Heparin combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Renal Cell Carcinoma Stage Unspecified Other Serious 9/20/2005 Female 157 lb 1/26/2006 Physician United Kingdom
Primary
Concomitant
Metastatic Renal Cell Carcinoma Hospitalization 9/13/2005 Female 157 lb 2/22/2006 Physician United Kingdom
Primary
Concomitant
Pleuritic Pain Hospitalization 9/13/2005 Female 157 lb 3/22/2006 Physician United Kingdom
Primary
Concomitant
Venoocclusive Liver Disease Hospitalization 2/19/2005 0 Male 12 lb 3/20/2006 Physician Japan
Primary
Secondary
Concomitant
Refractoriness To Platelet Transfusion Hospitalization 2/12/2005 0 Male 12 lb 4/7/2006 Physician Japan
Primary
Secondary
Concomitant
Weight Decrease Neonatal Hospitalization 2/12/2005 0 Male 12 lb 4/7/2006 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 7/2/2006 Male 9 lb 7/5/2006 United States
Primary
Secondary
Concomitant
Visual Disturbance Other Serious 3/1/2006 61 Male 196 lb 8/8/2006 Pharmacist United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 9/30/2006 60 Female 10/9/2006 Consumer United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 9/30/2006 60 Female 1/8/2007 Consumer United States
Primary
Concomitant
Myoclonus Disability 1/19/2007 58 Female 174 lb 2/7/2007 Physician France
Primary
Secondary
Concomitant
Skin Lesion Other Serious 0 Male 2/15/2007 Other Health Professional Turkey
Primary
Secondary
Concomitant
Myoclonus Disability 1/19/2007 58 Female 174 lb 3/16/2007 Physician France
Primary
Secondary
Concomitant
Ventricular Dysfunction Other Serious 2/26/2007 Male 173 lb 4/11/2007 Physician United States
Primary
Concomitant
Stomatitis Life Threatening 4/2/2007 81 Male 220 lb 6/29/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Loss Of Consciousness Death 8/5/2003 Female 99 lb 7/2/2007 Other Health Professional Denmark
Primary
Secondary
Concomitant
Weight Decreased Other Serious 11/1/2006 Female 143 lb 7/6/2007 Physician France
Primary
Secondary
Concomitant
Ruptured Cerebral Aneurysm Death 8/5/2003 73 Female 99 lb 7/16/2007 Denmark
Primary
Secondary
Concomitant
Musculoskeletal Chest Pain Hospitalization 11/15/2006 Female 269 lb 7/27/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ruptured Cerebral Aneurysm Death 8/5/2003 73 Female 99 lb 8/24/2007 United States
Primary
Secondary
Concomitant
Troponin Increased Other Serious 6/6/2007 56 Female 9/7/2007 Other Health Professional Argentina
Primary
Secondary
Concomitant
Nephrolithiasis Other Serious 3/14/2007 61 Female 9/11/2007 United States
Primary
Concomitant
Rheumatoid Lung Hospitalization 8/1/2007 82 Female 154 lb 10/4/2007 Consumer United States
Primary
Concomitant
Cardiac Failure Other Serious 6/29/2006 2 Male 10/18/2007 Consumer United States
Primary
Secondary
Concomitant
Shock Hospitalization 10/21/2007 Male 84 lb 11/13/2007 United States
Primary
Secondary
Concomitant
Septic Shock Hospitalization 10/21/2007 Male 84 lb 11/27/2007 United States
Primary
Secondary
Concomitant
Cardiac Failure Other Serious 6/29/2006 2 Male 12/7/2007 Consumer United States
Primary
Secondary
Concomitant
Thrombocytopenia Disability 8/5/2007 68 Female 234 lb 12/4/2007 Pharmacist United States
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 9/12/2007 72 Female 12/18/2007 Other Health Professional France
Primary
Secondary
Concomitant
Injection Site Haemorrhage Other Serious 1/2/2008 Female 1/14/2008 Consumer United States
Primary
Concomitant
Venous Thrombosis Hospitalization 10/1/2007 Female 143 lb 1/28/2008 Consumer Germany
Primary
Concomitant
Venous Thrombosis Hospitalization 8/1/2007 Female 143 lb 2/8/2008 Consumer Germany
Primary
Concomitant
Shock Hospitalization 10/21/2007 Male 84 lb 2/20/2008 United States
Primary
Secondary
Concomitant
Venous Thrombosis Hospitalization 8/1/2007 Female 143 lb 3/7/2008 Consumer Germany
Primary
Concomitant
Wheezing Death 1/19/2008 49 Male 154 lb 3/29/2008 Physician France
Primary
Secondary
Concomitant
Aspergillosis Death 1/20/2008 Male 4/2/2008 Physician France
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 9/21/2007 25 Male 112 lb 6/4/2008 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious 21 Male 6/24/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 9/21/2007 25 Male 112 lb 6/19/2008 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 9/21/2007 25 Male 7/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9/21/2007 25 Male 112 lb 6/27/2008 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 9/21/2007 25 Male 112 lb 7/28/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Transverse Sinus Thrombosis Hospitalization 8/28/2008 Male 197 lb 9/3/2008 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 43 Male 9/26/2008 Other Health Professional United States
Primary
Concomitant
Sepsis Death 44 Male 9/26/2008 Other Health Professional United States
Primary
Concomitant
Pyrexia Other Serious 26 Female 6/14/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Cytomegalovirus Infection Other Serious 30 Male 6/14/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Pyrexia Other Serious 21 Male 6/14/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 5 Male 10/1/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Streptococcal Sepsis Other Serious 12/19/2001 5 Male 10/1/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious Male 10/17/2008 Other Health Professional Japan
Primary
Concomitant
Staphylococcal Sepsis Other Serious 5 Male 10/28/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Gingival Hyperplasia 7/20/2008 Male 11/24/2008 Physician United States
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 4/12/2006 Male 12/3/2008 Physician France
Primary
Concomitant
Histiocytosis Haematophagic Other Serious 51 Female 12/23/2008
Primary
Secondary
Concomitant
Malaise Other Serious 4/26/2007 64 Male 4/14/2009 Other Health Professional Japan
Primary
Concomitant
Malaise Other Serious 4/26/2007 64 Male 112 lb 4/21/2009 Other Health Professional Japan
Primary
Concomitant
Staphylococcal Sepsis Other Serious 51 Male 5/12/2009
Primary
Secondary
Concomitant
Hypocalcaemia Other Serious 64 Male 112 lb 5/25/2009 Other Health Professional Japan
Primary
Concomitant
Malaise Hospitalization 4/26/2007 Male 112 lb 6/10/2009 Other Health Professional Japan
Primary
Concomitant
Hypocalcaemia Other Serious 64 Male 112 lb 6/11/2009 Other Health Professional Japan
Primary
Concomitant
Pulmonary Embolism Hospitalization 3/5/2009 Female 6/17/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Malaise Life Threatening 3/1/2007 Male 134 lb 6/18/2009 Physician Japan
Primary
Concomitant
Subcutaneous Abscess Hospitalization 5/28/2009 Male 6/19/2009 Other Health Professional France
Primary
Secondary
Concomitant
Urticaria Other Serious 12/9/2008 7 Female 7/13/2009 Other Health Professional Japan
Primary
Concomitant
Febrile Neutropenia Hospitalization 7/24/2009 50 Male 160 lb 7/24/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Rash Other Serious 50 Male 9/4/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Rash Other Serious 50 Male 9/14/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Vomiting Death 3/2/2008 69 Female 9/8/2009 United States
Primary
Concomitant
Urticaria Other Serious 12/9/2008 7 Female 10/15/2009 Physician Japan
Primary
Concomitant
Vomiting Death 3/2/2008 78 Female 10/17/2009 United States
Primary
Concomitant
Sinusitis Hospitalization 11/2/2009 49 Female 11/20/2009 Consumer South Africa
Primary
Secondary
Concomitant
Inappropriate Schedule Of Drug Administration Hospitalization 10/26/2009 89 Female 11/20/2009 Pharmacist Canada
Primary
Concomitant
Sinusitis Hospitalization 11/2/2009 49 Female 12/8/2009 Other Health Professional South Africa
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 3/26/2008 Female 121 lb 12/15/2009 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 11/9/2009 Female 121 lb 12/16/2009 Physician United States
Primary
Concomitant
Systemic Candida Hospitalization 10/4/2009 11 Female 81 lb 12/22/2009 Physician United States
Primary
Secondary
Concomitant
Inappropriate Schedule Of Drug Administration Hospitalization 10/26/2009 89 Female 12/21/2009 Pharmacist Canada
Primary
Concomitant
Throat Irritation Other Serious 1/1/2005 Female 153 lb 1/11/2010 Pharmacist United States
Primary
Concomitant
Throat Irritation Other Serious 1/1/2005 Female 153 lb 1/21/2010 Pharmacist United States
Primary
Concomitant
Screaming Hospitalization 10/4/2009 11 Female 81 lb 1/19/2010 Physician United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 1/1/2005 Female 153 lb 1/30/2010 Pharmacist United States
Primary
Concomitant
Sinusitis Hospitalization 11/2/2009 49 Female 2/7/2010 Other Health Professional South Africa
Primary
Secondary
Concomitant
Vision Blurred Other Serious 1/1/2005 Female 153 lb 2/8/2010 Pharmacist United States
Primary
Concomitant
Pyelonephritis Hospitalization 11/9/2009 Female 121 lb 2/10/2010 United States
Primary
Concomitant
Sinusitis Hospitalization 11/2/2009 49 Female 3/11/2010 Other Health Professional South Africa
Primary
Secondary
Concomitant
Organising Pneumonia Hospitalization 4/16/2009 Male 3/25/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 12/16/2008 73 Male 117 lb 3/24/2010 Physician Japan
Primary
Concomitant
Post Herpetic Neuralgia Other Serious 1/10/2010 71 Female 134 lb 4/17/2010 Physician France
Primary
Concomitant
Respiratory Failure Hospitalization 12/16/2008 73 Male 117 lb 4/13/2010 Physician Japan
Primary
Concomitant
Weight Increased Hospitalization 1/1/2002 Female 4/22/2010 Physician Japan
Primary
Concomitant
Systemic Mycosis Hospitalization 12/1/2009 76 Female 160 lb 5/24/2010 Consumer United States
Primary
Concomitant
Post Herpetic Neuralgia Other Serious 1/10/2010 71 Female 134 lb 5/26/2010 Physician France
Primary
Concomitant
Product Contamination 5/20/2010 17 Male 169 lb 6/3/2010 United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 6/11/2010 United States
Primary
Concomitant
Shock Disability 7/1/2009 47 Female 164 lb 6/16/2010 United States
Primary
Concomitant
Urinary Incontinence Hospitalization 1/1/2009 61 Female 6/15/2010 Physician Germany
Primary
Secondary
Concomitant
Systemic Mycosis Hospitalization 12/1/2009 76 Female 160 lb 6/25/2010 Consumer United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/26/2009 11 Male 77 lb 7/21/2010 Physician Japan
Primary
Concomitant
Urinary Tract Infection Life Threatening 2/26/2010 74 Female 7/28/2010 Physician Germany
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 7/27/2010 United States
Primary
Concomitant
Urticaria Hospitalization 5/17/2010 49 Female 249 lb 8/5/2010 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 6/1/2010 56 Male 8/10/2010 Consumer United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/26/2009 11 Male 77 lb 8/11/2010 Physician Japan
Primary
Concomitant
Sputum Discoloured Hospitalization 1/1/2010 49 Female 243 lb 8/19/2010 Other Health Professional United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 8/20/2010 United States
Primary
Concomitant
Urinary Incontinence Other Serious 1/1/2009 59 Female 132 lb 8/23/2010 Consumer United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 6/1/2009 59 Female 132 lb 9/1/2010 Physician Germany
Primary
Secondary
Concomitant
Urosepsis Hospitalization 4/1/2010 74 Male 9/2/2010 Consumer Colombia
Primary
Concomitant
White Blood Cell Count Increased Other Serious 7/1/2010 56 Male 200 lb 9/10/2010 Physician United States
Primary
Concomitant
Urosepsis Hospitalization 4/1/2010 74 Male 9/13/2010 Consumer Colombia
Primary
Concomitant
Weight Increased Other Serious 1/1/2005 71 Female 9/20/2010 Physician Switzerland
Primary
Secondary
Concomitant
Stomatitis Other Serious 1 Male 9/21/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Stomatitis Other Serious 1 Male 9/21/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2005 71 Female 9/23/2010 Physician Switzerland
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2005 71 Female 9/24/2010 Physician Switzerland
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 1/1/2005 59 Female 131 lb 9/28/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 9/16/2009 22 Male 169 lb 9/28/2010 Physician United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 10/1/2010 United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 11/4/2009 17 Male 10/14/2010 Other Health Professional France
Primary
Secondary
Concomitant
Pruritus Hospitalization 9/30/2009 18 Female 137 lb 10/18/2010 Physician Japan
Primary
Concomitant
Sepsis Other Serious 5/26/2009 7 Female 29 lb 11/11/2010 Physician Japan
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/8/2009 15 Male 157 lb 11/11/2010 Physician Japan
Primary
Secondary
Concomitant
Shock Life Threatening 11/11/2007 12 Female 80 lb 11/15/2010 Physician Japan
Primary
Secondary
Concomitant
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 12/2/2010 United States
Primary
Concomitant
Shock Life Threatening 11/11/2007 12 Female 80 lb 12/6/2010 Physician Japan
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/8/2009 15 Male 157 lb 12/6/2010 Physician Japan
Primary
Secondary
Concomitant
Oedema Other Serious 8/16/2009 7 Male 66 lb 12/10/2010 Physician Hungary
Primary
Secondary
Concomitant
Engraftment Syndrome Other Serious 8/23/2009 8 Female 71 lb 12/10/2010 Physician Hungary
Primary
Secondary
Concomitant
Herpes Zoster Other Serious 1/10/2010 71 Female 134 lb 1/3/2011 Consumer France
Primary
Concomitant
Acute Respiratory Distress Syndrome Life Threatening 11/11/2007 12 Female 80 lb 1/6/2011 Physician Japan
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/8/2009 15 Male 157 lb 1/6/2011 Physician Japan
Primary
Secondary
Concomitant
Aplasia Other Serious 12/21/2009 30 Female 119 lb 1/18/2011 Physician France
Primary
Concomitant
Graft Versus Host Disease Hospitalization 9/30/2009 18 Female 137 lb 1/28/2011 Physician Japan
Primary
Concomitant
Pigmentation Disorder Hospitalization 1/8/2011 36 Female 2/8/2011 Other Health Professional France
Primary
Secondary
Concomitant
Blood Glucose Increased 7/13/2010 16 Male 226 lb 2/8/2011 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 2/7/2011 31 Female 139 lb 2/11/2011 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Hospitalization 8/1/2010 52 Male 2/18/2011 Consumer France
Primary
Secondary
Concomitant
Acute Respiratory Distress Syndrome Other Serious 12/9/2010 2/22/2011 Other Health Professional Canada
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 8/1/2010 52 Male 3/24/2011 Consumer France
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 4/15/2011 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Septic Shock Death 4/15/2011 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Pneumonia Cytomegaloviral Death 4/15/2011 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Pneumonia Cytomegaloviral Death 4/15/2011 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Breast Mass Hospitalization 1/1/2007 59 Female 4/28/2011 Consumer United States
Primary
Secondary
Concomitant
Emotional Distress Other Serious 9/23/2005 59 Male 212 lb 5/13/2011 Other Health Professional United States
Primary
Concomitant
Hip Fracture Hospitalization 1/1/2007 59 Female 5/13/2011 Physician United States
Primary
Secondary
Concomitant
Renal Impairment Other Serious 1/1/2006 71 Male 150 lb 5/24/2011 Consumer United States
Primary
Concomitant
Venoocclusive Disease Other Serious 22 Male 4/1/2011 Physician United States
Primary
Concomitant
Bacterial Infection Life Threatening 11/29/2008 8 Male 46 lb 6/2/2011 Physician Japan
Primary
Concomitant

Drug Data