Insulin combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Rheumatoid Arthritis Other Serious 12/25/2003 56 Female 101 lb 1/2/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Neoplasm Malignant Hospitalization 3/1/2000 48 Female 150 lb 1/23/2006 Lawyer United States
Primary
Concomitant
Pneumonia Other Serious 1/17/2003 64 Female 2/10/2006 Physician Australia
Primary
Concomitant
Postoperative Wound Infection Other Serious Female 210 lb 2/7/2006 Physician United States
Primary
Concomitant
Photophobia Other Serious 3/16/2006 Male 240 lb 4/10/2006 Consumer United States
Primary
Concomitant
Ventricular Dysfunction Other Serious 81 Male 4/6/2006 United States
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 8/11/2005 61 Male 154 lb 4/12/2006 Consumer France
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 1/1/2005 64 Female 207 lb 5/31/2006 Physician United States
Primary
Concomitant
Hypoglycaemia Other Serious 5/20/2006 61 Female 159 lb 6/5/2006 Consumer United States
Primary
Concomitant
Cardiac Failure Congestive Death Female 6/12/2006 Physician United States
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 11/30/2004 69 Female 6/30/2006 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 6/21/2006 82 Male 174 lb 7/6/2006 Physician United States
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 11/30/2004 69 Female 7/17/2006 Physician Japan
Primary
Concomitant
Wheezing Hospitalization 6/21/2006 82 Male 174 lb 7/20/2006 Physician United States
Primary
Concomitant
Wheezing Hospitalization 6/21/2006 82 Male 174 lb 7/28/2006 Physician United States
Primary
Concomitant
Injection Site Pain 10/1/2004 58 Female 172 lb 8/9/2006 Consumer United States
Primary
Concomitant
Disease Progression Death 2/1/2006 Male 197 lb 8/10/2006 Physician United States
Primary
Concomitant
Vertigo Hospitalization 7/16/2006 57 Male 198 lb 9/5/2006 United Kingdom
Primary
Concomitant
Procedural Complication Other Serious 1/1/2005 Female 168 lb 10/6/2006 Consumer United States
Primary
Concomitant
Bladder Cancer Other Serious 11/1/2006 Female 182 lb 11/20/2006 Physician United States
Primary
Concomitant
Osteonecrosis Other Serious 1/1/2005 64 Female 207 lb 12/5/2006 Physician United States
Primary
Concomitant
Sepsis Hospitalization 9/1/2003 Female 12/13/2006 Consumer United States
Primary
Concomitant
Tooth Discolouration Other Serious 6/1/2006 12/13/2006 Physician
Primary
Concomitant
Humerus Fracture 7/5/2006 Female 12/15/2006 Other Health Professional United States
Primary
Concomitant
Ureteral Neoplasm Other Serious 11/1/2006 Female 182 lb 12/18/2006 Physician United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 9/30/2006 60 Female 1/8/2007 Consumer United States
Primary
Concomitant
Pneumonia Hospitalization 9/4/2006 Male 145 lb 1/18/2007 Physician United States
Primary
Secondary
Concomitant
Hepatitis B Other Serious Female 234 lb 1/30/2007 Other Health Professional United Kingdom
Primary
Concomitant
Uterine Leiomyoma Other Serious 2/6/2006 Female 2/2/2007 Physician United States
Primary
Concomitant
Splenomegaly Other Serious 2/24/2007 51 Male 300 lb 3/8/2007 Physician United States
Primary
Concomitant
B-cell Lymphoma Other Serious 2/13/2007 Male 181 lb 3/26/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pneumatosis Intestinalis Other Serious 53 Female 3/28/2007 Other Health Professional Japan
Primary
Secondary
Pneumonia Necrotising Hospitalization 9/5/2006 Male 145 lb 3/29/2007 Physician United States
Primary
Secondary
Concomitant
Subcutaneous Emphysema Hospitalization 53 Female 4/3/2007
Primary
Secondary
Headache 10/24/2006 85 Male 1/12/2007 Consumer United States
Primary
Concomitant
Pyrexia Hospitalization 8/29/2006 Male 145 lb 4/27/2007 Physician United States
Primary
Secondary
Concomitant
Subcutaneous Emphysema Other Serious 53 Female 4/25/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Fall Hospitalization 1/26/2007 Male 229 lb 5/15/2007 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 1/1/2005 44 Male 168 lb 5/16/2007 Physician United Kingdom
Primary
Concomitant
Tachycardia Other Serious 1/1/2007 14 Female 5/22/2007 Physician Norway
Primary
Concomitant
Tachycardia Hospitalization 4/23/2007 Female 256 lb 5/18/2007 United States
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 4/23/2007 Female 256 lb 6/1/2007 United States
Primary
Secondary
Concomitant
Toothache Hospitalization 1/25/2005 41 Female 244 lb 6/12/2007 United States
Primary
Concomitant
Facial Palsy Other Serious 5/8/2007 Male 230 lb 6/12/2007 Physician United States
Primary
Concomitant
Weight Decreased Female 115 lb 6/25/2007 Consumer United States
Primary
Concomitant
Breast Cancer Other Serious 6/21/2005 Female 6/26/2007 Physician United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Life Threatening 1/1/2007 59 Male 254 lb 6/28/2007 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Nodule Hospitalization 5/28/2007 Female 145 lb 6/29/2007 Consumer Canada
Primary
Concomitant
Toothache Other Serious 1/25/2005 41 Female 244 lb 7/16/2007 United States
Primary
Secondary
Concomitant
Rheumatoid Nodule Hospitalization 5/28/2007 Female 145 lb 7/20/2007 Canada
Primary
Concomitant
Myocardial Infarction Other Serious Male 190 lb 7/30/2007 Other Health Professional Canada
Primary
Concomitant
Weight Increased Other Serious 1/1/2000 Female 8/13/2007 Consumer United States
Primary
Secondary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 1/1/1998 Female 8/16/2007 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/18/2007 Female 181 lb 9/7/2007 Other Health Professional United Kingdom
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 78 Female 181 lb 9/7/2007 Other Health Professional United Kingdom
Primary
Concomitant
Subdural Haematoma Evacuation Life Threatening 7/3/2007 65 Female 163 lb 9/8/2007 France
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2005 48 Female 179 lb 10/1/2007 Physician Sweden
Primary
Concomitant
Hypotension 1/1/2006 62 Female 11/14/2007 Consumer United States
Primary
Concomitant
Wound Treatment Hospitalization 1/25/2005 41 Female 220 lb 11/14/2007 United States
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 9/19/2006 Male 11/28/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Weight Increased Required Intervention 1/1/2007 70 Female 145 lb 11/26/2007 Consumer United States
Primary
Concomitant
Sepsis Death 7/11/2007 Female 154 lb 12/3/2007 United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 5/15/2006 Female 200 lb 12/6/2007 Physician United States
Primary
Concomitant
Injection Site Pain 5/1/2007 Female 150 lb 12/8/2007 Consumer
Primary
Concomitant
Erythema Hospitalization 7/25/2007 65 Female 12/4/2007 Pharmacist United States
Primary
Concomitant
Staphylococcal Infection 7/1/2007 Female 129 lb 12/14/2007 United States
Primary
Concomitant
Drug Ineffective 1/1/2005 Female 223 lb 12/14/2007 Consumer United States
Primary
Concomitant
Osteonecrosis Other Serious 1/1/2006 60 Female 11/28/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 10/15/2006 60 Female 256 lb 11/28/2007 Other Health Professional United States
Primary
Concomitant
Hypoglycaemia Other Serious Male 1/18/2008 Other Health Professional United Kingdom
Primary
Concomitant
Trichophytosis Other Serious 64 Female 1/31/2008
Primary
Secondary
Concomitant
Death Other Serious Female 143 lb 2/13/2008 Other Health Professional United Kingdom
Primary
Concomitant
Drug Ineffective Other Serious 1/1/2003 Female 2/13/2008 Consumer United States
Primary
Concomitant
Therapeutic Agent Toxicity Death 11/19/2007 49 Female 516 lb 2/7/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Coccidioidomycosis Other Serious 11/1/2007 Male 220 lb 2/22/2008 Physician United States
Primary
Concomitant
Urinary Tract Infection Other Serious 10/31/2007 Female 143 lb 2/29/2008 Other Health Professional United Kingdom
Primary
Concomitant
Blood Glucose Decreased Other Serious 2/7/2008 Female 2/29/2008 Consumer United States
Primary
Concomitant
Oesophageal Carcinoma Other Serious 1/1/2008 Male 3/14/2008 Physician United States
Primary
Concomitant
Injection Site Swelling 11/21/2007 Female 250 lb 3/14/2008 Consumer United States
Primary
Concomitant
Injection Site Pruritus 12/1/2003 Female 173 lb 3/14/2008 Consumer United States
Primary
Concomitant
Accidental Exposure 1/8/2008 Female 185 lb 3/15/2008 Consumer United States
Primary
Concomitant
Injection Site Pain 11/25/2007 Male 139 lb 3/15/2008 Consumer United States
Primary
Concomitant
Knee Arthroplasty Other Serious 1/7/2008 24 Female 3/19/2008 Brazil
Primary
Concomitant
Intervertebral Disc Degeneration Hospitalization 1/1/2003 Female 3/20/2008 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/7/2008 60 Female 3/27/2008 Physician Canada
Primary
Secondary
Concomitant
Sepsis Death 7/11/2007 Female 154 lb 3/31/2008 United Kingdom
Primary
Concomitant
Sepsis Death 7/11/2007 Female 154 lb 4/8/2008 United Kingdom
Primary
Concomitant
Pneumonia Life Threatening 5/1/2007 Female 159 lb 4/8/2008 Physician United States
Primary
Concomitant
Pneumonia Other Serious 9/1/2007 Male 220 lb 4/10/2008 Physician United States
Primary
Secondary
Concomitant
Rash Pustular Hospitalization 4/10/2007 Male 146 lb 4/18/2008 United Kingdom
Primary
Concomitant
Pneumonia Other Serious 9/1/2007 Male 220 lb 4/30/2008 Consumer United States
Primary
Secondary
Concomitant
Pneumonia Other Serious 9/1/2007 Male 220 lb 5/7/2008 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/7/2008 60 Female 5/12/2008 Physician Canada
Primary
Secondary
Concomitant
Pneumonia Other Serious 9/1/2007 Male 220 lb 5/12/2008 Physician United States
Primary
Secondary
Concomitant
Pneumonia Other Serious 1/1/2007 Male 220 lb 5/19/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 7/1/2007 Male 5/21/2008 Germany
Primary
Secondary
Concomitant
Septic Shock Hospitalization Male 5/28/2008 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 Male 6/6/2008 Germany
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization Female 6/6/2008 Physician United States
Primary
Concomitant
Renal Failure Hospitalization 12/1/2005 Female 6/9/2008 Physician United States
Primary
Concomitant
Suicidal Ideation 1/1/2008 Female 6/11/2008 United States
Primary
Concomitant
Lung Neoplasm Hospitalization 4/24/2008 Male 6/12/2008 Physician United Kingdom
Primary
Concomitant
Drug Ineffective 3/23/2008 Female 287 lb 6/12/2008 United States
Primary
Concomitant
Injection Site Pain 1/1/2007 Female 6/12/2008 Consumer United States
Primary
Concomitant
Oedema Peripheral 4/28/2008 Female 6/13/2008 United States
Primary
Concomitant
Tuberculosis Other Serious 6/4/2008 Female 154 lb 6/25/2008 Physician Brazil
Primary
Concomitant
Infusion Related Reaction Hospitalization 3/5/2008 29 Female 6/30/2008 Consumer United States
Primary
Concomitant
Drug Ineffective 55 Female 185 lb 6/30/2008 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 Male 8/8/2008 Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 8/13/2008 Other Health Professional Brazil
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/7/2008 60 Female 8/13/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/7/2008 60 Female 8/14/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 4/24/2008 Male 8/15/2008 Physician United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 Male 8/19/2008 Germany
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 9/21/2007 Female 104 lb 8/25/2008 Physician Brazil
Primary
Concomitant
Suicidal Ideation 1/1/2008 Female 9/12/2008
Primary
Concomitant
Accidental Exposure 6/18/2008 Female 241 lb 9/12/2008 Consumer United States
Primary
Concomitant
Injection Site Haemorrhage 7/14/2008 163 lb 9/12/2008 Consumer United States
Primary
Concomitant
Lymphoma Hospitalization 8/27/2007 Female 137 lb 9/19/2008 Physician Japan
Primary
Concomitant
Pruritus Hospitalization 9/1/2007 29 Female 9/25/2008 Other Health Professional United States
Primary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 10/10/2008 Other Health Professional Brazil
Primary
Concomitant
Xanthochromia Hospitalization 6/5/2008 Male 162 lb 10/13/2008 United States
Primary
Secondary
Concomitant
Death Death 8/1/2008 Male 10/31/2008 Other Health Professional United Kingdom
Primary
Concomitant
Shock Other Serious 11/30/2007 Male 35 lb 11/3/2008 Other Health Professional Brazil
Primary
Concomitant
Pyrexia Hospitalization 6/5/2008 27 Male 163 lb 11/3/2008 Physician United States
Primary
Secondary
Microsurgery To Hand Hospitalization 1/19/2006 Female 170 lb 11/3/2008 United Kingdom
Primary
Concomitant
Visual Acuity Reduced Other Serious 4/18/2008 Male 57 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Soft Tissue Disorder Hospitalization 1/19/2006 Female 170 lb 11/4/2008 United Kingdom
Primary
Concomitant
Visual Impairment Other Serious 4/21/2008 Male 36 lb 11/4/2008 Pharmacist Brazil
Primary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Pyrexia Hospitalization 6/5/2008 27 Male 163 lb 11/6/2008 Physician United States
Primary
Secondary
Melaena Hospitalization 2/13/2008 61 Female 234 lb 11/11/2008 Pharmacist United States
Primary
Concomitant
Dyspnoea Hospitalization 9/1/2008 Male 278 lb 11/17/2008 Physician
Primary
Concomitant
Mucosal Inflammation Life Threatening 5/25/2008 Female 187 lb 6/3/2008 United States
Primary
Secondary
Concomitant
Palpitations Other Serious 10/9/2008 Female 172 lb 11/24/2008 Other Health Professional United Kingdom
Primary
Concomitant
Abortion Missed Other Serious 8/26/2008 34 Female 139 lb 11/28/2008 Germany
Primary
Concomitant
Oropharyngeal Pain 2/22/2008 Female 175 lb 12/8/2008 Physician United States
Primary
Concomitant
Wound Other Serious 1/8/2008 Female 185 lb 12/10/2008 Consumer United States
Primary
Secondary
Concomitant
Nasopharyngitis 8/1/2008 Female 207 lb 12/12/2008 United States
Primary
Concomitant
Psoriasis Hospitalization 7/1/2008 Female 212 lb 12/12/2008 United States
Primary
Concomitant
Urinary Tract Infection 11/1/2005 Female 12/12/2008 Consumer United States
Primary
Concomitant
Muscular Weakness 9/20/2007 Female 162 lb 12/15/2008 Consumer United States
Primary
Concomitant
Therapeutic Response Decreased 10/16/2007 Male 210 lb 12/15/2008 Physician United States
Primary
Concomitant
Temporal Arteritis Other Serious 9/1/2008 Male 143 lb 12/29/2008 Physician United Kingdom
Primary
Concomitant
Immunodeficiency Hospitalization Female 1/20/2009 Brazil
Primary
Concomitant
Immune System Disorder Hospitalization Female 1/21/2009 Brazil
Primary
Concomitant
Temporal Arteritis Other Serious 9/1/2008 Male 143 lb 2/3/2009 Physician United Kingdom
Primary
Concomitant
Pneumonia Hospitalization 11/1/2008 Female 2/3/2009 Brazil
Primary
Concomitant
Sudden Death Hospitalization 1/1/2009 Female 2/11/2009 Physician United Kingdom
Primary
Concomitant
Pulmonary Embolism Hospitalization 12/30/2008 Male 3/19/2009 United Kingdom
Primary
Concomitant

Drug Data