Hydrochlorothiazide combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Sudden Death Hospitalization 11/11/2002 73 Female 106 lb 1/10/2006 Physician Israel
Primary
Concomitant
Platelet Count Decreased Hospitalization 4/1/2004 59 Male 203 lb 1/23/2006 Physician United States
Primary
Concomitant
Abdominal Abscess Hospitalization 11/8/2004 Female 148 lb 1/25/2006 Netherlands
Primary
Concomitant
Respiratory Rate Increased Life Threatening 1/26/2005 69 Male 220 lb 1/26/2006 Pharmacist United States
Primary
Secondary
Concomitant
Fat Tissue Increased Hospitalization 12/15/2003 53 Female 1/25/2006 Netherlands
Primary
Concomitant
Swelling Other Serious 12/7/2005 72 Male 220 lb 12/12/2005 Pharmacist United States
Primary
Concomitant
Erectile Dysfunction 62 Male 12/28/2005 United States
Primary
Concomitant
Angioneurotic Oedema Hospitalization 10/24/2005 Male 211 lb 12/15/2005 Pharmacist United States
Primary
Concomitant
Mental Status Changes Hospitalization 11/14/2005 Male 236 lb 12/28/2005 Pharmacist United States
Primary
Concomitant
Neuropathy Peripheral Required Intervention 1/15/2006 Male 400 lb 2/3/2006 Consumer United States
Primary
Concomitant
Lactic Acidosis Required Intervention 11/14/2005 57 Male 286 lb 1/24/2006 Pharmacist United States
Primary
Concomitant
Faeces Discoloured Hospitalization 10/24/2005 72 Male 296 lb 10/25/2005 Pharmacist United States
Primary
Concomitant
Weight Decreased Hospitalization 10/24/2005 58 Male 203 lb 12/1/2005 Pharmacist United States
Primary
Concomitant
Hypoglycaemia Life Threatening 12/7/2005 48 Male 187 lb 2/7/2006 Pharmacist United States
Primary
Concomitant
Haemolytic Anaemia Hospitalization 12/11/2005 86 Male Pharmacist United States
Primary
Secondary
Concomitant
Mental Status Changes Hospitalization 10/11/2005 79 Male Pharmacist United States
Primary
Concomitant
Spleen Disorder Hospitalization 12/21/2005 77 Male 2/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Lymphadenopathy Other Serious 11/1/2004 68 Female 194 lb 2/9/2006 Physician Germany
Primary
Secondary
Concomitant
Spinal Column Stenosis Hospitalization 4/1/2004 59 Male 209 lb 2/21/2006 Physician United States
Primary
Concomitant
Subdural Haemorrhage Hospitalization 8/1/2005 58 Male 160 lb 2/14/2006 Physician South Africa
Primary
Concomitant
Pruritus Generalised 9/13/2005 66 Female 222 lb 1/5/2006 Consumer United States
Primary
Concomitant
Syncope Hospitalization 11/10/2005 Female 2/21/2006 Pharmacist United States
Primary
Concomitant
Troponin Increased Hospitalization 11/13/2005 73 Male 134 lb 12/13/2005 Pharmacist United States
Primary
Concomitant
Flatulence 12/1/2005 65 Male 2/27/2006 Consumer United States
Primary
Secondary
Concomitant
Ischaemic Stroke Hospitalization 5/9/2005 77 Male 220 lb 2/21/2006 Other Health Professional Poland
Primary
Secondary
Concomitant
Pyrexia 7/22/2005 63 Female 183 lb 1/10/2006 United States
Primary
Concomitant
Subdural Haemorrhage Hospitalization 8/1/2005 58 Male 160 lb 2/24/2006 Physician South Africa
Primary
Concomitant
Rash Hospitalization 1/1/2004 75 Female 2/27/2006 Other Health Professional Spain
Primary
Concomitant
Troponin Increased Hospitalization 5/9/2005 77 Male 220 lb 2/28/2006 Poland
Primary
Secondary
Concomitant
Hypotension Hospitalization 8/1/2005 77 Male 190 lb 12/27/2005 Consumer United States
Primary
Concomitant
Neutropenia Other Serious 2/22/2005 38 Male 245 lb 4/1/2005 Pharmacist United States
Primary
Concomitant
Skin Cancer Life Threatening 5/9/2005 77 Male 220 lb 3/10/2006 Poland
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 76 Female 130 lb 3/24/2006 Physician Canada
Primary
Concomitant
Interacting
Urticaria Hospitalization 9/30/2005 81 Male 11/8/2005 Other Health Professional United States
Primary
Concomitant
Pneumonitis Hospitalization 3/27/2006 72 Male 75 lb 4/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Erythema 9/21/2005 Male 167 lb 3/31/2006 Pharmacist United States
Primary
Concomitant
Vision Blurred Hospitalization 1/5/1999 69 Male 155 lb 2/24/2006 Pharmacist United States
Primary
Concomitant
Wound Infection Hospitalization 3/27/2006 72 Male 75 lb 4/10/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Haemorrhage 2/1/2006 61 Female 136 lb 3/29/2006 United States
Primary
Concomitant
Pulmonary Embolism Life Threatening 2/21/2006 74 Female 168 lb 4/12/2006 Physician Israel
Primary
Concomitant
Rhabdomyolysis Hospitalization 76 Female 130 lb 4/12/2006 Physician Canada
Primary
Concomitant
Interacting
Myalgia Other Serious 7/22/2005 51 Male 227 lb 4/13/2006 Pharmacist United States
Primary
Concomitant
Skin Disorder Hospitalization 3/27/2006 72 Male 75 lb 4/18/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Hypoaesthesia Other Serious 1/6/2006 88 Male 182 lb 4/14/2006 Pharmacist United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 72 Male 170 lb 4/10/2006 Physician United States
Primary
Secondary
Concomitant
Myalgia Other Serious 3/2/2006 64 Male 180 lb 3/2/2006 Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Other Serious 6/22/2005 45 Female 150 lb 4/25/2006 Pharmacist United States
Primary
Concomitant
Skin Disorder Hospitalization 3/27/2006 72 Male 75 lb 5/1/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Neutrophil Count Decreased Other Serious 3/14/2006 49 Male 212 lb 5/8/2006 United States
Primary
Concomitant
Hallucination 1/17/2006 Male 121 lb 5/18/2006 Pharmacist United States
Primary
Concomitant
Haemorrhage Required Intervention 3/20/2006 62 Male 123 lb 4/16/2006 Pharmacist United States
Primary
Secondary
Concomitant
Stent Occlusion Hospitalization 10/5/2005 73 Female 129 lb 5/26/2006 Physician Korea, Republic Of
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 5/21/2006 77 Male 211 lb 5/25/2006 Pharmacist United States
Primary
Concomitant
Insomnia 12/7/2005 56 Male 180 lb 4/3/2006 Consumer United States
Primary
Concomitant
Tinnitus Life Threatening 1/10/2006 66 Female 132 lb 5/13/2006 United States
Primary
Concomitant
Blood Creatine Phosphokinase Increased Required Intervention 6/6/2006 82 Male 204 lb 6/7/2006 Pharmacist United States
Primary
Concomitant
Cystitis Hospitalization 11/3/2005 78 Female 6/9/2006 Other Health Professional Germany
Primary
Concomitant
Rash Hospitalization 2/12/2006 66 Male 268 lb 2/13/2006 Other Health Professional United States
Primary
Concomitant
Cystitis Hospitalization 6/17/2005 77 Female 150 lb 6/13/2006 Other Health Professional Germany
Primary
Concomitant
Swelling Other Serious 11/1/2005 Male 200 lb 4/20/2006 Consumer United States
Primary
Concomitant
Thrombosis Other Serious 51 Male 215 lb 6/7/2006 United States
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 9/21/2004 72 Male 170 lb 6/7/2006 United States
Primary
Secondary
Concomitant
Hypotension Required Intervention 6/8/2006 80 Male 201 lb 6/8/2006 Pharmacist United States
Primary
Concomitant
Drug Ineffective 1/1/2006 77 Male 5/5/2006 Consumer United States
Primary
Concomitant
Amnesia 1/1/2005 59 Male 5/5/2006 Consumer United States
Primary
Concomitant
Rhabdomyolysis Other Serious 9/14/2004 72 Male 170 lb 6/21/2006 Physician United States
Primary
Secondary
Concomitant
Urine Output Increased 4/1/2006 59 Female 248 lb 5/23/2006 Consumer United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 4/24/2006 67 Male 7/5/2006 Pharmacist United States
Primary
Secondary
Concomitant
Angioneurotic Oedema Hospitalization 1/30/2006 60 Male 195 lb 7/3/2006 Pharmacist United States
Primary
Concomitant
Hepatic Lesion Hospitalization 5/25/2006 64 Female 6/28/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pain Hospitalization 72 Male 6/30/2006 United States
Primary
Secondary
Concomitant
Angioneurotic Oedema Life Threatening 6/9/2006 72 Female 144 lb 6/14/2006 Other Health Professional United States
Primary
Concomitant
Muscular Weakness Hospitalization 5/5/2006 Male 7/19/2006 Pharmacist United States
Primary
Concomitant
Bradycardia Hospitalization 6/5/2006 71 Male Pharmacist United States
Primary
Concomitant
Heart Rate Irregular Hospitalization 5/21/2006 64 Male 224 lb 5/23/2006 Pharmacist United States
Primary
Concomitant
Renal Failure Hospitalization 6/29/2006 49 Male 190 lb 7/26/2006 Physician Spain
Primary
Concomitant
Granulocytopenia Required Intervention 10/3/2005 42 Male 1/25/2006 United States
Primary
Concomitant
Hypomagnesaemia Hospitalization 7/3/2006 86 Male 160 lb 7/27/2006 Physician United States
Primary
Concomitant
Loss Of Consciousness Other Serious 1/1/2006 72 Female 7/19/2006 Physician Germany
Primary
Concomitant
Dermatitis Other Serious 7/25/2006 77 Male 226 lb 7/25/2006 Pharmacist United States
Primary
Concomitant
Renal Failure Hospitalization 6/29/2006 49 Male 190 lb 7/28/2006 Physician Spain
Primary
Concomitant
Insomnia 4/1/2006 67 Female 230 lb 7/12/2006 Consumer United States
Primary
Concomitant
Dyspnoea Hospitalization 7/26/2006 57 Male 160 lb 8/2/2006 Pharmacist United States
Primary
Secondary
Concomitant
Self-medication 7/1/2006 66 Male 165 lb 8/14/2006 United States
Primary
Concomitant
Infection Hospitalization 6/5/2006 86 Male 160 lb 8/21/2006 Physician United States
Primary
Concomitant
Therapy Non-responder Hospitalization 6/3/2006 Male 197 lb 6/27/2006 United States
Primary
Concomitant
Small Intestinal Haemorrhage Hospitalization 6/12/2006 64 Male 198 lb 7/14/2006 Pharmacist United States
Primary
Concomitant
Transplant Rejection Hospitalization 4/17/2006 55 Male 261 lb 5/10/2006 Pharmacist United States
Primary
Concomitant
Syncope Hospitalization 6/21/2006 70 Male 189 lb 7/17/2006 Pharmacist United States
Primary
Concomitant
Haemorrhoids Hospitalization 6/26/2006 51 Male 220 lb 7/18/2006 Pharmacist United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 6/29/2006 49 Male 190 lb 8/25/2006 Physician Spain
Primary
Concomitant
Rhabdomyolysis Other Serious 9/14/2004 72 Male 170 lb 8/23/2006 Physician United States
Primary
Secondary
Concomitant
Tendonitis Other Serious 12/17/2005 59 Female 190 lb 8/29/2006 Other Health Professional Netherlands
Primary
Concomitant
Epididymitis Hospitalization 7/27/2006 Male 8/23/2006 Other Health Professional Austria
Primary
Concomitant
Rhabdomyolysis Other Serious 9/1/2004 72 Male 170 lb 8/22/2006 Physician United States
Primary
Secondary
Concomitant
Rash Other Serious 6/30/2006 66 Male 208 lb 6/30/2006 Pharmacist United States
Primary
Concomitant
Tachycardia Life Threatening 5/21/2006 73 Female 207 lb 6/15/2006 Pharmacist United States
Primary
Concomitant
Headache Other Serious 8/28/2006 Male 9/6/2006 United States
Primary
Concomitant
Pneumonia Aspiration Death 52 Female 9/13/2006 Physician United States
Primary
Secondary
Gastrointestinal Haemorrhage Hospitalization 6/20/2006 Male 9/11/2006 Pharmacist United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2005 71 Female 9/5/2006 Physician Germany
Primary
Concomitant
Guillain-barre Syndrome Hospitalization 9/4/2006 Male 9/18/2006 Pharmacist Canada
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 51 Male 215 lb 9/13/2006 United States
Primary
Secondary
Concomitant
Insulin-like Growth Factor Decreased Other Serious 8/4/2006 57 Male 211 lb 9/20/2006 Other Health Professional United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 1/22/2006 68 Male 9/21/2006 Germany
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 51 Male 215 lb 9/22/2006 United States
Primary
Secondary
Concomitant
Nausea Hospitalization 9/25/2006 44 Male 283 lb 9/26/2006 Pharmacist United States
Primary
Concomitant
Cerebrovascular Accident Hospitalization 6/18/2006 87 Male 179 lb 10/4/2006 Pharmacist United States
Primary
Concomitant
Epididymitis Hospitalization 7/27/2006 Male 10/3/2006 Physician Austria
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 3/14/2006 49 Male 212 lb 10/4/2006 United States
Primary
Concomitant
Impaired Work Ability Other Serious 8/4/2006 57 Male 211 lb 10/9/2006 Physician United States
Primary
Concomitant
Urinary Incontinence Hospitalization 10/3/2006 74 Male 210 lb 10/12/2006 Pharmacist United States
Primary
Concomitant
Therapeutic Response Unexpected With Drug Substitution Other Serious 10/8/2006 74 Female 162 lb 10/20/2006 Physician Germany
Primary
Concomitant
Pancreatitis Hospitalization 9/12/2006 44 Male 9/29/2006 Pharmacist United States
Primary
Secondary
Muscle Spasms Other Serious 8/2/2006 79 Male 165 lb 9/15/2006 Pharmacist United States
Primary
Concomitant
Cerebral Infarction Other Serious 5/28/2006 69 Male 154 lb 10/31/2006 Physician United States
Primary
Concomitant
Loss Of Consciousness Other Serious 8/27/2006 66 Male 219 lb 9/29/2006 Pharmacist United States
Primary
Secondary
Concomitant
Pulmonary Oedema Other Serious 7/1/2006 57 Male 172 lb 8/11/2006 Pharmacist United States
Primary
Secondary
Concomitant
Refusal Of Treatment By Patient Required Intervention 10/13/2006 51 Male 270 lb 10/16/2006 Pharmacist United States
Primary
Concomitant
Blood Glucose Increased Other Serious 1/1/2006 54 Male 185 lb 10/27/2006 United States
Primary
Concomitant
Blood Creatine Increased Other Serious 57 Male 185 lb 10/30/2006 United Kingdom
Primary
Concomitant
Renal Failure Acute Other Serious 76 Female 11/7/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Blood Pressure Increased 5/1/2006 73 Male 180 lb 6/1/2006 Physician United States
Primary
Secondary
Concomitant
Convulsion Other Serious 8/1/2006 42 Male 11/2/2006 Consumer United States
Primary
Concomitant
Suicide Attempt Life Threatening 10/26/2006 Female 11/27/2006 Physician United States
Primary
Secondary
Concomitant
Guillain-barre Syndrome Hospitalization 9/4/2006 Male 206 lb 11/27/2006 Pharmacist Canada
Primary
Concomitant
Thrombosis Other Serious 1/24/2006 Male 176 lb 11/28/2006 Other Health Professional United States
Primary
Concomitant
Muscular Weakness 79 Female United States
Primary
Concomitant
Drug Eruption Other Serious 5/14/2006 82 Male 224 lb 5/16/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Headache Other Serious 4/22/2006 64 Male 182 lb 5/1/2006 Other Health Professional United States
Primary
Concomitant
Cardiac Failure Hospitalization 11/17/2006 64 Female 293 lb 11/27/2006 Other Health Professional United States
Primary
Concomitant
Guillain-barre Syndrome Hospitalization 9/4/2006 Male 206 lb 12/5/2006 Pharmacist Canada
Primary
Concomitant
Non-cardiac Chest Pain Hospitalization 11/14/2006 69 Male 202 lb 12/1/2006 Consumer United States
Primary
Concomitant
Skin Disorder Hospitalization 3/27/2006 72 Male 75 lb 12/18/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Urticaria Other Serious 9/1/2006 79 Male 160 lb 12/21/2006 Consumer United States
Primary
Concomitant
Cerebral Infarction Other Serious 5/28/2006 Male 154 lb 12/21/2006 Physician United States
Primary
Concomitant
Peritonitis Hospitalization 11/29/2005 64 Male 209 lb 12/12/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 2/7/2006 59 Female 198 lb 12/12/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Pallor Hospitalization 10/5/2006 Female 88 lb 12/22/2006 Physician Germany
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/7/2006 59 Female 198 lb 12/20/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Radiation Oesophagitis Hospitalization 12/23/2005 61 Male 12/29/2006 United States
Primary
Secondary
Concomitant
Thyroid Cancer Hospitalization 12/14/2006 82 Male 177 lb 1/4/2007 Physician United States
Primary
Concomitant
Renal Impairment Hospitalization 11/8/2006 75 Male 1/8/2007
Primary
Secondary
Concomitant
Spermatocele Hospitalization 7/27/2006 63 Male 1/3/2007 Other Health Professional Austria
Primary
Concomitant
Sensation Of Heaviness Other Serious Female 1/9/2007 Consumer Brazil
Primary
Secondary
Concomitant
Rectal Polyp Life Threatening 8/5/2006 Male 166 lb 10/7/2006 Pharmacist United States
Primary
Secondary
Concomitant
Self-medication Other Serious 35 Male 154 lb 1/5/2007 Physician United States
Primary
Concomitant
Skin Cancer Other Serious 72 Male 250 lb 1/8/2007 Consumer United States
Primary
Concomitant
Hyponatraemia Other Serious 7/21/2006 1/12/2007 Physician Netherlands
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 8/1/2005 43 Male 185 lb 10/4/2006 Other Health Professional United States
Primary
Secondary
Concomitant

Drug Data