Glyceryl Trinitrate combined with Isosorbide Mononitrate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Thrombosis Hospitalization 1/20/2001 Male 1/3/2006 France
Primary
Concomitant
Skin Ulcer Hospitalization 2/13/2002 Female 1/4/2006 France
Primary
Concomitant
Renal Failure Life Threatening 9/2/2003 Male 1/4/2006 Finland
Primary
Concomitant
Coronary Ostial Stenosis Hospitalization 11/21/2005 71 Male 192 lb 1/4/2006 United States
Primary
Secondary
Concomitant
Somnolence Hospitalization 9/4/2005 89 Male 170 lb 1/10/2006 United States
Primary
Concomitant
Stent Occlusion Hospitalization 7/25/2005 64 Male 183 lb 1/12/2006 Poland
Primary
Secondary
Concomitant
Extrasystoles Other Serious 12/1/2005 Male 1/20/2006 Physician Sweden
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 2/9/2006 United States
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 2/9/2006 United States
Primary
Concomitant
Parkinsonism Hospitalization 9/5/2005 52 Male 2/6/2006 Germany
Primary
Secondary
Concomitant
Subcutaneous Haematoma Hospitalization 6/15/2005 66 Male 198 lb 2/9/2006 Poland
Primary
Concomitant
Interacting
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 2/23/2006 United States
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 3/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Contusion Hospitalization 3/17/2004 53 Female 190 lb 12/27/2005 Consumer United States
Primary
Concomitant
Traumatic Intracranial Haemorrhage Death 10/1/2005 95 Male 12/27/2005 United States
Primary
Concomitant
Rectal Haemorrhage Hospitalization 7/1/2004 80 Male 190 lb 12/21/2005 Physician United States
Primary
Concomitant
Haemoptysis Other Serious 2/26/2006 72 Male 224 lb 3/28/2006 Consumer United Kingdom
Primary
Concomitant
Skin Exfoliation Other Serious 3/2/2006 61 Male 4/11/2006 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 4/13/2006 Other Health Professional United Kingdom
Primary
Concomitant
Hypoglycaemia Hospitalization 3/17/2006 46 Female 4/13/2006 Other Health Professional Netherlands
Primary
Concomitant
Hypoglycaemia Hospitalization 3/17/2006 46 Female 4/17/2006 Other Health Professional Netherlands
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 5/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Ventricular Extrasystoles Other Serious 12/1/2005 Male 5/8/2006 Physician Sweden
Primary
Concomitant
Arthralgia Other Serious 4/3/2006 49 Female 181 lb 5/11/2006 Consumer United Kingdom
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 5/19/2006 Other Health Professional United Kingdom
Primary
Concomitant
Hepatic Function Abnormal Other Serious 2/21/2005 68 Male 154 lb 5/25/2006 Other Health Professional United Kingdom
Primary
Concomitant
Ventricular Hypertrophy Other Serious 12/1/2005 Male 6/6/2006 Physician Sweden
Primary
Concomitant
Toxic Epidermal Necrolysis Death 7/14/2005 79 Male 7/17/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Hypertension Other Serious 1/1/2000 73 Male 217 lb 7/19/2006 Consumer United Kingdom
Primary
Concomitant
Ventricular Extrasystoles Other Serious 12/1/2005 Male 8/21/2006 Physician Sweden
Primary
Concomitant
Angina Pectoris Other Serious 71 Male 8/21/2006 Other Health Professional United Kingdom
Primary
Concomitant
Retroperitoneal Haemorrhage Other Serious 9/17/2004 74 Female 141 lb 8/28/2006 Australia
Primary
Secondary
Concomitant
Steatorrhoea Life Threatening Male 230 lb 9/25/2006 Physician United Kingdom
Primary
Concomitant
Myalgia Other Serious 5/9/2006 79 Male 182 lb 9/19/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ventricular Extrasystoles Hospitalization 12/1/2005 Male 10/12/2006 Physician Sweden
Primary
Concomitant
Panic Attack Hospitalization 9/3/2006 63 Male 258 lb 10/5/2006 Germany
Primary
Concomitant
Vomiting Hospitalization 10/5/2006 91 Female 11/3/2006 Sweden
Primary
Secondary
Concomitant
Tremor Other Serious 3/1/2006 66 Female 140 lb 11/16/2006 Physician United States
Primary
Concomitant
Death Death 10/17/2006 71 Male 11/17/2006 Other Health Professional United States
Primary
Concomitant
Vertigo Hospitalization 5/1/2006 91 Male 11/28/2006 Sweden
Primary
Concomitant
Skin Oedema Hospitalization 76 Male 12/14/2006 Other Health Professional United States
Primary
Concomitant
Ventricular Fibrillation Life Threatening 3/4/2004 62 Male 10/6/2006 United States
Primary
Secondary
Concomitant
Hypotension Other Serious 1/16/2007 51 Female 2/22/2007 Consumer United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 1/16/2007 51 Female 104 lb 3/5/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 1/15/2007 51 Female 104 lb 3/9/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 63 Female 3/20/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
International Normalised Ratio Increased Other Serious 9/1/2006 46 Male 344 lb 3/27/2007 Physician United Kingdom
Primary
Concomitant
Vomiting Death 1/1/2007 77 Female 4/13/2007 Other Health Professional United Kingdom
Primary
Concomitant
Retinopathy Other Serious 3/1/2006 Female 5/14/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Diabetic Retinopathy Other Serious 3/1/2006 Female 5/4/2007 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Hospitalization 5/1/2006 82 Male 140 lb 12/13/2006 United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 5/24/2007 Female 119 lb 6/8/2007 Other Health Professional United States
Primary
Concomitant
Rash Generalised Other Serious 4/18/2007 Female 161 lb 6/18/2007 Consumer United Kingdom
Primary
Concomitant
Rash Generalised Other Serious 4/18/2007 Female 161 lb 6/22/2007 Consumer United Kingdom
Primary
Concomitant
Platelet Count Decreased Other Serious 11/1/2005 75 Female 7/17/2007 Other Health Professional China
Primary
Concomitant
Interacting
Chest Discomfort Hospitalization 4/14/2007 66 Female 110 lb 7/31/2007 United States
Primary
Concomitant
Drug Interaction Death 83 Male 8/16/2007 Sweden
Primary
Concomitant
Interacting
Drug Interaction Death 77 Female 8/16/2007 Sweden
Primary
Concomitant
Interacting
Paraesthesia Disability 67 Female 9/5/2007 Physician
Primary
Concomitant
Mouth Ulceration Disability 5/8/2007 89 Female 9/10/2007 Other Health Professional United Kingdom
Primary
Concomitant
Visual Disturbance Disability 2/19/2007 67 Female 181 lb 9/12/2007 Physician
Primary
Concomitant
Vomiting Hospitalization 8/11/2007 89 Female 9/14/2007 Other Health Professional France
Primary
Concomitant
Hypotension Life Threatening 7/18/2007 47 Female 126 lb 10/5/2007 Physician United States
Primary
Secondary
Concomitant
Headache Other Serious 6/1/2007 Female 73 lb 10/9/2007 Physician Denmark
Primary
Concomitant
Malaise Other Serious Female 189 lb 10/12/2007 Physician United Kingdom
Primary
Concomitant
Sleep Disorder Hospitalization 6/1/2005 62 Male 11/9/2007 Other Health Professional United Kingdom
Primary
Concomitant
Nausea Other Serious 2/27/2007 62 Male 11/27/2007 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Other Serious 11/30/2007 76 Female 154 lb 12/28/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 1/1/2005 1/23/2008 Other Health Professional United Kingdom
Primary
Concomitant
Hypotension Life Threatening 7/18/2007 47 Female 126 lb 2/6/2008 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 11/28/2007 61 Female 2/8/2008 Sweden
Primary
Concomitant
Rectal Haemorrhage Hospitalization 9/1/2007 Male 114 lb 12/5/2007 Consumer United States
Primary
Concomitant
Myocardial Infarction Other Serious 1/1/2005 3/24/2008 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 11/28/2007 61 Female 3/28/2008 Sweden
Primary
Concomitant
Rash Generalised Other Serious 4/18/2007 Female 161 lb 4/18/2008 Consumer United Kingdom
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 4/18/2008 United States
Primary
Concomitant
Myocardial Ischaemia Life Threatening 8/30/2005 Male 139 lb 4/22/2008 United States
Primary
Concomitant
Cardio-respiratory Arrest Death 4/10/2008 69 Female 207 lb 4/28/2008 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 4/30/2008 United States
Primary
Concomitant
Disease Progression Death 69 Female 208 lb 5/2/2008 Consumer United Kingdom
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 5/9/2008 United States
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 5/15/2008 United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 2/28/2008 89 Male 5/23/2008 Other Health Professional United Kingdom
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 5/7/2008 62 Female 6/6/2008 Sweden
Primary
Concomitant
Pharyngolaryngeal Pain 4/18/2008 Female 140 lb 6/13/2008 United States
Primary
Concomitant
Pancreatitis Other Serious 55 Male 304 lb 6/2/2009 Physician United Kingdom
Primary
Concomitant
Swelling Face Other Serious 5/21/2009 6/18/2009 Consumer Italy
Primary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 7/7/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Procedural Complication 6/20/2009 71 Male 7/2/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 360 lb 7/13/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 360 lb 7/16/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 7/17/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Life Threatening 7/10/2009 71 Female 269 lb 8/19/2009 Physician United Kingdom
Primary
Concomitant
Hyperkalaemia Other Serious 9/1/2009 78 Male 9/25/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Other Serious 9/1/2009 78 9/25/2009 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Peritonitis Bacterial Life Threatening 8/20/2009 78 Male 9/29/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Other Serious 9/1/2009 78 Male 9/24/2009 United Kingdom
Primary
Concomitant
Hyperkalaemia Other Serious 9/1/2009 78 Male 9/25/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 9/8/2009 66 Female 229 lb 10/1/2009 Pharmacist United States
Primary
Secondary
Concomitant
Nausea Hospitalization 86 Male 10/17/2009 Other Health Professional United States
Primary
Secondary
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 11/3/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Polyp Other Serious 2/4/2004 77 Female 11/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 11/4/2009
Primary
Secondary
Concomitant
Polyp Other Serious 2/4/2004 77 Female 11/13/2009 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 11/16/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 11/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 5/1/2007 43 Female 360 lb 11/25/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 11/30/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 11/30/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 11/23/2009 Other Health Professional United Kingdom
Primary
Concomitant
Palpitations Other Serious 12/22/2009 Consumer Italy
Primary
Concomitant
Rhabdomyolysis Other Serious 1/1/2008 2/5/2010 Other Health Professional United Kingdom
Primary
Concomitant
Rhabdomyolysis Other Serious 4/1/2008 85 Female 117 lb 2/8/2010
Primary
Concomitant
Rib Fracture Hospitalization 7/18/2007 76 Female 238 lb 2/25/2010 Physician United Kingdom
Primary
Concomitant
Rib Fracture Hospitalization 7/18/2007 76 Female 238 lb 3/2/2010 Physician United Kingdom
Primary
Concomitant
Melaena Other Serious 11/24/2009 83 Male 127 lb 3/9/2010 Other Health Professional
Primary
Secondary
Concomitant
Haemoglobin Decreased Life Threatening 11/24/2009 83 Male 3/17/2010 Other Health Professional United Kingdom
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 2/13/2010 78 Male 3/26/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Other Serious 2/26/2010 71 Male 3/26/2010 Other Health Professional United Kingdom
Primary
Concomitant
Withdrawal Syndrome Hospitalization 2/2/2010 45 Male 154 lb 4/20/2010 Other Health Professional United Kingdom
Primary
Concomitant
Withdrawal Syndrome Hospitalization 2/2/2010 45 Male 154 lb 4/21/2010 Other Health Professional United Kingdom
Primary
Concomitant
Withdrawal Syndrome Hospitalization 2/2/2010 4/23/2010 Other Health Professional United Kingdom
Primary
Concomitant
Withdrawal Syndrome Hospitalization 2/2/2010 45 Male 154 lb 4/27/2010 Other Health Professional United Kingdom
Primary
Concomitant
Drug Withdrawal Syndrome Hospitalization 45 Male 4/30/2010 United Kingdom
Primary
Concomitant
Dermatitis Exfoliative Other Serious 3/11/2010 5/12/2010 Consumer United Kingdom
Primary
Concomitant
Vitrectomy Other Serious 4/1/2009 65 Male 5/21/2010 Consumer Switzerland
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Hospitalization 6/3/2010 Other Health Professional Italy
Primary
Concomitant
Sinus Bradycardia Life Threatening 4/13/2010 63 Male 154 lb 6/17/2010 Other Health Professional United Kingdom
Primary
Concomitant
Tachycardia Hospitalization 6/22/2010 71 Female 7/12/2010 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Tachycardia Other Serious 6/22/2010 71 Female 7/14/2010 Other Health Professional
Primary
Secondary
Concomitant
Wheezing Other Serious 2/18/2008 66 Female 227 lb 7/16/2010 Physician United Kingdom
Primary
Concomitant
Impaired Gastric Emptying Hospitalization 3/17/2010 41 Male 273 lb 7/21/2010 Physician Denmark
Primary
Concomitant
Tachycardia Hospitalization 6/22/2010 71 Female 7/23/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Death Death 2/10/2010 76 Female 203 lb 7/30/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Multiple Drug Overdose Hospitalization 76 Female 203 lb 8/3/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Drug Administration Error Death 2/10/2010 76 Female 203 lb 8/5/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Intentional Drug Misuse Death 2/10/2010 76 Female 8/5/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Intentional Drug Misuse Death 2/10/2010 76 Female 8/5/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sinus Bradycardia Life Threatening 4/13/2010 63 Male 154 lb 9/30/2010 Other Health Professional United Kingdom
Primary
Concomitant
Sudden Cardiac Death Death 2/10/2010 76 Female 203 lb 10/6/2010 Other Health Professional
Primary
Secondary
Concomitant
Glycosylated Haemoglobin Increased Other Serious 63 Male 190 lb 11/23/2010 Physician United Kingdom
Primary
Concomitant
Troponin Increased Hospitalization 11/9/2010 70 Male 11/24/2010 Other Health Professional United Kingdom
Primary
Concomitant
Mental Disorder Hospitalization 45 Female 11/8/2010 United States
Primary
Secondary
Troponin Increased Hospitalization 11/9/2010 70 Male 12/2/2010 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Other Serious 1/8/2009 12/6/2010 Other Health Professional United States
Primary
Concomitant
Myocardial Infarction Life Threatening 11/11/2010 Male 12/9/2010 Other Health Professional United Kingdom
Primary
Concomitant
Ventricular Arrhythmia Other Serious 10/5/2010 57 Male 12/21/2010 Other Health Professional
Primary
Secondary
Concomitant
Cardiac Failure Congestive Hospitalization 1/6/2011 81 Male 1/27/2011 Other Health Professional United Kingdom
Primary
Concomitant
Gastritis Hospitalization 1/6/2011 81 Male 2/3/2011 United Kingdom
Primary
Secondary
Concomitant
Bronchospasm Other Serious 71 Male 2/28/2011 Other Health Professional United Kingdom
Primary
Concomitant

Drug Data