2006 Male 9/15/2009 Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 4/3/2009 Female 126 lb 11/24/2009 Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Hospitalization 7/30/2007 Male 141 lb 12/23/2009 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 12/13/2009 76 Female 1/4/2010 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 11/10/2009 Male 128 lb 1/5/2010 Physician Japan
Primary
Secondary
Concomitant
Cerebral Haemorrhage Other Serious 11/16/2009 Female 1/21/2010 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 6/26/2009 Female 2/2/2010 Physician Japan
Primary
Secondary
Concomitant
C-reactive Protein Increased Hospitalization 1/30/2010 Female 86 lb 2/12/2010 Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 4/21/2009 Male 139 lb 2/22/2010 Physician Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Hospitalization 7/30/2007 Male 141 lb 2/25/2010 Physician Japan
Primary
Secondary
Concomitant
C-reactive Protein Increased Hospitalization 1/30/2010 Female 86 lb 2/25/2010 Japan
Primary
Concomitant
Spinal Compression Fracture Life Threatening 6/1/2009 Female 73 lb 3/1/2010 Physician Japan
Primary
Secondary
Concomitant
C-reactive Protein Increased Hospitalization 1/30/2010 Female 86 lb 3/8/2010 Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 11/10/2009 Male 128 lb 3/8/2010 Physician Japan
Primary
Secondary
Concomitant
Uterine Cancer Hospitalization 12/21/2009 Female 99 lb 3/11/2010 Other Health Professional Japan
Primary
Secondary
Interstitial Lung Disease Hospitalization 12/16/2009 Female 82 lb 3/15/2010 Physician Japan
Primary
Secondary
Concomitant
C-reactive Protein Increased Hospitalization 1/30/2010 69 Female 86 lb 4/9/2010 Japan
Primary
Concomitant
Knee Arthroplasty Other Serious 10/22/2009 68 Female 115 lb 4/16/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 3/30/2010 Female 256 lb 5/3/2010 Physician United States
Primary
Secondary
Concomitant
Histiocytosis Haematophagic Hospitalization 10/3/2009 46 Male 5/19/2010 Physician Japan
Primary
Secondary
Concomitant
Uterine Cancer Hospitalization 12/21/2009 47 Female 99 lb 5/21/2010 Other Health Professional Japan
Primary
Secondary
Bile Duct Cancer Death Female 5/24/2010 Physician Japan
Primary
Concomitant
Lymphoma Hospitalization 2/15/2010 49 Male 152 lb 5/24/2010 Physician Japan
Primary
Secondary
Concomitant
Hypercholesterolaemia Other Serious 11/10/2009 56 Female 5/27/2010 Physician Japan
Primary
Concomitant
Cerebral Infarction Hospitalization Female 6/3/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 3/30/2010 39 Female 116 lb 6/8/2010 Physician United States
Primary
Secondary
Concomitant
Vision Blurred Hospitalization 8/11/2009 62 Female 110 lb 6/8/2010 Physician Japan
Primary
Concomitant
Cerebral Infarction Hospitalization 3/28/2010 74 Female 6/16/2010 Physician Japan
Primary
Concomitant
Haemoptysis Other Serious 6/16/2010 53 Female 123 lb 6/25/2010 Physician Japan
Primary
Secondary
Concomitant
C-reactive Protein Increased Hospitalization 1/30/2010 69 Female 86 lb 7/2/2010 Physician Japan
Primary
Concomitant
Pemphigoid Other Serious 6/13/2010 63 Female 7/14/2010 Physician Japan
Primary
Concomitant
Pyrexia Life Threatening 7/1/2010 64 Male 84 lb 7/16/2010 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased 1/25/2010 68 Female 75 lb 7/23/2010 Physician Japan
Primary
Secondary
Concomitant
Tuberculin Test Positive Hospitalization 3/23/2010 29 Female 8/6/2010 Japan
Primary
Concomitant
Herpes Zoster Life Threatening 4/8/2010 67 Male 121 lb 8/17/2010 Physician Japan
Primary
Concomitant
Pyrexia Life Threatening 7/1/2010 64 Male 84 lb 8/17/2010 Physician Japan
Primary
Secondary
Concomitant
Uterine Cancer Death 8/25/2007 54 Female 8/18/2010 Physician Japan
Primary
Concomitant
Tuberculosis Other Serious 7/24/2006 72 Male 117 lb 8/23/2010 Physician Japan
Primary
Secondary
Concomitant
Cerebral Infarction Hospitalization 3/28/2010 74 Female 9/2/2010 Physician Japan
Primary
Concomitant
Herpes Zoster Life Threatening 4/8/2010 67 Male 121 lb 9/7/2010 Physician Japan
Primary
Concomitant
Threatened Labour Hospitalization 3/23/2010 29 Female 9/10/2010 Japan
Primary
Concomitant
Necrotising Granulomatous Lymphadenitis Other Serious 9/26/2009 54 Female 121 lb 9/20/2010 Physician Japan
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 8/1/2010 Female 9/23/2010 Physician Japan
Primary
Secondary
Knee Arthroplasty Other Serious 10/22/2009 68 Female 115 lb 9/24/2010 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 10/15/2009 56 Female 86 lb 9/27/2010 Physician Japan
Primary
Concomitant
Vision Blurred Hospitalization 8/11/2009 62 Female 110 lb 10/4/2010 Physician Japan
Primary
Secondary
Concomitant
Subarachnoid Haemorrhage Disability 6/7/2010 49 Female 10/7/2010 Physician Japan
Primary
Concomitant
Reflux Oesophagitis Hospitalization 9/24/2009 57 Female 115 lb 10/8/2010 Other Health Professional Japan
Primary
Secondary
Concomitant

Drug Data