Fosamax combined with Loxonin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Rash Other Serious 11/28/2005 70 Male 3/16/2006 Physician Japan
Primary
Secondary
Concomitant
Rash Other Serious 11/28/2005 70 Male 5/24/2006 Physician Japan
Primary
Secondary
Concomitant
Gastric Cancer Life Threatening 5/29/2006 74 Female 95 lb 8/11/2006 Physician Japan
Primary
Secondary
Concomitant
Rash Other Serious 8/8/2006 76 Female 9/11/2006 Physician Japan
Primary
Concomitant
Rash Other Serious 8/8/2006 76 Female 9/25/2006 Physician Japan
Primary
Concomitant
Rash Other Serious 8/8/2006 76 Female 9/29/2006 Physician Japan
Primary
Concomitant
Rash Other Serious 8/8/2006 76 Female 10/10/2006 Physician Japan
Primary
Concomitant
Eosinophil Count Increased Hospitalization 8/11/2006 76 Female 10/23/2006 Physician Japan
Primary
Concomitant
Eosinophilia Hospitalization 8/11/2006 76 Female 11/2/2006 Physician Japan
Primary
Secondary
Eosinophilia Hospitalization 8/11/2006 76 Female 11/6/2006 Physician Japan
Primary
Secondary
Vomiting Other Serious 1/1/2006 88 Female 2/28/2007 Physician Japan
Primary
Secondary
Vomiting Other Serious 1/1/2006 88 Female 4/13/2007 Physician Japan
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization 8/1/2006 85 Female 5/8/2007 Physician Japan
Primary
Concomitant
Osteonecrosis Hospitalization 8/1/2006 84 Female 82 lb 5/29/2007 Physician Japan
Primary
Concomitant
Swelling Other Serious 6/19/2007 78 Female 123 lb 7/12/2007 Physician Japan
Primary
Concomitant
Swelling Other Serious 6/19/2007 78 Female 123 lb 8/1/2007 Physician Japan
Primary
Concomitant
Gastric Ulcer Haemorrhage Hospitalization 78 Female 9/6/2007 Physician Japan
Primary
Secondary
Panniculitis Hospitalization 12/1/2006 Female 110 lb 9/18/2007 Physician Japan
Primary
Concomitant
Nephrotic Syndrome Hospitalization 3/30/2007 Female 104 lb 10/25/2007 Physician Japan
Primary
Secondary
Concomitant
International Normalised Ratio Increased Other Serious 3/7/2007 75 Female 11/27/2007 Physician Japan
Primary
Secondary
Concomitant
Anaphylactic Shock Hospitalization 11/16/2007 88 Female 12/3/2007 Physician Japan
Primary
Concomitant
Gastric Ulcer Haemorrhage Other Serious 12/17/2007 89 Female 1/4/2008 Physician Japan
Primary
Secondary
Concomitant
Gastric Ulcer Haemorrhage Other Serious 11/25/2007 89 Female 1/30/2008 Physician Japan
Primary
Secondary
Concomitant
Gastric Ulcer Haemorrhage Other Serious 11/25/2007 89 Female 2/29/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 11/13/2007 60 Female 115 lb 3/14/2008 Physician Japan
Primary
Concomitant
Hepatic Function Abnormal Other Serious 3/8/2008 85 Female 4/3/2008 Physician Japan
Primary
Secondary
Concomitant
Large Intestine Perforation Death 8/9/2007 Female 4/7/2008 Physician Japan
Primary
Concomitant
Femur Fracture Other Serious 2/27/2007 76 Female 4/21/2008 Physician Japan
Primary
Concomitant
Femur Fracture Other Serious 2/27/2007 76 Female 4/25/2008 Physician Japan
Primary
Concomitant
Staphylococcal Infection Hospitalization 8/16/2007 Female 4/28/2008 Physician Japan
Primary
Secondary
Concomitant
Septic Shock Hospitalization 1/17/2008 77 Female 5/1/2008 Physician Japan
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 1/1/2008 75 Female 5/13/2008 Physician Japan
Primary
Concomitant
Large Intestine Perforation Hospitalization 8/9/2007 Female 5/22/2008 Physician Japan
Primary
Secondary
Femur Fracture Other Serious 2/27/2007 76 Female 5/27/2008 Physician Japan
Primary
Concomitant
Vitamin D Deficiency Other Serious 4/1/2006 Male 112 lb 5/30/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Femur Fracture Other Serious 2/27/2007 76 Female 6/4/2008 Physician Japan
Primary
Concomitant
Vasculitis Other Serious 5/28/2008 Female 99 lb 7/11/2008 Physician Japan
Primary
Concomitant
Staphylococcal Infection Hospitalization 1/1/2008 Female 7/15/2008 Physician Japan
Primary
Secondary
Concomitant
Vitamin D Deficiency Other Serious 4/1/2006 Male 112 lb 7/29/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Neutropenia Hospitalization 7/18/2008 77 Female 7/29/2008 Pharmacist Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 6/14/2008 83 Female 7/31/2008 Physician Japan
Primary
Secondary
Concomitant
Vitamin D Deficiency Other Serious 4/1/2006 Male 112 lb 8/7/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 6/30/2008 Female 88 lb 8/18/2008 Physician Japan
Primary
Secondary
Concomitant
International Normalised Ratio Increased Life Threatening 2/1/2007 75 Female 9/4/2008 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 6/30/2008 Female 88 lb 9/8/2008 Physician Japan
Primary
Secondary
Concomitant
Blood Creatine Phosphokinase Increased Hospitalization 9/17/2008 74 Female 10/3/2008 Pharmacist Japan
Primary
Concomitant
Nephrotic Syndrome Hospitalization 6/28/2006 Female 101 lb 10/6/2008 Physician Japan
Primary
Concomitant
Femur Fracture Other Serious 2/27/2007 76 Female 10/8/2008 Other Health Professional Japan
Primary
Concomitant
Femur Fracture Other Serious 2/27/2007 76 Female 10/15/2008 Other Health Professional Japan
Primary
Concomitant
Blood Creatine Phosphokinase Increased 9/17/2008 74 Female 10/15/2008 Pharmacist Japan
Primary
Concomitant
Injury Other Serious 2/27/2007 76 Female 10/20/2008 Other Health Professional Japan
Primary
Concomitant
Osteonecrosis Other Serious 58 Female 10/30/2008 Other Health Professional Japan
Primary
Concomitant
Osteonecrosis Other Serious 5/1/2008 58 Female 11/14/2008 Other Health Professional Japan
Primary
Concomitant
Femur Fracture Other Serious 2/27/2007 76 Female 11/17/2008 Other Health Professional Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 6/14/2008 83 Female 2/5/2009 Physician Japan
Primary
Secondary
Concomitant
Trismus Other Serious 1/1/2008 67 Female 82 lb 2/25/2009 Physician Japan
Primary
Concomitant
Trismus Other Serious 1/1/2008 67 Female 82 lb 4/7/2009 Physician Japan
Primary
Concomitant
Trismus Other Serious 1/1/2008 67 Female 82 lb 4/16/2009 Physician Japan
Primary
Concomitant
Tooth Fracture Other Serious 5/26/2008 77 Female 4/17/2009 Physician Japan
Primary
Concomitant
Neutropenia Hospitalization 7/18/2008 4/23/2009 Other Health Professional Japan
Primary
Concomitant
Thrombocytopenia Other Serious 6/30/2008 Female 88 lb 4/27/2009 Physician Japan
Primary
Secondary
Concomitant
Tooth Fracture Other Serious 5/26/2008 77 Female 4/28/2009 Physician Japan
Primary
Concomitant
Tooth Fracture Other Serious 5/26/2008 77 Female 5/4/2009 Physician Japan
Primary
Concomitant
Sudden Hearing Loss Other Serious 1/1/2009 Female 5/8/2009 Consumer Japan
Primary
Concomitant
Sudden Hearing Loss 1/1/2009 Female 5/13/2009 Consumer Japan
Primary
Concomitant
Trismus Other Serious 1/1/2008 67 Female 82 lb 5/27/2009 Physician Japan
Primary
Concomitant
Optic Neuritis Other Serious 2/28/2008 39 Female 139 lb 6/5/2009 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 6/1/2007 54 Female 6/8/2009 Physician Japan
Primary
Secondary
Concomitant
Optic Neuritis Other Serious 2/28/2008 39 Female 139 lb 6/12/2009 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 6/1/2007 55 Female 6/12/2009 Physician Japan
Primary
Secondary
Concomitant
Aplasia Pure Red Cell Hospitalization 3/9/2009 69 Male 6/16/2009 Other Health Professional Japan
Primary
Concomitant
Aplasia Pure Red Cell Hospitalization 3/3/2009 Male 6/19/2009 Physician Japan
Primary
Secondary
Concomitant
Aplasia Pure Red Cell Life Threatening 3/3/2009 Male 6/30/2009 Physician Japan
Primary
Secondary
Concomitant
Tooth Fracture 5/26/2008 77 Female 6/30/2009 Physician Japan
Primary
Concomitant
Superior Vena Caval Occlusion Other Serious 6/1/2007 55 Female 7/6/2009 Physician Japan
Primary
Secondary
Concomitant
Gastric Ulcer Haemorrhage Hospitalization 7/14/2009 67 Female 7/27/2009 Physician Japan
Primary
Secondary
Concomitant
Spondylolisthesis Hospitalization 7/1/2009 78 Female 8/21/2009 Japan
Primary
Secondary
Concomitant
Gastric Ulcer Other Serious 7/14/2009 67 Female 9/11/2009 Physician Japan
Primary
Secondary
Concomitant
Gastric Ulcer Haemorrhage Other Serious 7/14/2009 67 Female 9/22/2009 Physician Japan
Primary
Secondary
Concomitant
Spondylolisthesis Hospitalization 7/6/2009 78 Female 9/24/2009 Physician Japan
Primary
Secondary
Concomitant
Gastric Ulcer Haemorrhage Other Serious 7/14/2009 67 Female 10/5/2009 Physician Japan
Primary
Secondary
Concomitant
Gastric Ulcer Haemorrhage Other Serious 7/14/2009 67 Female 10/19/2009 Physician Japan
Primary
Secondary
Concomitant
Gastric Ulcer Haemorrhage Other Serious 7/14/2009 67 Female 11/3/2009 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 7/24/2008 Female 86 lb 11/20/2009 Physician Japan
Primary
Secondary
Concomitant
Hallucination Other Serious 4/10/2009 79 Female 11/16/2009 Japan
Primary
Secondary
Concomitant
Lymphoproliferative Disorder Other Serious 1/20/2010 Female 99 lb 2/11/2010 Physician Japan
Primary
Secondary
Concomitant
Spondylolisthesis Hospitalization 7/6/2009 78 Female 2/2/2010 Physician Japan
Primary
Secondary
Concomitant
Lymphoproliferative Disorder Other Serious 1/20/2010 Female 99 lb 2/17/2010 Physician Japan
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 6/1/2007 73 Female 99 lb 2/22/2010 Physician Japan
Primary
Concomitant
Oedema Peripheral Hospitalization 10/2/2008 28 Female 112 lb 3/4/2010 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 7/24/2008 Female 86 lb 3/15/2010 Physician Japan
Primary
Secondary
Concomitant
Melaena Hospitalization 7/15/2009 Female 165 lb 3/17/2010 Physician Japan
Primary
Secondary
Concomitant
Lymphoproliferative Disorder Other Serious 1/4/2010 Female 104 lb 3/19/2010 Physician Japan
Primary
Secondary
Concomitant
Femur Fracture Other Serious 3/1/2010 62 Female 3/22/2010 Physician Japan
Primary
Secondary
Concomitant
Osteomyelitis Other Serious 3/1/2010 84 Female 3/22/2010 Physician Japan
Primary
Concomitant
Oedema Peripheral Hospitalization 10/2/2008 28 Female 112 lb 4/6/2010 Physician Japan
Primary
Secondary
Concomitant
Hand Fracture Disability 3/24/2009 62 Female 4/7/2010 Physician Japan
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 6/1/2007 73 Female 99 lb 4/20/2010 Physician Japan
Primary
Concomitant
Stress Fracture Other Serious 2/27/2007 76 Female 4/23/2010 Physician Japan
Primary
Concomitant
Urinary Tract Infection Life Threatening 1/19/2010 70 Female 84 lb 4/26/2010 Physician Japan
Primary
Secondary
Hand Fracture Hospitalization 3/24/2009 61 Female 5/3/2010 Physician Japan
Primary
Secondary
Concomitant
Osteomyelitis Other Serious 2/1/2010 84 Female 5/3/2010 Physician Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 3/27/2010 57 Female 132 lb 5/3/2010 Physician Japan
Primary
Secondary
Concomitant
Pruritus Hospitalization 4/1/2008 83 Female 5/10/2010 Japan
Primary
Concomitant
Sepsis Other Serious 3/27/2010 57 Female 132 lb 5/13/2010 Physician Japan
Primary
Secondary
Concomitant
Osteomyelitis Other Serious 2/1/2010 84 Female 5/24/2010 Physician Japan
Primary
Secondary
Concomitant
Sepsis Life Threatening 3/19/2010 66 Female 132 lb 5/24/2010 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Life Threatening 2/5/2010 70 Female 84 lb 6/1/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Lip And/or Oral Cavity Cancer Hospitalization 9/1/2009 66 Female 6/2/2010 Physician Japan
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 7/24/2008 81 Female 86 lb 6/10/2010 Physician Japan
Primary
Secondary
Concomitant
Pruritus Hospitalization 4/1/2008 83 Male 6/7/2010 Physician Japan
Primary
Concomitant
Weight Decreased Death 7/16/2009 74 Male 6/15/2010 Physician Japan
Primary
Secondary
Concomitant
Panniculitis Hospitalization 12/1/2006 64 Female 110 lb 6/25/2010 Japan
Primary
Concomitant
Lymphoproliferative Disorder Other Serious 3/27/2010 57 Female 132 lb 7/1/2010 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 4/1/2010 78 Male 7/2/2010 Physician Japan
Primary
Concomitant
Sepsis Life Threatening 3/19/2010 66 Female 132 lb 7/7/2010 Physician Japan
Primary
Secondary
Concomitant
Primary Cerebellar Degeneration Other Serious 9/18/2008 67 Female 110 lb 7/9/2010 Physician Japan
Primary
Secondary
Concomitant
Primary Cerebellar Degeneration Other Serious 9/18/2008 67 Female 110 lb 7/19/2010 Physician Japan
Primary
Secondary
Concomitant
Lymphoproliferative Disorder Other Serious 3/27/2010 57 Female 132 lb 7/23/2010 Physician Japan
Primary
Secondary
Concomitant
Influenza Hospitalization 6/2/2009 35 Male 231 lb 7/27/2010 Physician Switzerland
Primary
Secondary
Concomitant
Osteomyelitis Other Serious 5/27/2010 88 Female 7/30/2010 Physician Japan
Primary
Concomitant
Osteomyelitis Other Serious 5/20/2010 75 Female 8/2/2010 Physician Japan
Primary
Concomitant
Breast Cancer Female Life Threatening 4/26/2010 71 Female 165 lb 8/10/2010 Other Health Professional Japan
Primary
Concomitant
Rib Fracture Other Serious 9/18/2008 67 Female 110 lb 8/12/2010 Physician Japan
Primary
Secondary
Concomitant
Lymphoproliferative Disorder Other Serious 3/27/2010 57 Female 132 lb 8/16/2010 Physician Japan
Primary
Secondary
Concomitant
Rib Fracture Other Serious 9/18/2008 67 Female 110 lb 9/1/2010 Physician Japan
Primary
Secondary
Concomitant
Influenza Hospitalization 6/2/2009 35 Male 231 lb 9/1/2010 Physician Switzerland
Primary
Secondary
Concomitant
Breast Cancer Female Life Threatening 4/26/2010 71 Female 165 lb 9/1/2010 Other Health Professional Japan
Primary
Concomitant
Osteomyelitis Hospitalization 3/1/2009 86 Female 9/16/2010 Physician Japan
Primary
Concomitant
Osteomyelitis Hospitalization 3/1/2009 86 Female 9/17/2010 Physician Japan
Primary
Concomitant
Vasculitis Life Threatening 1/1/2010 69 Female 84 lb 10/11/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Lip And/or Oral Cavity Cancer Hospitalization 9/1/2009 66 Female 10/13/2010 Physician Japan
Primary
Concomitant
Lip And/or Oral Cavity Cancer Hospitalization 8/27/2009 66 Female 10/27/2010 Physician Japan
Primary
Concomitant
Osteomyelitis Hospitalization 3/1/2009 86 Female 10/27/2010 Physician Japan
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/2010 1/10/2011 Physician Japan
Primary
Secondary
Concomitant
Melaena Hospitalization 7/15/2009 49 Female 165 lb 1/19/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Osteomyelitis Other Serious 12/10/2010 71 Female 150 lb 2/8/2011 Physician Japan
Primary
Secondary
Concomitant
Melaena Hospitalization 7/15/2009 49 Female 165 lb 2/14/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Melaena Hospitalization 7/15/2009 49 Female 165 lb 3/7/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Osteomyelitis Other Serious 12/10/2010 71 Female 150 lb 3/8/2011 Physician Japan
Primary
Secondary
Concomitant
Diffuse Large B-cell Lymphoma Hospitalization 3/20/2010 57 Female 110 lb 4/20/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Death 3/27/2010 57 Female 132 lb 4/20/2011 Physician Japan
Primary
Secondary
Concomitant
Lymphoproliferative Disorder Other Serious 3/27/2010 57 Female 132 lb 4/28/2011 Physician Japan
Primary
Secondary
Concomitant
Large Intestine Perforation Disability 4/19/2011 64 Male 108 lb 6/24/2011 Physician Japan
Primary
Secondary
Concomitant
Diverticulitis Disability 4/19/2011 64 Male 108 lb 7/5/2011 Physician Japan
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 10/2/2008 28 Female 112 lb 7/25/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 1/1/2010 70 Female 84 lb 8/11/2011 Physician Japan
Primary
Secondary
Concomitant
Lymphoma Life Threatening 10/20/2008 76 Male 154 lb 9/23/2011 Other Health Professional Japan
Primary
Concomitant
Vasculitis Cerebral Life Threatening 1/1/2010 70 Female 88 lb 10/6/2011 Physician Japan
Primary
Concomitant
Cerebral Infarction Life Threatening 1/1/2010 70 Female 88 lb 10/11/2011 Physician Japan
Primary
Secondary
Concomitant

Drug Data