Hydrochlorothiazide combined with Isosorbide

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Mental Status Changes Hospitalization 10/11/2005 79 Male Pharmacist United States
Primary
Concomitant
Drug Ineffective Other Serious 2/28/2006 86 Female 3/2/2006 Consumer United States
Primary
Concomitant
Ventricular Tachycardia Hospitalization 8/1/2001 81 Female 143 lb 3/2/2006 Physician United States
Primary
Concomitant
Sepsis Hospitalization 2/23/2006 Male 188 lb 2/24/2006 Other Health Professional United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 2/21/2001 62 Male 212 lb 3/28/2006 Physician United States
Primary
Concomitant
Wheezing Hospitalization 2/23/2006 67 Male 188 lb 3/20/2006 Physician United States
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 2/28/2006 86 Female 3/30/2006 Consumer United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 1/27/2003 44 Female 205 lb 4/6/2006 Lawyer United States
Primary
Concomitant
Tooth Disorder Other Serious 3/1/2006 Female 180 lb 4/6/2006 Consumer United States
Primary
Secondary
Concomitant
Respiratory Disorder Other Serious 75 Female 180 lb 4/7/2006 United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 2/23/2006 67 Male 188 lb 4/7/2006 Physician United States
Primary
Secondary
Concomitant
Uterine Leiomyoma Hospitalization 9/1/2002 62 Female 110 lb 4/19/2006 Lawyer United States
Primary
Concomitant
Weight Increased Hospitalization 9/1/1999 60 Female 165 lb 5/1/2006 Physician United States
Primary
Concomitant
Wheezing Hospitalization 2/23/2006 67 Male 188 lb 4/28/2006 Physician United States
Primary
Secondary
Concomitant
Visual Disturbance Hospitalization 9/1/2002 62 Female 110 lb 5/16/2006 Physician United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 1/22/2006 58 Male Pharmacist United States
Primary
Secondary
Concomitant
Ventricular Hypertrophy Hospitalization 5/10/2005 73 Female 162 lb 5/25/2006 Physician United States
Primary
Concomitant
Throat Tightness Hospitalization 1/1/2006 57 Female 213 lb 5/30/2006 Consumer United States
Primary
Concomitant
Throat Tightness Hospitalization 1/1/2006 57 Female 213 lb 6/1/2006 Physician United States
Primary
Concomitant
Throat Tightness Hospitalization 1/1/2006 57 Female 213 lb 6/7/2006 Physician United States
Primary
Concomitant
Throat Tightness Hospitalization 1/1/2006 57 Female 213 lb 6/8/2006 Physician United States
Primary
Concomitant
Throat Tightness Hospitalization 1/1/2006 57 Female 213 lb 6/9/2006 Physician United States
Primary
Concomitant
Treatment Noncompliance Other Serious 3/1/2005 59 Male 180 lb 6/13/2006 Other Health Professional United States
Primary
Concomitant
Ventricular Hypertrophy Other Serious 5/10/2005 73 Female 162 lb 6/21/2006 Physician United States
Primary
Concomitant
High Density Lipoprotein Decreased Other Serious 3/1/2006 Female 180 lb 7/10/2006 Consumer United States
Primary
Secondary
Concomitant
Ventricular Hypertrophy Other Serious 5/10/2005 73 Female 162 lb 7/14/2006 Physician United States
Primary
Concomitant
Pyrexia Other Serious 1/1/2001 62 Female 8/22/2006 Consumer United States
Primary
Concomitant
Myocardial Infarction Hospitalization 4/1/2006 Female 10/30/2006 Physician United States
Primary
Concomitant
Tongue Paralysis Hospitalization 12/7/2006 74 Male 156 lb 12/18/2006 Pharmacist United States
Primary
Concomitant
Syncope Hospitalization 11/3/2006 82 Male 2/16/2007 Pharmacist United States
Primary
Concomitant
Toothache Other Serious 12/30/2006 Female 180 lb 3/26/2007 Consumer United States
Primary
Concomitant
Suicide Attempt Other Serious 8/31/2003 57 Male 4/11/2007 Consumer United States
Primary
Concomitant
Toothache Other Serious 12/30/2006 Female 180 lb 5/4/2007 Consumer United States
Primary
Concomitant
Vomiting Other Serious 2/22/2007 78 Female 122 lb 5/8/2007
Primary
Concomitant
Off Label Use Hospitalization 12/24/2006 86 Male 140 lb 2/15/2007 Other Health Professional United States
Primary
Concomitant
Ventricular Hypertrophy Hospitalization 2/20/2007 80 Female 118 lb 8/18/2008 Physician United States
Primary
Concomitant
Syncope Other Serious 6/1/2008 Male 221 lb 8/21/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Impairment Other Serious 4/1/2006 53 Male 239 lb 8/29/2008 Lawyer United States
Primary
Concomitant
Retinopathy Hospitalization Female 9/8/2008 Physician United States
Primary
Concomitant
Hot Flush Other Serious 6/18/2008 83 Male 161 lb 9/22/2008 Pharmacist United States
Primary
Concomitant
Myocardial Infarction Death 62 Male 230 lb 9/22/2008 Lawyer United States
Primary
Concomitant
Tremor Other Serious 10/6/2006 92 Female 154 lb 9/29/2008 United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 86 Female 10/8/2008
Primary
Secondary
Concomitant
Swelling Face Other Serious 5/29/2008 Female 200 lb 10/14/2008 United States
Primary
Concomitant
Pruritus 3/11/2008 81 Female 172 lb 11/4/2008 Consumer United States
Primary
Concomitant
Tooth Infection Other Serious 1/1/2003 75 Female 154 lb 11/11/2008 Physician United States
Primary
Concomitant
Tooth Infection Hospitalization 1/1/2003 74 Female 154 lb 1/16/2009 Physician United States
Primary
Concomitant
Vision Blurred Hospitalization 84 Female 2/25/2009 United States
Primary
Concomitant
Type 2 Diabetes Mellitus Death 1/1/1996 45 Male 4/2/2009 United States
Primary
Concomitant
Death Death 1/18/2009 61 Female 4/20/2009 Consumer United States
Primary
Concomitant
Myocardial Infarction Death 62 Male 230 lb 4/27/2009 Pharmacist United States
Primary
Concomitant
Death Death 1/18/2009 61 Female 5/5/2009 Consumer United States
Primary
Concomitant
Productive Cough 5/6/2009 Male 5/13/2009 Consumer
Primary
Concomitant
Vomiting Hospitalization 5/1/2009 Female 5/19/2009 United States
Primary
Concomitant
Productive Cough 5/6/2009 Male 5/22/2009 Consumer
Primary
Concomitant
Psychomotor Hyperactivity 2/18/2009 85 Female 5/15/2009 Other Health Professional United States
Primary
Concomitant
Flushing 3/28/2009 Female 5/27/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 59 Male 215 lb 6/1/2009 United States
Primary
Concomitant
Pain Hospitalization 1/30/2006 50 Male 211 lb 6/5/2009 Lawyer United States
Primary
Concomitant
Malaise 5/11/2009 Female 151 lb 6/15/2009 Physician United States
Primary
Concomitant
Hypertension Other Serious 1/1/1999 Female 6/11/2009 Consumer United States
Primary
Concomitant
Sinusitis 5/6/2009 Male 6/17/2009 Consumer
Primary
Concomitant
Blood Glucose Increased 3/1/2008 70 Male 4/25/2008 Other Health Professional United States
Primary
Concomitant
Myocardial Ischaemia Hospitalization 6/30/2003 63 Female 7/7/2009 Physician United States
Primary
Secondary
Concomitant
Thirst Other Serious 6/2/2009 Female 140 lb 8/11/2009 Other Health Professional United States
Primary
Concomitant
Muscular Weakness Other Serious 1/1/2009 85 Female 150 lb 9/2/2009 Physician United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 8/10/2009 Male 9/10/2009 Physician Switzerland
Primary
Secondary
Concomitant
Injection Site Extravasation Hospitalization 9/12/2007 Female 175 lb 9/12/2009 Physician United States
Primary
Concomitant
Injury Death 64 Female 9/10/2009 Lawyer United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 8/10/2009 Male 9/18/2009 Physician Switzerland
Primary
Secondary
Concomitant
Muscular Weakness Other Serious 1/1/2009 85 Female 150 lb 9/21/2009 Physician United States
Primary
Concomitant
Septic Shock Life Threatening 9/9/2009 77 Male 269 lb 9/23/2009 Physician United States
Primary
Secondary
Concomitant
Tardive Dyskinesia Other Serious Male 265 lb 9/23/2009 United States
Primary
Concomitant
Muscular Weakness Other Serious 1/1/2009 85 Female 150 lb 9/23/2009 Physician United States
Primary
Concomitant
Visual Impairment Other Serious 60 Male 215 lb 9/16/2009 United States
Primary
Concomitant
Weight Increased 82 Female 208 lb 10/2/2009 United States
Primary
Concomitant
Vomiting Death 86 Female 9/23/2009 United States
Primary
Concomitant
Weight Increased Other Serious 55 Male 215 lb 9/28/2009 United States
Primary
Concomitant
Ill-defined Disorder Disability Female 215 lb 10/16/2009 Other Health Professional United States
Primary
Concomitant
Weight Increased Other Serious 55 Male 215 lb 10/17/2009 United States
Primary
Concomitant
Septic Shock Life Threatening 9/9/2009 77 Male 269 lb 11/2/2009 Physician United States
Primary
Secondary
Concomitant
Wheezing Other Serious 9/3/2009 59 Female 386 lb 11/3/2009 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 55 Male 215 lb 11/4/2009 United States
Primary
Concomitant
Weight Decreased Death 73 Female 11/5/2009 United States
Primary
Concomitant
Weight Decreased Other Serious Male 11/9/2009 United States
Primary
Concomitant
Death Death 11/5/2009 Male 11/19/2009 Consumer United States
Primary
Concomitant
Weight Decreased Other Serious 73 Male 11/17/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization 61 Female 11/17/2009 Lawyer United States
Primary
Concomitant
Weight Increased Other Serious 55 Male 215 lb 11/24/2009 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2005 Female 185 lb 12/1/2009 Physician United States
Primary
Concomitant
Death Death 11/5/2009 Male 12/3/2009 Physician United States
Primary
Concomitant
Retinopathy Hospitalization Female 12/1/2009 Physician United States
Primary
Concomitant
Nasal Congestion 11/1/2008 81 Male 12/9/2009 Consumer United States
Primary
Concomitant
Urticaria Hospitalization 4/1/2009 81 Male 12/9/2009 Consumer United States
Primary
Concomitant
Local Swelling Male 12/9/2009 Consumer United States
Primary
Concomitant
Visual Impairment Other Serious 73 Female 12/11/2009 United States
Primary
Concomitant
Headache 69 Female 200 lb 12/21/2009 Physician United States
Primary
Concomitant
Expired Drug Administered Other Serious 2/14/2009 70 Female 180 lb 11/5/2009 Consumer United States
Primary
Concomitant
Occult Blood Positive Other Serious 12/22/2009 73 Female 1/4/2010 Consumer United States
Primary
Secondary
Concomitant
Occult Blood Positive Other Serious 12/22/2009 73 Female 1/11/2010 Consumer United States
Primary
Secondary
Concomitant
Skin Ulcer Other Serious 9/1/2006 79 Male 152 lb 1/21/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Visual Impairment Other Serious 73 Female 1/7/2010 United States
Primary
Concomitant
Skin Ulcer Other Serious 9/1/2006 79 Male 152 lb 1/22/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Occult Blood Positive Other Serious 12/22/2009 73 Female 1/27/2010 Consumer United States
Primary
Secondary
Concomitant
Occult Blood Positive Other Serious 12/22/2009 73 Female 178 lb 1/29/2010 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 64 Female 1/21/2010 Lawyer United States
Primary
Concomitant
Wound Infection Hospitalization 73 Male 1/22/2010 United States
Primary
Concomitant
Visual Impairment Other Serious 73 Female 1/22/2010 United States
Primary
Concomitant
Occult Blood Positive Other Serious 12/22/2009 73 Female 178 lb 2/16/2010 Physician United States
Primary
Secondary
Concomitant
Systemic Lupus Erythematosus Disability 63 Female 2/5/2010 United States
Primary
Concomitant
Tooth Infection Hospitalization 1/1/2003 74 Female 154 lb 2/25/2010 Physician United States
Primary
Concomitant
Tooth Infection Hospitalization 1/1/2003 74 Female 154 lb 3/5/2010 Physician United States
Primary
Concomitant
Alopecia 5/1/2007 Female 198 lb 3/15/2010 Other Health Professional United States
Primary
Concomitant
Product Quality Issue Other Serious 12/22/2009 73 Female 178 lb 3/16/2010 Physician United States
Primary
Secondary
Concomitant
Malaise 5/11/2009 Female 151 lb 3/16/2010 Physician United States
Primary
Concomitant
Pancreatitis Acute Other Serious 12/1/2008 Female 138 lb 3/17/2010 Consumer United States
Primary
Concomitant
Tooth Infection Hospitalization 1/1/2003 74 Female 154 lb 3/19/2010 Physician United States
Primary
Concomitant
Vomiting Life Threatening 2/11/2010 Female 3/19/2010 Physician Argentina
Primary
Concomitant
Tooth Infection Hospitalization 1/1/2003 74 Female 154 lb 3/31/2010 Physician United States
Primary
Concomitant
Vomiting Life Threatening 2/11/2010 81 Female 5/4/2010 Physician Argentina
Primary
Concomitant
Tooth Infection Hospitalization 1/1/2003 74 Female 154 lb 5/5/2010 Physician United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2003 74 Female 154 lb 5/7/2010 Physician United States
Primary
Concomitant
Cerebrovascular Accident Hospitalization Female 158 lb 5/17/2010 Physician United States
Primary
Concomitant
Fatigue 5/1/2010 50 Female 5/17/2010 United States
Primary
Concomitant
Skin Reaction Other Serious 1/1/2008 Female 6/29/2010 Physician United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 6/5/2010 84 Female 6/30/2010 United States
Primary
Secondary
Concomitant
Skin Ulcer Other Serious 9/1/2006 79 Male 152 lb 7/2/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Hospitalization 55 Female 6/25/2010 United States
Primary
Concomitant
Vomiting 1/1/2007 59 Female 165 lb 7/9/2010 Consumer United States
Primary
Concomitant
Psychomotor Hyperactivity Other Serious 1/1/2007 53 Female 160 lb 7/12/2010 Consumer United States
Primary
Concomitant
Malaise 1/29/2007 63 Female 200 lb 7/12/2010 Consumer United States
Primary
Concomitant
Palpitations Other Serious 2/1/2007 47 Male 336 lb 7/12/2010 Consumer United States
Primary
Concomitant
Weight Decreased 4/1/2007 55 Female 187 lb 7/13/2010 Other Health Professional United States
Primary
Concomitant
Lung Disorder Other Serious 9/1/2007 75 Male 235 lb 7/16/2010 Other Health Professional United States
Primary
Concomitant
Weight Increased Hospitalization 6/5/2010 84 Female 7/20/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Life Threatening 2/11/2010 81 Female 7/20/2010 Physician Argentina
Primary
Concomitant
Skin Ulcer Other Serious 9/1/2006 79 Male 152 lb 7/23/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Somnolence 63 Female 7/28/2010 United States
Primary
Concomitant
Paraesthesia Female 7/30/2010 Consumer United States
Primary
Concomitant
Interacting
Vomiting Hospitalization 86 Female 7/26/2010 United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2003 74 Female 154 lb 8/12/2010 Physician United States
Primary
Concomitant
Skin Ulcer Other Serious 9/1/2006 79 Male 152 lb 8/20/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Skin Ulcer Other Serious 9/1/2006 79 Male 152 lb 8/24/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2003 74 Female 154 lb 8/24/2010 Physician United States
Primary
Concomitant
Pruritus Generalised Male 155 lb 8/28/2010 United States
Primary
Concomitant
Flushing Female 8/28/2010 United States
Primary
Concomitant
Flushing 1/1/2009 63 Female 200 lb 8/28/2010 Consumer United States
Primary
Concomitant
Pruritus 3/15/2010 60 Female 250 lb 8/28/2010 Consumer United States
Primary
Concomitant
Poor Peripheral Circulation 62 Male 235 lb 8/29/2010 Consumer United States
Primary
Concomitant
Pleuritic Pain Other Serious 7/5/2006 36 Female 161 lb 9/21/2010 Other Health Professional United States
Primary
Secondary
Concomitant

Drug Data