Glyburide combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vertigo Hospitalization 8/28/2003 73 Female 258 lb 1/4/2006 Physician United States
Primary
Concomitant
Sudden Death Death 6/3/2005 1/2/2006 Physician United States
Primary
Secondary
Concomitant
Tongue Disorder Hospitalization 9/28/2005 75 Female 115 lb 11/19/2005 Pharmacist United States
Primary
Concomitant
Renal Failure Required Intervention 8/25/2005 61 Male 11/15/2005 Other Health Professional United States
Primary
Concomitant
Renal Failure Hospitalization 8/25/2005 61 Male 2/8/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 8/25/2005 61 Male 3/24/2006 Other Health Professional United States
Primary
Concomitant
Vertigo Hospitalization 12/5/2000 73 Female 258 lb 4/25/2006 Physician United States
Primary
Concomitant
Vertigo Hospitalization 12/5/2000 73 Female 258 lb 5/5/2006 Physician United States
Primary
Concomitant
Myocardial Infarction Other Serious 11/20/2003 66 Male 209 lb 5/18/2006 Lawyer United Kingdom
Primary
Concomitant
Weight Increased Other Serious 7/1/2005 65 Female 279 lb 6/14/2006 Physician Canada
Primary
Concomitant
Non-hodgkin's Lymphoma Other Serious 10/1/2003 Female 294 lb 6/15/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased 7/1/2005 57 Female 156 lb 4/17/2006 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 6/21/2006 82 Male 174 lb 7/6/2006 Physician United States
Primary
Concomitant
Tooth Disorder Required Intervention 5/1/2006 Male 143 lb 7/7/2006 Pharmacist United States
Primary
Secondary
Concomitant
Burkitt's Lymphoma Other Serious 77 Male 7/11/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Wheezing Hospitalization 6/21/2006 82 Male 174 lb 7/20/2006 Physician United States
Primary
Concomitant
Wheezing Hospitalization 6/21/2006 82 Male 174 lb 7/28/2006 Physician United States
Primary
Concomitant
Arthropathy Other Serious Female 149 lb 10/9/2006 Consumer Canada
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 9/30/2006 60 Female 10/9/2006 Consumer United States
Primary
Concomitant
Neoplasm Malignant Other Serious Female 205 lb 11/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Bladder Cancer Other Serious 11/1/2006 Female 182 lb 11/20/2006 Physician United States
Primary
Concomitant
Ureteral Neoplasm Other Serious 11/1/2006 Female 182 lb 12/18/2006 Physician United States
Primary
Concomitant
Headache 1/1/2006 58 Female 258 lb 12/22/2006 Consumer United States
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 9/30/2006 60 Female 1/8/2007 Consumer United States
Primary
Concomitant
Respiratory Failure Hospitalization 88 Female 3/19/2007 Physician United States
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 1/1/2007 Female 5/15/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 4/28/2007 Male 286 lb 5/23/2007 Consumer United States
Primary
Concomitant
Swelling Other Serious 12/1/2006 Female 150 lb 6/26/2007 Physician United States
Primary
Concomitant
Vomiting Hospitalization 2/21/2007 66 Male 206 lb 4/10/2007 Consumer United States
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 7/19/2007 Male 148 lb 8/3/2007 Canada
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 7/19/2007 Male 148 lb 9/5/2007 Canada
Primary
Concomitant
Thalassaemia Other Serious Male 9/20/2007 Belgium
Primary
Concomitant
Pelvic Pain 7/27/2007 63 Female 159 lb 9/26/2007 Consumer United States
Primary
Concomitant
Thalassaemia Other Serious Male 9/27/2007 Belgium
Primary
Concomitant
Weight Decreased Other Serious 1/1/2004 Male 230 lb 10/5/2007 Consumer United States
Primary
Concomitant
Upper Respiratory Tract Infection 12/11/2006 70 Female 4/19/2007 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 10/8/2007 Female 180 lb 11/1/2007 Canada
Primary
Concomitant
Visual Acuity Reduced Other Serious 10/5/2007 68 Male 11/6/2007 Consumer United States
Primary
Concomitant
Coronary Artery Occlusion Other Serious 10/18/2007 Male 148 lb 11/9/2007 Canada
Primary
Concomitant
Cerebrovascular Accident Hospitalization 7/4/2007 Female 205 lb 11/30/2007 Other Health Professional United States
Primary
Concomitant
Oedema Peripheral 1/1/2007 Male 240 lb 12/14/2007 Consumer United States
Primary
Concomitant
Drug Ineffective 9/1/2007 Female 266 lb 12/14/2007 Consumer United States
Primary
Concomitant
Skin Irritation 8/1/2007 Male 12/14/2007 United States
Primary
Secondary
Concomitant
Urticaria 4/1/2007 Female 226 lb 12/14/2007 Consumer United States
Primary
Concomitant
Blood Creatinine Increased Hospitalization 10/10/2007 76 Female 165 lb 12/21/2007 Greece
Primary
Secondary
Concomitant
Pulmonary Toxicity Hospitalization 7/15/2007 58 Female 143 lb 11/5/2007 Pharmacist United States
Primary
Concomitant
Tinnitus Hospitalization 1/7/2008 Female 110 lb 1/16/2008 Physician Brazil
Primary
Concomitant
Tinnitus Hospitalization 1/7/2008 Female 110 lb 1/22/2008 Physician Brazil
Primary
Concomitant
Tinnitus Hospitalization 1/7/2008 Female 110 lb 1/28/2008 Physician Brazil
Primary
Concomitant
Small Intestinal Obstruction Other Serious 12/19/2007 72 Female 150 lb 2/6/2008 Physician United States
Primary
Concomitant
Pulmonary Hypertension Hospitalization 10/1/2007 65 Female 2/6/2008 Physician Canada
Primary
Concomitant
Blood Glucose Increased 1/1/2007 74 Male 2/15/2008 United States
Primary
Concomitant
Red Blood Cell Sedimentation Rate Increased Other Serious 2/1/2008 Female 122 lb 3/24/2008 Physician United States
Primary
Concomitant
Staphylococcal Infection Hospitalization 3/22/2008 Female 4/18/2008 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 2/22/2006 79 Female 5/19/2008 Physician United States
Primary
Secondary
Concomitant
Pulmonary Hypertension Hospitalization 10/1/2007 65 Female 6/2/2008 Physician Canada
Primary
Concomitant
Ill-defined Disorder Other Serious 7/4/2007 Female 205 lb 6/9/2008 Other Health Professional United States
Primary
Concomitant
Speech Disorder Other Serious 7/4/2007 Female 190 lb 6/13/2008 Physician United States
Primary
Concomitant
Rectal Haemorrhage Hospitalization 2/24/2008 79 Female 168 lb 5/21/2008 Pharmacist United States
Primary
Concomitant
Pyrexia Hospitalization 6/8/2008 76 Male 6/18/2008 Physician Japan
Primary
Secondary
Concomitant
Heart Rate Increased 1/1/1999 53 Female 7/24/2008 Consumer United States
Primary
Concomitant
Blood Glucose Decreased Hospitalization 11/1/2006 81 Female 7/24/2008 Consumer United States
Primary
Concomitant
Psoriasis 12/1/2006 Female 190 lb 9/12/2008 Consumer United States
Primary
Concomitant
Superinfection Hospitalization 69 Male 9/17/2008
Primary
Secondary
Concomitant
Lymphoma Hospitalization 8/27/2007 Female 137 lb 9/19/2008 Physician Japan
Primary
Concomitant
Atrial Fibrillation Hospitalization 10/24/2008 62 Male 234 lb 11/21/2008 Physician United States
Primary
Secondary
Concomitant
Mass Other Serious 12/1/2007 Female 11/24/2008 Consumer Canada
Primary
Concomitant
Breast Cancer Other Serious 9/1/2008 Female 12/4/2008 Physician Iran (Islamic Republic Of)
Primary
Concomitant
Visual Impairment 4/1/2008 Female 250 lb 12/12/2008 United States
Primary
Concomitant
Red Blood Cell Sedimentation Rate Increased 3/1/2008 Male 172 lb 12/12/2008 United States
Primary
Concomitant
Hepatic Enzyme Increased 1/1/2007 Female 198 lb 12/12/2008 Physician United States
Primary
Secondary
Concomitant
Injection Site Pain 1/1/2007 Female 240 lb 12/12/2008 Consumer United States
Primary
Concomitant
Staphylococcal Infection Hospitalization 3/1/2008 Female 12/18/2008 Physician United States
Primary
Secondary
Concomitant
Blood Pressure Increased 71 Female 12/31/2008 Physician United States
Primary
Secondary
Concomitant
Psoriasis Hospitalization Male 380 lb 2/20/2009 Consumer United States
Primary
Concomitant
Coronary Artery Occlusion Hospitalization 2/19/2009 68 Female 141 lb 3/3/2009 Consumer United States
Primary
Concomitant
Coronary Artery Disease Death 6/3/2005 Male 226 lb 3/10/2009 Physician United States
Primary
Secondary
Concomitant
Injection Site Papule 1/1/2007 Female 240 lb 3/14/2009 Consumer United States
Primary
Concomitant
Pain In Extremity 12/1/2008 Female 190 lb 3/14/2009 Other Health Professional United States
Primary
Concomitant
Nasopharyngitis 1/7/2009 Female 247 lb 3/14/2009 Physician United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2005 Female 3/25/2009 Consumer United States
Primary
Concomitant
Gallbladder Disorder Hospitalization 3/16/2009 Male 223 lb 4/17/2009 Canada
Primary
Concomitant
Nausea Other Serious 8/1/2008 Female 234 lb 5/19/2009 Physician Canada
Primary
Concomitant
Insulin-requiring Type 2 Diabetes Mellitus Other Serious 4/29/2002 50 Female 388 lb 6/1/2009 United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 5/1/2008 35 Female 240 lb 6/4/2009 Consumer United States
Primary
Concomitant
Swelling Face 1/1/2009 Female 285 lb 6/12/2009 Consumer United States
Primary
Secondary
Concomitant
Swelling 4/1/2009 Female 246 lb 6/12/2009 United States
Primary
Concomitant
General Physical Health Deterioration Hospitalization 4/29/2009 Male 6/12/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Non-small Cell Lung Cancer Stage Iv Hospitalization 2/1/2002 Male 7/17/2009 Other Health Professional Sweden
Primary
Concomitant
Platelet Count Decreased Hospitalization 12/22/2007 72 Female 189 lb 7/22/2009 Physician United States
Primary
Concomitant
Lymphoma Other Serious 7/1/2009 66 Male 210 lb 8/17/2009 Other Health Professional Canada
Primary
Concomitant
Lymphoma Other Serious 7/1/2009 66 Male 210 lb 8/19/2009 Other Health Professional Canada
Primary
Secondary
Concomitant
Pruritus 12/1/2008 Female 8/22/2009 United States
Primary
Concomitant
Lung Adenocarcinoma Metastatic Death Male 128 lb 8/26/2009 Physician United States
Primary
Concomitant
Streptococcal Infection Other Serious Female 276 lb 8/31/2009 Other Health Professional Canada
Primary
Concomitant
Wrist Fracture Other Serious 1/1/2009 Female 187 lb 9/2/2009 United States
Primary
Secondary
Concomitant
Suicidal Ideation Other Serious 10/5/2001 64 Female 9/18/2009 Physician Spain
Primary
Concomitant
Rheumatoid Arthritis 1/1/2007 Female 9/19/2009 United States
Primary
Concomitant
Wound Secretion 7/7/2009 Female 258 lb 9/19/2009 United States
Primary
Concomitant
Pain 4/1/2009 Female 219 lb 9/19/2009 United States
Primary
Concomitant
Wrist Fracture Other Serious 1/1/2009 Female 187 lb 9/23/2009 United States
Primary
Secondary
Concomitant
Suicidal Ideation Other Serious 10/5/2001 64 Female 9/29/2009 Physician Spain
Primary
Concomitant
B-cell Lymphoma Other Serious 7/29/2009 Female 140 lb 11/30/2009 Physician United States
Primary
Secondary
Concomitant
Volvulus Other Serious 11/17/2009 Male 225 lb 12/1/2009 Canada
Primary
Concomitant
Vertigo Other Serious 10/5/2001 64 Female 1/11/2010 Physician Spain
Primary
Concomitant
Vertigo Other Serious 10/5/2001 64 Female 1/19/2010 Physician Spain
Primary
Concomitant
Pyrexia Other Serious 8/20/2009 Female 1/29/2010 Other Health Professional United States
Primary
Concomitant
Pain In Jaw 8/19/2009 Male 235 lb 1/29/2010 Consumer United States
Primary
Concomitant
Palpitations 7/1/2009 Female 140 lb 1/30/2010 Physician United States
Primary
Concomitant
Oropharyngeal Pain 11/1/2009 Female 200 lb 1/30/2010 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis 64 Male 2/22/2010 Consumer United States
Primary
Concomitant
Renal Disorder Other Serious 3/1/2009 Female 214 lb 3/17/2010 Physician United States
Primary
Concomitant
Wound Dehiscence Other Serious 1/1/2008 Female 220 lb 3/19/2010 Canada
Primary
Concomitant
Myalgia Other Serious 3/6/2010 83 Male 190 lb 3/23/2010 Pharmacist Brazil
Primary
Concomitant
Weight Increased Other Serious Female 170 lb 5/7/2010 United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 3/1/2010 61 Female 169 lb 5/18/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/1/2008 62 Male 243 lb 5/17/2010 Consumer United States
Primary
Concomitant
Muscle Necrosis Life Threatening 5/7/2010 54 Female 159 lb 6/8/2010 Physician Mexico
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 88 Female 6/15/2010 Physician United States
Primary
Secondary
Nausea 10/1/2006 58 Female 170 lb 7/8/2010 Consumer United States
Primary
Concomitant
Oedema Peripheral Other Serious Female 167 lb 7/22/2010 Consumer United States
Primary
Concomitant
Vertigo Other Serious 51 Female 220 lb 7/16/2010 United States
Primary
Concomitant
Muscle Necrosis Life Threatening 5/7/2010 54 Female 117 lb 8/5/2010 Physician Mexico
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 10/15/2009 71 Male 8/19/2010 Physician Canada
Primary
Concomitant
Soft Tissue Infection Life Threatening 5/7/2010 54 Female 117 lb 8/30/2010 Physician Mexico
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 8/26/2009 9/7/2010 Other Health Professional Canada
Primary
Concomitant
Platelet Count Decreased Other Serious 11/4/2010 Other Health Professional United States
Primary
Concomitant
Hypotension Hospitalization 8/23/2010 50 Female 11/5/2010 Physician Switzerland
Primary
Concomitant
Vascular Rupture Other Serious 9/1/2010 11/16/2010 Other Health Professional United States
Primary
Concomitant
Vasculitis Other Serious 4/1/2010 61 Male 172 lb 11/23/2010 Physician Japan
Primary
Concomitant
Psoriasis Life Threatening 3/3/2010 63 Male 198 lb 11/24/2010 Physician Brazil
Primary
Concomitant
Rheumatoid Arthritis Other Serious 9/4/2010 62 Female 12/7/2010 Consumer Brazil
Primary
Concomitant
Melaena Other Serious 6/7/2010 58 Female 162 lb 12/10/2010 Physician Dominican Republic
Primary
Concomitant
Septic Shock Life Threatening 5/7/2010 54 Female 117 lb 12/28/2010 Physician Mexico
Primary
Secondary
Concomitant
Pyrexia Other Serious 12/1/2009 45 Male 150 lb 1/28/2011 United States
Primary
Concomitant
Wrong Technique In Drug Usage Process 4/28/2010 51 Female 300 lb 1/29/2011 Consumer United States
Primary
Concomitant
Injection Site Pain 57 Female 1/29/2011 Consumer United States
Primary
Concomitant
Headache 8/16/2010 59 Female 1/29/2011 Consumer United States
Primary
Concomitant
Pain In Extremity 10/1/2010 61 Female 168 lb 1/30/2011 Consumer United States
Primary
Concomitant
Pain 12/8/2010 62 Male 1/30/2011 Consumer United States
Primary
Concomitant
Red Blood Cell Sedimentation Rate Increased 8/1/2010 59 Female 152 lb 1/30/2011 Consumer United States
Primary
Concomitant
Blood Creatine Increased Hospitalization 11/1/2008 63 Male 243 lb 3/22/2011 Other Health Professional United States
Primary
Concomitant
Localised Infection Other Serious 11/19/2010 62 Female 190 lb 4/7/2011 Consumer United States
Primary
Concomitant
Vomiting Life Threatening 3/28/2011 71 Male 213 lb 4/8/2011 Other Health Professional Canada
Primary
Concomitant
Localised Infection Other Serious 11/19/2010 62 Female 190 lb 4/8/2011 Consumer Canada
Primary
Concomitant
Postoperative Wound Infection Disability 5/7/2010 54 Female 117 lb 4/19/2011 Physician Mexico
Primary
Secondary
Concomitant
Pulmonary Alveolar Haemorrhage Death 1/26/2011 81 Female 129 lb 4/21/2011 Physician Japan
Primary
Concomitant
Localised Infection Other Serious 11/19/2010 62 Female 190 lb 4/25/2011 Physician Canada
Primary
Concomitant
Epistaxis Other Serious 1/15/2011 66 Female 207 lb 5/3/2011 Other Health Professional Canada
Primary
Concomitant
Osteoporosis Other Serious 1/1/2004 52 Female 132 lb 5/5/2011 Consumer Brazil
Primary
Secondary
Concomitant

Drug Data