Herceptin combined with Perjeta

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Death Death 51 Female 7/24/2012 Pharmacist United States
Primary
Secondary
Pneumonitis Hospitalization Female 8/9/2012 Physician United States
Primary
Secondary
Concomitant
Drug Ineffective Other Serious Female 8/17/2012 Consumer United States
Primary
Secondary
Concomitant
Pain Other Serious Female 8/24/2012 Consumer United States
Primary
Secondary
Concomitant
No Therapeutic Response Other Serious Female 8/29/2012 Consumer Us
Primary
Secondary
Pulmonary Mass Hospitalization Female 9/6/2012 Consumer Us
Primary
Secondary
Weight Decreased Other Serious Female 9/7/2012 Consumer Us
Primary
Secondary
Death Death 9/9/2012 70 Female 10/10/2012 Consumer Us
Primary
Secondary
Vitiligo Hospitalization Female 11/5/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Death Death Female 4/11/2013 Physician Us
Primary
Secondary
Death Death 11/26/2012 Female 11/29/2012 Consumer Us
Primary
Secondary
Breast Cancer Metastatic Death Female 210 lb 9/5/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Skin Exfoliation Hospitalization 11/2012 Female 244 lb 3/18/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Weight Decreased Other Serious 51 Female 120 lb 12/24/2012 Physician Us
Primary
Secondary
Concomitant
Metastases To Central Nervous System Other Serious Female 2/8/2013 Consumer Us
Primary
Secondary
Respiratory Depression Hospitalization NotSpecified 1/24/2013 Consumer Us
Primary
Secondary
Concomitant
Pleuritic Pain Hospitalization 2/5/2012 Female 59 lb 3/1/2013 Other Health Professional Us
Primary
Concomitant
Ejection Fraction Decreased Other Serious 59 Female 2/18/2013 Physician Us
Primary
Secondary
Concomitant
Stomatitis Other Serious Female 2/14/2013 Consumer Us
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious Female 3/1/2013 Physician De
Primary
Secondary
Concomitant
Papilloedema Other Serious 49 Female 6/26/2013 Physician Il
Primary
Secondary
Nausea Other Serious 12/28/2012 Female 3/25/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Tachycardia Hospitalization Female 3/15/2013 Physician Us
Primary
Secondary
Concomitant
Oral Mucosal Discolouration Other Serious 11/16/2012 43 Female 135 lb 4/26/2013 Physician Us
Primary
Concomitant
Papilloedema Other Serious 49 Female 7/1/2013 Physician Il
Primary
Secondary
Diarrhoea Hospitalization Female 3/13/2013 Other Health Professional Us
Primary
Secondary
Pyrexia Other Serious 1/2013 Female 3/29/2013 Physician De
Primary
Secondary
Disease Progression Other Serious Female 4/8/2013 Physician Us
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 4/2013 56 Female 4/23/2013 Consumer Hu
Primary
Secondary
Concomitant
Tachycardia Hospitalization 63 Female 4/25/2013 Other Health Professional Us
Primary
Secondary
Syncope Hospitalization 3/19/2013 76 Female 5/3/2013 Pharmacist Us
Primary
Secondary
Hepatic Failure Hospitalization 4/2013 Female 5/14/2013 Physician Mx
Primary
Concomitant
Death Death Female 10/24/2013 Physician Us
Primary
Secondary
Renal Failure Chronic Death Female 5/20/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Pain Hospitalization 4/19/2013 Female 5/21/2013 Other Health Professional Gb
Primary
Secondary
Disease Progression Other Serious 5/2013 62 Female 6/21/2013 Other Health Professional Au
Primary
Secondary
Pain Hospitalization 4/19/2013 Female 5/29/2013 Other Health Professional Gb
Primary
Secondary
Death Death Female 5/30/2013 Physician Us
Primary
Secondary
Pain Hospitalization 4/19/2013 Female 7/22/2013 Other Health Professional Gb
Primary
Secondary
Tremor Other Serious Female 6/3/2013 Consumer Se
Primary
Concomitant
Pain Hospitalization 4/19/2013 Female 6/4/2013 Other Health Professional Gb
Primary
Secondary
Alopecia Other Serious 5/8/2013 45 Female 193 lb 6/24/2013 Physician De
Primary
Secondary
Hepatic Cirrhosis Hospitalization Female 123 lb 11/7/2013 Physician Il
Primary
Secondary
Concomitant
Pneumonitis Other Serious 5/9/2013 33 Female 137 lb 6/5/2013 Pharmacist Us
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/7/2013 47 Female 150 lb 7/12/2013 Physician De
Primary
Secondary
Disease Progression Other Serious Female 6/13/2013 Physician Au
Primary
Secondary
Pseudomembranous Colitis Other Serious 3/17/2013 49 Female 198 lb 7/22/2013 Physician De
Primary
Secondary
Concomitant
Pleural Effusion Other Serious Female 6/17/2013 Physician At
Primary
Secondary
Concomitant
Vertigo Hospitalization 5/13/2013 57 Female 220 lb 6/21/2013 Physician De
Primary
Concomitant
Lower Respiratory Tract Infection Hospitalization Female 6/21/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Acute Febrile Neutrophilic Dermatosis Hospitalization Female 201 lb 7/22/2013 Pharmacist Gb
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Hospitalization Male 6/25/2013 Consumer Ca
Primary
Secondary
Cardiotoxicity Other Serious 54 Female 6/25/2013 Physician Us
Primary
Secondary
Death Death 53 Male 6/25/2013 Physician Us
Primary
Secondary
Febrile Neutropenia Other Serious 62 Female 6/25/2013 Physician Us
Primary
Secondary
Rectal Haemorrhage Other Serious 6/4/2013 57 Female 171 lb 11/13/2013 Consumer Ca
Primary
Secondary
Concomitant
Cardiotoxicity Other Serious 61 Female 6/26/2013 Physician Us
Primary
Secondary
Cerebrovascular Accident Hospitalization Female 6/28/2013 Consumer Us
Primary
Secondary
Sepsis Other Serious 59 Female 7/30/2013 Physician Ie
Primary
Secondary
Concomitant
Diarrhoea Other Serious Female 7/1/2013 Pharmacist Us
Primary
Secondary
Concomitant
Pulmonary Fibrosis Other Serious 5/2013 51 Female 132 lb 9/25/2013 Physician De
Primary
Secondary
Concomitant
Pruritus Other Serious 5/2/2013 54 Female 139 lb 7/2/2013 Pharmacist Sg
Primary
Concomitant
White Blood Cell Count Decreased Other Serious Female 7/4/2013 Consumer Ca
Primary
Secondary
White Blood Cell Count Decreased Other Serious Female 7/5/2013 Consumer Ca
Primary
Secondary
Gastric Ulcer Hospitalization 6/4/2013 79 Female 172 lb 8/30/2013 Physician De
Primary
Secondary
Concomitant
Lung Neoplasm Malignant Other Serious Female 7/19/2013 Consumer Us
Primary
Secondary
Concomitant
Death Death Female 7/22/2013 Physician Us
Primary
Secondary
Concomitant
Paraesthesia Other Serious Female 191 lb 7/26/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Spinal Pain Other Serious 7/12/2013 39 Female 8/1/2013 Consumer Us
Primary
Secondary
Concomitant
Cardiotoxicity Other Serious Female 8/2/2013 Pharmacist Us
Primary
Secondary
Neuropathy Peripheral Other Serious Female 130 lb 9/9/2013 Pharmacist Ca
Primary
Secondary
Concomitant
Splenomegaly Hospitalization 7/26/2013 Female 8/24/2013 Physician De
Primary
Secondary
Neuropathy Peripheral Other Serious Female 8/26/2013 Physician Sg
Primary
Secondary
Concomitant
Cardiotoxicity Other Serious NotSpecified 8/16/2013 Physician Us
Primary
Secondary
Cardiotoxicity Other Serious NotSpecified 8/16/2013 Physician Us
Primary
Secondary
Cardiotoxicity Other Serious NotSpecified 8/16/2013 Physician Us
Primary
Secondary
Cardiotoxicity Other Serious NotSpecified 8/16/2013 Physician Us
Primary
Secondary
Cardiotoxicity Other Serious NotSpecified 8/16/2013 Physician Us
Primary
Secondary
Urticaria Other Serious 7/2013 40 Female 8/19/2013 Other Health Professional Fi
Primary
Secondary
Concomitant
Recall Phenomenon Other Serious 6/30/2013 37 Female 8/28/2013 Physician Gb
Primary
Secondary
Recall Phenomenon Other Serious 37 Female 9/6/2013 Other Health Professional Gb
Primary
Secondary
Heart Rate Decreased Other Serious 8/28/2013 54 Female 9/16/2013 Consumer Ca
Primary
Secondary
Toxicity To Various Agents Other Serious 5/10/2011 69 Female 149 lb 9/7/2013 Physician Us
Primary
Secondary
Concomitant
Disease Progression Other Serious 56 Female 9/10/2013 Physician Us
Primary
Secondary
Concomitant
Disease Progression Other Serious 47 Female 9/13/2013 Physician Us
Primary
Secondary
Concomitant
Skin Ulcer Death 2/2012 51 Female 137 lb 10/22/2013 Physician Us
Primary
Secondary
Concomitant
Spinal Disorder Hospitalization 6/6/2013 58 Female 141 lb 11/4/2013 Consumer Ca
Primary
Secondary
Concomitant
Paraesthesia Disability 7/23/2013 77 Female 125 lb 9/25/2013 Consumer Us
Primary
Secondary
Concomitant
Sepsis Other Serious 8/15/2013 49 Female 10/24/2013 Physician Gb
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious Female 183 lb 9/18/2013 Physician Us
Primary
Secondary
Concomitant
Fall Death Female 9/21/2013 Other Health Professional Us
Primary
Secondary
Metastases To Central Nervous System Other Serious Female 9/23/2013 Physician Us
Primary
Secondary
Concomitant
Weight Increased Hospitalization Female 206 lb 9/23/2013 Physician Us
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 72 Female 9/26/2013 Physician Us
Primary
Secondary
Concomitant
Off Label Use Other Serious Female 9/27/2013 Physician Jp
Primary
Secondary
Vomiting Other Serious 9/13/2013 55 Female 158 lb 10/11/2013 Physician Us
Primary
Secondary
Concomitant
Skin Reaction Other Serious 8/5/2013 41 Female 194 lb 9/28/2013 Physician De
Primary
Secondary
Concomitant
Stomatitis Hospitalization Female 11/21/2013 Physician Us
Primary
Secondary
Concomitant
Mucous Membrane Disorder Other Serious 5/15/2013 73 Female 165 lb 10/7/2013 Physician De
Primary
Secondary
Concomitant
Infusion Related Reaction Other Serious 9/20/2013 Female 11/18/2013 Physician Jp
Primary
Secondary
Back Pain Female 10/8/2013 Consumer Us
Primary
Concomitant
Pruritus Other Serious 8/17/2013 38 Female 129 lb 12/9/2013 Consumer Ca
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 10/8/2013 62 Female 110 lb 12/20/2013 Physician Jp
Primary
Secondary
Vomiting Hospitalization 2/2013 48 Female 129 lb 10/22/2013 Consumer Us
Primary
Secondary
Concomitant
Cardiac Disorder Other Serious Female 10/21/2013 Consumer Us
Primary
Secondary
Concomitant
Fluid Retention Hospitalization 9/13/2013 46 Female 11/13/2013 Other Health Professional Au
Primary
Secondary
Concomitant
Tremor Other Serious Female 10/29/2013 Physician It
Primary
Secondary
Ejection Fraction Decreased Other Serious Female 10/29/2013 Physician Gb
Primary
Secondary
Concomitant
Disease Progression Other Serious 9/24/2013 67 Female 110 lb 10/29/2013 Physician De
Primary
Secondary
Concomitant
Off Label Use Other Serious 40 Female 10/29/2013 Physician De
Primary
Secondary
Gastrointestinal Haemorrhage Hospitalization Female 11/13/2013 Physician Gb
Primary
Secondary
Concomitant
Skin Toxicity Other Serious Female 10/31/2013 Physician Nl
Primary
Secondary
Metastases To Central Nervous System Other Serious NotSpecified 11/6/2013 Physician Au
Primary
Secondary
Death Death NotSpecified 11/7/2013 Physician Us
Primary
Secondary
Malignant Neoplasm Progression Death Female 11/7/2013 Physician De
Primary
Secondary
Tremor Other Serious 7/2/2013 61 Female 101 lb 11/8/2013 Pharmacist Jp
Primary
Secondary
Concomitant
Skin Necrosis Other Serious 1/12/2013 54 Female 130 lb 11/27/2013 Physician Jp
Primary
Secondary
Concomitant
Vitamin D Deficiency Death 7/11/2013 78 Female 11/14/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Pyrexia Hospitalization Female 11/13/2013 Physician Us
Primary
Secondary
Concomitant
Scleroderma Disability 3/2013 48 Female 12/26/2013 Physician De
Primary
Secondary
Concomitant
Pneumonitis Other Serious Female 11/25/2013 Physician Pt
Primary
Secondary
Concomitant
Death Death Female 11/25/2013 Physician Gb
Primary
Secondary
Metastases To Liver Other Serious 10/2012 37 Female 163 lb 11/26/2013 Physician At
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/13/2013 Female 12/5/2013 Other Health Professional Nl
Primary
Secondary
No Therapeutic Response Death 9/30/2013 65 Female 12/5/2013 Consumer Us
Primary
Secondary
Concomitant
Death Death Male 12/5/2013 Other Health Professional Us
Primary
Secondary
Diarrhoea Haemorrhagic Other Serious 40 Female 12/5/2013 Physician De
Primary
Concomitant
Vision Blurred Hospitalization 10/6/2013 65 Female 12/6/2013 Consumer Us
Primary
Secondary
Concomitant
Death Death Female 12/6/2013 Consumer Gb
Primary
Secondary
Cardiotoxicity Other Serious 59 Female 12/7/2013 Physician Us
Primary
Secondary
Concomitant
Cardiotoxicity Other Serious 55 Female 12/7/2013 Physician Us
Primary
Secondary
Concomitant
Performance Status Decreased Other Serious 93 Female 12/7/2013 Physician Us
Primary
Secondary
Performance Status Decreased Death 63 Female 12/7/2013 Physician Us
Primary
Secondary
Concomitant
Metastatic Neoplasm Other Serious Female 12/7/2013 Other Health Professional Us
Primary
Secondary
Cardiotoxicity Other Serious 73 Female 12/7/2013 Physician Us
Primary
Secondary
Concomitant
Cardiotoxicity Other Serious 74 Female 12/7/2013 Physician Us
Primary
Secondary
Concomitant
Cardiotoxicity Other Serious 59 Female 12/9/2013 Physician Us
Primary
Secondary
Respiratory Failure Death 11/10/2013 52 Female 95 lb 12/13/2013 Physician Hk
Primary
Concomitant
Cardiotoxicity Other Serious 68 Female 12/9/2013 Physician Us
Primary
Secondary
Concomitant
Cardiotoxicity Other Serious 66 Male 12/10/2013 Physician Us
Primary
Secondary
Concomitant
Cardiotoxicity Other Serious 57 Female 12/11/2013 Physician Us
Primary
Secondary
Concomitant
White Blood Cell Count Increased Death 12/1/2013 55 Female 130 lb 12/26/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Death Death 60 NotSpecified 12/11/2013 Physician Us
Primary
Secondary
Death Death 65 NotSpecified 12/11/2013 Physician Us
Primary
Secondary
Death Death 73 NotSpecified 12/11/2013 Physician Us
Primary
Secondary
Death Death 74 NotSpecified 12/11/2013 Physician Us
Primary
Secondary
Death Death 49 NotSpecified 12/17/2013 Physician Us
Primary
Secondary
Death Death 59 NotSpecified 12/11/2013 Physician Us
Primary
Secondary
Death Death 48 NotSpecified 12/11/2013 Physician Us
Primary
Secondary
Death Death 48 NotSpecified 12/11/2013 Physician Us
Primary
Secondary

Drug Data