Insulin combined with Metformin Hydrochloride

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pulmonary Embolism Life Threatening 4/22/2003 Female 1/4/2006 France
Primary
Concomitant
Tendon Disorder Hospitalization 6/18/2003 Male 1/4/2006 Australia
Primary
Concomitant
Fat Tissue Increased Hospitalization 12/15/2003 53 Female 1/25/2006 Netherlands
Primary
Concomitant
Syncope Other Serious 7/26/2005 Male 2/3/2006 Puerto Rico
Primary
Concomitant
Injection Site Irritation 11/27/2005 75 Female 1/20/2006 Consumer United States
Primary
Concomitant
Pleural Effusion Other Serious 7/26/2005 Male 215 lb 2/16/2006 Puerto Rico
Primary
Concomitant
Thrombocytopenia Other Serious 7/26/2005 Male 215 lb 4/7/2006 Puerto Rico
Primary
Concomitant
Syncope Other Serious 65 Male 4/28/2006 United Kingdom
Primary
Secondary
Concomitant
Leukopenia Required Intervention 9/13/2005 48 Male 1/13/2006 United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 1/1/2003 79 Female 154 lb 8/1/2006 Consumer United States
Primary
Secondary
Concomitant
Oedema Peripheral 74 8/1/2006 Consumer United States
Primary
Concomitant
Thrombosis Other Serious 66 Male 7/28/2006 Pharmacist Germany
Primary
Concomitant
Rectal Haemorrhage Hospitalization 9/14/2006 65 Female 9/30/2006 Physician Turkey
Primary
Concomitant
Erythema Other Serious 63 Female 10/19/2006 Consumer France
Primary
Concomitant
Rectal Haemorrhage Hospitalization 9/14/2006 65 Female 11/15/2006 Physician Turkey
Primary
Concomitant
Granulocytopenia Life Threatening 12/12/2006 67 Male 1/2/2007 Germany
Primary
Concomitant
Renal Failure Hospitalization 9/18/2006 74 Female 152 lb 1/23/2007 Physician Japan
Primary
Concomitant
Erythema Other Serious 11/7/2005 63 Female 2/5/2007 Consumer France
Primary
Concomitant
Renal Failure Hospitalization 9/18/2006 74 Female 152 lb 3/26/2007 Physician Japan
Primary
Concomitant
Drug Ineffective Hospitalization 3/4/2006 56 Female 120 lb 12/13/2006 Pharmacist United States
Primary
Concomitant
Hyperglycaemia Other Serious 64 Female 4/26/2007 United States
Primary
Secondary
Concomitant
Shock Required Intervention 73 Male 7/26/2007 Spain
Primary
Concomitant
Viral Infection Other Serious 6/1/2007 Male 9/7/2007 Other Health Professional France
Primary
Secondary
Concomitant
Interacting
Viral Infection Other Serious 6/1/2007 Male 9/19/2007 Other Health Professional France
Primary
Secondary
Concomitant
Interacting
Ventricular Fibrillation Required Intervention 39 Female 10/3/2007 Netherlands
Primary
Concomitant
Red Blood Cell Count Decreased Hospitalization 8/1/2007 Male 220 lb 11/13/2007 Consumer United States
Primary
Concomitant
Paraesthesia Other Serious 88 Female 2/14/2008 Other Health Professional Canada
Primary
Concomitant
Vasculitis Other Serious 71 Male 2/15/2008 Physician France
Primary
Concomitant
Urinary Tract Infection Other Serious 10/1/2007 56 Female 4/3/2008 Physician France
Primary
Concomitant
Vomiting Other Serious 12/1/2007 55 Female 4/21/2008 Physician Portugal
Primary
Concomitant
Nausea Other Serious 3/26/2008 63 Female 184 lb 5/8/2008 Other Health Professional United Kingdom
Primary
Concomitant
Pitting Oedema Other Serious 4/17/2008 71 Male 5/14/2008 Other Health Professional Denmark
Primary
Concomitant
Uveitis Other Serious 33 Female 5/14/2008 Other Health Professional United Kingdom
Primary
Concomitant
Protein Urine Present Hospitalization 38 Female 6/2/2008 Physician Japan
Primary
Concomitant
Pregnancy Induced Hypertension Hospitalization 8/1/2006 38 Female 6/6/2008 Physician Japan
Primary
Concomitant
Protein Urine Present Hospitalization 38 Female 6/9/2008 Physician Japan
Primary
Concomitant
Urinary Incontinence Other Serious Male 6/11/2008 Consumer Brazil
Primary
Concomitant
Uveitis Required Intervention 33 Female 6/9/2008
Primary
Secondary
Concomitant
Pregnancy Induced Hypertension Hospitalization 8/1/2006 38 Female 6/19/2008 Physician Japan
Primary
Concomitant
Sepsis Hospitalization 7/1/2006 Male 171 lb 7/21/2008 United States
Primary
Concomitant
Visual Impairment Other Serious 4/10/2006 52 Male 7/15/2008 Physician Italy
Primary
Concomitant
Pyrexia Hospitalization 5/9/2008 Female 8/25/2008 Physician Germany
Primary
Concomitant
Dyspnoea Disability 11/1/2007 82 Male 10/16/2008 Other Health Professional United Kingdom
Primary
Concomitant
Diabetes Mellitus Inadequate Control Other Serious 66 Male 10/15/2008 Physician United Kingdom
Primary
Secondary
Vomiting Hospitalization 8/5/2008 71 Male 223 lb 10/3/2008 Physician Canada
Primary
Secondary
Concomitant
Oropharyngeal Pain Other Serious 9/1/2008 51 Female 10/17/2008 Physician United Kingdom
Primary
Concomitant
Tachypnoea Life Threatening 6/23/2008 Male 259 lb 10/17/2008 Physician United Kingdom
Primary
Concomitant
Pancreatitis Hospitalization 1/1/2008 65 Female 10/21/2008 Physician United States
Primary
Concomitant
Dyspnoea Disability 11/1/2007 82 Male 10/22/2008 Other Health Professional United Kingdom
Primary
Concomitant
Guillain-barre Syndrome Other Serious 31 Male 10/29/2008 Other Health Professional United States
Primary
Concomitant
Intentional Drug Misuse Hospitalization 89 Female 11/21/2008 Physician Australia
Primary
Concomitant
Intussusception Life Threatening 87 Female 12/3/2008 Physician Australia
Primary
Concomitant
Nephrolithiasis 5/16/2008 Male 12/12/2008 Other Health Professional United States
Primary
Concomitant
Renal Failure Hospitalization 9/18/2006 Female 152 lb 12/18/2008 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 69 Female 1/21/2009 Other Health Professional Netherlands
Primary
Concomitant
Dyspnoea Other Serious 12/25/2008 68 Female 3/23/2009 Consumer Brazil
Primary
Concomitant
Sudden Death Death 49 Female 4/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Sudden Death Death 49 Female 4/29/2009 Other Health Professional United Kingdom
Primary
Concomitant
Blood Glucose Increased Other Serious 5/25/2009 71 Female 161 lb 6/2/2009 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 4/19/2005 52 Female 6/4/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 9/1/2002 46 Male 180 lb 6/5/2009 Pharmacist United States
Primary
Concomitant
Ventricular Tachycardia Hospitalization 7/1/2006 49 Female 200 lb 6/8/2009 Physician United States
Primary
Concomitant
Fatigue Other Serious 1/1/2007 Female 200 lb 6/8/2009 Consumer United States
Primary
Secondary
Concomitant
Drug Ineffective 6/1/2008 Female 6/11/2009 Consumer United States
Primary
Concomitant
Injection Site Irritation 2/24/2009 Female 149 lb 6/11/2009 Consumer United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 12/1/2005 65 Male 220 lb 6/12/2009 Other Health Professional United States
Primary
Concomitant
Vomiting Hospitalization 12/17/2008 185 lb 6/15/2009 Physician Netherlands
Primary
Secondary
Concomitant
Renal Injury Hospitalization 1/1/1999 48 Female 250 lb 6/15/2009 Pharmacist United States
Primary
Concomitant
Ventricular Tachycardia Hospitalization 7/1/2006 49 Female 200 lb 6/15/2009 Physician United States
Primary
Concomitant
Sick Sinus Syndrome Hospitalization 12/1/2005 41 Male 205 lb 6/15/2009 Other Health Professional United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 6/1/2004 46 Female 160 lb 6/15/2009 Pharmacist United States
Primary
Concomitant
Sudden Death Death 49 Female 8/25/2009 Other Health Professional United Kingdom
Primary
Concomitant
Gangrene Hospitalization 7/19/2009 Female 223 lb 9/24/2009 Physician Poland
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 68 Male 183 lb 9/21/2009 United States
Primary
Concomitant
Renal Failure Hospitalization 1/1/2008 71 Female 179 lb 9/29/2009 Lawyer United States
Primary
Concomitant
Stent Placement Hospitalization 8/12/2009 67 Male 265 lb 9/30/2009 Consumer United States
Primary
Concomitant
Ventricular Fibrillation Death 4/15/2008 60 Female 250 lb 9/24/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 50 Male 354 lb 9/22/2009 United States
Primary
Concomitant
Skin Ulcer Hospitalization 1/1/2009 Male 10/8/2009 Physician Canada
Primary
Concomitant
Renal Failure Hospitalization 1/1/2000 60 Male 230 lb 10/14/2009 Other Health Professional United States
Primary
Concomitant
Myocardial Infarction Hospitalization 6/1/2006 62 Female 226 lb 10/14/2009 Consumer United States
Primary
Concomitant
Myocardial Infarction Life Threatening Male 204 lb 10/15/2009 Physician Canada
Primary
Concomitant
Tachyarrhythmia Hospitalization 6/27/2009 Female 151 lb 10/19/2009 United States
Primary
Concomitant
Therapeutic Response Decreased Other Serious 1/1/2009 Female 139 lb 11/5/2009 Physician United States
Primary
Concomitant
Therapeutic Response Decreased Other Serious 1/1/2009 Female 139 lb 12/14/2009 Physician United States
Primary
Concomitant
Respiratory Arrest Death 44 Female 1/11/2010 Other Health Professional United States
Primary
Secondary
Transient Ischaemic Attack Hospitalization 1/1/2003 53 Male 1/12/2010 Other Health Professional United States
Primary
Concomitant
Injury Other Serious Female 1/13/2010 Other Health Professional Canada
Primary
Concomitant
Weight Decreased Hospitalization 64 Male 12/28/2009 United States
Primary
Concomitant
Therapeutic Response Decreased Other Serious 1/1/2009 Female 139 lb 1/13/2010 Physician United States
Primary
Concomitant
Swelling Face Other Serious 12/1/2009 59 Female 128 lb 1/18/2010 Consumer Brazil
Primary
Concomitant
Premature Baby Congenital Anomaly 11/27/2009 Female 2/2/2010 Other Health Professional United Kingdom
Primary
Concomitant
Premature Baby Congenital Anomaly 11/27/2009 Female 2/5/2010 United Kingdom
Primary
Secondary
Concomitant
Rash Other Serious 8/21/2009 55 Male 2/26/2010 Physician United States
Primary
Concomitant
Pallor Hospitalization 2/6/2010 97 Male 2/26/2010 Consumer United States
Primary
Concomitant
Myocardial Infarction Other Serious 8/1/2009 67 Female 201 lb 3/1/2010 Consumer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process 1/22/2010 Female 200 lb 3/3/2010 Consumer United States
Primary
Concomitant
Premature Baby Congenital Anomaly 11/27/2009 Female 2/17/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 10/1/2007 61 Male 214 lb 3/3/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Urticaria 2/13/2010 60 Male 3/3/2010 Consumer
Primary
Concomitant
Completed Suicide Death 3/4/2010 Physician United States
Primary
Secondary
Renal Failure Other Serious Male 3/4/2010 Consumer Germany
Primary
Concomitant
Ventricular Tachycardia Other Serious 11/1/2007 58 Male 137 lb 3/4/2010 Lawyer United States
Primary
Concomitant
Ischaemic Stroke Hospitalization 48 Male 170 lb 3/4/2010 Other Health Professional United States
Primary
Concomitant
Tardive Dyskinesia Required Intervention 2/26/2010 85 Male 130 lb 3/2/2010 Pharmacist United States
Primary
Secondary
Concomitant
Completed Suicide Death 3/5/2010 Physician United States
Primary
Secondary
Pathological Gambling 56 Female 3/5/2010 Pharmacist United States
Primary
Concomitant
Pancreatitis Other Serious 1/1/2010 Male 3/9/2010 Physician Singapore
Primary
Concomitant
Sciatica Other Serious Female 3/9/2010 Other Health Professional Canada
Primary
Concomitant
Urinary Retention Hospitalization 9/10/2009 Male 240 lb 3/10/2010 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 11/19/2008 Male 149 lb 3/16/2010 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2007 Male 210 lb 3/16/2010 Physician United States
Primary
Concomitant
Pancreatitis Acute Other Serious 10/1/2006 59 Male 297 lb 3/17/2010 Physician United States
Primary
Concomitant
Sleep Apnoea Syndrome Other Serious 8/1/2007 Male 295 lb 3/17/2010 Physician United States
Primary
Concomitant
Sepsis Hospitalization 2/1/2010 Female 149 lb 3/19/2010 Physician Canada
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 1/1/2010 Female 3/22/2010 Other Health Professional Belgium
Primary
Concomitant
Pancreatitis Other Serious 2/1/2010 Male 3/25/2010 Consumer United States
Primary
Concomitant
Thyroid Disorder Other Serious Male 4/21/2010 Other Health Professional United States
Primary
Secondary
Thyroid Disorder Other Serious Male 4/22/2010 Other Health Professional United States
Primary
Secondary
Somnolence Other Serious 8/1/2009 77 Male 196 lb 5/3/2010 Consumer Brazil
Primary
Concomitant
Thyroid Disorder Other Serious Male 5/10/2010 Other Health Professional United States
Primary
Secondary
Thyroid Disorder Other Serious Male 5/10/2010 Other Health Professional United States
Primary
Secondary
Weight Increased Hospitalization 1/7/2007 49 Male 4/28/2010 United States
Primary
Concomitant
Venous Stent Insertion Hospitalization Male 5/11/2010 Other Health Professional Canada
Primary
Concomitant
Suicidal Ideation Hospitalization 85 Female 172 lb 5/13/2010 Physician Canada
Primary
Concomitant
Overdose Hospitalization 5/5/2010 Male 5/13/2010 Pharmacist United States
Primary
Concomitant
Heart Rate Irregular Other Serious 2/1/2010 78 Male 5/14/2010 United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/5/2010 54 Male 199 lb 5/14/2010 Physician United States
Primary
Secondary
Concomitant
Motor Dysfunction Hospitalization 12/30/2009 66 Male 190 lb 5/17/2010 Physician Switzerland
Primary
Concomitant
Blood Glucose Abnormal Male 256 lb 5/17/2010 United States
Primary
Concomitant
Generalised Erythema 3/1/2010 42 Male 258 lb 5/17/2010 United States
Primary
Concomitant
Sick Sinus Syndrome Hospitalization 41 Male 205 lb 5/18/2010 Other Health Professional United States
Primary
Concomitant
Central Nervous System Inflammation Hospitalization 1/20/2010 36 Male 176 lb 5/19/2010 Physician Germany
Primary
Concomitant
Sinus Bradycardia Hospitalization 48 Female 250 lb 5/19/2010 Pharmacist United States
Primary
Concomitant
Weight Increased Hospitalization 1/7/2007 49 Male 5/11/2010 United States
Primary
Concomitant
Epilepsy Hospitalization 44 Male 5/19/2010 Pharmacist Netherlands
Primary
Secondary
Concomitant
Renal Failure Chronic Other Serious 8/20/2008 67 Female 5/20/2010 Lawyer United States
Primary
Concomitant
Osmotic Demyelination Syndrome Disability 10/28/2009 42 Female 182 lb 5/26/2010 Physician Canada
Primary
Secondary
Concomitant
Hyperglycaemia Other Serious 67 Male 5/25/2010 Netherlands
Primary
Concomitant
Interacting
Weight Decreased 1/1/2005 Male 165 lb 5/26/2010 Consumer United States
Primary
Secondary
Concomitant
Urine Albumin/creatinine Ratio Other Serious 3/11/2010 50 Male 5/27/2010 Physician Canada
Primary
Concomitant
Liver Injury Other Serious 1/13/2010 54 Male 183 lb 5/27/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Ventricular Tachycardia Other Serious 11/1/2007 58 Male 137 lb 5/28/2010 Physician United States
Primary
Secondary
Concomitant
Somnolence Other Serious 8/1/2009 77 Male 196 lb 6/2/2010 Consumer Brazil
Primary
Concomitant
Pain Other Serious 1/1/2008 63 Female 223 lb 7/9/2010 Consumer Brazil
Primary
Secondary
Concomitant
Pain Other Serious 1/1/2008 63 Female 223 lb 8/27/2010 Physician Brazil
Primary
Secondary
Concomitant
Thrombotic Stroke Other Serious 1/1/2009 57 Female 139 lb 9/28/2010 Other Health Professional United States
Primary
Concomitant
Product Quality Issue Hospitalization Female 143 lb 10/6/2010 Lawyer Brazil
Primary
Secondary
Concomitant
Malaise Other Serious 69 Male 10/26/2010 Consumer United Kingdom
Primary
Concomitant
Malaise Other Serious 69 Male 11/29/2010 Consumer United Kingdom
Primary
Concomitant

Drug Data