Heparin combined with Spironolactone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Urticaria Death 70 Male 2/13/2006 Canada
Primary
Concomitant
Treatment Noncompliance Hospitalization 57 Female 3/17/2006 United States
Primary
Secondary
Concomitant
Cystitis Haemorrhagic Hospitalization 4/27/2005 61 Male 4/18/2006 Consumer United States
Primary
Concomitant
Methaemoglobinaemia Life Threatening 6/20/2005 17 Female 117 lb 4/25/2006 Pharmacist United States
Primary
Concomitant
Urticaria Death 1/9/2004 71 Male 4/26/2006 Canada
Primary
Concomitant
Varicose Vein Operation Hospitalization 1/1/2000 53 Male 351 lb 5/5/2006 Lawyer United States
Primary
Concomitant
Varicose Vein Operation Hospitalization 1/1/2000 53 Male 351 lb 5/9/2006 Physician United States
Primary
Concomitant
Rash Maculo-papular Required Intervention 9/24/2005 76 Female 159 lb United States
Primary
Concomitant
Respiratory Failure Hospitalization 10/31/2005 45 Female 7/28/2006 Physician Germany
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 7/12/2006 47 Male 198 lb 8/29/2006 Romania
Primary
Secondary
Concomitant
Oesophagitis Life Threatening 11/16/2005 88 Female 165 lb 9/14/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pneumonia Hospitalization 8/19/2006 28 Female 137 lb 9/15/2006 Consumer United States
Primary
Concomitant
Oesophagitis Life Threatening 11/16/2005 88 Female 165 lb 9/13/2006 United Kingdom
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 8/19/2006 28 Female 137 lb 9/22/2006 Consumer United States
Primary
Concomitant
Pneumonia Hospitalization 8/19/2006 28 Female 115 lb 9/25/2006 Consumer United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 9/30/2006 60 Female 10/9/2006 Consumer United States
Primary
Concomitant
Vomiting Life Threatening 9/23/2006 Male 240 lb 11/29/2006 Physician Canada
Primary
Concomitant
Rash Other Serious 8/2/2006 65 Male 185 lb 9/18/2006 Physician United States
Primary
Concomitant
Vena Cava Thrombosis Life Threatening 9/23/2006 Male 240 lb 12/14/2006 Physician Canada
Primary
Concomitant
Vena Cava Thrombosis Life Threatening 9/23/2006 Male 240 lb 1/4/2007 Physician Canada
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 9/30/2006 60 Female 1/8/2007 Consumer United States
Primary
Concomitant
Cardiac Failure Death 10/18/2005 65 Male 121 lb 10/6/2006 United States
Primary
Secondary
Concomitant
Sinus Arrest Hospitalization 5/25/2006 Male 2/9/2007 Japan
Primary
Secondary
Concomitant
Sick Sinus Syndrome Hospitalization 5/25/2006 Male 97 lb 2/22/2007 Japan
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 10/9/2004 176 lb 2/23/2007 Physician Germany
Primary
Concomitant
Pneumonia Hospitalization 8/19/2006 28 Female 115 lb 3/5/2007 Consumer United States
Primary
Concomitant
Urticaria 9/1/2006 28 Female 200 lb 1/23/2007 Pharmacist United States
Primary
Concomitant
Vena Cava Thrombosis Life Threatening 9/23/2006 Male 196 lb 4/16/2007 Physician Canada
Primary
Concomitant
Pain Hospitalization 58 Female 6/6/2007 Physician United States
Primary
Concomitant
Ventricular Tachycardia Other Serious 2/11/2004 52 Male 7/31/2007 Canada
Primary
Concomitant
Syncope Hospitalization 5/25/2006 71 Female 8/3/2007 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/27/2007 80 Female 9/13/2007 Physician Canada
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/27/2007 80 Female 11/8/2007 Physician Canada
Primary
Secondary
Concomitant
Septic Shock Life Threatening 8/6/2007 53 Male 11/20/2007 Germany
Primary
Concomitant
Orthostatic Hypotension Hospitalization 11/20/2007 68 Male 11/29/2007 Physician United States
Primary
Secondary
Concomitant
X-ray Abnormal Other Serious 11/6/2007 50 Male 12/7/2007 Physician Canada
Primary
Concomitant
Orthostatic Hypotension Hospitalization 11/20/2007 68 Male 12/10/2007 Physician United States
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Hospitalization 8/4/2003 Female 1/25/2008 Physician Germany
Primary
Secondary
Concomitant
Ventricular Tachycardia Life Threatening 2/13/2008 64 Female 2/18/2008 Pharmacist United States
Primary
Secondary
Concomitant
Oedema Peripheral Life Threatening 9/20/2007 73 Female 3/4/2008 Pharmacist United States
Primary
Concomitant
Vena Cava Thrombosis Life Threatening 9/23/2006 Male 196 lb 3/6/2008 Physician Canada
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 8/4/2003 68 Female 3/4/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Septic Shock Life Threatening 8/6/2007 53 Male 4/16/2008 Germany
Primary
Concomitant
Liver Function Test Abnormal Other Serious 3/10/2003 85 Female 168 lb 4/29/2008 Pharmacist United States
Primary
Concomitant
Septic Shock Life Threatening 8/6/2007 53 Male 5/9/2008 Germany
Primary
Concomitant
Urinary Tract Infection Other Serious 2/26/2008 57 Male 286 lb 5/20/2008 Pharmacist United States
Primary
Concomitant
Hypotension Required Intervention 2/22/2008 50 Male 163 lb 3/12/2008 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 9/1/2007 Female 7/11/2008 Physician United Kingdom
Primary
Concomitant
Cardiac Failure Death 6/19/2007 56 Female 112 lb 8/5/2008 Physician Japan
Primary
Concomitant
Cardiac Failure Life Threatening 6/19/2007 56 Female 112 lb 9/15/2008 Physician Japan
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 7/19/2008 Male 185 lb 9/26/2008 United States
Primary
Concomitant
Pulmonary Artery Stenosis Other Serious 5 Female 10/13/2008
Primary
Secondary
International Normalised Ratio Increased Other Serious 3/10/2003 85 Female 185 lb 12/4/2008 Pharmacist United States
Primary
Concomitant
Liver Function Test Abnormal Other Serious 3/10/2003 85 Female 168 lb 12/12/2008 Pharmacist United States
Primary
Concomitant
Convulsion Other Serious 7/31/2008 Female 243 lb 12/19/2008 Physician Chile
Primary
Concomitant
Pleural Effusion Death 9/4/2008 85 Female 12/26/2008 Physician Germany
Primary
Concomitant
Convulsion Other Serious 7/31/2008 Female 243 lb 12/29/2008 Physician Chile
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 1/12/2009 84 Female 2/5/2009 Physician France
Primary
Concomitant
Urinary Tract Infection Pseudomonal Other Serious 1/1/1991 45 Female 270 lb 2/12/2009 United States
Primary
Concomitant
Convulsion Other Serious 7/31/2008 Female 243 lb 2/23/2009 Physician Chile
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 64 Female 3/30/2009
Primary
Secondary
Orthostatic Hypotension Hospitalization 11/20/2007 68 Male 4/28/2009 Physician United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Life Threatening 4/26/2009 51 Male 271 lb 5/5/2009 Pharmacist United States
Primary
Concomitant
Meningitis Hospitalization 5/20/2006 53 Female 5/19/2009 United States
Primary
Concomitant
Skin Necrosis Other Serious 64 Female 176 lb 6/11/2009 United States
Primary
Secondary
Concomitant
Mental Status Changes Required Intervention 5/18/2009 73 Female 126 lb 5/18/2009 United States
Primary
Concomitant
Liver Injury Other Serious 6/17/2009 0 Female 19 lb 7/7/2009 Pharmacist United States
Primary
Concomitant
Torsade De Pointes Life Threatening 5/28/2009 Male 7/23/2009 Other Health Professional France
Primary
Secondary
Concomitant
Torsade De Pointes Life Threatening 5/23/2009 Male 7/24/2009 Other Health Professional France
Primary
Concomitant
Interacting
Right Ventricular Failure Hospitalization 2/5/2009 Female 8/10/2009 Physician Germany
Primary
Concomitant
Respiratory Failure Other Serious 8/26/2009 66 9/4/2009 Physician Germany
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 8/26/2009 66 9/11/2009 Physician Germany
Primary
Secondary
Concomitant
Ventricular Failure Hospitalization 49 Female 9/14/2009 United States
Primary
Concomitant
Ventricular Tachycardia Hospitalization 5/27/2005 58 Male 9/16/2009 Lawyer United States
Primary
Concomitant
Oesophagitis Life Threatening 11/16/2005 88 Female 9/16/2009 United Kingdom
Primary
Concomitant
Tibia Fracture Required Intervention 7/12/2009 61 Male 195 lb 7/13/2009 United States
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 8/29/2009 Female 115 lb 10/1/2009 Physician Germany
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Other Serious 51 Female 9/25/2009 United States
Primary
Concomitant
Ventricular Tachycardia Hospitalization 5/27/2005 58 Male 195 lb 9/28/2009 United States
Primary
Concomitant
Wound Infection Hospitalization 29 Female 276 lb 9/29/2009 United States
Primary
Concomitant
Respiratory Failure Other Serious 8/26/2009 66 10/8/2009 Physician Germany
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Other Serious 51 Female 10/9/2009 United States
Primary
Concomitant
Ventricular Tachycardia Hospitalization 5/27/2005 58 Male 195 lb 10/17/2009 Lawyer United States
Primary
Concomitant
Ventricular Failure Hospitalization 49 Female 10/16/2009 Lawyer United States
Primary
Concomitant
Paraesthesia Hospitalization 5/27/2005 58 Male 195 lb 11/4/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 46 Female 11/18/2009 United States
Primary
Concomitant
Hospitalisation Other Serious 11/21/2009 62 Male 12/4/2009 Physician United States
Primary
Concomitant
Respiratory Failure Other Serious 8/26/2009 66 Female 115 lb 12/11/2009 Physician Germany
Primary
Secondary
Concomitant
Right Ventricular Failure Hospitalization 2/5/2009 Female 12/11/2009 Physician Germany
Primary
Concomitant
Haemoglobin Decreased Required Intervention 10/26/2009 56 Male 130 lb 10/28/2009 United States
Primary
Secondary
Concomitant
Constipation Required Intervention 10/13/2009 Male 284 lb 10/13/2009 Pharmacist United States
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 1/1/2007 50 Male 1/7/2010 Lawyer United States
Primary
Concomitant
Pruritus Other Serious 63 Female 2/9/2010 Other Health Professional Poland
Primary
Concomitant
Respiratory Failure Other Serious 8/26/2009 66 Female 115 lb 2/18/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
International Normalised Ratio Increased 3/10/2003 85 Female 185 lb 6/24/2009 Pharmacist United States
Primary
Concomitant
Uterine Cancer Hospitalization 29 Female 276 lb 2/24/2010 United States
Primary
Concomitant
Thrombosis Other Serious 11/1/2009 78 Female 3/17/2010 Consumer Mexico
Primary
Concomitant
White Blood Cells Urine Positive Hospitalization 16 Male 95 lb 3/9/2010 United States
Primary
Concomitant
Wound Infection Hospitalization 29 Female 276 lb 3/23/2010 United States
Primary
Concomitant
Pulmonary Congestion 1/1/2010 68 Female 280 lb 3/31/2010 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 1/7/2007 49 Male 4/7/2010 United States
Primary
Concomitant
Ventricular Hypokinesia Hospitalization 60 Female 155 lb 4/20/2010 Lawyer United States
Primary
Concomitant
Right Ventricular Failure Hospitalization 2/5/2009 61 Female 5/10/2010 Physician Germany
Primary
Concomitant
Weight Increased Hospitalization 1/7/2007 49 Male 4/28/2010 United States
Primary
Concomitant
Weight Increased Hospitalization 1/7/2007 49 Male 5/11/2010 United States
Primary
Concomitant
Vomiting Other Serious 10/1/2007 56 Male 5/24/2010 Lawyer United States
Primary
Concomitant
Ventricular Tachycardia Other Serious 4/8/2010 54 Male 6/7/2010 Germany
Primary
Concomitant
Wheezing Other Serious 29 Female 125 lb 6/14/2010 United States
Primary
Concomitant
Hepatic Failure Hospitalization 2/24/2010 51 Male 146 lb 6/29/2010 Pharmacist United States
Primary
Secondary
Concomitant
Pneumonia Death 11/7/2009 65 Male 104 lb 7/13/2010 Physician Japan
Primary
Concomitant
Arrhythmia Death 1/22/2010 79 Female 108 lb 7/13/2010 Physician Japan
Primary
Concomitant
Venous Insufficiency Other Serious 76 Female 7/26/2010 United States
Primary
Concomitant
Drug Ineffective Other Serious 16 Female 106 lb 8/16/2010 United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 49 Male 8/10/2010 United States
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 4/30/2010 32 Female 9/7/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 5/1/2006 53 Female 163 lb 9/8/2010 United States
Primary
Concomitant
Venoocclusive Disease Hospitalization 4/30/2010 31 Female 9/8/2010 Other Health Professional United States
Primary
Concomitant
Venoocclusive Disease Other Serious 4/30/2010 31 Female 176 lb 9/9/2010 Other Health Professional United States
Primary
Concomitant
Haematoma Infection Hospitalization 7/16/2010 34 Male 168 lb 9/29/2010 Physician Australia
Primary
Secondary
Concomitant
Haematoma Infection Hospitalization 7/16/2010 34 Male 168 lb 10/1/2010 Physician Australia
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 7/31/2010 19 Male 198 lb 10/11/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 7/31/2010 19 Male 198 lb 10/13/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Haematoma Infection Hospitalization 7/16/2010 34 Male 168 lb 10/18/2010 Physician Australia
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 7/31/2010 19 Male 198 lb 10/9/2010 United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 7/31/2010 19 Male 198 lb 10/14/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 7/31/2010 10/21/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombosis In Device Other Serious 46 Female 11/15/2010
Primary
Secondary
White Blood Cell Count Increased Other Serious 62 Male 11/17/2010 United States
Primary
Concomitant
Wound Infection Other Serious 29 Female 276 lb 11/17/2010 United States
Primary
Concomitant
Death Death 12/15/2010 Physician Spain
Primary
Secondary
Concomitant
Ventricular Tachycardia Life Threatening 12/11/2010 0 Male 5 lb 12/13/2010 Physician United States
Primary
Concomitant
Death Death 12/23/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Vomiting Other Serious 29 Female 276 lb 12/15/2010 United States
Primary
Concomitant
Jaundice Cholestatic Other Serious 9/1/2010 56 Male 212 lb 12/29/2010 Other Health Professional Russian Federation
Primary
Secondary
Concomitant
Renal Impairment Death 1/3/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Gastritis Erosive Other Serious 9/1/2010 56 Male 212 lb 1/4/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 9/1/2010 56 Male 212 lb 1/5/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Rash Macular Hospitalization 11/6/2010 64 Female 1/17/2011 Physician France
Primary
Secondary
Concomitant
Death Death 1/17/2011 Physician Japan
Primary
Secondary
Concomitant
Drug Interaction Death 1/17/2011 Physician Japan
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 45 Male 1/18/2011 Pharmacist United States
Primary
Concomitant
Left Ventricular Dysfunction Hospitalization 45 Male 1/19/2011 Other Health Professional United States
Primary
Concomitant
Jaundice Cholestatic Other Serious 9/1/2010 56 Male 212 lb 1/24/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Myocardial Infarction Death 11/26/2010 79 Female 1/24/2011 Physician United States
Primary
Concomitant
Leg Amputation Other Serious 29 Female 276 lb 1/5/2011 United States
Primary
Concomitant
Drug Interaction Death 1/25/2011 Consumer Japan
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 9/1/2010 56 Male 212 lb 1/25/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Cystitis Other Serious 12/3/2010 Female 1/24/2011 Consumer Germany
Primary
Concomitant
Dizziness Hospitalization 1/27/2007 32 Female 209 lb 1/28/2011 Physician United States
Primary
Secondary
Concomitant
Silent Myocardial Infarction Other Serious 11/26/2010 79 Female 2/2/2011 Physician United States
Primary
Concomitant

Drug Data