Irinotecan Hydrochloride combined with Oxaliplatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Depressed Level Of Consciousness Other Serious 8/6/2006 42 Male 9/20/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 8/18/2006 65 Female 189 lb 9/22/2006 Physician United States
Primary
Secondary
Concomitant
Intestinal Ulcer Hospitalization 10/1/2007 Female 3/6/2008 Physician United Kingdom
Primary
Concomitant
Platelet Count Decreased Life Threatening 10/2/2007 Female 3/10/2008 Physician Japan
Primary
Secondary
Concomitant
Hypersensitivity Hospitalization 1/16/2008 Male 3/13/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Pathological Fracture Hospitalization 11/16/2007 Male 4/11/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 4/9/2008 Male 4/29/2008 Consumer United Kingdom
Primary
Concomitant
Pulmonary Embolism Life Threatening 65 Male 168 lb 10/8/2008 Other Health Professional United Kingdom
Primary
Concomitant
Convulsion Hospitalization 10/1/2008 Female 283 lb 10/10/2008 Consumer United States
Primary
Secondary
Rhabdomyolysis Hospitalization 9/1/2008 Male 10/10/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Keratoconjunctivitis Sicca Hospitalization 9/5/2008 68 Male 10/13/2008 Consumer Germany
Primary
Secondary
Neutrophil Count Decreased Disability 11/22/2007 Female 98 lb 10/14/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 4/2/2008 Male 134 lb 10/15/2008 Physician Japan
Primary
Secondary
Concomitant
Sepsis Life Threatening 7/11/2008 Male 10/17/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Hypovolaemic Shock Life Threatening 10/5/2008 Female 10/21/2008 Physician Switzerland
Primary
Secondary
Hypovolaemic Shock Life Threatening 10/8/2008 Female 10/22/2008 Physician United Kingdom
Primary
Secondary
Anaphylactic Shock Other Serious 5/15/2008 Female 10/23/2008 Consumer Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/14/2008 70 Male 10/24/2008 Consumer Germany
Primary
Secondary
Abdominal Rigidity Other Serious 7/1/2008 Male 10/29/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 10/9/2008 35 Male 10/30/2008 Other Health Professional France
Primary
Secondary
Sinus Tachycardia Other Serious 9/1/2008 69 Male 10/31/2008 Physician Switzerland
Primary
Concomitant
Neuropathy Peripheral Disability 63 Male 11/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Vomiting Hospitalization 10/14/2008 70 Male 11/4/2008 Consumer Germany
Primary
Secondary
Ileus Other Serious 9/17/2008 Male 207 lb 11/5/2008 Physician Germany
Primary
Secondary
Rectal Haemorrhage Other Serious 10/1/2008 45 Female 11/5/2008 Physician Russian Federation
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 9/29/2008 68 Male 11/7/2008 Consumer Germany
Primary
Secondary
Hypovolaemic Shock Life Threatening 10/5/2008 65 Female 11/3/2008 Physician Switzerland
Primary
Secondary
Aortic Valve Incompetence Other Serious Male 11/10/2008 Consumer United Kingdom
Primary
Secondary
Neuropathy Peripheral Disability 63 Male 176 lb 11/7/2008 Consumer United Kingdom
Primary
Secondary
Interstitial Lung Disease Other Serious 4/2/2008 Male 115 lb 11/11/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Keratoconjunctivitis Sicca Hospitalization 9/5/2008 68 Male 11/11/2008 Consumer United States
Primary
Secondary
Hypovolaemic Shock Life Threatening 10/8/2008 Female 11/11/2008 Physician United Kingdom
Primary
Secondary
Keratoconjunctivitis Sicca Hospitalization 9/10/2008 Male 11/12/2008 Physician Switzerland
Primary
Secondary
Ileus Other Serious 9/19/2008 Male 11/14/2008 Physician Germany
Primary
Secondary
Hyperammonaemia Other Serious 66 Male 11/18/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ileus Hospitalization 9/17/2008 Male 207 lb 11/19/2008 Physician Germany
Primary
Secondary
Anaemia Other Serious 11/19/2008 Physician United Kingdom
Primary
Secondary
White Blood Cell Count Decreased Other Serious 8/11/2007 Male 11/19/2008 Physician United Kingdom
Primary
Secondary
Vomiting Other Serious 10/11/2008 70 Male 11/20/2008 Consumer Germany
Primary
Secondary
White Blood Cell Count Decreased Other Serious 8/11/2007 Male 11/20/2008 Physician United Kingdom
Primary
Secondary
Vitreous Haemorrhage Other Serious 8/4/2008 Male 11/21/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 10/5/2008 Female 11/24/2008 Physician Switzerland
Primary
Secondary
Pulmonary Embolism Life Threatening 10/8/2008 Female 11/25/2008 Physician United Kingdom
Primary
Secondary
Renal Failure Other Serious 10/14/2008 Male 11/25/2008 Physician United Kingdom
Primary
Secondary
Diarrhoea Hospitalization 9/29/2008 Male 11/26/2008 Physician Switzerland
Primary
Secondary
C-reactive Protein Increased Hospitalization 9/29/2008 Male 11/26/2008 Consumer United States
Primary
Secondary
Keratoconjunctivitis Sicca Hospitalization 9/10/2008 Male 12/2/2008 Physician Switzerland
Primary
Secondary
Renal Failure Acute Other Serious 10/5/2008 Female 12/2/2008 Physician Switzerland
Primary
Secondary
Abdominal Rigidity Other Serious 7/1/2008 Male 12/10/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Keratoconjunctivitis Sicca Hospitalization 9/5/2008 68 Male 12/12/2008 Consumer United States
Primary
Secondary
Interstitial Lung Disease Hospitalization 11/1/2008 71 Male 12/15/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Abnormal Other Serious 8/4/2008 Male 12/31/2008 Consumer Japan
Primary
Secondary
Concomitant
Anaphylactoid Reaction Other Serious 11/4/2008 Male 110 lb 1/16/2009 Consumer Japan
Primary
Concomitant
Anaphylactoid Reaction Other Serious 11/4/2008 Male 110 lb 2/3/2009 Consumer Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 10/8/2008 Male 132 lb 2/19/2009 Consumer Japan
Primary
Secondary
Concomitant
Hypertension Other Serious 12/23/2007 Male 3/31/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Drug Exposure During Pregnancy Other Serious 17 Female 4/2/2009 Other Health Professional United States
Primary
Secondary
Tracheo-oesophageal Fistula Other Serious 4/2/2009 Other Health Professional United States
Primary
Secondary
Chronic Myeloid Leukaemia Other Serious 56 Male 4/30/2009 Other Health Professional Germany
Primary
Secondary
Acute Promyelocytic Leukaemia Other Serious 65 Female 4/30/2009 Other Health Professional Turkey
Primary
Secondary
Concomitant
Chronic Myeloid Leukaemia Hospitalization 1/1/2008 66 Male 4/30/2009 Other Health Professional Turkey
Primary
Secondary
Concomitant
Pyrexia Life Threatening 12/28/2007 Male 165 lb 5/4/2009 Physician Japan
Primary
Secondary
Concomitant
Hypertension Other Serious 12/23/2007 Male 5/6/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Stress Cardiomyopathy Hospitalization 1/1/2008 75 Female 5/13/2009 Physician United States
Primary
Secondary
Pyrexia Other Serious 7/1/2009 Male 119 lb 10/8/2009 Pharmacist Japan
Primary
Concomitant
Dyspnoea Other Serious 8/19/2009 58 Male 10/30/2009 Other Health Professional United Kingdom
Primary
Concomitant
Intestinal Obstruction Other Serious 62 Female 12/3/2009 Consumer United Kingdom
Primary
Concomitant
Pyrexia Other Serious 7/1/2009 Male 119 lb 12/4/2009 Pharmacist Japan
Primary
Concomitant
Neuropathy Peripheral Disability 5/1/2008 60 Male 1/19/2010 Other Health Professional United Kingdom
Primary
Concomitant
Venous Thrombosis Other Serious 9/22/2008 59 Male 152 lb 4/15/2010 Physician Japan
Primary
Concomitant
Pulmonary Embolism Hospitalization 12/24/2008 48 Female 121 lb 5/27/2010 Other Health Professional Japan
Primary
Secondary
Urinary Tract Infection Other Serious 6/1/2009 71 Female 6/22/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Ventricular Fibrillation Other Serious 1/1/2009 Male 8/16/2010 Consumer Japan
Primary
Secondary
Concomitant
Stomatitis Other Serious 11/18/2009 56 Female 139 lb 10/13/2010 Physician United States
Primary
Concomitant
Hyperammonaemia Hospitalization 6/14/2010 60 Female 10/29/2010 Physician Japan
Primary
Secondary
Concomitant
Dermatitis Acneiform Death 7/13/2010 11/5/2010 Other Health Professional Japan
Primary
Concomitant
Dermatitis Acneiform Other Serious 7/13/2010 11/9/2010 Physician Japan
Primary
Concomitant
Dermatitis Acneiform Other Serious 7/13/2010 12/10/2010 Physician Japan
Primary
Concomitant
Hypoaesthesia Other Serious 9/1/2009 75 Male 1/5/2011 Physician Japan
Primary
Secondary
Concomitant
Urinary Retention Hospitalization 6/28/2010 1/12/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Rash Other Serious 10/21/2010 71 Female 104 lb 1/24/2011 Physician Japan
Primary
Secondary
Concomitant
Hypoaesthesia Other Serious 9/1/2009 75 Male 2/8/2011 Physician Japan
Primary
Secondary
Concomitant
Cheilitis Hospitalization 6/28/2010 56 Female 104 lb 2/10/2011 Physician Japan
Primary
Secondary
Concomitant
Asthenia Hospitalization 2/10/2011 67 Female 106 lb 3/2/2011 Other Health Professional United States
Primary
Secondary
Hypertension Other Serious 3/15/2011 Physician Finland
Primary
Secondary
Proteinuria Other Serious 3/25/2011 Consumer United Kingdom
Primary
Secondary
Pulmonary Artery Thrombosis Hospitalization 1/21/2011 64 Male 143 lb 3/28/2011 Consumer Germany
Primary
Concomitant
Confusional State Hospitalization 10/16/2010 77 Male 3/28/2011 Physician Spain
Primary
Concomitant
Diarrhoea 1/1/2010 69 Female 5/9/2011 Consumer United States
Primary
Concomitant
Interstitial Lung Disease Death 12/10/2010 77 Female 126 lb 5/16/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Neuropathy Peripheral Death 12/10/2010 77 Female 126 lb 5/16/2011 Physician Japan
Primary
Secondary
Concomitant
Decreased Appetite Death Female 5/16/2011 Other Health Professional Japan
Primary
Secondary
Interstitial Lung Disease Hospitalization 58 Male 5/17/2011 Other Health Professional Japan
Primary
Secondary
Interstitial Lung Disease Hospitalization 70 Male 5/17/2011 Other Health Professional Japan
Primary
Secondary
Interstitial Lung Disease Other Serious 58 Male 5/16/2011 Other Health Professional Japan
Primary
Secondary
Interstitial Lung Disease Other Serious 58 Male 5/18/2011 Other Health Professional Japan
Primary
Secondary
Renal Infarct Other Serious 2/1/2011 62 Male 5/18/2011 Physician Finland
Primary
Concomitant
Toxicity To Various Agents Other Serious Female 5/18/2011 Physician United States
Primary
Concomitant
Interstitial Lung Disease Other Serious 70 Male 5/18/2011 Other Health Professional Japan
Primary
Secondary
Respiratory Failure Hospitalization 70 Female 110 lb 5/22/2011 Other Health Professional Japan
Primary
Secondary
Gastrointestinal Haemorrhage Hospitalization 3/28/2011 Male 5/23/2011 Consumer Canada
Primary
Concomitant
Haematotoxicity Other Serious Female 5/20/2011 Physician Germany
Primary
Concomitant
C-reactive Protein Increased Other Serious 15 Male 5/20/2011 Physician Germany
Primary
Concomitant
Death Other Serious 16 Female 5/20/2011 Physician Germany
Primary
Concomitant
Haematotoxicity Death Male 5/20/2011 Physician Germany
Primary
Concomitant
Cerebral Ischaemia Disability 8/29/2010 56 Female 108 lb 5/27/2011 Physician France
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 3/1/2011 79 Female 5/27/2011 Consumer Austria
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 58 Male 5/27/2011 Other Health Professional Japan
Primary
Secondary
Haematotoxicity Other Serious 6/1/2011 Other Health Professional Korea, Republic Of
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 61 6/3/2011 Other Health Professional Austria
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 58 Male 6/4/2011 Other Health Professional Japan
Primary
Secondary
Neutrophil Count Decreased Death 1/1/2009 79 Female 6/8/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 8/29/2010 56 Female 6/9/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Dermatitis Acneiform Death 6/1/2009 76 Male 6/9/2011 Other Health Professional United States
Primary
Secondary
Renal Impairment Hospitalization 40 6/13/2011 Consumer United States
Primary
Secondary
Respiratory Failure Hospitalization Female 6/14/2011 Other Health Professional Japan
Primary
Secondary
Pyrexia Death 61 Female 152 lb 6/27/2011 Physician Israel
Primary
Concomitant
Deep Vein Thrombosis Other Serious 5/10/2009 71 Female 152 lb 6/28/2011 Physician Israel
Primary
Concomitant
Pleural Effusion Other Serious 50 Female 126 lb 6/28/2011 Physician Israel
Primary
Secondary
Concomitant
Vomiting Other Serious 1/15/2010 65 Male 97 lb 6/29/2011 Consumer China
Primary
Concomitant
Fatigue Hospitalization 3/1/2007 76 Male 6/30/2011 Physician Israel
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 5/18/2011 56 Male 216 lb 6/30/2011 Physician Ireland
Primary
Concomitant
Dyspnoea Hospitalization 3/10/2011 70 Male 134 lb 7/1/2011 Physician Italy
Primary
Concomitant
Malaise Other Serious 74 Female 7/1/2011 Physician Japan
Primary
Concomitant
Atrial Tachycardia Hospitalization 1/19/2011 62 Female 119 lb 7/6/2011 Physician France
Primary
Secondary
Concomitant
Abscess Death 5/25/2011 57 Female 146 lb 7/7/2011 Physician Germany
Primary
Secondary
Concomitant
Pancreatitis Acute Hospitalization 5/15/2011 75 Male 172 lb 7/8/2011 Physician Canada
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/1/2010 46 Female 115 lb 7/11/2011 Consumer Mexico
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 3/1/2007 76 Male 170 lb 7/15/2011 Physician Israel
Primary
Secondary
Concomitant
Gastrointestinal Toxicity Other Serious 14 Male 9/7/2011 Germany
Primary
Secondary
Thrombocytopenia Hospitalization 16 Male 9/6/2011 Germany
Primary
Secondary
Leukopenia Other Serious 58 Female 9/23/2011 Other Health Professional Japan
Primary
Secondary
Gastrointestinal Toxicity Other Serious 58 Female 10/24/2011 Other Health Professional Japan
Primary
Secondary
Acute Pulmonary Oedema Hospitalization 10/23/2011 68 Male 159 lb 11/11/2011 Physician Italy
Primary
Secondary
Subileus Hospitalization 4/7/2010 58 Male 152 lb 11/23/2011 Physician Italy
Primary
Secondary
Concomitant
Intervertebral Disc Protrusion Hospitalization 4/7/2010 58 Male 152 lb 11/28/2011 Physician Italy
Primary
Secondary
Concomitant
Colon Cancer Metastatic Other Serious 48 Male 11/23/2011 Other Health Professional Denmark
Primary
Secondary
Mechanical Ileus Death 1/1/2008 59 Male 11/29/2011 Other Health Professional Japan
Primary
Concomitant
Colitis Hospitalization 8/5/2011 68 Male 170 lb 12/2/2011 Physician Canada
Primary
Secondary
Concomitant
Colon Cancer Metastatic Other Serious 48 Male 11/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Paronychia Hospitalization 8/10/2010 69 Male 126 lb 12/8/2011 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Hospitalization 5/27/2011 75 Male 119 lb 12/12/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Rash Other Serious 11/18/2010 75 Male 93 lb 12/12/2011 Other Health Professional Japan
Primary
Concomitant
Shock Haemorrhagic Death Male 106 lb 12/12/2011 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 11/18/2011 76 Female 12/12/2011 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 11/18/2011 76 Female 12/12/2011 Physician Japan
Primary
Secondary
Concomitant
Laryngospasm Other Serious 12/8/2011 73 Male 117 lb 12/20/2011 Pharmacist Malaysia
Primary
Concomitant
Hypoaesthesia Other Serious 12/8/2011 64 Female 89 lb 12/21/2011 Pharmacist Malaysia
Primary
Concomitant
Infectious Peritonitis Death 4/1/2009 73 Male 1/2/2012 Physician Japan
Primary
Concomitant
Liver Disorder Other Serious 48 Male 12/29/2011 Other Health Professional United Kingdom
Primary
Secondary

Drug Data