Irinotecan Hcl combined with Leucovorin Calcium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Metastases To Liver Hospitalization 75 Female 1/4/2006 Physician France
Primary
Concomitant
Tremor Hospitalization 11/21/2005 56 Female 106 lb 1/13/2006 Physician Canada
Primary
Secondary
Concomitant
Urosepsis Disability 10/8/2005 66 Male 1/18/2006 Netherlands
Primary
Secondary
Concomitant
Tremor Hospitalization 11/21/2005 56 Female 106 lb 1/18/2006 Physician Canada
Primary
Secondary
Concomitant
Neutropenia Hospitalization 11/28/2005 42 Female 205 lb 1/18/2006 Physician Canada
Primary
Secondary
Concomitant
Lymphoma Other Serious Female 1/19/2006 Physician United States
Primary
Secondary
Gastritis Hospitalization 9/11/2005 57 Female 180 lb 1/20/2006 Physician Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/25/2005 63 Female 101 lb 1/24/2006 Other Health Professional Canada
Primary
Secondary
White Blood Cell Count Increased Hospitalization 11/22/2005 74 Male 437 lb 1/24/2006 Physician Australia
Primary
Secondary
Concomitant
Death Death 59 Male 1/26/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Pyrexia Life Threatening 12/1/2005 75 Female 1/27/2006 Physician France
Primary
Concomitant
Scab Other Serious 55 Male 2/1/2006 Physician Netherlands
Primary
Concomitant
Death Death 59 Male 345 lb 2/2/2006 Canada
Primary
Secondary
Concomitant
Viral Infection Hospitalization 1/13/2006 39 Female 227 lb 2/2/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 10/21/2005 60 Male 2/6/2006 Other Health Professional Australia
Primary
Secondary
Concomitant
Vomiting Other Serious 2/6/2006 Male 150 lb 2/17/2006 United States
Primary
Secondary
Concomitant
Thrombosis Hospitalization 2/7/2006 Female 2/22/2006 Physician Slovakia (Slovak Republic)
Primary
Concomitant
Pyrexia Hospitalization 1/25/2006 40 Female 2/24/2006 Physician Norway
Primary
Concomitant
Rash Pustular 9/30/2005 26 Female 3/3/2006 Other Health Professional United States
Primary
Concomitant
Vomiting 12/1/2005 60 Female 130 lb 3/3/2006 Consumer United States
Primary
Concomitant
No Adverse Effect 1/10/2006 72 Male 3/3/2006 Consumer United States
Primary
Concomitant
Stomatitis Other Serious 2/11/2006 59 Male 3/6/2006 Consumer United States
Primary
Concomitant
Syncope Other Serious 10/1/2005 69 Male 3/10/2006 Physician Canada
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/25/2005 63 Female 101 lb 3/20/2006 Other Health Professional Canada
Primary
Secondary
Menorrhagia Hospitalization 44 Female 86 lb 3/21/2006 Other Health Professional Hong Kong
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/7/2006 61 Female 3/24/2006 Physician Germany
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 3/18/2006 78 Female 100 lb 3/30/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/8/2005 55 Male 181 lb 3/30/2006 Physician Canada
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 3/18/2006 78 Female 100 lb 4/6/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/13/2006 55 Male 128 lb 4/12/2006 Physician France
Primary
Secondary
Concomitant
Skin Exfoliation Required Intervention 2/15/2006 63 Male 221 lb 4/14/2006 Physician United States
Primary
Concomitant
Deep Vein Thrombosis Death 3/15/2006 59 Male 4/17/2006 Physician Mexico
Primary
Secondary
Concomitant
Deep Vein Thrombosis Death 3/15/2006 59 Male 4/20/2006 Physician Mexico
Primary
Secondary
Concomitant
Pneumonia Hospitalization 1/16/2006 55 Male 156 lb 4/21/2006 Physician Canada
Primary
Secondary
Concomitant
Vomiting Other Serious 3/23/2006 67 Male 137 lb 4/24/2006 Other Health Professional Japan
Primary
Secondary
Vomiting Hospitalization 5/18/2005 57 Female 142 lb 4/26/2006 Physician Australia
Primary
Secondary
Concomitant
Urosepsis Hospitalization 8/14/2005 68 Male 150 lb 4/26/2006 Physician Australia
Primary
Secondary
Concomitant
Blood Bilirubin Increased Hospitalization 4/7/2006 62 Male 190 lb 4/26/2006 Physician Canada
Primary
Secondary
Platelet Count Decreased Death 3/15/2006 59 Male 5/3/2006 Physician Mexico
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 3/22/2006 46 Male 182 lb 5/8/2006 Other Health Professional United Kingdom
Primary
Secondary
Peritonitis Bacterial Hospitalization 4/14/2006 20 Male 185 lb 5/10/2006 Physician Bulgaria
Primary
Concomitant
Duodenal Perforation Required Intervention 64 Female 101 lb 5/9/2006 Physician United States
Primary
Concomitant
Gastritis Hospitalization 9/11/2005 57 Female 180 lb 5/11/2006 Other Health Professional Germany
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 9/26/2005 50 Male 190 lb 5/11/2006 Physician United States
Primary
Secondary
Nausea 64 Male 3/1/2006 Consumer United States
Primary
Concomitant
Catheter Related Complication 12/16/2005 62 Male 3/1/2006 Physician United States
Primary
Concomitant
Neuropathy 11/16/2005 63 Male 3/1/2006 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/22/2006 46 Male 182 lb 5/15/2006 Other Health Professional United Kingdom
Primary
Secondary
Pulmonary Embolism Hospitalization 10/13/2005 51 Male 3/1/2006 Other Health Professional United States
Primary
Secondary
Tremor Hospitalization 11/21/2005 56 Female 106 lb 5/16/2006 Physician Canada
Primary
Secondary
Concomitant
Peritonitis Life Threatening 47 Male 139 lb 5/19/2006 Physician France
Primary
Concomitant
Pneumonia Hospitalization 3/6/2006 74 Female 194 lb 5/19/2006 Physician Belgium
Primary
Concomitant
Nausea Hospitalization 9/26/2004 65 Female 370 lb 5/20/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Death Death 59 Male 346 lb 5/20/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Uterine Leiomyoma Hospitalization 44 Female 86 lb 5/20/2006 Other Health Professional Hong Kong
Primary
Secondary
Concomitant
Ureteric Obstruction Other Serious 38 Female 5/23/2006 Physician France
Primary
Concomitant
Thrombosis Hospitalization 2/7/2006 Female 5/23/2006 Physician Slovakia (Slovak Republic)
Primary
Concomitant
Peripheral Ischaemia Hospitalization 11/29/2005 60 Male 168 lb 5/23/2006 Other Health Professional Italy
Primary
Concomitant
Stomatitis Other Serious 2/11/2006 59 Male 5/24/2006 Consumer United States
Primary
Concomitant
Pyrexia Hospitalization 1/25/2006 40 Female 5/24/2006 Physician Norway
Primary
Concomitant
Vomiting Hospitalization 5/3/2006 43 Female 153 lb 5/25/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Shock Other Serious 3/23/2006 67 Male 137 lb 5/26/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 5/3/2006 43 Female 153 lb 5/30/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 2/1/2006 59 Male 6/5/2006 Consumer France
Primary
Concomitant
Nasal Septum Perforation Other Serious 55 Male 6/5/2006 Physician Netherlands
Primary
Concomitant
Septic Shock Hospitalization 54 Female 126 lb 6/8/2006 Physician France
Primary
Secondary
Concomitant
Deafness Other Serious 67 Female 6/14/2006 Physician Germany
Primary
Concomitant
Gas Gangrene Death Female 6/21/2006 Physician France
Primary
Concomitant
Vomiting Hospitalization 5/3/2006 43 Female 153 lb 6/27/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pulmonary Embolism Life Threatening 3/1/2006 49 Male 5/31/2006 Physician United States
Primary
Concomitant
Duodenal Perforation Other Serious 4/7/2006 64 Female 101 lb 5/31/2006 Physician United States
Primary
Concomitant
Myocardial Ischaemia Other Serious 4/1/2006 49 Male 5/31/2006 Physician United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 10/26/2005 51 Male 5/31/2006 Other Health Professional United States
Primary
Concomitant
Diarrhoea 36 Female 5/31/2006 Physician United States
Primary
Secondary
Wound Infection Hospitalization 43 Female 200 lb 6/30/2006 United States
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 7/1/2005 51 Male 249 lb 7/18/2006 Physician Germany
Primary
Concomitant
Small Intestinal Perforation Life Threatening 3/30/2006 57 Female 7/21/2006 Consumer Australia
Primary
Secondary
Loss Of Consciousness Other Serious 7/4/2006 66 Male 8/1/2006 Physician Germany
Primary
Concomitant
Febrile Neutropenia Hospitalization 9/26/2005 59 Female 216 lb 7/28/2006 Physician Australia
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 7/28/2006 49 Male 172 lb 8/7/2006 Other Health Professional Belgium
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 7/24/2006 72 Male 137 lb 8/7/2006 Other Health Professional Belgium
Primary
Secondary
Concomitant
Seroma Hospitalization 8/3/2006 52 Male 184 lb 8/10/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 7/28/2006 74 Male 8/21/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Hospitalization 11/25/2005 61 Male 209 lb 8/17/2006 Physician Australia
Primary
Secondary
Concomitant
Seroma Hospitalization 8/3/2006 52 Male 184 lb 8/18/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Coronary Artery Disease Other Serious 62 Male 8/21/2006 Physician United States
Primary
Secondary
Dermatitis Acneiform 6/1/2006 60 Male 8/29/2006 Pharmacist United States
Primary
Concomitant
Seroma Hospitalization 8/3/2006 52 Male 184 lb 8/25/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Neutropenia Other Serious 49 Female 183 lb 8/31/2006 Physician United Kingdom
Primary
Concomitant
Mitral Valve Incompetence Other Serious 8/8/2006 62 Male 154 lb 9/1/2006 Physician United States
Primary
Secondary
Concomitant
Gas Gangrene Death Female 9/6/2006 Physician France
Primary
Concomitant
Respiratory Failure Life Threatening 8/19/2005 74 Male 126 lb 9/13/2006 Physician Japan
Primary
Secondary
Concomitant
Hemiplegia Hospitalization Female 9/14/2006 Physician Finland
Primary
Concomitant
Renal Failure Acute Hospitalization 7/26/2006 54 Female 130 lb 9/21/2006 Physician France
Primary
Secondary
Toxic Epidermal Necrolysis Other Serious 7/28/2006 74 Male 10/11/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 9/6/2006 41 Male 10/7/2006 Physician United States
Primary
Secondary
Septic Shock Hospitalization 54 Female 126 lb 10/10/2006 Physician France
Primary
Secondary
Concomitant
Vision Blurred Hospitalization 8/24/2006 62 Female 10/18/2006 Physician Finland
Primary
Concomitant
Pancreatitis Acute Other Serious Male 10/18/2006 Physician France
Primary
Concomitant
Depressed Level Of Consciousness Other Serious 8/7/2006 42 Male 10/26/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 10/4/2006 56 Male 10/19/2006 Physician Canada
Primary
Secondary
Influenza Like Illness Hospitalization 6/20/2005 33 Female 10/20/2006 Other Health Professional France
Primary
Secondary
Concomitant
Malnutrition Hospitalization 10/10/2006 Female 10/30/2006 Physician United States
Primary
Secondary
Vomiting Hospitalization 5/24/2006 67 Male 10/31/2006 Consumer United States
Primary
Concomitant
White Blood Cell Count Increased Death 1/19/2005 65 Male 10/25/2006 Physician Ireland
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Death 56 Female 137 lb 11/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Malnutrition Hospitalization 10/10/2006 Female 11/8/2006 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Infection Death 11/8/2005 80 Female 11/3/2006 Physician Japan
Primary
Secondary
Toxic Epidermal Necrolysis Other Serious 7/28/2006 74 Male 11/13/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 9/19/2006 Female 11/13/2006 Physician United States
Primary
Secondary
Pyrexia Hospitalization 9/1/2001 70 Male 11/6/2006 Other Health Professional Hungary
Primary
Secondary
Concomitant
Retinal Haemorrhage Other Serious 9/6/2006 46 Male 11/15/2006 Other Health Professional Germany
Primary
Secondary
Small Intestinal Obstruction Hospitalization 5/26/2006 Female 167 lb 11/15/2006 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 9/25/2006 Male 11/17/2006 Physician Australia
Primary
Secondary
White Blood Cell Count Increased Hospitalization 9/29/2006 Male 11/20/2006 Physician Australia
Primary
Concomitant
Hypotension Hospitalization 11/11/2006 Female 11/22/2006 Physician United States
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 11/4/2006 Male 11/22/2006 Physician United States
Primary
Concomitant
Rash Hospitalization 10/27/2006 Female 11/22/2006 Physician Australia
Primary
Secondary
Concomitant
Gait Disturbance Hospitalization 11/13/2006 Male 11/22/2006 Physician Australia
Primary
Concomitant
Hypotension Hospitalization 11/7/2006 Male 11/22/2006 Physician Australia
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 52 Male 11/15/2006 United States
Primary
Secondary
Rectal Perforation Other Serious 67 Female 11/13/2006 Physician Germany
Primary
Concomitant
Abscess Hospitalization 11/11/2006 Male 11/28/2006 Physician United Kingdom
Primary
Concomitant
Intestinal Obstruction Hospitalization 10/4/2006 56 Male 162 lb 11/14/2006 Physician Canada
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 6/5/2006 82 Male 159 lb 11/14/2006 Physician France
Primary
Concomitant
Pneumonia Hospitalization 1/16/2006 55 Male 156 lb 11/15/2006 Physician Canada
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 10/4/2006 56 Male 162 lb 11/21/2006 Physician Canada
Primary
Secondary
Concomitant
Osteonecrosis Disability 9/4/2006 72 Male 11/17/2006 Physician Germany
Primary
Concomitant
Peritonitis Bacterial Hospitalization 20 Male 11/30/2006
Primary
Secondary
Pain In Extremity Life Threatening 1/26/2006 69 Male 12/1/2006 Consumer United States
Primary
Secondary
Concomitant
Abscess Hospitalization 11/11/2006 Male 12/4/2006 Physician United Kingdom
Primary
Concomitant
Upper Respiratory Tract Infection Hospitalization 9/6/2005 71 Female 12/4/2006 Other Health Professional Germany
Primary
Secondary
Malignant Neoplasm Progression Other Serious 11/25/2005 70 Male 12/4/2006 Other Health Professional Germany
Primary
Secondary
Hypotension Hospitalization 11/11/2006 Female 12/5/2006 Physician United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 10/13/2006 78 Male 11/22/2006 Physician Germany
Primary
Concomitant
Thrombocytopenia Other Serious 52 Male 11/23/2006 Physician United States
Primary
Secondary
Small Intestinal Obstruction Hospitalization 8/9/2006 Male 12/6/2006 Physician Australia
Primary
Secondary
Concomitant
Metastases To Liver Hospitalization 11/13/2006 Male 12/6/2006 Physician Australia
Primary
Concomitant
Vena Cava Thrombosis Other Serious 11/29/2006 Male 12/11/2006 Physician Australia
Primary
Concomitant
Tumour Necrosis Required Intervention 45 Female 11/29/2006 Physician Germany
Primary
Secondary
Concomitant
Pneumonia Hospitalization 1/16/2006 55 Male 156 lb 11/29/2006 Physician Canada
Primary
Secondary
International Normalised Ratio Increased Other Serious 10/10/2006 Female 12/11/2006 Physician United States
Primary
Concomitant
Wound Infection Staphylococcal Hospitalization 11/11/2006 Male 12/11/2006 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 11/26/2006 Female 12/11/2006 Physician United States
Primary
Secondary
Concomitant
Venous Thrombosis Hospitalization 10/2/2005 66 Male 12/11/2006 Other Health Professional Germany
Primary
Secondary
Peritonitis Bacterial Hospitalization 20 Male 185 lb 12/1/2006 Physician Bulgaria
Primary
Concomitant
Hypomagnesaemia Hospitalization 11/13/2006 Male 12/15/2006 Physician Australia
Primary
Concomitant
Splenomegaly Hospitalization 1/16/2006 55 Male 156 lb 12/6/2006 Physician Canada
Primary
Secondary
Concomitant
Splenomegaly Hospitalization 1/16/2006 55 Male 156 lb 12/13/2006 Canada
Primary
Secondary
Concomitant
Anterograde Amnesia Other Serious 12/8/2006 78 Male 12/13/2006 Physician France
Primary
Concomitant

Drug Data