Humira combined with Ledertrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
T-cell Lymphoma Other Serious 5/1/2006 81 Female 6/1/2006 Physician Belgium
Primary
Concomitant
Osteoporosis Other Serious 5/15/2006 81 Female 116 lb 6/15/2006 Physician Belgium
Primary
Concomitant
Breast Cancer Other Serious 12/14/2007 Female 146 lb 1/15/2008 Physician Belgium
Primary
Concomitant
Breast Cancer Other Serious 12/14/2007 Female 146 lb 1/28/2008 Physician Belgium
Primary
Concomitant
Breast Cancer Other Serious 12/14/2007 Female 146 lb 5/19/2008 Physician Belgium
Primary
Concomitant
Herpes Zoster Hospitalization 3/1/2008 Male 152 lb 8/14/2008 Physician Belgium
Primary
Secondary
Concomitant
Herpes Zoster Hospitalization 3/1/2008 Male 152 lb 8/19/2008 Physician Belgium
Primary
Secondary
Concomitant
Vomiting Other Serious 4/1/2008 Male 12/23/2008 Belgium
Primary
Concomitant
Osteoarthritis Hospitalization 2/11/2008 Male 12/26/2008
Primary
Concomitant
Nervous System Disorder Other Serious 12/16/2007 Male 12/26/2008 Belgium
Primary
Concomitant
Respiratory Failure Hospitalization Female 12/29/2008 Belgium
Primary
Concomitant
Rectal Neoplasm Other Serious 9/25/2007 Female 12/30/2008 Belgium
Primary
Secondary
Concomitant
Coronary Arterial Stent Insertion Hospitalization 10/1/2007 Male 1/2/2009 Belgium
Primary
Concomitant
Unintended Pregnancy Hospitalization 6/6/2008 Female 1/13/2009 Belgium
Primary
Concomitant
Liver Disorder Hospitalization 1/1/2008 Female 1/26/2009 Belgium
Primary
Concomitant
Musculoskeletal Stiffness Other Serious 7/24/2008 Female 1/29/2009 Belgium
Primary
Concomitant
Rectal Polyp Other Serious 10/1/2007 Male 1/30/2009 Belgium
Primary
Concomitant
Pleurisy Hospitalization 10/20/2008 Male 1/30/2009 Belgium
Primary
Concomitant
Polyneuropathy Hospitalization 2/1/2009 Female 2/12/2009 Belgium
Primary
Concomitant
Oropharyngeal Pain Other Serious 8/18/2008 Female 2/16/2009 Belgium
Primary
Concomitant
Rectal Polyp Other Serious 10/1/2007 Male 2/18/2009 Belgium
Primary
Concomitant
Polyneuropathy Hospitalization 2/1/2009 Female 2/25/2009 Belgium
Primary
Concomitant
Oropharyngeal Pain Other Serious 8/18/2008 Female 2/25/2009 Belgium
Primary
Concomitant
Weight Decreased Hospitalization 12/1/2008 Female 104 lb 3/4/2009 Physician
Primary
Concomitant
Weight Decreased Hospitalization 12/1/2008 Female 104 lb 3/6/2009 Physician
Primary
Concomitant
Respiratory Failure Hospitalization Female 3/6/2009 Belgium
Primary
Concomitant
Weight Decreased Hospitalization 4/9/2008 Female 104 lb 3/11/2009 Physician
Primary
Concomitant
Weight Decreased Hospitalization 4/9/2008 Female 104 lb 3/11/2009 Physician
Primary
Concomitant
Herpes Zoster Hospitalization 3/1/2008 Male 152 lb 4/7/2009 Physician Belgium
Primary
Secondary
Concomitant
Weight Decreased Other Serious 3/1/2008 Female 104 lb 4/15/2009 Physician
Primary
Concomitant
Weight Decreased Other Serious 3/1/2008 Female 104 lb 4/16/2009 Physician
Primary
Concomitant
Weight Decreased Other Serious 4/9/2008 Female 104 lb 4/20/2009 Physician
Primary
Concomitant
Rosacea Other Serious 10/1/2008 Female 4/28/2009 Belgium
Primary
Concomitant
Polyneuropathy Hospitalization 2/1/2009 Female 4/30/2009 Belgium
Primary
Concomitant
Bladder Disorder Other Serious 2/6/2009 Female 5/6/2009 Belgium
Primary
Concomitant
Herpes Zoster Hospitalization 3/1/2008 Male 152 lb 6/4/2009 Physician Belgium
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 6/10/2009 Male 6/22/2009 Physician Belgium
Primary
Concomitant
Meniscus Removal Other Serious 5/1/2008 Female 6/29/2009 Belgium
Primary
Concomitant
Synovial Rupture Other Serious 11/1/2008 Female 7/2/2009 Belgium
Primary
Concomitant
Cervical Root Pain Other Serious 2/1/2009 Male 7/9/2009 Belgium
Primary
Concomitant
Lymphadenopathy Other Serious 6/23/2009 Female 8/3/2009 Belgium
Primary
Secondary
Coronary Artery Disease Hospitalization 9/26/2008 Female 8/6/2009 Belgium
Primary
Concomitant
Intervertebral Disc Protrusion Other Serious 3/1/2007 Female 8/14/2009 Belgium
Primary
Concomitant
Synovial Rupture Other Serious 11/1/2008 Female 8/17/2009 Belgium
Primary
Concomitant
Cervical Root Pain Other Serious 2/1/2009 Male 8/17/2009 Belgium
Primary
Concomitant
Lymphadenopathy Other Serious 6/23/2009 Female 8/18/2009 Belgium
Primary
Secondary
Intervertebral Disc Protrusion Other Serious 3/1/2007 Female 8/20/2009 Belgium
Primary
Concomitant
Skin Ulcer Hospitalization 12/18/2007 Female 8/26/2009 Belgium
Primary
Concomitant
Shock Haemorrhagic Hospitalization 10/1/2007 Female 8/28/2009 Belgium
Primary
Concomitant
Skin Ulcer Hospitalization 12/18/2007 Female 9/2/2009 Belgium
Primary
Concomitant
Shock Haemorrhagic Hospitalization 10/1/2007 Female 9/2/2009 Belgium
Primary
Concomitant
Polyneuropathy Other Serious 2/1/2009 Female 9/3/2009 Belgium
Primary
Concomitant
Polyneuropathy Other Serious 2/1/2009 Female 9/8/2009 Belgium
Primary
Concomitant
Polyneuropathy Other Serious 2/1/2009 Female 9/9/2009 Belgium
Primary
Concomitant
Wound Other Serious 6/3/2009 Female 9/11/2009 Belgium
Primary
Concomitant
Skin Ulcer Hospitalization 12/18/2007 Female 9/16/2009 Belgium
Primary
Concomitant
Autoimmune Hepatitis Other Serious Female 9/17/2009 Physician United States
Primary
Concomitant
Hepatic Enzyme Abnormal Other Serious 10/1/2008 Female 9/25/2009 Physician United States
Primary
Concomitant
Cholelithiasis Hospitalization Female 9/28/2009 Belgium
Primary
Concomitant
Coma Hepatic Hospitalization Female 9/30/2009
Primary
Concomitant
Left Ventricular Dysfunction Hospitalization 8/6/2009 Male 9/30/2009 Belgium
Primary
Concomitant
Coma Hepatic Hospitalization Female 10/1/2009
Primary
Concomitant
Ligament Sprain Hospitalization 5/15/2009 Female 10/6/2009
Primary
Concomitant
Thrombocytopenia Hospitalization 1/6/2006 Female 141 lb 10/8/2009 Belgium
Primary
Concomitant
Venous Aneurysm Hospitalization 10/1/2007 Female 10/8/2009 Belgium
Primary
Concomitant
Lymphadenopathy Other Serious 6/23/2009 Female 10/8/2009 Belgium
Primary
Secondary
Concomitant
Wound Hospitalization 3/20/2009 Female 10/12/2009 Belgium
Primary
Concomitant
Wound Hospitalization 12/18/2007 Female 10/12/2009 Belgium
Primary
Concomitant
Lymphadenopathy Other Serious 6/23/2009 Female 10/15/2009 Belgium
Primary
Secondary
Concomitant
Venous Aneurysm Hospitalization 10/1/2007 Female 10/16/2009 Belgium
Primary
Concomitant
Skin Ulcer Hospitalization 12/18/2007 Female 10/20/2009 Belgium
Primary
Concomitant
Neuropathic Arthropathy Other Serious 6/1/2009 Male 10/21/2009 Physician Belgium
Primary
Concomitant
Coma Hospitalization Female 10/22/2009
Primary
Concomitant
Neuropathic Arthropathy Other Serious 6/1/2009 Male 10/23/2009 Physician Belgium
Primary
Concomitant
Synovitis Other Serious 11/23/2008 Male 10/23/2009 Belgium
Primary
Concomitant
Urinary Tract Infection Hospitalization 10/13/2009 Female 10/26/2009 Physician Belgium
Primary
Concomitant
Neuropathic Arthropathy Other Serious 6/1/2009 Male 10/26/2009 Physician Belgium
Primary
Concomitant
Urinary Tract Infection Hospitalization 10/13/2009 Female 10/27/2009 Physician Belgium
Primary
Concomitant
Synovitis Other Serious 11/23/2008 Male 10/27/2009 Belgium
Primary
Concomitant
Peripheral Sensory Neuropathy Other Serious 5/1/2009 Male 11/3/2009 Belgium
Primary
Concomitant
Urinary Tract Infection Hospitalization 10/13/2009 Female 11/5/2009 Physician Belgium
Primary
Concomitant
Polyneuropathy Other Serious 2/1/2009 Female 11/9/2009 Belgium
Primary
Concomitant
Renal Disorder Hospitalization 11/20/2009 Female 12/22/2009 Belgium
Primary
Concomitant
Cardiac Disorder Hospitalization 10/1/2009 Male 1/20/2010 Belgium
Primary
Concomitant
Stress Fracture Other Serious 9/1/2009 Female 1/20/2010 Belgium
Primary
Concomitant
Stress Fracture Other Serious 9/1/2009 Female 1/26/2010 Belgium
Primary
Concomitant
Peripheral Sensory Neuropathy Other Serious 5/1/2009 Male 2/10/2010 Belgium
Primary
Concomitant
Cholangitis Hospitalization 4/21/2009 Female 2/15/2010 Belgium
Primary
Concomitant
Cholangitis Hospitalization 4/21/2009 Female 2/23/2010 Belgium
Primary
Concomitant
Thrombocytopenia Hospitalization 12/19/2006 Female 141 lb 2/23/2010 Belgium
Primary
Concomitant
Rheumatoid Arthritis Other Serious 10/1/2008 Female 3/3/2010 Belgium
Primary
Concomitant
Tuberculosis Hospitalization 9/1/2009 Male 3/10/2010 Belgium
Primary
Concomitant
Cardiac Disorder Other Serious 9/1/2009 Male 3/10/2010 Belgium
Primary
Concomitant
Pneumonia Other Serious 8/27/2009 Female 3/11/2010 Belgium
Primary
Concomitant
Rheumatoid Arthritis Other Serious 10/1/2008 Female 3/15/2010 Belgium
Primary
Concomitant
Tuberculosis Hospitalization 9/1/2009 Male 3/15/2010 Belgium
Primary
Concomitant
Thrombocytopenia Hospitalization 12/19/2006 Female 141 lb 3/26/2010 Belgium
Primary
Concomitant
Rectal Haemorrhage Other Serious 1/1/2009 55 Female 121 lb 4/5/2010 Belgium
Primary
Concomitant
Coma Hospitalization Female 5/10/2010 Belgium
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2007 52 Male 5/12/2010
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 3/29/2010 49 Female 5/13/2010 Belgium
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2007 52 Male 5/14/2010
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 3/29/2010 49 Female 5/17/2010 Belgium
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2007 52 Male 5/17/2010
Primary
Concomitant
Pleurisy Hospitalization Male 5/27/2010 Belgium
Primary
Concomitant
Tinea Pedis Hospitalization 9/15/2009 39 Female 5/28/2010
Primary
Concomitant
Pneumonia Hospitalization Male 6/2/2010 Physician Belgium
Primary
Concomitant
Tinea Pedis Hospitalization 9/15/2009 39 Female 6/8/2010 Physician
Primary
Concomitant
Oropharyngeal Pain Other Serious 8/18/2008 56 Female 6/18/2010 Physician Belgium
Primary
Concomitant
Linitis Plastica Life Threatening 12/29/2009 55 Female 6/25/2010 Physician Belgium
Primary
Concomitant
Weight Decreased Other Serious 1/1/2007 52 Male 6/30/2010 Physician
Primary
Concomitant
Myopathy Other Serious 1/1/2006 51 Male 7/1/2010 Physician Belgium
Primary
Concomitant
Tuberculosis Other Serious 4/21/2010 70 Female 7/2/2010 Physician Belgium
Primary
Concomitant
Tuberculosis Other Serious 4/21/2010 70 Female 7/2/2010 Physician Belgium
Primary
Concomitant
Tuberculosis Other Serious 4/21/2010 70 Female 7/6/2010 Physician Belgium
Primary
Concomitant
Weight Decreased Other Serious 1/1/2007 52 Male 7/8/2010 Physician
Primary
Concomitant
Rectal Haemorrhage Other Serious 1/1/2009 55 Female 121 lb 7/20/2010 Physician Belgium
Primary
Concomitant
Ventricular Extrasystoles Other Serious 6/1/2009 65 Male 7/30/2010 Physician Belgium
Primary
Concomitant
Ventricular Extrasystoles Other Serious 6/1/2009 65 Male 8/2/2010 Physician Belgium
Primary
Concomitant
Fracture Nonunion Disability 9/1/2009 83 Female 8/16/2010 Physician Belgium
Primary
Concomitant
Intervertebral Disc Protrusion Hospitalization Male 8/17/2010 Physician Belgium
Primary
Concomitant
Fracture Nonunion Disability 9/1/2009 83 Female 8/20/2010 Physician Belgium
Primary
Concomitant
Lumbar Spinal Stenosis Hospitalization 1/1/2009 69 Female 8/23/2010 Physician Belgium
Primary
Concomitant
Intervertebral Disc Protrusion Hospitalization Male 8/23/2010 Physician Belgium
Primary
Concomitant
Lumbar Spinal Stenosis Hospitalization 1/1/2009 69 Female 8/25/2010 Physician Belgium
Primary
Concomitant
Thrombocytopenia Hospitalization 12/19/2006 75 Female 141 lb 9/2/2010 Physician Belgium
Primary
Concomitant
Intervertebral Disc Protrusion Hospitalization 6/1/2010 41 Male 9/15/2010 Physician Belgium
Primary
Concomitant
Intervertebral Disc Protrusion Hospitalization Male 9/17/2010 Physician Belgium
Primary
Concomitant
Polyneuropathy Other Serious 5/1/2009 58 Male 9/30/2010 Physician Belgium
Primary
Concomitant
Renal Neoplasm Other Serious 46 Male 187 lb 10/8/2010 Physician Belgium
Primary
Concomitant
Rectal Haemorrhage Other Serious 1/1/2009 55 Female 121 lb 10/13/2010 Physician Belgium
Primary
Concomitant
Epididymal Cyst Other Serious 3/24/2010 67 Male 10/15/2010 Physician Belgium
Primary
Concomitant
Transient Ischaemic Attack Other Serious 12/1/2009 68 Female 132 lb 10/22/2010 Physician Belgium
Primary
Secondary
Concomitant
Tuberculosis Other Serious 4/21/2010 70 Female 10/27/2010 Physician Belgium
Primary
Concomitant
Transient Ischaemic Attack Other Serious 12/1/2009 68 Female 132 lb 10/28/2010 Physician Belgium
Primary
Secondary
Concomitant
Tuberculosis Other Serious 4/21/2010 70 Female 10/29/2010 Physician Belgium
Primary
Concomitant
Hepatic Cirrhosis Other Serious 58 Male 11/12/2010 Physician Belgium
Primary
Secondary
Myopathy Life Threatening 10/3/2010 71 Female 128 lb 11/23/2010 Consumer Belgium
Primary
Secondary
Concomitant
Cardiac Failure Other Serious 11/17/2010 50 Male 159 lb 11/30/2010 Physician Belgium
Primary
Secondary
Concomitant
Cerebral Haemorrhage Other Serious 7/1/2010 65 Female 12/9/2010 Physician Belgium
Primary
Secondary
Concomitant
Skin Lesion Other Serious 11/17/2010 50 Male 159 lb 12/10/2010 Physician Belgium
Primary
Secondary
Concomitant
Myopathy Life Threatening 10/3/2010 71 Female 128 lb 12/17/2010 Consumer Belgium
Primary
Secondary
Concomitant
Liver Disorder Other Serious 2/1/2009 44 Male 187 lb 1/6/2011 Physician Belgium
Primary
Concomitant
Skin Lesion Other Serious 7/1/2010 49 Male 159 lb 1/12/2011 Consumer Belgium
Primary
Secondary
Concomitant
Femoral Artery Occlusion Hospitalization 1/10/2011 74 Female 139 lb 1/18/2011 Physician Belgium
Primary
Concomitant
Femoral Artery Occlusion Hospitalization 1/10/2011 74 Female 139 lb 1/20/2011 Physician Belgium
Primary
Concomitant
Anal Abscess Hospitalization 1/1/2011 56 Female 1/27/2011 Physician Belgium
Primary
Concomitant
Atrial Fibrillation Hospitalization Male 2/16/2011 Physician Belgium
Primary
Concomitant
Anal Abscess Hospitalization 1/1/2011 56 Female 2/17/2011 Physician Belgium
Primary
Concomitant
Aortitis Hospitalization 9/1/2010 55 Female 123 lb 2/21/2011 Physician Belgium
Primary
Concomitant

Drug Data