Irradiation combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tracheostomy Other Serious 36 Male 2/15/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 19 Female 3/4/2006 Physician Korea, Republic Of
Primary
Concomitant
Neurotoxicity Other Serious 26 Female 3/4/2006 Physician United States
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 19 Male 3/4/2006 Physician United States
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 17 Female 3/4/2006 Physician United States
Primary
Concomitant
Trichosporon Infection Other Serious 1/1/2004 30 Male 3/9/2006 Japan
Primary
Concomitant
Visual Field Defect Other Serious 1/1/2005 49 Female 3/14/2006 Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 15 Male 3/14/2006 Japan
Primary
Concomitant
Sepsis Other Serious 15 Male 3/30/2006 Japan
Primary
Concomitant
Trichosporon Infection Other Serious 1/1/2004 30 Male 3/29/2006 Japan
Primary
Secondary
Concomitant
Visual Field Defect Other Serious 1/1/2005 49 Female 4/11/2006 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Death 38 Female 5/9/2006 Other Health Professional Turkey
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 32 Female 5/12/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Thyroxine Free Increased Other Serious 32 Female 6/16/2006 Other Health Professional Japan
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 1/1/2002 32 Female 9/5/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 35 Male 9/5/2006 Japan
Primary
Secondary
Concomitant
Viraemia Other Serious 28 Male 10/2/2006 Japan
Primary
Concomitant
Tuberculosis Other Serious 6/1/1994 38 Male 11/15/2006 Other Health Professional Turkey
Primary
Secondary
Concomitant
Weight Increased Hospitalization 56 Female 12/9/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Mucous Stools Other Serious 4 Female 12/14/2006 Japan
Primary
Concomitant
Thrombocytopenia Hospitalization 11/12/2001 23 Female 12/19/2006 Other Health Professional Japan
Primary
Concomitant
Mucous Stools Other Serious 4 Female 1/3/2007 Japan
Primary
Concomitant
Respiratory Failure Other Serious 8 Male 1/16/2007 Other Health Professional Germany
Primary
Concomitant
Partial Seizures Hospitalization 7 Female 1/26/2007 Other Health Professional Spain
Primary
Concomitant
Status Epilepticus Hospitalization 7 Female 2/9/2007 Other Health Professional Spain
Primary
Concomitant
Thrombocytopenia Hospitalization 11/12/2001 23 Female 2/19/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/12/2001 23 Female 2/19/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/12/2001 23 Female 86 lb 2/23/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/12/2001 23 Female 2/19/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 58 Female 3/14/2007 Japan
Primary
Concomitant
Ureteric Stenosis Other Serious 35 Male 3/14/2007 Japan
Primary
Secondary
Concomitant
Somnolence Other Serious 13 Male 3/14/2007 Japan
Primary
Secondary
Serum Ferritin Increased Other Serious 54 Male 3/15/2007 Japan
Primary
Concomitant
Somnolence Other Serious 16 Female 3/15/2007 Japan
Primary
Secondary
Somnolence Other Serious 16 Male 3/15/2007 Japan
Primary
Secondary
Papilloedema Other Serious 15 Female 3/24/2007 Other Health Professional Canada
Primary
Concomitant
Vomiting Other Serious 12 Male 3/24/2007 Other Health Professional Canada
Primary
Concomitant
Ureteric Stenosis Other Serious 35 Male 3/28/2007 Japan
Primary
Secondary
Concomitant
Serum Ferritin Increased Other Serious 54 Male 4/17/2007 Japan
Primary
Concomitant
Reticulocyte Count Decreased Other Serious Male 6/23/2007 Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 1/1/2003 31 Male 6/23/2007 Japan
Primary
Concomitant
Viral Dna Test Positive Other Serious 38 Male 6/26/2007 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/3/2007 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/3/2007 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 7/10/2007 Other Health Professional Sweden
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/12/2007 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 8/3/2007 Other Health Professional Sweden
Primary
Concomitant
Vomiting Other Serious 10/1/2000 35 Male 9/25/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 44 Male 10/5/2007 Other Health Professional Japan
Primary
Secondary
Sinus Tachycardia Other Serious 57 Male 10/24/2007 Japan
Primary
Concomitant
Reticulocyte Count Decreased Other Serious Male 11/7/2007 Japan
Primary
Secondary
Concomitant
Reticulocyte Count Decreased Other Serious Male 11/7/2007 Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious 28 Female 11/9/2007 Japan
Primary
Concomitant
Febrile Neutropenia Other Serious 10/1/2005 28 Female 11/23/2007 Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 56 Male 12/8/2007 Other Health Professional Japan
Primary
Concomitant
Renal Transplant Other Serious 11/1/2005 22 Female 12/10/2007 Japan
Primary
Concomitant
Renal Transplant Other Serious 11/1/2005 22 Female 12/21/2007 Japan
Primary
Concomitant
Stomatitis Other Serious 6 Male 12/23/2007 Japan
Primary
Concomitant
Stomatitis Other Serious 5/1/2007 6 Male 1/3/2008 Japan
Primary
Concomitant
Vomiting Other Serious 6 Male 1/12/2008 Other Health Professional United States
Primary
Concomitant
Subcutaneous Emphysema Other Serious 17 Male 1/19/2008 Other Health Professional Japan
Primary
Concomitant
Nuclear Magnetic Resonance Imaging Brain Abnormal Death 11 Female 1/22/2008 Other Health Professional Saudi Arabia
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 8/27/2003 44 Female 134 lb 3/6/2008 Physician Spain
Primary
Secondary
Concomitant
Rash Other Serious 56 Male 3/9/2008 Japan
Primary
Secondary
Concomitant
Rash Other Serious 12/1/2006 56 Male 3/11/2008 Japan
Primary
Secondary
Concomitant
Oedema Mucosal Hospitalization 27 Female 3/12/2008 Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 11/1/2005 55 Male 3/13/2008 Japan
Primary
Concomitant
Pulmonary Alveolar Haemorrhage Other Serious 39 Female 3/17/2008 Japan
Primary
Concomitant
Weight Decreased Other Serious 1/1/2007 Female 3/17/2008 Japan
Primary
Concomitant
Toxic Encephalopathy Other Serious 1/1/2003 11 Male 3/18/2008 Physician Japan
Primary
Concomitant
Oedema Mucosal Hospitalization 27 Female 4/16/2008 Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 11/1/1999 Male 5/22/2008 Japan
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 7/25/2008 Other Health Professional Japan
Primary
Concomitant
Transplant Rejection Hospitalization 8/13/2008 Other Health Professional Denmark
Primary
Concomitant
Septic Shock Other Serious 29 Female 10/14/2008 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious Male 10/17/2008 Other Health Professional Japan
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 34 Male 11/8/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 43 Female 11/11/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 28 Female 168 lb 11/14/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 11/26/2007 43 Female 11/26/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 11/26/2007 43 Female 11/26/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Orchidectomy Hospitalization 1 Male 12/4/2008 Other Health Professional Japan
Primary
Concomitant
Myelodysplastic Syndrome Other Serious 1/1/2006 49 Male 1/29/2009 Other Health Professional Japan
Primary
Concomitant
Thrombotic Microangiopathy Hospitalization 36 Male 2/3/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Residual Urine Other Serious 25 Male 2/3/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Splenic Neoplasm Malignancy Unspecified Other Serious 47 Male 2/3/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Rash Other Serious 8 Male 2/3/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Tachyarrhythmia Other Serious 57 Female 2/12/2009 Other Health Professional Germany
Primary
Concomitant
Rash Other Serious 8 Male 2/19/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 36 Male 2/24/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Toxic Encephalopathy Other Serious 1/1/2003 11 Male 3/24/2009 Japan
Primary
Concomitant
Lip And/or Oral Cavity Cancer Death 21 Female 3/31/2009 Other Health Professional France
Primary
Concomitant
Lip And/or Oral Cavity Cancer Other Serious 43 Male 3/31/2009 Other Health Professional France
Primary
Concomitant
Pyrexia Hospitalization 9/1/2008 48 Male 4/1/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Stridor Hospitalization 17 4/3/2009 Other Health Professional Japan
Primary
Concomitant
Swollen Tongue Other Serious 16 Male 4/3/2009 Other Health Professional Japan
Primary
Concomitant
Toxic Encephalopathy Other Serious 1/1/2003 11 Female 4/4/2009 Japan
Primary
Concomitant
Swollen Tongue Other Serious 16 Male 4/3/2009 Other Health Professional Japan
Primary
Concomitant
Splenic Neoplasm Malignancy Unspecified Other Serious 11/24/2005 Male 154 lb 4/8/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Respiratory Distress Other Serious 58 Male 4/20/2009 Japan
Primary
Secondary
Concomitant
Sinusitis Fungal Other Serious 8/1/2006 28 Male 4/24/2009 Other Health Professional Italy
Primary
Concomitant
Swollen Tongue Other Serious 1/1/2007 16 Male 4/24/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Sputum Abnormal Other Serious 58 Male 5/4/2009 Other Health Professional Japan
Primary
Secondary
Respiratory Distress Other Serious 58 Male 5/4/2009 Japan
Primary
Secondary
Concomitant
Multi-organ Failure Other Serious 19 5/23/2009 Other Health Professional Tunisia
Primary
Secondary
Concomitant
Multi-organ Failure Other Serious 22 5/23/2009 Other Health Professional Tunisia
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Disability 4/29/2008 58 Male 6/8/2009 Physician Japan
Primary
Secondary
Concomitant
Toxic Encephalopathy Other Serious 66 Male 6/16/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Toxic Encephalopathy Other Serious 43 Female 6/16/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Toxic Encephalopathy Other Serious 36 Male 6/16/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Rash Other Serious 50 Male 9/4/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Splenic Neoplasm Malignancy Unspecified Other Serious 6/18/2005 Male 154 lb 9/8/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 48 Female 9/9/2009 Other Health Professional Japan
Primary
Concomitant
Rash Other Serious 50 Male 9/14/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Respiratory Tract Inflammation Other Serious 42 Male 10/28/2009 Other Health Professional Denmark
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 1/1/2005 47 Male 10/30/2009 Japan
Primary
Concomitant
Respiratory Tract Inflammation Other Serious 42 Male 11/2/2009 Other Health Professional Denmark
Primary
Secondary
Concomitant
Wheezing Other Serious 4 Male 12/2/2009 Other Health Professional Japan
Primary
Concomitant
Scleroderma Other Serious 27 Male 12/10/2009 Japan
Primary
Concomitant
Weight Increased Other Serious 1/1/2008 48 Female 12/18/2009 Other Health Professional Japan
Primary
Concomitant
Wheezing Other Serious 4 Male 12/21/2009 Other Health Professional Japan
Primary
Concomitant
Weight Increased Other Serious 1/1/2008 Female 2/5/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 6/8/2008 2 Male 3/3/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Skin Lesion Other Serious 6/15/2009 Male 3/19/2010 Physician France
Primary
Concomitant
Scleroderma Other Serious 34 Male 3/19/2010 Other Health Professional Turkey
Primary
Secondary
Concomitant
Renal Impairment Other Serious 40 Male 3/22/2010 Other Health Professional Japan
Primary
Concomitant
Interacting
Tonsillectomy Other Serious 10 Male 4/5/2010 Other Health Professional Italy
Primary
Secondary
Concomitant
Vomiting Other Serious 18 Male 4/19/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Multi-organ Failure Other Serious 36 Female 4/19/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Retroperitoneal Abscess Other Serious 40 Male 4/21/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 2/28/2007 36 Female 5/20/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 2/28/2007 36 Female 5/20/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Pulmonary Congestion Hospitalization 5/4/2010 56 Male 234 lb 5/24/2010 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 5/4/2010 56 Male 234 lb 6/4/2010 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 5/4/2010 56 Male 234 lb 6/7/2010 Physician United States
Primary
Concomitant
Bone Marrow Transplant Other Serious 6/1/2006 36 Female 7/15/2010 Other Health Professional Korea, Republic Of
Primary
Concomitant
Stem Cell Transplant Other Serious 2/1/2004 23 Female 7/15/2010 Other Health Professional Korea, Republic Of
Primary
Concomitant
Stomatitis Other Serious 1 Male 9/21/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 30 Male 10/5/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Stenotrophomonas Sepsis Other Serious 8/11/2009 58 Female 10/20/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Respiratory Distress Life Threatening 9/26/2010 28 Female 3/1/2011 Physician Australia
Primary
Secondary
Concomitant
Human Herpesvirus 8 Infection Other Serious 10 Male 3/17/2011 Other Health Professional Italy
Primary
Secondary
Concomitant
Obstructive Airways Disorder Other Serious 10 Male 3/17/2011 Other Health Professional Italy
Primary
Secondary
Venoocclusive Liver Disease Other Serious 16 Female 3/21/2011 Other Health Professional Japan
Primary
Concomitant
Graft Versus Host Disease Other Serious 16 Female 3/30/2011 Other Health Professional Japan
Primary
Concomitant
Cytomegalovirus Viraemia Other Serious 56 Female 5/19/2011 Other Health Professional Japan
Primary
Concomitant
Graft Versus Host Disease Other Serious 16 Female 6/22/2011 Other Health Professional Japan
Primary
Concomitant
Hepatic Enzyme Increased Other Serious 56 Female 8/12/2011 Other Health Professional Japan
Primary
Concomitant
Overdose Hospitalization 38 Female 9/16/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Acute Respiratory Distress Syndrome Hospitalization 38 Female 9/22/2011 Other Health Professional United States
Primary
Concomitant

Drug Data