Gleevec combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tachycardia Hospitalization 2/7/2006 28 Male 123 lb 3/16/2006 Other Health Professional France
Primary
Secondary
Concomitant
Septic Shock Hospitalization 4/1/2005 76 Male 3/18/2006 Pharmacist Japan
Primary
Concomitant
Thrombocytopenia Hospitalization 1/25/2006 28 Male 123 lb 3/24/2006 France
Primary
Secondary
Concomitant
Colitis Erosive Hospitalization 15 Male 6/17/2006 Physician United States
Primary
Concomitant
Vitreous Haemorrhage Other Serious 12/1/2003 38 Male 9/6/2006 Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 17 Female 88 lb 10/10/2006 Consumer Brazil
Primary
Concomitant
Vomiting Hospitalization 17 Female 88 lb 10/10/2006 Consumer Brazil
Primary
Concomitant
Subdural Haematoma Hospitalization 11/13/2006 58 Female 11/29/2006 France
Primary
Secondary
Concomitant
Vomiting Life Threatening 11/1/2006 58 Female 150 lb 1/6/2007 France
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 11/29/2006 17 Female 1/10/2007 Consumer
Primary
Concomitant
Meningitis Aseptic Other Serious 3/10/2007 59 Female 4/9/2007 Physician Switzerland
Primary
Secondary
Concomitant
Pyrexia Other Serious 3/7/2007 38 Female 189 lb 5/8/2007 Pharmacist United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 3/7/2007 38 Female 189 lb 5/8/2007 Pharmacist United States
Primary
Secondary
Concomitant
Retinal Vein Thrombosis Hospitalization 4/21/2007 8 8/15/2007 Physician United States
Primary
Concomitant
Subdural Haematoma Evacuation Life Threatening 7/3/2007 65 Female 163 lb 9/8/2007 France
Primary
Secondary
Concomitant
Subdural Haematoma Life Threatening 8/6/2007 65 Female 163 lb 9/11/2007
Primary
Secondary
Concomitant
Thrombophlebitis Life Threatening 6/1/2007 56 Female 198 lb 9/13/2007 France
Primary
Secondary
Concomitant
Retinal Vein Thrombosis Hospitalization 4/21/2007 8 Male 9/19/2007 Physician United States
Primary
Concomitant
Stomatitis Other Serious 12 Male 9/26/2007 Japan
Primary
Secondary
Concomitant
Status Epilepticus Life Threatening 2/10/2005 39 Male 10/26/2007 Japan
Primary
Secondary
Concomitant
Skin Ulcer Other Serious 3/28/2007 29 Male 163 lb 12/14/2007 Physician Japan
Primary
Concomitant
Wheezing Death 1/19/2008 49 Male 154 lb 2/8/2008 Physician France
Primary
Secondary
Stomatitis Hospitalization Male 2/20/2008 Physician France
Primary
Secondary
Stomatitis Hospitalization Male 2/22/2008 Physician France
Primary
Secondary
Thrombocytopenia Other Serious 8/27/2003 44 Female 134 lb 3/6/2008 Physician Spain
Primary
Secondary
Concomitant
Wheezing Death 1/19/2008 49 Male 154 lb 3/29/2008 Physician France
Primary
Secondary
Concomitant
Ventricular Fibrillation Death 1/1/2008 Male 4/10/2008 Other Health Professional France
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Hospitalization 1/1/2008 14 Male 143 lb 9/26/2008 Consumer United States
Primary
Secondary
Concomitant
Chemotherapeutic Drug Level Increased Other Serious 10/21/2008 Pharmacist United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 10/2/2008 64 Female 10/18/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Other Serious 64 Female 10/23/2008 Other Health Professional Japan
Primary
Concomitant
Vomiting Other Serious 10/1/2004 64 Female 11/3/2008 Physician Japan
Primary
Concomitant
Monoplegia Disability 7/1/2008 59 Female 11/6/2008 Physician Japan
Primary
Concomitant
Engraftment Syndrome Other Serious 10 Female 12/1/2008 Japan
Primary
Secondary
Concomitant
Somnolence Life Threatening 10/3/2008 Female 131 lb 11/28/2008 Physician Germany
Primary
Secondary
Vomiting Other Serious 8 Male 12/1/2008 Japan
Primary
Concomitant
Skin Ulcer Other Serious 29 Female 12/3/2008 Other Health Professional Greece
Primary
Concomitant
Hypomagnesaemia Other Serious Male 12/9/2008 Other Health Professional United States
Primary
Concomitant
Monoplegia Disability 7/1/2008 59 Female 12/10/2008 Physician Japan
Primary
Concomitant
Hypomagnesaemia Other Serious 6/1/2008 Male 12/12/2008 Other Health Professional United States
Primary
Concomitant
Vasodilatation Other Serious 1/25/2008 66 Male 1/13/2009 Physician Japan
Primary
Concomitant
Engraftment Syndrome Other Serious 4/1/2008 10 Female 1/15/2009 Japan
Primary
Secondary
Concomitant
Visual Field Defect Other Serious 12/29/2008 74 Male 2/5/2009 Other Health Professional France
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 34 Male 2/6/2009 Other Health Professional Japan
Primary
Concomitant
Engraftment Syndrome Other Serious 4/1/2008 10 Female 2/23/2009 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 34 Male 3/6/2009 Other Health Professional Japan
Primary
Concomitant
Visual Field Defect Other Serious 3/1/2006 74 Male 3/16/2009 Other Health Professional France
Primary
Concomitant
Ventriculo-peritoneal Shunt Other Serious 10/15/2008 6 Male 4/9/2009 Pharmacist United States
Primary
Concomitant
Vasodilatation Other Serious 1/25/2008 66 Male 4/17/2009 Physician Japan
Primary
Concomitant
Vasodilatation Life Threatening 1/25/2008 66 Male 5/15/2009 Physician Japan
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 1/1/2008 14 Male 205 lb 5/29/2009 Other Health Professional France
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 5/1/2008 Male 205 lb 6/2/2009 Other Health Professional France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 5/21/2008 14 Male 205 lb 6/5/2009 Other Health Professional France
Primary
Secondary
Renal Failure Chronic Other Serious 8/1/2008 14 Male 7/20/2009 Japan
Primary
Secondary
Concomitant
Renal Failure Chronic Other Serious 8/1/2008 14 Male 8/14/2009 Japan
Primary
Secondary
Concomitant
Thyroid Disorder Other Serious Male 10/12/2009 United States
Primary
Concomitant
Rash Life Threatening 2/27/2009 57 Male 126 lb 10/26/2009 Physician Japan
Primary
Secondary
Concomitant
Subdural Haematoma Other Serious 1/1/2009 42 Female 1/7/2010 Other Health Professional Japan
Primary
Secondary
Rash Generalised Life Threatening 4/1/2008 55 Male 126 lb 1/22/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Tubular Necrosis Other Serious 14 Male 79 lb 1/20/2010 Physician Canada
Primary
Concomitant
Subdural Haematoma Other Serious 1/1/2009 43 Female 1/29/2010 Other Health Professional Japan
Primary
Secondary
Subdural Haematoma Other Serious 1/1/2009 43 Female 2/16/2010 Other Health Professional Japan
Primary
Secondary
Leukocytosis Other Serious 1/1/2009 Male 220 lb 3/19/2010 Germany
Primary
Concomitant
Urinary Retention Hospitalization Female 4/7/2010 Physician Belgium
Primary
Secondary
Viral Infection Other Serious 7/1/2009 50 Female 5/11/2010 Physician Belgium
Primary
Secondary
Concomitant
Hypokinesia Hospitalization 5/16/2010 48 Female 6/1/2010 Other Health Professional United States
Primary
Concomitant
Viral Infection Other Serious 7/1/2009 50 Female 6/1/2010 Physician Belgium
Primary
Secondary
Concomitant
Leukocytosis Other Serious 1/1/2009 57 Male 220 lb 6/10/2010 Physician Germany
Primary
Concomitant
Vena Cava Filter Insertion Other Serious 4/26/2009 23 Male 225 lb 6/22/2010 Other Health Professional United States
Primary
Concomitant
Leukocytosis Other Serious 1/1/2009 57 Male 220 lb 6/24/2010 Physician Germany
Primary
Concomitant
Pancytopenia Hospitalization 4/26/2010 61 Female 6/29/2010 Physician United States
Primary
Concomitant
Vena Cava Filter Insertion Other Serious 4/26/2009 23 Male 225 lb 6/30/2010 Other Health Professional United States
Primary
Concomitant
Subcutaneous Nodule Other Serious 54 Male 7/2/2010 Other Health Professional Hungary
Primary
Concomitant
Visual Field Defect Other Serious 12/24/2008 74 Male 8/5/2010 Other Health Professional France
Primary
Concomitant
Pancytopenia Hospitalization 4/26/2010 61 Female 7/29/2010 Physician United States
Primary
Concomitant
Pneumatosis Intestinalis Other Serious 5/21/2007 18 Male 132 lb 8/18/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Bone Disorder Other Serious 6/29/2010 69 Female 8/24/2010 Physician Germany
Primary
Concomitant
Drug Clearance Decreased Hospitalization 10 Female 95 lb 9/13/2010 Other Health Professional Canada
Primary
Secondary
Concomitant
Temperature Intolerance Other Serious 1/1/2009 45 Male 9/23/2010 Other Health Professional Japan
Primary
Concomitant
Poor Peripheral Circulation Other Serious 6/29/2010 69 Female 9/24/2010 Physician Germany
Primary
Concomitant
Temperature Intolerance Other Serious 1/1/2009 45 Male 10/15/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Drug Clearance Decreased Hospitalization 11/1/2009 10 Female 95 lb 10/18/2010 Other Health Professional Canada
Primary
Secondary
Concomitant
Sepsis Hospitalization 5/14/2010 4 Male 10/22/2010 Physician Mexico
Primary
Concomitant
Drug Clearance Decreased Hospitalization 11/1/2009 10 Female 95 lb 10/24/2010 Other Health Professional Canada
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 9/29/2010 55 Male 10/25/2010 Physician South Africa
Primary
Concomitant
Subdural Haematoma Life Threatening 7/3/2007 64 Female 163 lb 11/15/2010 Other Health Professional France
Primary
Concomitant
Interacting
Fatigue Disability Male 196 lb 1/3/2011 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Disability 5/17/2010 84 Female 1/5/2011 Other Health Professional France
Primary
Secondary
Concomitant
Csf Protein Increased Hospitalization 9/1/2010 84 Female 12/29/2010 Other Health Professional France
Primary
Secondary
Cholestasis Hospitalization 5/1/2008 14 Male 205 lb 1/11/2011 Other Health Professional France
Primary
Secondary
Concomitant
Gait Disturbance Other Serious 5/17/2010 84 Female 1/19/2011 Other Health Professional France
Primary
Secondary
Concomitant
Pancytopenia Other Serious 44 1/21/2011 Physician Spain
Primary
Concomitant
Ataxia Disability 9/1/2010 84 Female 1/12/2011 Other Health Professional France
Primary
Secondary
Chest Discomfort Other Serious 12/21/2010 72 Female 1/24/2011 Consumer United States
Primary
Secondary
Concomitant
Ataxia Disability 11/1/2010 24 Female 1/25/2011 United States
Primary
Concomitant
Toxicity To Various Agents Other Serious 8/1/2010 44 Male 1/26/2011 Physician Spain
Primary
Concomitant
Renal Tubular Necrosis Hospitalization 1/12/2011 18 Male 148 lb 3/7/2011 Physician France
Primary
Concomitant
Fluid Retention Other Serious 10/18/2010 24 Female 3/24/2011 United States
Primary
Concomitant
Liver Function Test Abnormal Other Serious Female 4/5/2011 Physician Germany
Primary
Concomitant
Mucosal Inflammation Other Serious 1/12/2011 18 Male 148 lb 4/11/2011 Physician France
Primary
Concomitant
Ataxia Disability 5/17/2010 84 Female 4/13/2011 Other Health Professional France
Primary
Secondary
Concomitant
Neutrophil Count Increased Hospitalization 5/17/2010 84 Female 4/13/2011 Other Health Professional France
Primary
Secondary
Concomitant
Subileus Other Serious 4/20/2011 4 37 lb 4/29/2011 Physician Netherlands
Primary
Secondary
Concomitant
Ascites Hospitalization 4/20/2011 4 37 lb 5/23/2011 Physician Netherlands
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 4/12/2011 11 Female 6/9/2011 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 6/5/2011 14 Female 6/22/2011 United States
Primary
Concomitant
Gastrointestinal Haemorrhage Life Threatening 4/12/2011 11 Female 6/22/2011 Physician United Kingdom
Primary
Concomitant
General Physical Health Deterioration Death 1/1/2009 60 Male 106 lb 6/30/2011 Physician France
Primary
Secondary
Concomitant
Neoplasm Malignant Death 9 Male 7/25/2011 Other Health Professional Japan
Primary
Concomitant
Interacting
Bone Marrow Failure Hospitalization Female 8/4/2011 Physician Chile
Primary
Concomitant
Psoriatic Arthropathy Other Serious 4/1/2011 57 Female 250 lb 8/8/2011 Consumer United States
Primary
Concomitant
Nausea Hospitalization 6/5/2011 14 Female 9/21/2011 Consumer United States
Primary
Concomitant
Fluid Retention Other Serious 10/18/2010 24 Female 9/27/2011 Consumer United States
Primary
Concomitant
Muscle Spasms Hospitalization 6/5/2011 14 Female 115 lb 10/18/2011 Other Health Professional United States
Primary
Concomitant
Haemorrhage Hospitalization 10/21/2011 15 Male 77 lb 11/29/2011 Other Health Professional Austria
Primary
Concomitant
Death Death 11/25/2011 68 Male 12/1/2011 Consumer United States
Primary
Concomitant
Stomatococcal Infection Hospitalization Male 40 lb 12/31/2011 Other Health Professional France
Primary
Secondary
Pyrexia Life Threatening Male 40 lb 12/31/2011 Other Health Professional France
Primary
Secondary
Death Death 11/8/2011 20 Female 179 lb 1/2/2012 Chile
Primary
Concomitant
Fluid Retention Other Serious 10/18/2010 24 Female 1/5/2012 United States
Primary
Secondary
Concomitant
Sepsis Life Threatening 10/16/2011 5 Male 40 lb 1/5/2012 Other Health Professional France
Primary
Secondary
Aplasia Hospitalization Male 40 lb 1/9/2012 Other Health Professional France
Primary
Secondary
Generalised Oedema Hospitalization Male 40 lb 1/9/2012 Other Health Professional France
Primary
Secondary
Cerebral Disorder Other Serious 1/1/2011 71 Male 152 lb 1/16/2012 Consumer Germany
Primary
Concomitant
Generalised Oedema Life Threatening 10/16/2011 5 Male 40 lb 1/16/2012 Other Health Professional France
Primary
Secondary
Muscle Spasms Hospitalization 6/5/2011 14 Female 115 lb 2/6/2012 Other Health Professional United States
Primary
Concomitant
Food Intolerance Death 10/27/2011 68 Female 2/17/2012 Consumer United States
Primary
Secondary
Concomitant
Toxicity To Various Agents Hospitalization 10/27/2011 68 Female 2/17/2012 Physician United States
Primary
Secondary
Concomitant
Ataxia Other Serious 10/18/2010 24 Female 3/12/2012 Consumer United States
Primary
Secondary
Concomitant
Mouth Injury Hospitalization 2/9/2012 4 Male 35 lb 3/14/2012 Physician France
Primary
Concomitant
Interacting
Pericardial Effusion Life Threatening 49 Female 204 lb 7/8/2009 Physician United States
Primary
Concomitant
Vomiting Other Serious 4 Male 7/8/2009 Pharmacist United States
Primary
Concomitant
Generalised Oedema Life Threatening 49 Female 204 lb 7/8/2009 Physician United States
Primary
Concomitant
Vomiting Other Serious 4 Male 7/8/2009 Pharmacist United States
Primary
Concomitant
Dyspnoea Other Serious 52 Male 5/28/2010 Physician United States
Primary
Concomitant
Liver Function Test Abnormal Hospitalization 2/28/2012 34 Female 5/14/2012 Consumer United States
Primary
Concomitant
Hepatic Function Abnormal Other Serious 6/16/2009 37 Female 5/15/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 6/16/2009 37 Female 5/15/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 2/28/2012 34 Female 5/18/2012 Physician United States
Primary
Concomitant
Gastrooesophageal Reflux Disease Other Serious 5/1/2012 72 Female 184 lb 7/3/2012 Consumer United States
Primary
Concomitant
Vomiting Hospitalization Female 3/15/2013 Physician Us
Primary
Concomitant
Headache Hospitalization 11/1/2012 15 Female 116 lb 12/21/2012 Consumer Us
Primary
Concomitant
Death Death NotSpecified 1/30/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Venoocclusive Disease Death NotSpecified 2/12/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Influenza Death NotSpecified 2/12/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Asthenia Other Serious NotSpecified 2/15/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Ileus Other Serious NotSpecified 2/13/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Subdural Haematoma Other Serious NotSpecified 2/11/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Multi-organ Failure Death NotSpecified 2/11/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Myopathy Other Serious NotSpecified 2/12/2013 Other Health Professional Ca
Primary
Secondary
Concomitant

Drug Data