Folinic Acid combined with Irinotecan

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pancytopenia Life Threatening 6/13/2005 43 Female 1/23/2006 Other Health Professional Germany
Primary
Secondary
Intestinal Haemorrhage Hospitalization 3/4/2006 73 Male 3/23/2006 Other Health Professional Germany
Primary
Secondary
Venous Thrombosis Hospitalization 10/2/2005 66 Male 3/24/2006 Other Health Professional Germany
Primary
Secondary
Mucosal Inflammation Hospitalization 2/16/2006 48 Female 3/24/2006 Other Health Professional Germany
Primary
Secondary
Vomiting Hospitalization 4/3/2005 56 Female 7/7/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Acute Myocardial Infarction Death 6/4/2006 74 Male 271 lb 7/17/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Septic Shock Other Serious 5/31/2006 58 Male 7/18/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Convulsion Life Threatening 1/26/2006 69 Male 7/24/2006 Other Health Professional United States
Primary
Secondary
Respiratory Tract Infection Life Threatening 9/26/2005 71 Female 7/24/2006 Consumer Germany
Primary
Secondary
Shock Other Serious 5/31/2006 58 Male 8/14/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Pulmonary Fibrosis Disability 5/1/2006 74 161 lb 12/27/2006 Physician Germany
Primary
Secondary
Concomitant
Hypophosphataemia Other Serious 66 Male 1/8/2007 Other Health Professional Germany
Primary
Concomitant
Vomiting Other Serious 7/27/2006 Female 147 lb 1/26/2007 Physician United States
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 5/26/2006 Female 167 lb 2/2/2007 Physician United States
Primary
Concomitant
Rash Hospitalization 10/27/2006 Female 2/5/2007 Physician Australia
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 12/16/2006 Female 2/26/2007 Physician United States
Primary
Concomitant
Hypotension Hospitalization 11/5/2006 Male 4/30/2007 Physician Australia
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2/20/2007 74 Male 4/19/2007 Germany
Primary
Secondary
Septic Shock Life Threatening 12/16/2006 Female 1/8/2008 Physician United States
Primary
Concomitant
Metastases To Liver Other Serious 12/1/2007 Male 1/9/2008 Physician United Kingdom
Primary
Secondary
Bone Disorder Other Serious 12/3/2007 Male 216 lb 1/15/2008 Other Health Professional Germany
Primary
Concomitant
Tumour Lysis Syndrome Death 62 Male 1/15/2008 Physician Germany
Primary
Concomitant
Dermatitis Exfoliative Other Serious 11/8/2007 Female 110 lb 1/18/2008 Pharmacist United Kingdom
Primary
Concomitant
Diarrhoea Hospitalization 1/14/2008 Male 168 lb 1/21/2008 Physician Belgium
Primary
Secondary
Concomitant
Urinary Fistula Hospitalization 4/1/2006 Male 172 lb 1/22/2008 Other Health Professional United Kingdom
Primary
Concomitant
Ileus Hospitalization 10/24/2007 58 Male 1/22/2008 Consumer United States
Primary
Secondary
Malnutrition Hospitalization 12/1/2007 82 Female 1/25/2008 Physician United Kingdom
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 1/14/2008 62 Male 1/25/2008 Other Health Professional Germany
Primary
Secondary
Myocardial Infarction Life Threatening 7/25/2005 78 Male 1/25/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Epilepsy Other Serious 37 Male 1/26/2008 Physician United Kingdom
Primary
Concomitant
Ventricular Fibrillation Hospitalization 5/16/2007 70 Male 1/21/2008 Physician New Zealand
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 1/14/2008 62 Male 1/30/2008 Other Health Professional Germany
Primary
Secondary
Vomiting Other Serious 5/1/2007 82 Female 2/1/2008 Physician Taiwan, Province Of China
Primary
Secondary
Jaundice Hospitalization 8/30/2007 Male 176 lb 2/4/2008 Physician United Kingdom
Primary
Concomitant
Metastases To Liver Hospitalization 12/1/2007 Male 134 lb 2/7/2008 Physician United Kingdom
Primary
Secondary
Thrombosis Hospitalization 2/2/2008 66 Female 2/11/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Other Serious Male 2/9/2008 Other Health Professional Germany
Primary
Secondary
Ventricular Fibrillation Death 70 Male 2/20/2008 New Zealand
Primary
Concomitant
Vomiting Hospitalization 8/14/2007 Male 2/22/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Sudden Death Death 12/1/2007 Male 2/22/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/29/2006 62 Female 2/25/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Ileus Life Threatening 9/18/2007 Female 160 lb 3/5/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Shock Haemorrhagic Death 10/21/2007 Male 3/6/2008 Other Health Professional France
Primary
Concomitant
Nephrotic Syndrome Other Serious 3/18/2006 Male 186 lb 3/11/2008 Other Health Professional Canada
Primary
Concomitant
Haemorrhage Other Serious Male 3/11/2008 Consumer United Kingdom
Primary
Concomitant
Prothrombin Level Decreased Other Serious Female 7/14/2008 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 4/10/2009 Female 12/30/2009 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Sepsis Hospitalization 2/3/2010 61 Male 155 lb 3/2/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Staphylococcal Sepsis Hospitalization 2/3/2010 61 Male 155 lb 3/12/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Tumour Perforation Hospitalization 9/16/2009 Female 132 lb 3/18/2010 Physician France
Primary
Concomitant
Retroperitoneal Abscess Life Threatening 5/15/2008 66 Male 181 lb 5/11/2010 Physician Poland
Primary
Secondary
Pancreatitis Acute Hospitalization 11/2/2008 54 Female 150 lb 5/12/2010 Physician Russian Federation
Primary
Secondary
Pneumocystis Jiroveci Pneumonia Hospitalization 12/28/2009 71 Female 126 lb 5/12/2010 Physician Germany
Primary
Secondary
Concomitant
Autoimmune Thrombocytopenia Other Serious 3/9/2010 68 Male 212 lb 5/18/2010 Physician Germany
Primary
Secondary
Sepsis Death 1/15/2010 51 Male 5/18/2010 Physician United States
Primary
Secondary
Perineal Infection Death 9/24/2009 53 Male 6/1/2010 Physician France
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 11/1/2009 Female 6/7/2010 Other Health Professional United States
Primary
Concomitant
Death Death 5/1/2010 Female 6/11/2010 Physician Belgium
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 11/1/2009 Female 6/14/2010 Other Health Professional United States
Primary
Concomitant
Septic Shock Hospitalization 6/28/2007 51 Female 6/24/2010 Physician France
Primary
Secondary
Tubulointerstitial Nephritis Hospitalization 5/25/2010 57 Male 159 lb 6/24/2010 Physician Germany
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 5/1/2007 50 Female 6/25/2010 Physician United States
Primary
Secondary
Tubulointerstitial Nephritis Hospitalization 5/25/2010 57 Male 159 lb 6/29/2010 Physician Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 2/9/2010 65 Female 119 lb 10/6/2010 Physician Germany
Primary
Secondary
Death Death 10/12/2010 Other Health Professional United Kingdom
Primary
Concomitant
Odynophagia Other Serious 30 Female 12/17/2010 Physician Brazil
Primary
Secondary
Pyrexia Hospitalization 9/25/2006 55 Male 12/17/2010 Physician Australia
Primary
Secondary
Hypokalaemia Life Threatening 12/23/2010 47 Male 165 lb 12/30/2010 Consumer Germany
Primary
Secondary
Stomatitis Other Serious 1/19/2011 Other Health Professional Italy
Primary
Secondary
Focal Segmental Glomerulosclerosis Hospitalization 4/1/2010 60 Male 1/20/2011 Physician France
Primary
Concomitant
Intestinal Obstruction Other Serious Male 152 lb 2/14/2011 Physician Australia
Primary
Secondary
Concomitant
Hypophosphataemia Life Threatening 12/23/2010 47 Male 165 lb 2/21/2011 Other Health Professional Germany
Primary
Secondary
Neoplasm Malignant Other Serious Male 152 lb 2/21/2011 Physician Australia
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 3/11/2010 73 Female 115 lb 2/25/2011 Physician Italy
Primary
Secondary
Concomitant
Diarrhoea Life Threatening 8/11/2008 71 Female 2/28/2011 Physician Germany
Primary
Concomitant
Oesophagitis Hospitalization 2/25/2011 3/8/2011 Physician Sweden
Primary
Secondary
Abnormal Behaviour Hospitalization 2/4/2011 66 Male 3/9/2011 Other Health Professional Italy
Primary
Concomitant
Cerebrovascular Accident Disability 8/29/2010 56 Female 108 lb 3/10/2011 Physician France
Primary
Secondary
Concomitant
Hypophosphataemia Life Threatening 12/23/2010 47 Male 165 lb 3/15/2011 Consumer Germany
Primary
Secondary
Rash Pustular Other Serious 6/15/2010 56 Male 205 lb 3/21/2011 Other Health Professional Germany
Primary
Concomitant
Cerebral Ischaemia Hospitalization 3/13/2011 67 Male 176 lb 3/29/2011 Physician Italy
Primary
Secondary
Concomitant
Cytomegalovirus Infection Other Serious Male 4/1/2011 Other Health Professional France
Primary
Secondary
Concomitant
Device Related Infection Hospitalization 8/4/2010 75 Male 4/7/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 3/11/2011 76 Male 227 lb 4/7/2011 Physician Germany
Primary
Secondary
Concomitant
Dermatitis Other Serious 1/1/2011 60 Female 4/11/2011 Other Health Professional United States
Primary
Concomitant
Hypersensitivity Hospitalization 11/8/2010 63 Male 4/13/2011 Other Health Professional United States
Primary
Concomitant
Neoplasm Malignant Other Serious Female 4/13/2011 Physician United States
Primary
Secondary
Dyspnoea Other Serious 12/1/2010 Male 4/13/2011 Consumer United States
Primary
Concomitant
Device Related Infection Hospitalization 8/4/2010 75 Male 4/13/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 80 Male 4/13/2011 Consumer United Kingdom
Primary
Secondary
Pyrexia Hospitalization 8/4/2010 75 Male 4/15/2011 Physician United States
Primary
Secondary
Concomitant
Grand Mal Convulsion Death 50 Female 4/18/2011 Physician Turkey
Primary
Secondary
Pneumonitis Hospitalization 8/4/2010 75 Male 4/19/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Grand Mal Convulsion Death 50 Female 4/26/2011 Physician Turkey
Primary
Secondary
Grand Mal Convulsion Death 9/3/2010 50 Female 165 lb 4/28/2011 Consumer Turkey
Primary
Concomitant
Respiratory Failure Life Threatening 4/12/2010 66 Female 264 lb 5/2/2011 Physician United States
Primary
Concomitant
Neoplasm Malignant Death Male 165 lb 5/3/2011 Consumer Germany
Primary
Concomitant
No Therapeutic Response Death Female 172 lb 5/3/2011 Consumer Germany
Primary
Concomitant
Neoplasm Malignant Death Female 154 lb 5/3/2011 Physician Germany
Primary
Concomitant
Neoplasm Malignant Death Male 172 lb 5/4/2011 Consumer Germany
Primary
Concomitant
Multi-organ Failure Hospitalization 8/11/2011 68 Male 190 lb 10/16/2012 Consumer De
Primary
Secondary
Concomitant
Pulmonary Embolism Death 8/20/2010 76 Female 157 lb 11/23/2012 Physician De
Primary
Secondary
Concomitant
Cholelithiasis Hospitalization 7/20/2012 69 Female 123 lb 10/19/2012 Physician De
Primary
Concomitant
Hypokalaemia Hospitalization 6/11/2012 71 Male 9/5/2012 Other Health Professional Fr
Primary
Secondary
Concomitant
Vomiting Other Serious 9/6/2012 Other Health Professional Country Not Specified
Primary
Secondary
Disease Progression Other Serious 53 9/12/2012 Physician Ca
Primary
Secondary
Death Death 65 9/12/2012 Physician Ca
Primary
Secondary
Platelet Count Decreased Other Serious 9/10/2012 55 Male 125 lb 9/13/2012 Physician Us
Primary
Concomitant
Skin Toxicity Hospitalization 72 Male 9/14/2012 Consumer De
Primary
Secondary
Fatigue Hospitalization 62 Female 181 lb 9/12/2012 Other Health Professional In
Primary
Secondary
Disease Progression Death Female 11/1/2012 Physician Us
Primary
Concomitant
Toxicity To Various Agents Other Serious 5/2/2011 64 Female 9/17/2012 Physician Us
Primary
Concomitant
Death Death 70 9/20/2012 Physician Ca
Primary
Secondary
Death Death 52 9/20/2012 Physician Ca
Primary
Secondary
Vomiting Other Serious Female 12/27/2012 Physician Us
Primary
Concomitant
Haematotoxicity Other Serious 9/14/2012 Other Health Professional Kr
Primary
Secondary
Concomitant
Metastases To Lung Death 6/2005 Female 9/25/2012 Physician Us
Primary
Concomitant
Weight Decreased Other Serious Female 9/26/2012 Physician Us
Primary
Secondary
Concomitant
Generalised Oedema Other Serious 9/27/2012 Physician Cn
Primary
Concomitant
Liver Function Test Abnormal Hospitalization Female 9/27/2012 Physician Us
Primary
Secondary
Concomitant
Nausea Hospitalization 8/21/2012 Male 143 lb 10/5/2012 Other Health Professional De
Primary
Secondary
Pancytopenia Other Serious 2011 Male 152 lb 10/8/2012 Physician De
Primary
Concomitant
Vein Pain Other Serious 2008 48 Male 159 lb 10/10/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 4/14/2010 51 Female 202 lb 10/10/2012 Physician De
Primary
Secondary
Concomitant
Venous Thrombosis Other Serious 1/2010 Female 148 lb 10/12/2012 Physician De
Primary
Secondary
Concomitant
Paraesthesia Other Serious 8/27/2008 63 Male 174 lb 10/15/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Pyrexia Other Serious 64 Female 168 lb 10/10/2012 Other Health Professional Gb
Primary
Secondary
Tenosynovitis Hospitalization 8/5/2012 10/16/2012 Consumer De
Primary
Secondary
Upper Respiratory Tract Infection Other Serious 66 Male 10/19/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 9/19/2012 71 Male 10/19/2012 Physician Be
Primary
Secondary
Concomitant
Skin Toxicity Other Serious 10/19/2012 Physician Us
Primary
Secondary
Vomiting Hospitalization 9/21/2012 73 Male 181 lb 10/31/2012 Physician De
Primary
Secondary
Concomitant
Cardiac Failure Death 9/22/2012 71 Male 10/22/2012 Consumer De
Primary
Secondary
Concomitant
Neoplasm Malignant Other Serious 10/23/2012 Other Health Professional Us
Primary
Secondary
Thrombocytopenia Other Serious 5/14/2008 62 Female 10/29/2012 Other Health Professional Gb
Primary
Secondary
Neuropathy Peripheral Other Serious 4/11/2008 63 Female 10/29/2012 Other Health Professional Gb
Primary
Secondary
Rash Pustular Hospitalization 8/18/2012 58 Male 11/23/2012 Consumer It
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 10/13/2008 68 Male 10/30/2012 Other Health Professional Gb
Primary
Secondary
Paraesthesia Other Serious 7/18/2006 71 Female 183 lb 10/23/2012 Other Health Professional Gb
Primary
Secondary
Paraesthesia Other Serious 9/12/2007 71 Male 10/23/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/3/2012 74 Male 12/10/2012 Consumer De
Primary
Secondary
Vomiting Hospitalization 7/14/2012 74 Male 12/10/2012 Consumer De
Primary
Secondary
Respiratory Distress Hospitalization 9/6/2011 Female 11/7/2012 Physician Fr
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/21/2012 72 Male 181 lb 11/8/2012 Physician De
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 3/31/2009 62 Female 10/30/2012 Other Health Professional Gb
Primary
Secondary
Paraesthesia Required Intervention 9/12/2007 71 Male 10/26/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 10/8/2012 Female 148 lb 11/15/2012 Physician De
Primary
Secondary
Concomitant
Skin Infection Required Intervention 5/7/2008 63 Female 10/31/2012 Gb
Primary
Secondary
Urinary Tract Infection Required Intervention 2/16/2009 68 Male 10/30/2012 Gb
Primary
Secondary
Thrombosis In Device Life Threatening 4/2009 41 Female 11/16/2012 Physician Country Not Specified
Primary
Concomitant

Drug Data