Herceptin combined with Lapatinib

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Ejection Fraction Decreased Other Serious 7/18/2005 46 Female 7/24/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pancytopenia Life Threatening 12/1/2006 37 Female 4/12/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 1/5/2007 Female 100 lb 5/16/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 1/5/2007 Female 100 lb 5/16/2007 Physician United States
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 12/6/2006 52 Female 185 lb 5/25/2007 Physician Croatia (Local Name: Hrvatska)
Primary
Secondary
Disease Progression Death 1/1/2007 Female 6/20/2007 Consumer United States
Primary
Secondary
Disease Progression Death 1/1/2007 Female 6/26/2007 Consumer United States
Primary
Secondary
Pulmonary Hypertension Other Serious 1/5/2007 Female 100 lb 9/19/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 1/5/2007 Female 100 lb 9/19/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 1/5/2007 Female 100 lb 10/8/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 1/5/2007 Female 100 lb 10/8/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 1/5/2007 Female 100 lb 11/13/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 1/5/2007 Female 100 lb 11/13/2007 Physician United States
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 11/1/2007 60 Female 12/20/2007 Physician Ireland
Primary
Concomitant
Tooth Extraction Other Serious 1/11/2008 49 Female 266 lb 5/10/2008 Other Health Professional United States
Primary
Concomitant
Pyrexia Hospitalization 4/13/2008 56 Female 212 lb 5/8/2008 Other Health Professional United States
Primary
Concomitant
Hyperbilirubinaemia Other Serious 5/14/2008 63 Female 159 lb 7/17/2008 Physician South Africa
Primary
Concomitant
Aspartate Aminotransferase Increased Other Serious 6/24/2008 33 Female 132 lb 8/1/2008 Physician China
Primary
Concomitant
Headache Other Serious Female 8/11/2008 Consumer United States
Primary
Secondary
Concomitant
Pulmonary Toxicity Hospitalization 7/25/2008 Female 8/12/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Drug Ineffective Other Serious Female 8/13/2008 Consumer United States
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Other Serious 6/24/2008 33 Female 132 lb 9/12/2008 Physician China
Primary
Concomitant
Aspartate Aminotransferase Increased Other Serious 6/24/2008 33 Female 132 lb 9/18/2008 Physician China
Primary
Concomitant
Drug Ineffective Other Serious Female 9/23/2008 Consumer United States
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 9/26/2008 55 Female 183 lb 10/10/2008 Physician United States
Primary
Secondary
Concomitant
Wheezing Hospitalization 9/26/2008 55 Female 183 lb 10/17/2008 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 10/8/2008 50 Female 128 lb 11/19/2008 Physician China
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 64 Female 168 lb 11/25/2008 Physician United States
Primary
Secondary
Hepatic Enzyme Increased Hospitalization 10/30/2008 Female 12/15/2008 Consumer United Kingdom
Primary
Secondary
White Blood Cell Count Decreased Other Serious 10/8/2008 50 Female 128 lb 12/23/2008 Physician China
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Hospitalization 10/30/2008 Female 12/23/2008 Consumer United Kingdom
Primary
Secondary
White Blood Cell Count Decreased Other Serious 10/8/2008 50 Female 128 lb 12/30/2008 Physician China
Primary
Secondary
Concomitant
Blood Bilirubin Increased Other Serious 10/2/2008 54 Female 176 lb 2/20/2009 Physician Hungary
Primary
Concomitant
Hepatic Enzyme Increased Other Serious 2/3/2009 Female 3/13/2009 Physician United Kingdom
Primary
Secondary
Hepatic Enzyme Increased Other Serious 2/16/2009 Female 3/18/2009 Physician United Kingdom
Primary
Secondary
Anaemia Life Threatening 11/6/2008 77 Female 3/25/2009 Physician France
Primary
Secondary
Concomitant
Rash Other Serious 12/30/2008 60 Female 168 lb 4/14/2009 Physician United States
Primary
Secondary
Metastases To Liver Hospitalization Female 4/28/2009 Consumer United States
Primary
Concomitant
No Therapeutic Response Other Serious 4/1/2009 48 Female 5/13/2009 Consumer Greece
Primary
Concomitant
Ocular Neoplasm Other Serious 34 Female 5/13/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Metastases To Liver Hospitalization Female 5/26/2009 Consumer United States
Primary
Concomitant
Hepatic Enzyme Increased Other Serious 2/16/2009 Female 6/18/2009 Physician United Kingdom
Primary
Secondary
Lung Neoplasm Malignant Other Serious Female 8/11/2009 Consumer United States
Primary
Secondary
Rash Other Serious 8/12/2009 Consumer United Kingdom
Primary
Secondary
Lung Neoplasm Malignant Other Serious Female 9/1/2009 Consumer United States
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 34 Female 9/30/2009 Physician Poland
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious 9/24/2009 Consumer United States
Primary
Concomitant
Treatment Failure Other Serious 1/1/2007 27 Female 10/9/2009 Consumer United Kingdom
Primary
Secondary
Metastases To Eye Other Serious 37 Female 10/13/2009 Other Health Professional United Kingdom
Primary
Secondary
Malignant Neoplasm Progression Other Serious Female 10/15/2009 Physician United States
Primary
Secondary
Treatment Failure Other Serious 1/1/2007 29 Female 10/28/2009 Consumer United Kingdom
Primary
Secondary
Skin Fissures Other Serious 11/1/2006 Female 10/30/2009 Consumer United States
Primary
Secondary
Concomitant
Salpingo-oophoritis Other Serious 1/1/2007 29 Female 11/11/2009 Consumer United Kingdom
Primary
Secondary
Skin Fissures Other Serious 1/1/2008 Female 11/11/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Arrhythmia Hospitalization Female 11/16/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Arrhythmia Hospitalization 10/24/2009 Female 11/19/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Pericardial Effusion Other Serious 10/22/2009 Female 126 lb 11/23/2009 Physician Germany
Primary
Secondary
Concomitant
Pericardial Effusion Other Serious 10/22/2009 Female 126 lb 12/9/2009 Physician Germany
Primary
Secondary
Concomitant
Blood Bilirubin Increased Other Serious 7/17/2008 Female 176 lb 1/11/2010 Physician Hungary
Primary
Concomitant
Metastatic Gastric Cancer Death 1/1/2009 1/27/2010 Physician Netherlands
Primary
Secondary
Vomiting Hospitalization 48 Female 2/25/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 48 Female 3/2/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 2/1/2010 65 Female 3/5/2010 Physician Venezuela
Primary
Concomitant
Vomiting Hospitalization 48 Female 3/16/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Disease Progression Death 1/1/2008 Female 3/31/2010 Physician Netherlands
Primary
Secondary
Disease Progression Death 1/1/2008 51 Female 4/1/2010 Physician Netherlands
Primary
Secondary
Disease Progression Death 1/1/2008 51 Female 4/28/2010 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 47 Female 5/11/2010 Other Health Professional Germany
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 9/1/2006 44 Female 6/1/2010 Physician Poland
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 3/25/2010 46 Female 139 lb 6/1/2010 Other Health Professional Germany
Primary
Secondary
Disease Progression Other Serious 36 Female 6/9/2010 Consumer Canada
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/4/2010 56 Female 106 lb 6/28/2010 Physician Ireland
Primary
Secondary
Metastases To Central Nervous System Other Serious Female 6/28/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/4/2010 56 Female 106 lb 7/7/2010 Physician Ireland
Primary
Secondary
Disease Progression Other Serious 8/17/2010 Consumer United States
Primary
Secondary
Drug Toxicity Other Serious 8/24/2010 Consumer United Kingdom
Primary
Secondary
Rash Other Serious 9/2/2010 Consumer United Kingdom
Primary
Secondary
Urinary Tract Infection Other Serious Male 9/28/2010 United States
Primary
Secondary
Concomitant
Skin Ulcer Other Serious Female 10/4/2010 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 7/26/2006 59 Male 10/13/2010 United States
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Other Serious Female 10/14/2010 Consumer Spain
Primary
Concomitant
Pure White Cell Aplasia Other Serious 10/25/2010 Consumer Greece
Primary
Secondary
Transaminases Increased Female 10/29/2010 Physician United States
Primary
Secondary
Concomitant
Toxic Skin Eruption Other Serious 1/1/2007 52 Female 11/5/2010 Consumer Spain
Primary
Secondary
Urinary Tract Infection Other Serious 7/1/2009 55 Female 11/16/2010 Consumer United States
Primary
Secondary
Disease Progression Other Serious 65 Female 11/17/2010 Consumer China
Primary
Concomitant
Disease Progression Other Serious 1/1/2008 11/18/2010 Consumer Finland
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Other Serious 11/18/2010 Consumer Finland
Primary
Concomitant
Weight Decreased Other Serious 7/26/2006 59 Male 11/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/11/2010 47 Female 136 lb 11/19/2010 Physician United States
Primary
Secondary
Skin Nodule Other Serious 1/1/2008 65 Female 11/22/2010 Physician Brazil
Primary
Secondary
Malignant Neoplasm Progression Other Serious Female 11/24/2010 Consumer Spain
Primary
Secondary
Concomitant
Disease Progression Death Female 11/30/2010 Other Health Professional Australia
Primary
Secondary
Intestinal Obstruction Other Serious 11/30/2010 Other Health Professional Australia
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 11/30/2010 Physician Australia
Primary
Concomitant
Vomiting Other Serious Female 12/2/2010 Physician Australia
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 12/6/2010 Consumer Netherlands
Primary
Secondary
Malignant Neoplasm Progression Other Serious 12/7/2010 Physician Netherlands
Primary
Secondary
Weight Decreased Other Serious 7/26/2006 59 Male 12/14/2010 United States
Primary
Secondary
Concomitant
Vomiting Death Female 1/21/2011 Other Health Professional Australia
Primary
Secondary
Pneumomediastinum Death 48 Female 1/21/2011 Physician Ireland
Primary
Secondary
Disease Progression Death Female 1/24/2011 Other Health Professional Australia
Primary
Secondary
Neoplasm Malignant Other Serious Female 1/31/2011 Physician New Zealand
Primary
Concomitant
Neoplasm Malignant Other Serious Female 2/2/2011 Consumer New Zealand
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 11/1/2010 64 Female 2/4/2011 Other Health Professional Poland
Primary
Secondary
Concomitant
Renal Mass Other Serious Male 2/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Hypokalaemia Other Serious 3/15/2011 44 Female 198 lb 4/7/2011 Consumer United Kingdom
Primary
Concomitant
Diarrhoea Death 9/27/2010 66 Female 5/9/2011 Other Health Professional United Kingdom
Primary
Secondary
Diarrhoea Hospitalization 4/23/2011 49 Female 145 lb 5/10/2011 Physician United States
Primary
Secondary
Concomitant
Myocardial Infarction Life Threatening 3/17/2011 60 Female 157 lb 5/10/2011 Physician Germany
Primary
Secondary
Febrile Neutropenia Other Serious 3/28/2011 61 Female 143 lb 5/10/2011 Physician Italy
Primary
Secondary
Hypernatraemia Hospitalization 4/23/2011 49 Female 145 lb 5/13/2011 Physician United States
Primary
Secondary
Concomitant
Monoclonal Gammopathy Other Serious 10/13/2010 47 Female 163 lb 5/13/2011 Physician France
Primary
Secondary
Febrile Neutropenia Other Serious 3/28/2011 61 Female 143 lb 5/25/2011 Physician Italy
Primary
Secondary
Drug Ineffective Other Serious 8/1/2007 49 Female 5/26/2011 Consumer United States
Primary
Secondary
Diarrhoea Death 11/3/2010 71 Female 5/31/2011 Consumer Italy
Primary
Secondary
Concomitant
Disease Progression Death 10/1/2010 49 Female 6/6/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious 3/28/2011 61 Female 143 lb 6/9/2011 Physician Italy
Primary
Secondary
Dehydration Hospitalization 6/2/2011 51 Female 194 lb 6/10/2011 Physician Ireland
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 6/2/2011 51 Female 194 lb 6/20/2011 Physician Ireland
Primary
Secondary
Concomitant
Disease Progression Other Serious 7/19/2011 Other Health Professional Australia
Primary
Concomitant
Hypokalaemia Other Serious 10/23/2004 55 Female 133 lb 7/26/2011 Lawyer United States
Primary
Secondary
Concomitant
Blood Bilirubin Increased Other Serious Female 8/1/2011 Consumer United States
Primary
Secondary
Concomitant
Atrial Fibrillation Hospitalization 10/25/2010 72 Female 8/12/2011 Other Health Professional United Kingdom
Primary
Secondary
Dyspnoea Death 10/23/2004 55 Female 133 lb 8/26/2011 Physician United States
Primary
Secondary
Concomitant
Metastases To Nervous System Other Serious 8/30/2011 Physician Australia
Primary
Secondary
Concomitant
Blood Bilirubin Increased Other Serious Female 9/2/2011 Consumer United States
Primary
Secondary
Concomitant
Atelectasis Other Serious 10/23/2004 55 Female 133 lb 9/4/2011 Lawyer United States
Primary
Secondary
Concomitant
Rash Pruritic Hospitalization 6/7/2011 61 Female 10/7/2011 Physician France
Primary
Secondary
Alanine Aminotransferase Increased Other Serious 10/1/2009 59 Female 10/10/2011 Other Health Professional France
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 2/24/2011 38 10/15/2011 United States
Primary
Secondary
Seroma Hospitalization 10/1/2010 39 Female 10/17/2011 United States
Primary
Secondary
Fatigue Hospitalization 4/17/2011 46 Female 10/17/2011 United States
Primary
Secondary
Ejection Fraction Decreased Other Serious 47 Female 10/20/2011 Consumer United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 4/17/2011 46 Female 10/20/2011 United States
Primary
Secondary
Deep Vein Thrombosis Hospitalization 8/1/2011 64 Female 139 lb 10/20/2011 Other Health Professional Germany
Primary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 2/24/2011 38 10/21/2011 Physician United States
Primary
Secondary
Hypotension Other Serious 47 Female 10/21/2011 Consumer United States
Primary
Secondary
Concomitant
Gastritis Hospitalization 10/12/2011 40 Female 119 lb 10/24/2011 Physician Ireland
Primary
Secondary
Stomatitis Hospitalization 10/12/2011 40 Female 119 lb 11/1/2011 Physician Ireland
Primary
Secondary
Deafness Other Serious 10/23/2004 55 Female 133 lb 11/1/2011 Physician United States
Primary
Secondary
Concomitant
Hepatomegaly Hospitalization 6/7/2011 61 Female 11/7/2011 Physician France
Primary
Secondary
Concomitant
Endocrine Neoplasm Hospitalization 10/1/2009 59 Female 11/8/2011 Other Health Professional France
Primary
Concomitant
Haematuria Hospitalization 9/12/2009 47 11/16/2011 United States
Primary
Secondary
Neutropenic Sepsis Hospitalization 11/3/2011 45 Female 159 lb 11/18/2011 Physician Ireland
Primary
Secondary
Concomitant
Neutropenic Sepsis Hospitalization 11/3/2011 45 Female 159 lb 11/22/2011 Physician Ireland
Primary
Secondary
Concomitant
Cellulitis Hospitalization 5/3/2011 55 Female 11/23/2011 United States
Primary
Secondary
Concomitant
Dizziness Hospitalization 9/21/2010 69 Female 11/24/2011 Germany
Primary
Secondary
Plasma Protein Metabolism Disorder Other Serious Male 11/24/2011 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 11/3/2011 45 Female 159 lb 11/28/2011 Physician Ireland
Primary
Secondary
Concomitant

Drug Data