Folinic Acid combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Respiratory Distress Hospitalization 12/9/2005 72 Male 163 lb 1/13/2006 Consumer United States
Primary
Secondary
Concomitant
Amyotrophic Lateral Sclerosis Hospitalization 3/1/2005 46 Male 1/16/2006 Physician Spain
Primary
Secondary
Concomitant
Respiratory Distress Hospitalization 12/12/2005 72 Male 1/12/2006 France
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 3/1/2005 46 Male 1/26/2006 Physician Spain
Primary
Secondary
Concomitant
Femur Fracture Hospitalization 1/8/2006 Female 135 lb 1/26/2006 Canada
Primary
Concomitant
Tachycardia Hospitalization 10/6/2005 Female 129 lb 2/21/2006 Other Health Professional United Kingdom
Primary
Concomitant
Gastric Perforation Hospitalization 11/9/2005 Female 199 lb 3/2/2006 United States
Primary
Concomitant
Road Traffic Accident Death 8/18/2005 Female 134 lb 4/6/2006 Physician United States
Primary
Concomitant
Urethral Operation Other Serious 3/30/2006 Female 155 lb 5/5/2006 Consumer Canada
Primary
Concomitant
Erythema Multiforme Other Serious 3/1/2006 55 Female 5/26/2006 Physician Spain
Primary
Concomitant
Gastrointestinal Haemorrhage Other Serious 7/6/2006 63 Female 7/19/2006 Consumer Spain
Primary
Concomitant
Urethral Operation Other Serious 3/30/2006 Female 155 lb 7/26/2006 Consumer Canada
Primary
Concomitant
Testis Cancer Other Serious 2/1/2006 35 Male 9/11/2006 Other Health Professional Denmark
Primary
Concomitant
Septic Shock Life Threatening 8/29/2006 50 Male 9/18/2006 Physician Israel
Primary
Concomitant
Fungal Infection Death 10/2/2006 Physician United States
Primary
Concomitant
Mucormycosis Death 10/2/2006 Physician United States
Primary
Concomitant
Osteonecrosis Hospitalization 12/21/2004 58 Female 173 lb 10/13/2006 Physician United Kingdom
Primary
Concomitant
Neck Pain Other Serious 64 Male 201 lb 10/16/2006 Other Health Professional France
Primary
Secondary
Concomitant
Neck Pain Other Serious 64 Male 201 lb 10/16/2006 Other Health Professional France
Primary
Secondary
Concomitant
Mucormycosis Death 10/13/2006 Physician United States
Primary
Concomitant
Renal Failure Acute Hospitalization 7/6/2006 77 Male 11/10/2006 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Stridor Other Serious 9/27/2006 37 Female 125 lb 11/13/2006 Other Health Professional Denmark
Primary
Concomitant
Squamous Cell Carcinoma Other Serious 47 Female 12/4/2006 Other Health Professional United States
Primary
Secondary
Stridor Other Serious 9/26/2006 35 Female 203 lb 1/19/2007 Other Health Professional Denmark
Primary
Concomitant
Stridor Other Serious 9/27/2006 37 Female 125 lb 1/19/2007 Other Health Professional Denmark
Primary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/2005 64 Male 201 lb 2/2/2007 Other Health Professional France
Primary
Secondary
Concomitant
Neutropenic Sepsis Death 2/20/2007 Consumer Australia
Primary
Secondary
Thrombocytopenia Other Serious 2/20/2007 Consumer Australia
Primary
Secondary
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 16 Female 3/14/2007 Other Health Professional France
Primary
Secondary
Stomatitis Life Threatening 1/29/2007 68 Male 159 lb 3/19/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 2/25/2007 Female 149 lb 3/21/2007 Other Health Professional Canada
Primary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 16 Female 110 lb 3/21/2007 Other Health Professional France
Primary
Secondary
Stomatitis Life Threatening 1/29/2007 68 Male 3/22/2007 United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 2/25/2007 Female 149 lb 3/29/2007 Other Health Professional Canada
Primary
Concomitant
Pain Hospitalization 4/2/2007 Female 190 lb 4/25/2007 Consumer Canada
Primary
Concomitant
Pain Hospitalization 4/2/2007 Female 190 lb 5/2/2007 Physician Canada
Primary
Concomitant
Suicidal Ideation Other Serious 7/1/2006 Female 7/23/2007 Other Health Professional Norway
Primary
Concomitant
Tooth Extraction Other Serious 8/1/2006 Female 110 lb 7/27/2007 Canada
Primary
Concomitant
Suicidal Ideation Other Serious 7/1/2006 Female 8/13/2007 Other Health Professional Norway
Primary
Concomitant
Ectopic Pregnancy Other Serious Female 8/31/2007
Primary
Concomitant
Ectopic Pregnancy Other Serious Female 9/14/2007
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 8/22/2007 Female 165 lb 9/21/2007 Canada
Primary
Concomitant
Tooth Loss Hospitalization 4/2/2007 Female 190 lb 9/28/2007 Physician Canada
Primary
Concomitant
Myelodysplastic Syndrome Death 54 9/27/2007 Physician United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Death 61 9/27/2007 Physician United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Death 79 9/27/2007 Physician United States
Primary
Secondary
Concomitant
Skin Lesion Hospitalization 8/22/2007 Female 165 lb 10/4/2007 Canada
Primary
Concomitant
Tooth Loss Hospitalization 4/2/2007 Female 190 lb 10/8/2007 Physician Canada
Primary
Concomitant
Rash Pruritic Other Serious 74 Male 10/17/2007 United States
Primary
Secondary
Sepsis Death 10/22/2007 Other Health Professional United Kingdom
Primary
Secondary
Knee Arthroplasty Hospitalization 5/1/2006 Female 11/28/2007 Brazil
Primary
Concomitant
Rhinorrhoea 5/1/2007 Female 133 lb 12/14/2007 Physician United States
Primary
Concomitant
Injection Site Pain 11/6/2007 Female 153 lb 12/14/2007 Consumer United States
Primary
Concomitant
Injection Site Bruising 9/13/2007 Female 150 lb 12/14/2007 Physician
Primary
Concomitant
Thrombocytopenia Other Serious 37 Male 12/14/2007 Consumer Turkey
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 37 Male 12/20/2007 Physician Turkey
Primary
Concomitant
Mucosal Inflammation Hospitalization 37 Male 12/28/2007 Physician Turkey
Primary
Concomitant
Respiratory Failure Other Serious 2/25/2007 Female 149 lb 1/16/2008 Canada
Primary
Concomitant
Renal Failure Hospitalization 7/21/2007 57 Male 1/23/2008 Consumer United States
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Death 9/24/2007 46 Female 146 lb 1/24/2008 United Kingdom
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 6 Male 1/30/2008 Other Health Professional Turkey
Primary
Secondary
White Blood Cell Count Decreased Life Threatening 8/8/1998 42 Male 1/30/2008 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 6/10/1999 40 Male 1/30/2008 United States
Primary
Secondary
Concomitant
Sepsis Life Threatening 5/2/2001 32 Male 1/30/2008 United States
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 6 Male 2/7/2008 Turkey
Primary
Secondary
Concomitant
Renal Failure Hospitalization 7/21/2007 57 Male 2/11/2008 Consumer United States
Primary
Secondary
Concomitant
Therapeutic Product Ineffective Other Serious 71 Female 2/15/2008
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Other Serious 6 Male 2/21/2008 Turkey
Primary
Secondary
Concomitant
Hypocalcaemia Hospitalization 1/30/2008 9 Male 77 lb 2/28/2008 Physician France
Primary
Concomitant
Hypocalcaemia Hospitalization 1/30/2008 9 Male 77 lb 3/11/2008 Physician France
Primary
Concomitant
Toxic Skin Eruption Hospitalization 10/16/2007 Female 3/21/2008 Other Health Professional France
Primary
Secondary
Concomitant
Vertigo Other Serious 67 Male 3/28/2008
Primary
Secondary
Exsanguination Life Threatening 10/23/1986 23 Male 154 lb 3/31/2008 Physician United Kingdom
Primary
Concomitant
Renal Failure Hospitalization 7/21/2007 57 Male 4/3/2008 Consumer United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 7/21/2007 Male 4/11/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Life Threatening Male 24 lb 4/25/2008 Pharmacist Spain
Primary
Concomitant
Rash Other Serious 3/1/2008 Female 160 lb 5/28/2008 United States
Primary
Concomitant
Cardio-respiratory Arrest Life Threatening Male 24 lb 5/29/2008 Pharmacist Spain
Primary
Concomitant
Musculoskeletal Stiffness 10/1/2006 Female 113 lb 5/30/2008 Consumer United States
Primary
Concomitant
Pain 2/1/2008 Male 205 lb 6/12/2008 Consumer United States
Primary
Concomitant
Mobility Decreased 4/23/2008 Female 145 lb 6/13/2008 United States
Primary
Concomitant
Mucosal Inflammation Hospitalization 15 Male 93 lb 7/10/2008 Belgium
Primary
Secondary
Concomitant
Intra-abdominal Haemorrhage Death 8/8/1998 7/30/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 8/12/2008 Canada
Primary
Secondary
Concomitant
Pupils Unequal Hospitalization 12/1/2007 7 Male 11/10/2008 Consumer France
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 15 Male 93 lb 11/18/2008
Primary
Secondary
Concomitant
Pupils Unequal Hospitalization 12/1/2007 7 Male 12/1/2008 Other Health Professional France
Primary
Secondary
Concomitant
Sciatica Other Serious 33 Female 12/11/2008
Primary
Secondary
Concomitant
Sinus Congestion 5/1/2007 Female 133 lb 12/12/2008 Physician United States
Primary
Concomitant
Vitamin D Decreased 12/1/2007 Female 172 lb 12/12/2008 Consumer United States
Primary
Concomitant
Vomiting Other Serious 77 Female 12/12/2008
Primary
Concomitant
Weight Increased Other Serious 48 Female 1/8/2009
Primary
Secondary
Pupils Unequal Hospitalization 12/1/2007 7 Male 2/2/2009 Consumer France
Primary
Secondary
Concomitant
Renal Failure Other Serious Male 2/11/2009 Consumer United Kingdom
Primary
Secondary
Renal Failure Death 12/10/2008 Male 2/19/2009 Consumer United Kingdom
Primary
Secondary
Nuclear Magnetic Resonance Imaging Brain Abnormal Other Serious 16 Male 2/17/2009 Physician United States
Primary
Concomitant
Mucosal Inflammation Other Serious 9 Female 2/23/2009
Primary
Secondary
Leukoencephalopathy Death Female 2/27/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Leukoencephalopathy Death 5/1/2008 64 Female 3/9/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Leukoencephalopathy Death 5/1/2008 64 Female 3/12/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Parosmia 11/1/2008 Female 191 lb 3/14/2009 Physician United States
Primary
Concomitant
Urticaria Vesiculosa Hospitalization 4/5/2009 Male 26 lb 5/18/2009 Consumer France
Primary
Secondary
Urticaria Vesiculosa Hospitalization 4/5/2009 Male 26 lb 6/29/2009 Consumer France
Primary
Secondary
Weight Decreased Other Serious 3/1/2004 75 Female 7/2/2009
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 7/16/2009 Other Health Professional United Kingdom
Primary
Secondary
Thrombocytopenia Other Serious 7/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Osteonecrosis Hospitalization 12/21/2004 Female 173 lb 8/6/2009 Physician United Kingdom
Primary
Concomitant
Incorrect Dose Administered 11/2/2006 Female 180 lb 9/11/2009 Consumer United States
Primary
Concomitant
Injection Site Pain 6/16/2007 Female 105 lb 9/11/2009 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis 5/1/2007 Female 132 lb 9/12/2009 Consumer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process 9/13/2007 Female 150 lb 9/12/2009 Physician
Primary
Concomitant
Pain 2/1/2008 Male 205 lb 9/12/2009 Consumer United States
Primary
Concomitant
Injection Site Pain 5/1/2008 Female 131 lb 9/12/2009 Consumer United States
Primary
Concomitant
Febrile Neutropenia Death 8/25/2009 19 Male 9/16/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Septic Shock Death 8/25/2009 19 Male 10/29/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Pyrexia Other Serious 12 Male 117 lb 11/3/2009
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 10/6/2009 15 Male 11/5/2009 Physician France
Primary
Concomitant
Interacting
Drug Interaction Hospitalization 10/6/2009 Male 11/6/2009 Other Health Professional France
Primary
Secondary
Concomitant
Diarrhoea Other Serious 9/26/2007 Male 11/11/2009 Physician France
Primary
Secondary
Concomitant
Neurotoxicity Other Serious 10 Male 12/7/2009
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 11/18/2009 77 Female 12/9/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Other Serious 55 Female 12/17/2009 Consumer United Kingdom
Primary
Secondary
Renal Failure Acute Other Serious 14 Male 1/4/2010
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 11/18/2009 77 Female 1/11/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Myelitis Other Serious 13 1/11/2010 Physician United States
Primary
Secondary
Concomitant
Myelitis Other Serious 16 1/11/2010 Physician United States
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 11/18/2009 Female 2/3/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 11/18/2009 77 Female 2/4/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pupils Unequal Hospitalization 12/1/2007 7 Male 2/11/2010 Consumer France
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 11/10/2009 Female 2/17/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 11/18/2009 77 Female 3/3/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 11/10/2009 Female 3/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Fat Embolism Hospitalization 22 Male 3/26/2010 Greece
Primary
Secondary
Fat Embolism Hospitalization 22 Male 4/6/2010 Other Health Professional Greece
Primary
Interacting
Pyrexia Hospitalization 1/6/2010 69 Female 203 lb 4/23/2010 Other Health Professional United States
Primary
Secondary
Uterine Enlargement Other Serious 32 Female 5/6/2010 Physician Greece
Primary
Secondary
Red Blood Cell Sedimentation Rate Increased 10/6/2009 15 Male 5/13/2010 Other Health Professional France
Primary
Concomitant
Interacting
Thrombophlebitis Other Serious 5/18/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 36 Male 5/27/2010 Physician United States
Primary
Concomitant
Uterine Enlargement Other Serious 32 Female 5/27/2010 Physician Greece
Primary
Secondary
Uterine Enlargement Other Serious 32 Female 5/28/2010 Physician Greece
Primary
Secondary
Drug Interaction Hospitalization 10/6/2009 15 Male 6/1/2010 Other Health Professional France
Primary
Concomitant
Interacting
Pleuropericarditis Other Serious 57 Male 6/7/2010 Other Health Professional Italy
Primary
Concomitant
Rectal Neoplasm Other Serious 12/1/2008 52 Male 7/9/2010 Physician Spain
Primary
Concomitant
Drug Toxicity Hospitalization 7/12/2010 8 Male 80 lb 8/13/2010 Physician France
Primary
Concomitant
Interacting
Hypokalaemia Hospitalization 8/22/2010 72 Male 9/16/2010 Physician Germany
Primary
Concomitant
Weight Increased Other Serious 8/1/2009 49 Female 194 lb 9/21/2010 Consumer Brazil
Primary
Concomitant
Vomiting Hospitalization 8/22/2010 72 Male 10/1/2010 Other Health Professional Germany
Primary
Concomitant
Pulmonary Arterial Hypertension Hospitalization 9/17/2010 62 Female 168 lb 10/13/2010 Pharmacist Australia
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/22/2010 72 Male 10/15/2010 Other Health Professional Germany
Primary
Concomitant

Drug Data