Gleevec combined with Tasigna

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Death Death 2/14/2008 41 Female 3/29/2008 United States
Primary
Secondary
Pain In Extremity Other Serious 1/1/2008 30 Male 5/5/2008 Physician Germany
Primary
Concomitant
Treatment Noncompliance Other Serious 1/1/2008 33 Male 5/12/2008 Physician Germany
Primary
Concomitant
Cerebrovascular Accident Hospitalization 5/11/2008 39 Male 5/22/2008 Physician Greece
Primary
Secondary
Concomitant
Ventricular Fibrillation Other Serious 6/6/2007 60 Male 5/23/2008 Switzerland
Primary
Secondary
Concomitant
Vascular Encephalopathy Hospitalization 6/29/2005 63 Female 150 lb 5/23/2008 Physician Hungary
Primary
Secondary
Concomitant
Headache Other Serious 3/7/2008 Female 143 lb 6/6/2008 Turkey
Primary
Secondary
Pleural Effusion Other Serious 5/16/2008 Female 7/14/2008 Pharmacist United Kingdom
Primary
Secondary
Visual Acuity Reduced Other Serious 6/1/2008 Female 7/15/2008 Consumer United States
Primary
Concomitant
Interacting
Skin Toxicity Other Serious 3/1/2008 Female 7/25/2008 Physician Austria
Primary
Concomitant
Thrombocytopenia Other Serious 3/1/2008 Female 123 lb 7/30/2008 Physician Austria
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 3/28/2008 Female 8/7/2008 Physician United States
Primary
Secondary
Concomitant
Pleural Effusion Life Threatening 5/19/2008 Female 8/14/2008 United Kingdom
Primary
Secondary
Drug Interaction Other Serious 9/2/2008 Physician United States
Primary
Secondary
Concomitant
Hyperbilirubinaemia Hospitalization 9/23/2008 Female 9/30/2008 Physician Belgium
Primary
Secondary
Hyperbilirubinaemia Hospitalization 9/23/2008 Female 10/6/2008 Physician Belgium
Primary
Secondary
Vocal Cord Disorder Other Serious 4/1/2008 70 Male 10/14/2008 Consumer Germany
Primary
Secondary
Concomitant
Pulmonary Oedema Other Serious 10/23/2008 Physician Belgium
Primary
Secondary
Weight Increased Other Serious 2/1/2006 Female 11/3/2008 Physician New Zealand
Primary
Secondary
Testicular Pain Other Serious 11/5/2008 Male 11/11/2008 United States
Primary
Secondary
Concomitant
Pulmonary Oedema Other Serious 8/1/2008 11/14/2008 Physician Belgium
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 11/5/2008 Male 168 lb 11/14/2008 United States
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 2/1/2008 Female 11/20/2008 Physician United States
Primary
Secondary
Weight Increased Other Serious 2/1/2006 Female 11/25/2008 Physician New Zealand
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Death Female 11/27/2008 United States
Primary
Secondary
White Blood Cell Count Decreased Death Female 12/3/2008 Pharmacist United States
Primary
Secondary
Transfusion Other Serious 5/1/2008 Female 12/8/2008 Consumer Germany
Primary
Secondary
Concomitant
Cardiotoxicity Other Serious 12/8/2008 Physician United States
Primary
Secondary
Respiratory Failure Other Serious 12/14/2008 Female 12/19/2008 Physician United States
Primary
Secondary
Hyperbilirubinaemia Hospitalization 9/23/2008 Female 12/22/2008 Physician Belgium
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 8/1/2008 Female 12/23/2008 Physician Belgium
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 11/5/2008 Male 168 lb 1/6/2009 United States
Primary
Secondary
Concomitant
Extrasystoles Other Serious 1/17/2008 Male 1/23/2009 Physician France
Primary
Secondary
Concomitant
Extrasystoles Other Serious 1/17/2008 Male 1/28/2009 Physician France
Primary
Secondary
Concomitant
Extrasystoles Other Serious 1/17/2008 Male 1/29/2009 Physician France
Primary
Secondary
Concomitant
Pain Hospitalization Male 2/11/2009 Other Health Professional France
Primary
Secondary
Treatment Failure Other Serious 3/4/2009 Physician United States
Primary
Secondary
Panniculitis Other Serious 10/1/2008 Female 4/7/2009 Physician France
Primary
Secondary
Vomiting Disability 4/2/2009 Female 4/28/2009 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 10/28/2008 Female 4/30/2009 Pharmacist United States
Primary
Secondary
Concomitant
Vomiting Other Serious 4/2/2009 Female 5/4/2009 Physician Japan
Primary
Secondary
Concomitant
Polypectomy Other Serious 2/1/2007 70 Male 5/15/2009 Physician Japan
Primary
Concomitant
Thoracic Cavity Drainage Other Serious 3/2/2009 Male 5/21/2009 Physician Japan
Primary
Secondary
Concomitant
Heart Rate Increased Other Serious 4/13/2009 Male 5/22/2009 Physician Japan
Primary
Secondary
Ventricular Extrasystoles Other Serious 4/13/2009 Female 5/22/2009 Physician Japan
Primary
Secondary
Concomitant
Polypectomy Other Serious 2/1/2007 70 Male 5/22/2009 Physician Japan
Primary
Concomitant
Treatment Failure Other Serious Female 226 lb 5/28/2009 Physician United States
Primary
Secondary
Thoracic Cavity Drainage Other Serious 3/2/2009 Male 5/29/2009 Physician Japan
Primary
Secondary
Concomitant
Vocal Cord Disorder Other Serious 4/1/2008 70 Male 5/29/2009 Consumer Germany
Primary
Secondary
Concomitant
Stent Placement Other Serious 8/1/2008 Male 6/4/2009 Physician United States
Primary
Secondary
Concomitant
Ventricular Extrasystoles Other Serious 4/14/2009 Female 6/18/2009 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased 5/13/2009 Female 6/30/2009 Physician Japan
Primary
Concomitant
Death Death 10/15/2008 Male 7/1/2009 United States
Primary
Secondary
Ventricular Extrasystoles Other Serious 4/14/2009 Female 7/2/2009 Physician Japan
Primary
Secondary
Concomitant
Myeloproliferative Disorder Death Male 7/8/2009 United States
Primary
Secondary
Death Death 4/3/2009 Male 7/16/2009 Other Health Professional United States
Primary
Secondary
Platelet Count Decreased Other Serious 4/13/2009 Male 7/17/2009 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 4/13/2009 Male 8/10/2009 Physician Japan
Primary
Secondary
Concomitant
Fatigue Other Serious Male 8/26/2009 United States
Primary
Secondary
Concomitant
Leukopenia Other Serious Male 9/1/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Leukopenia Other Serious Male 9/1/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 73 Female 9/10/2009 Physician Sweden
Primary
Secondary
Concomitant
Neoplasm Malignant Other Serious 65 Female 9/21/2009 Physician New Zealand
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 4/13/2009 Male 9/28/2009 Physician Japan
Primary
Secondary
Concomitant
Syncope Other Serious 5/23/2009 Female 11/12/2009 United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious Female 11/13/2009 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 10/15/2009 61 Male 12/14/2009 United States
Primary
Secondary
Concomitant
Drug Ineffective Female 12/15/2009 Physician United Kingdom
Primary
Secondary
Pulmonary Oedema Other Serious 10/1/2009 Female 142 lb 12/18/2009 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 10/5/2009 Male 12/22/2009 United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 10/5/2009 Male 12/22/2009 United States
Primary
Secondary
Concomitant
Hyperhidrosis 8/15/2009 Male 12/28/2009 Physician Germany
Primary
Secondary
Rash Other Serious Male 1/4/2010 Consumer Korea, Republic Of
Primary
Secondary
Graft Versus Host Disease Other Serious 1/1/2008 Female 1/22/2010 United States
Primary
Secondary
Concomitant
Renal Impairment Other Serious 11/19/2009 80 Female 2/5/2010 Physician Japan
Primary
Secondary
White Blood Cell Count Decreased Other Serious 8/14/2004 Female 3/3/2010 Physician Japan
Primary
Secondary
Concomitant
Optic Neuritis Other Serious 10/1/2009 50 Male 3/10/2010 Physician Spain
Primary
Secondary
Concomitant
Urinary Tract Infection Life Threatening 2/6/2010 Female 220 lb 3/10/2010 United States
Primary
Concomitant
Pancreatitis Acute Other Serious 8/1/2009 50 3/11/2010 Physician Spain
Primary
Secondary
Concomitant
Graft Versus Host Disease Other Serious 1/1/2008 Female 3/19/2010 United States
Primary
Secondary
Concomitant
Pancytopenia Other Serious 61 3/23/2010 United States
Primary
Secondary
Renal Cancer Other Serious 1/1/2008 66 Male 4/9/2010 Physician France
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 8/14/2004 70 Female 4/12/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Cancer Hospitalization Male 220 lb 4/13/2010 Other Health Professional France
Primary
Secondary
Concomitant
Renal Cancer Hospitalization Male 220 lb 4/13/2010 Other Health Professional France
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 5/13/2009 29 Female 4/14/2010 Physician Japan
Primary
Concomitant
Rash Hospitalization 4/15/2010 Male 5/6/2010 Physician United States
Primary
Secondary
Drug Administration Error Female 5/9/2010 Physician United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 8/14/2004 70 Female 6/8/2010 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Life Threatening 2/6/2010 74 Female 220 lb 7/2/2010 United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 5/13/2009 29 Female 8/6/2010 Physician Japan
Primary
Concomitant
Death Death Male 8/10/2010 United States
Primary
Secondary
Drug Ineffective Male 8/24/2010 Consumer United States
Primary
Secondary
Renal Impairment Other Serious 12/18/2009 81 Female 9/6/2010 Physician Japan
Primary
Secondary
Concomitant
Apnoea Other Serious 56 Female 9/9/2010 Physician France
Primary
Secondary
Renal Cancer Hospitalization 6/1/2009 66 Male 220 lb 9/16/2010 Other Health Professional France
Primary
Secondary
Concomitant
Angioedema Hospitalization Female 9/27/2010 Physician Belgium
Primary
Secondary
Concomitant
Lung Disorder Hospitalization 9/27/2010 Physician Greece
Primary
Secondary
White Blood Cell Count Increased Hospitalization 9/15/2010 28 Female 9/28/2010 Consumer Venezuela
Primary
Secondary
Thrombocytopenia Hospitalization Male 10/1/2010 United States
Primary
Concomitant
Oedema Peripheral Death Female 10/11/2010 United States
Primary
Concomitant
Skin Fragility Other Serious Male 10/27/2010 Physician Sweden
Primary
Secondary
Rash 10/29/2010 United States
Primary
Secondary
Retinal Detachment Other Serious 5/1/2010 54 Female 11/9/2010 Consumer Taiwan, Province Of China
Primary
Concomitant
Drug Ineffective Other Serious Male 11/9/2010 United States
Primary
Secondary
Vomiting Other Serious Female 11/9/2010 United States
Primary
Secondary
White Blood Cell Count Increased Other Serious 3/1/2010 64 Female 11/10/2010 Physician Japan
Primary
Concomitant
Thrombocytopenia Hospitalization 8/12/2010 34 Male 11/10/2010 United States
Primary
Concomitant
Rash 3/12/2010 57 Female 340 lb 11/25/2010 United States
Primary
Secondary
Concomitant
Fall Hospitalization Male 12/1/2010 United States
Primary
Secondary
Rash Other Serious Male 12/22/2010 Pharmacist Belgium
Primary
Secondary
Rash Male 12/24/2010 Pharmacist Belgium
Primary
Secondary
Retinal Detachment Other Serious 5/1/2010 54 Female 12/24/2010 Consumer Taiwan, Province Of China
Primary
Concomitant
Abdominal Distension 12/1/2010 69 Female 1/3/2011 Consumer Taiwan, Province Of China
Primary
Secondary
Arthralgia Female 1/17/2011 Consumer United States
Primary
Secondary
Concomitant
Fatigue Other Serious 6/1/2006 43 Female 139 lb 1/18/2011 Physician France
Primary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2009 66 Female 132 lb 2/1/2011 Physician France
Primary
Secondary
Abdominal Distension Other Serious 5/1/2010 54 Female 2/23/2011 Consumer Taiwan, Province Of China
Primary
Concomitant
Eating Disorder Male 3/1/2011 United States
Primary
Secondary
Concomitant
Pruritus Other Serious 5/1/2010 54 Female 4/6/2011 Consumer Taiwan, Province Of China
Primary
Concomitant
Death Death 3/19/2011 81 Female 4/6/2011 United States
Primary
Concomitant
Fatigue Female 4/11/2011 Consumer United States
Primary
Concomitant
Generalised Oedema Other Serious Male 4/12/2011 Consumer Korea, Republic Of
Primary
Secondary
Concomitant
Asthenia 3/7/2010 50 Male 4/14/2011 Physician United States
Primary
Secondary
Concomitant
Ascites Hospitalization 4/1/2010 64 Female 4/15/2011 Consumer Taiwan, Province Of China
Primary
Secondary
Ascites Other Serious 4/1/2010 64 Female 4/15/2011 Consumer Taiwan, Province Of China
Primary
Secondary
Neoplasm Malignant Other Serious 12/1/2010 84 Female 4/15/2011 Physician France
Primary
Secondary
Death Death 1/1/2011 65 Female 4/18/2011 Consumer Taiwan, Province Of China
Primary
Secondary
Gene Mutation Identification Test Positive Other Serious 4/25/2011 Other Health Professional United States
Primary
Secondary
Breast Cancer Other Serious 12/21/2010 84 Female 154 lb 5/4/2011 Physician France
Primary
Secondary
Gene Mutation Identification Test Positive Other Serious 5/5/2011 Other Health Professional United States
Primary
Secondary
Thrombocytopenia Other Serious 9/3/2009 54 Female 5/6/2011 Consumer United States
Primary
Secondary
Concomitant
Cardiac Arrest Life Threatening 5/10/2011 Physician India
Primary
Secondary
Hepatic Enzyme Abnormal Other Serious Male 5/11/2011 Korea, Republic Of
Primary
Secondary
Gene Mutation Identification Test Positive Other Serious 12/21/2010 84 Female 154 lb 5/11/2011 Physician France
Primary
Secondary
Myositis Female 3/26/2011 Consumer United States
Primary
Secondary
Concomitant
Sensory Loss Life Threatening Male 5/12/2011 Physician India
Primary
Secondary
Concomitant
Breast Cancer Hospitalization 12/1/2010 83 Female 5/12/2011 Consumer France
Primary
Secondary
Tumour Marker Increased Other Serious Male 5/5/2011 Taiwan, Province Of China
Primary
Secondary
Eye Infection 1/1/2010 53 Female 5/4/2011 Consumer Germany
Primary
Secondary
Clostridial Infection Hospitalization Male 5/18/2011 United States
Primary
Secondary
Breast Cancer Hospitalization 12/1/2010 83 Female 5/23/2011 Consumer France
Primary
Secondary
Therapeutic Response Decreased Other Serious 12/21/2010 83 Female 154 lb 5/26/2011 Physician France
Primary
Secondary
Nausea Hospitalization 5/19/2011 71 Female 6/8/2011 United States
Primary
Secondary
Concomitant
Acute Left Ventricular Failure Hospitalization 78 Male 6/8/2011 Other Health Professional China
Primary
Secondary
Abdominal Discomfort Male 5/25/2011 Physician United States
Primary
Secondary
Concomitant
Angina Pectoris Other Serious 12/15/2009 77 Male 5/23/2011 Physician Japan
Primary
Concomitant
Dry Eye Hospitalization 6/6/2010 45 Male 6/9/2011 Consumer Taiwan, Province Of China
Primary
Secondary
White Blood Cell Count Decreased Death Female 6/14/2011 Pharmacist United States
Primary
Secondary
Breast Cancer Hospitalization 12/1/2010 83 Female 6/15/2011 Consumer France
Primary
Secondary

Drug Data