Irinotecan combined with Leucovorin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Rash Other Serious 5/31/2006 50 Male 172 lb 5/31/2006 Other Health Professional United States
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 11/23/2007 Male 176 lb 1/8/2008 Physician Australia
Primary
Secondary
Pulmonary Embolism Hospitalization 11/14/2007 Male 1/8/2008 Physician Australia
Primary
Secondary
Concomitant
Pruritus Hospitalization 12/10/2007 Female 1/8/2008 Physician Poland
Primary
Concomitant
Septic Shock Hospitalization 12/3/2007 Male 1/14/2008 Physician Australia
Primary
Secondary
Concomitant
Erythema Hospitalization 9/27/2007 Female 1/18/2008 Physician Belgium
Primary
Concomitant
Chest Pain Hospitalization 4/11/2009 69 Female 12/14/2010 Consumer United States
Primary
Secondary
Hypertension Other Serious 65 Female 1/19/2011 Physician Canada
Primary
Secondary
Concomitant
Haematemesis Hospitalization 1/9/2011 72 Male 226 lb 1/20/2011 Physician United States
Primary
Secondary
Concomitant
Portal Vein Thrombosis Other Serious 3/29/2011 Physician United States
Primary
Secondary
Toxicity To Various Agents Other Serious 4/8/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypersensitivity Hospitalization 11/8/2010 63 Male 4/13/2011 Other Health Professional United States
Primary
Concomitant
Acute Myocardial Infarction Other Serious 4/15/2011 Other Health Professional Italy
Primary
Secondary
Atrial Fibrillation Other Serious 2/23/2009 55 Male 4/20/2011 Consumer Croatia (Local Name: Hrvatska)
Primary
Concomitant
Atrial Fibrillation 2/23/2009 55 Male 4/20/2011 Consumer Croatia (Local Name: Hrvatska)
Primary
Concomitant
Liver Function Test Abnormal Hospitalization 1/25/2011 59 Male 165 lb 4/20/2011 Physician Germany
Primary
Secondary
Concomitant
Necrotising Fasciitis Life Threatening 5/6/2011 63 Male 146 lb 2/27/2013 Physician It
Primary
Concomitant
Syncope Hospitalization 4/11/2012 52 Female 181 lb 9/14/2012 Consumer De
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious NotSpecified 1/21/2013 Physician Cn
Primary
Secondary
Concomitant
Petechiae Hospitalization 4/9/2012 Female 165 lb 8/28/2012 Consumer De
Primary
Secondary
Concomitant
Embolism Hospitalization 6/26/2012 48 Female 132 lb 12/12/2012 Consumer De
Primary
Secondary
Death Death Male 8/28/2012 Physician Br
Primary
Concomitant
Death Death Female 8/29/2012 Physician Br
Primary
Concomitant
Death Death Male 8/30/2012 Physician Br
Primary
Concomitant
Death Death Male 8/31/2012 Physician Br
Primary
Concomitant
Death Death Female 8/31/2012 Physician Br
Primary
Concomitant
Death Death Male 8/31/2012 Physician Br
Primary
Concomitant
Muscular Weakness Hospitalization 9/3/2012 82 Male 149 lb 11/1/2012 Physician Us
Primary
Secondary
Atrial Fibrillation Hospitalization 8/30/2012 68 Male 170 lb 1/2/2013 Physician Us
Primary
Secondary
Skin Toxicity Other Serious 9/10/2012 Physician Us
Primary
Concomitant
Malnutrition Hospitalization 8/23/2012 59 Male 183 lb 9/28/2012 Physician Nl
Primary
Secondary
Concomitant
Oesophageal Adenocarcinoma Death 8/22/2012 Other Health Professional Fr
Primary
Secondary
Skin Toxicity Other Serious 9/14/2012 Consumer Us
Primary
Secondary
Disease Progression Other Serious 8/9/2012 44 Female 99 lb 9/20/2012 Physician Ru
Primary
Secondary
Concomitant
Anaphylactic Reaction Other Serious 7/2/2012 57 Female 117 lb 9/13/2012 Pharmacist De
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 9/14/2012 Other Health Professional Kr
Primary
Secondary
Concomitant
Disease Progression Death Female 9/27/2012 Physician Us
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 9/14/2012 Kr
Primary
Secondary
Concomitant
Haematotoxicity Other Serious 9/14/2012 Other Health Professional Kr
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 9/14/2012 Other Health Professional Kr
Primary
Secondary
Concomitant
Neutropenia Other Serious 9/17/2012 Kr
Primary
Secondary
Concomitant
Vomiting Other Serious 9/17/2012 Other Health Professional Kr
Primary
Secondary
Intestinal Obstruction Hospitalization 9/14/2012 69 Male 143 lb 2/15/2013 Consumer De
Primary
Secondary
Concomitant
Pneumonia Death 9/19/2012 Kr
Primary
Secondary
Disease Progression Other Serious Female 12/4/2012 Physician Us
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 9/19/2012 Other Health Professional Kr
Primary
Secondary
Concomitant
Neutrophil Count Decreased Death Male 9/27/2012 Physician Us
Primary
Secondary
Pulmonary Mass Death 5/2004 Male 9/27/2012 Physician Us
Primary
Secondary
Concomitant
Metastases To Liver Hospitalization 9/26/2012 63 Male 224 lb 9/28/2012 Us
Primary
Secondary
Concomitant
Sepsis Death 57 Male 10/5/2012 Country Not Specified
Primary
Secondary
Suicidal Ideation Other Serious 8/26/2010 73 Male 132 lb 11/5/2012 Consumer De
Primary
Concomitant
Disease Progression Other Serious 6/4/2012 60 Female 183 lb 10/10/2012 Physician Ru
Primary
Secondary
Concomitant
Disease Progression Other Serious 9/13/2012 69 Male 154 lb 10/10/2012 Physician Ru
Primary
Concomitant
Neutropenia Hospitalization 9/24/2012 59 Male 11/19/2012 Physician De
Primary
Secondary
Disease Progression Other Serious 60 Female 154 lb 10/18/2012 Physician Br
Primary
Concomitant
Disease Progression Other Serious 66 Male 150 lb 10/19/2012 Physician Br
Primary
Secondary
Disease Progression Hospitalization 10/15/2012 53 Female 159 lb 10/19/2012 Physician Ru
Primary
Concomitant
Dyspnoea Death 10/2012 35 Female 10/31/2012 Physician Us
Primary
Secondary
Concomitant
Disease Progression Other Serious 45 Female 123 lb 10/25/2012 Physician Br
Primary
Secondary
Concomitant
Disease Progression Other Serious 67 Male 179 lb 10/30/2012 Physician Br
Primary
Concomitant
Disease Progression Other Serious Male 148 lb 10/30/2012 Physician Br
Primary
Concomitant
Vomiting Hospitalization 7/10/2012 71 Male 10/30/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Uterine Perforation Other Serious 36 Female 11/1/2012 Other Health Professional Country Not Specified
Primary
Concomitant
Stomatitis Other Serious 11/2/2012 Tr
Primary
Secondary
Neutropenia Other Serious 11/2/2012 Other Health Professional Tr
Primary
Secondary
Concomitant
Haematotoxicity Other Serious 11/6/2012 Tr
Primary
Secondary
Vomiting Life Threatening 51 Female 11/15/2012 Physician Us
Primary
Secondary
Malaise 8/10/2012 47 Male 157 lb 11/15/2012 Physician Us
Primary
Concomitant
Drug Ineffective Female 11/15/2012 Pharmacist Us
Primary
Concomitant
Disease Progression Other Serious 10/11/2012 61 Female 154 lb 11/19/2012 Physician Ru
Primary
Concomitant
Liver Injury Other Serious 11/20/2012 Physician Country Not Specified
Primary
Secondary
Diarrhoea Hospitalization 11/21/2012 Physician Us
Primary
Secondary
Nausea Hospitalization 11/19/2012 66 Female 153 lb 11/28/2012 Physician Us
Primary
Secondary
Diarrhoea Hospitalization 11/20/2012 51 Male 181 lb 11/21/2012 Us
Primary
Secondary
Concomitant
Pulse Absent Death 11/18/2012 60 Male 260 lb 11/19/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Colonic Fistula Hospitalization 10/12/2012 59 Male 11/21/2012 Physician At
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 9/4/2012 66 Male 11/21/2012 Other Health Professional At
Primary
Secondary
Vomiting Life Threatening 11/11/2012 62 Female 11/30/2012 Other Health Professional Cn
Primary
Secondary
Concomitant
General Physical Health Deterioration Hospitalization 57 Male 11/21/2012 Other Health Professional At
Primary
Secondary
Concomitant
Nausea Hospitalization 12/5/2012 68 Male 138 lb 12/13/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Tooth Infection Hospitalization 12/9/2012 71 Female 146 lb 12/10/2012 Registered Nurse Us
Primary
Secondary
Concomitant
Pseudomonas Infection Hospitalization 11/14/2012 69 Male 2/4/2013 It
Primary
Secondary
No Therapeutic Response Other Serious 12/5/2012 Jp
Primary
Secondary
Concomitant
Deep Vein Thrombosis Other Serious Male 11/28/2012 Gb
Primary
Secondary
Diarrhoea Required Intervention 11/15/2012 66 Male 12/3/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Vomiting Other Serious 12/5/2012 12/5/2012 Other Health Professional Jp
Primary
Secondary
Concomitant
Diarrhoea Other Serious 12/5/2012 Other Health Professional Jp
Primary
Secondary
Vomiting Other Serious 12/6/2012 Other Health Professional Kr
Primary
Secondary
Neutropenic Sepsis Death 12/6/2012 Other Health Professional It
Primary
Secondary
Interstitial Lung Disease Death 12/6/2012 Other Health Professional Jp
Primary
Secondary
Thrombocytopenia Other Serious 12/6/2012 Other Health Professional Jp
Primary
Secondary
Sepsis Hospitalization 11/25/2012 66 Female 12/7/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 11/25/2012 66 Female 12/20/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Fatigue Other Serious 12/6/2012 Other Health Professional Jp
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Hospitalization 11/26/2012 65 Male 1/21/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Infection Other Serious 12/6/2012 Jp
Primary
Secondary
Concomitant
Neutropenia Other Serious 12/6/2012 Other Health Professional Jp
Primary
Secondary
Neuropathy Peripheral Other Serious 12/6/2012 Other Health Professional Jp
Primary
Secondary
Concomitant
Anaemia Other Serious 12/6/2012 Other Health Professional Jp
Primary
Secondary
Disease Progression Other Serious 12/20/2012 60 Female 170 lb 12/31/2012 Physician Ru
Primary
Concomitant
Infection Death 9/5/2012 56 Male 220 lb 1/9/2013 Physician De
Primary
Secondary
Concomitant
Skin Reaction Disability 11/11/2012 NotSpecified 1/2/2013 Physician My
Primary
Secondary
Disease Progression Death 6/5/2012 53 Male 187 lb 1/28/2013 Physician Ru
Primary
Concomitant
Disease Progression Other Serious 4/9/2012 52 Male 154 lb 1/2/2013 Physician Ru
Primary
Concomitant
Disease Progression Other Serious 5/29/2012 57 Male 216 lb 1/3/2013 Physician Ru
Primary
Concomitant
Febrile Neutropenia Hospitalization 12/25/2012 Female 2/11/2013 Physician Lb
Primary
Secondary
Sepsis Life Threatening 12/2/2012 73 Male 1/21/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Vomiting Other Serious NotSpecified 1/3/2013 Us
Primary
Secondary
Diverticulitis Hospitalization 11/24/2012 62 Female 12/10/2012 Physician Nl
Primary
Secondary
Concomitant
Pulmonary Haemorrhage Death 12/10/2012 Other Health Professional It
Primary
Secondary
Diarrhoea Death 12/10/2012 Other Health Professional It
Primary
Secondary
Tinea Pedis Other Serious Female 1/29/2013 Physician Us
Primary
Concomitant
Metastases To Liver Other Serious 53 Male 2/7/2013 Physician Country Not Specified
Primary
Secondary
Nausea Life Threatening 10/1/2012 30 Female 132 lb 2/11/2013 Physician Ru
Primary
Secondary
Concomitant
Vomiting Other Serious NotSpecified 2/4/2013 Other Health Professional Country Not Specified
Primary
Secondary
Hepatotoxicity Other Serious NotSpecified 2/13/2013 Other Health Professional Country Not Specified
Primary
Secondary
Syncope Life Threatening 1/8/2013 56 Male 1/21/2013 Other Health Professional Fi
Primary
Secondary
Concomitant
Hiccups Hospitalization 1/22/2013 Male 161 lb 1/29/2013 Physician De
Primary
Secondary
Intestinal Obstruction Hospitalization 10/4/2012 69 Male 143 lb 2/15/2013 Consumer De
Primary
Secondary
Concomitant
Faeces Discoloured Hospitalization 1/1/2013 72 Male 1/25/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 55 NotSpecified 2/15/2013 Physician Ca
Primary
Secondary
Death Death Female 2/19/2013 Other Health Professional Gr
Primary
Secondary
Concomitant
Disease Progression Other Serious 67 NotSpecified 2/18/2013 Physician Ca
Primary
Secondary
Toxicity To Various Agents Other Serious 41 NotSpecified 2/18/2013 Physician Ca
Primary
Secondary
General Physical Health Deterioration Hospitalization 10/22/2012 75 Male 3/6/2013 Physician Be
Primary
Secondary
Concomitant
Hypercalcaemia Hospitalization 1/3/2013 56 Female 3/12/2013 Physician Il
Primary
Secondary
Concomitant
Vomiting Other Serious NotSpecified 1/25/2013 Other Health Professional Country Not Specified
Primary
Secondary
Vomiting Hospitalization 10/19/2012 68 Male 1/12/2013 Physician Gb
Primary
Secondary
Concomitant
Pulmonary Embolism Death 1/2/2013 61 Male 2/13/2013 Other Health Professional Il
Primary
Secondary
Concomitant
Diarrhoea Death Female 2/25/2013 Other Health Professional Gr
Primary
Secondary
Concomitant
Thrombosis Other Serious 77 NotSpecified 3/11/2013 Physician Br
Primary
Secondary
Disease Progression Death Male 3/19/2013 Physician Gb
Primary
Secondary
Gastrointestinal Perforation Hospitalization 37 Female 3/12/2013 Physician Se
Primary
Secondary
Concomitant
Neoplasm Progression Other Serious 40 Female 3/12/2013 Physician Cn
Primary
Secondary
Concomitant
Systemic Inflammatory Response Syndrome Death 2/2013 73 Male 3/21/2013 Other Health Professional De
Primary
Secondary
Concomitant
Pneumonia Hospitalization 12/7/2012 72 NotSpecified 2/12/2013 Physician Gb
Primary
Secondary
Concomitant
Faeces Discoloured Hospitalization 72 Male 2/12/2013 Physician Gb
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 1/14/2013 64 Male 2/12/2013 Other Health Professional Es
Primary
Secondary
Hypertensive Crisis Hospitalization 1/14/2013 56 Female 2/18/2013 Physician My
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Hospitalization 11/26/2012 65 NotSpecified 2/13/2013 Physician Gb
Primary
Secondary
Concomitant
Diarrhoea Hospitalization NotSpecified 2/25/2013 Other Health Professional Gr
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/30/2013 69 Male 3/8/2013 Other Health Professional Se
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious Male 2/26/2013 Other Health Professional Gr
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious Female 2/26/2013 Other Health Professional Gr
Primary
Secondary
Concomitant
Disease Progression Other Serious 2/20/2013 67 Female 110 lb 3/25/2013 Physician Ru
Primary
Concomitant
Hepatic Steatosis Other Serious 64 Male 3/6/2013 Physician Cz
Primary
Concomitant
Toxicity To Various Agents Other Serious Male 3/6/2013 Other Health Professional Cz
Primary
Concomitant
Disease Progression Other Serious 57 Male 9/11/2012 Physician Us
Primary
Secondary
Concomitant
Disease Progression Other Serious 72 Male 152 lb 10/29/2012 Physician Br
Primary
Secondary
Concomitant
Disease Progression Other Serious 68 Female 154 lb 11/1/2012 Physician Br
Primary
Concomitant

Drug Data