Folinic Acid combined with Irinotecan Hydrochloride

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Thrombosis Hospitalization 2/2/2008 Female 163 lb 2/28/2008 Physician Germany
Primary
Secondary
Concomitant
Fistula Other Serious 2/23/2008 62 Male 3/21/2008 Physician Germany
Primary
Secondary
Convulsion Hospitalization 2/29/2008 Male 185 lb 3/27/2008 Physician Germany
Primary
Secondary
Concomitant
Convulsion Hospitalization 2/29/2008 Male 185 lb 3/31/2008 Consumer United States
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 1/23/2008 Female 121 lb 4/9/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombosis Hospitalization 9/13/2007 Female 179 lb 4/9/2008 Physician Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/23/2008 Female 121 lb 4/21/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 1/23/2008 Male 150 lb 4/24/2008 Physician Germany
Primary
Secondary
Concomitant
Fistula Hospitalization 3/27/2008 Female 5/1/2008 Physician Germany
Primary
Secondary
Vertigo Hospitalization 7/18/2008 70 Male 203 lb 10/10/2008 Consumer United States
Primary
Secondary
Concomitant
Pneumatosis Intestinalis Other Serious 6/26/2008 Female 10/23/2008 Physician Germany
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 8/9/2007 55 Male 10/24/2008 Consumer United States
Primary
Secondary
Death Death 1/25/2008 Male 11/4/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Lung Abscess Hospitalization 10/14/2008 Male 11/7/2008 Physician Singapore
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 10/5/2008 Male 11/7/2008 Physician Germany
Primary
Secondary
Diarrhoea Hospitalization 9/29/2008 68 Male 11/7/2008 Consumer Germany
Primary
Secondary
Neoplasm Progression Death 9/1/2008 Female 11/7/2008 Physician United Kingdom
Primary
Concomitant
Pelvic Venous Thrombosis Hospitalization 8/9/2007 Male 11/10/2008 Physician Germany
Primary
Secondary
Skin Discolouration Other Serious 10/14/2008 Female 11/12/2008 Physician United Kingdom
Primary
Concomitant
Keratoconjunctivitis Sicca Hospitalization 9/10/2008 Male 11/12/2008 Physician Switzerland
Primary
Secondary
Hyperammonaemia Other Serious 66 Male 11/18/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cerebral Infarction Hospitalization 8/23/2008 11/18/2008 Consumer United Kingdom
Primary
Secondary
Renal Failure Death 63 Female 11/19/2008 Physician Norway
Primary
Secondary
Respiratory Failure Death 58 Male 11/20/2008 Consumer Korea, Republic Of
Primary
Secondary
Concomitant
Anaemia Death 9/16/2008 Female 11/25/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 9/29/2008 Male 11/26/2008 Physician Switzerland
Primary
Secondary
Keratoconjunctivitis Sicca Hospitalization 9/10/2008 Male 12/2/2008 Physician Switzerland
Primary
Secondary
Renal Failure Acute Other Serious 10/5/2008 Female 12/2/2008 Physician Switzerland
Primary
Secondary
Death Death Male 12/5/2008 Physician United Kingdom
Primary
Concomitant
Death Death Male 12/5/2008 Physician United Kingdom
Primary
Concomitant
Death Death Male 12/5/2008 Consumer United Kingdom
Primary
Concomitant
Death Death Female 12/5/2008 Consumer United Kingdom
Primary
Concomitant
Death Death Female 12/5/2008 Physician Belgium
Primary
Concomitant
Thrombocytopenia Life Threatening 11/3/2008 Male 12/8/2008 Physician France
Primary
Secondary
Concomitant
Death Death Male 12/8/2008 Consumer United Kingdom
Primary
Concomitant
Generalised Oedema Hospitalization 10/25/2007 Male 12/9/2008 Physician Italy
Primary
Secondary
Deep Vein Thrombosis Other Serious 5/15/2008 Male 243 lb 12/11/2008 Physician Germany
Primary
Concomitant
Acute Myocardial Infarction Hospitalization 2/22/2008 Male 141 lb 12/15/2008 Physician
Primary
Secondary
Concomitant
Pancreatitis Acute Hospitalization 11/2/2008 Female 150 lb 12/17/2008 Physician Russian Federation
Primary
Secondary
Left Ventricular Dysfunction Life Threatening 11/26/2008 Male 12/19/2008 Physician France
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Hospitalization 10/25/2007 Male 12/22/2008 Physician Italy
Primary
Concomitant
Otosalpingitis Hospitalization 10/16/2008 Female 1/6/2009 Other Health Professional Spain
Primary
Secondary
Cardiomyopathy Life Threatening 12/13/2006 Male 176 lb 2/3/2009 Physician France
Primary
Secondary
Concomitant
Peritonitis Hospitalization 1/1/2009 Female 125 lb 2/9/2009 Physician Russian Federation
Primary
Secondary
Concomitant
Subileus Hospitalization 1/23/2009 Female 136 lb 2/12/2009 Physician Germany
Primary
Secondary
Concomitant
Otosalpingitis Hospitalization 10/16/2008 Female 2/13/2009 Other Health Professional Spain
Primary
Secondary
Fistula Hospitalization 3/27/2008 Female 2/23/2009 Physician Germany
Primary
Secondary
Haematemesis Hospitalization 3/21/2006 59 Male 2/20/2009 Physician France
Primary
Secondary
Concomitant
Sepsis Hospitalization 7/15/2008 Male 176 lb 2/27/2009 Physician Poland
Primary
Secondary
Concomitant
Otosalpingitis Hospitalization 10/16/2008 Female 3/4/2009 Other Health Professional Spain
Primary
Secondary
General Physical Health Deterioration Life Threatening 10/2/2008 Male 3/4/2009 Physician France
Primary
Secondary
Hyponatraemia Other Serious 2/24/2009 66 Male 134 lb 3/18/2009 Physician Taiwan, Province Of China
Primary
Secondary
Concomitant
Stomatitis Hospitalization 12/17/2008 Male 141 lb 3/25/2009 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Hepatic Steatosis Hospitalization 1/1/2009 55 Male 4/8/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Myocardial Infarction Death 10/30/2008 Female 104 lb 5/6/2009 Physician Japan
Primary
Secondary
Concomitant
Abdominal Distension Hospitalization 4/15/2009 Female 5/8/2009 Physician United Kingdom
Primary
Secondary
Lung Abscess Hospitalization 10/14/2008 Male 5/8/2009 Physician Singapore
Primary
Secondary
Concomitant
Retroperitoneal Abscess Life Threatening 5/15/2008 Male 181 lb 5/11/2009 Physician Poland
Primary
Secondary
Dyspnoea Hospitalization 10/5/2008 Male 6/22/2009 Physician Germany
Primary
Secondary
Myocardial Infarction Death 10/30/2008 Female 104 lb 8/24/2009 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 12/8/2008 Male 150 lb 10/16/2009 Other Health Professional United States
Primary
Secondary
Small Intestinal Perforation Hospitalization 9/13/2007 Male 190 lb 10/19/2009 Physician France
Primary
Secondary
Renal Failure Hospitalization 8/15/2006 72 Male 10/19/2009 Physician France
Primary
Secondary
Toxic Skin Eruption Other Serious 9/13/2009 Male 11/10/2009 Physician France
Primary
Secondary
Concomitant
Neutropenia Other Serious 9/5/2004 Male 157 lb 11/14/2009 Physician France
Primary
Secondary
Colitis Hospitalization 10/11/2007 Male 11/18/2009 Physician France
Primary
Secondary
Concomitant
Anal Abscess Hospitalization 5/13/2008 11/19/2009 Physician France
Primary
Secondary
Febrile Bone Marrow Aplasia Hospitalization 6/12/2007 Male 11/23/2009 Physician United States
Primary
Secondary
Concomitant
Intestinal Anastomosis Complication Hospitalization 12/16/2009 Male 3/8/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Lacrimation Increased Hospitalization 4/21/2009 58 Female 110 lb 3/25/2010 Other Health Professional United States
Primary
Concomitant
Nausea Death 76 Male 3/29/2010 Physician France
Primary
Secondary
Concomitant
Toxic Skin Eruption Other Serious 9/13/2009 67 Male 4/1/2010 Physician France
Primary
Secondary
Concomitant
Lung Abscess Hospitalization 1/1/2009 71 Female 4/12/2010 Physician Germany
Primary
Secondary
Pseudomonal Sepsis Hospitalization 1/23/2009 68 Male 161 lb 4/12/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 4/13/2008 74 Female 165 lb 4/13/2010 Physician Spain
Primary
Secondary
Vomiting Hospitalization 1/3/2010 50 Female 136 lb 4/15/2010 Physician United States
Primary
Secondary
Concomitant
Paraesthesia Hospitalization 7/12/2008 32 Male 165 lb 4/27/2010 Physician United States
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 10/26/2006 47 Female 4/27/2010 Physician United Kingdom
Primary
Concomitant
Pulmonary Embolism Other Serious 6/3/2008 76 Male 212 lb 4/27/2010 Other Health Professional Sweden
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 4/13/2008 74 Female 165 lb 5/4/2010 Physician Spain
Primary
Secondary
Amnesia Other Serious 11/28/2008 74 Female 5/4/2010 Other Health Professional United Kingdom
Primary
Secondary
Pseudomonal Sepsis Hospitalization 1/23/2009 68 Male 161 lb 5/4/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Hyperbilirubinaemia Hospitalization 3/10/2009 51 Female 151 lb 5/5/2010 Physician Ukraine
Primary
Secondary
Peritonitis Hospitalization 1/1/2009 58 Female 125 lb 5/5/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 4/30/2008 72 Male 5/7/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization 10/4/2005 Female 5/12/2010 Physician United States
Primary
Secondary
Lung Abscess Hospitalization 10/14/2008 62 Male 5/11/2010 Physician Singapore
Primary
Secondary
Concomitant
Bacterial Sepsis Hospitalization 5/17/2010 68 Male 6/9/2010 Physician United States
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 12/28/2009 71 Female 126 lb 6/11/2010 Physician Germany
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 5/7/2010 68 Male 168 lb 8/3/2010 Physician Germany
Primary
Secondary
Concomitant
Cerebrovascular Accident Life Threatening 5/8/2008 52 Male 183 lb 9/13/2010 Physician Germany
Primary
Secondary
Concomitant
Enterobacter Sepsis Hospitalization 8/28/2007 57 Male 136 lb 10/4/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Stomatitis Other Serious 11/18/2009 56 Female 139 lb 10/13/2010 Physician United States
Primary
Concomitant
Cerebrovascular Accident Life Threatening 5/8/2008 52 Male 183 lb 11/10/2010 Physician Germany
Primary
Secondary
Concomitant
Constipation Hospitalization 3/4/2010 74 Male 190 lb 11/18/2010 Physician Germany
Primary
Secondary
Concomitant
Ileus Hospitalization 11/20/2010 47 Male 187 lb 12/9/2010 Physician Germany
Primary
Secondary
Concomitant
Dystonia Other Serious 8/18/2010 66 Female 12/21/2010 Spain
Primary
Secondary
Colorectal Cancer Metastatic Other Serious Male 1/20/2011 Other Health Professional Australia
Primary
Concomitant
Hypertension Other Serious 3/15/2011 Physician Finland
Primary
Secondary
Deep Vein Thrombosis Other Serious 12/14/2008 57 Male 181 lb 3/22/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Cerebral Infarction Life Threatening 3/10/2011 56 Male 205 lb 3/23/2011 Physician Germany
Primary
Secondary
Cerebrovascular Accident Hospitalization 3/13/2011 67 Male 176 lb 3/23/2011 Physician Italy
Primary
Secondary
Pancreatitis Other Serious 3/23/2011 Other Health Professional Australia
Primary
Concomitant
Dehydration Hospitalization 3/11/2011 76 Male 227 lb 3/24/2011 Physician Germany
Primary
Secondary
Concomitant
Proteinuria Other Serious 3/25/2011 Consumer United Kingdom
Primary
Secondary
Pancreatitis Other Serious 3/25/2011 Other Health Professional Australia
Primary
Concomitant
Sepsis Hospitalization 2/16/2011 Male 226 lb 4/5/2011 Physician United States
Primary
Secondary
Pneumonia Fungal Hospitalization 3/8/2011 71 Female 216 lb 4/6/2011 Physician Germany
Primary
Secondary
No Therapeutic Response Death Male 172 lb 5/6/2011 Physician Germany
Primary
Concomitant
Syncope Hospitalization 5/18/2012 64 Female 161 lb 7/2/2012 Physician Germany
Primary
Secondary
Myoclonus Other Serious 1/1/2012 52 Female 7/9/2012 Other Health Professional France
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9/1/2007 46 Female 70 lb 7/11/2012 Physician United States
Primary
Secondary
Concomitant
Cystitis Hospitalization 7/3/2012 64 Female 174 lb 7/20/2012 Physician Germany
Primary
Secondary
Concomitant
Rash Other Serious 12/14/2008 70 Male 7/20/2012 Physician Germany
Primary
Secondary
Concomitant
Hepatitis Cholestatic Other Serious 4/1/2012 78 Male 8/2/2012 Physician France
Primary
Concomitant
Sudden Death Death 4/22/2010 73 Female 6/3/2013 Physician De
Primary
Secondary
Ileal Fistula Death 8/12/2010 66 Male 185 lb 9/13/2012 Physician De
Primary
Secondary
Concomitant
Pulmonary Embolism Death 7/22/2009 62 Female 139 lb 9/19/2012 Physician De
Primary
Secondary
Concomitant
Stomatitis Other Serious 9/10/2012 Other Health Professional Country Not Specified
Primary
Secondary
Metastases To Lung Other Serious 36 Female 8/31/2012 Other Health Professional Us
Primary
Secondary
Neuropathy Peripheral Other Serious 64 Female 168 lb 10/16/2012 Physician Gb
Primary
Secondary
Vein Pain Other Serious 2008 48 Male 159 lb 10/16/2012 Physician Gb
Primary
Secondary
Concomitant
Vein Pain Other Serious 2008 48 Male 10/16/2012 Physician Dk
Primary
Secondary
Upper Respiratory Tract Infection Other Serious 66 Male 10/23/2012 Physician Gb
Primary
Secondary
Concomitant
Paraesthesia Other Serious 8/27/2008 63 Male 10/8/2012 Physician Dk
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 7/20/2010 66 Female 10/30/2012 Other Health Professional It
Primary
Secondary
Concomitant
Neurotoxicity Other Serious 9/12/2007 71 Male 10/31/2012 Physician Gb
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 10/13/2008 68 Male 11/5/2012 Physician Gb
Primary
Secondary
Neuropathy Peripheral Other Serious 4/11/2008 63 Female 11/5/2012 Physician Gb
Primary
Secondary
Thrombocytopenia Other Serious 5/14/2008 62 Female 11/9/2012 Other Health Professional Gb
Primary
Secondary
Lower Respiratory Tract Infection Hospitalization 12/5/2011 73 Male 139 lb 12/10/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Vomiting Other Serious NotSpecified 9/13/2013 Physician Es
Primary
Secondary
Weight Decreased Hospitalization 2009 73 Male 161 lb 1/21/2013 Physician Gb
Primary
Secondary
Concomitant
Scrotal Swelling Hospitalization 4/11/2009 53 Male 152 lb 1/21/2013 Physician Gb
Primary
Secondary
Disease Progression Other Serious Male 172 lb 2/4/2013 Consumer Ca
Primary
Concomitant
Thrombocytopenia Life Threatening 35 Male 2/7/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 11/2012 Male 2/19/2013 Physician Us
Primary
Secondary
Concomitant
Disease Progression Other Serious 65 NotSpecified 3/1/2013 Physician Ca
Primary
Secondary
Disease Progression Other Serious 75 NotSpecified 3/1/2013 Physician Ca
Primary
Secondary
Disease Progression Other Serious 81 NotSpecified 3/1/2013 Physician Ca
Primary
Secondary
Disease Progression Other Serious NotSpecified 3/6/2013 Physician Ca
Primary
Secondary
Disease Progression Other Serious NotSpecified 3/7/2013 Physician Ca
Primary
Secondary
Headache Other Serious 2/2013 Male 195 lb 3/18/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 12/2/2010 Female 115 lb 9/12/2012 Pharmacist Ca
Primary
Secondary
Concomitant
Oral Pain Other Serious NotSpecified 4/1/2013 Other Health Professional Us
Primary
Secondary
Gamma-glutamyltransferase Increased Other Serious 10/4/2012 60 Male 196 lb 4/19/2013 Physician De
Primary
Secondary
Concomitant
Sudden Death Death 4/22/2010 73 Female 5/20/2013 Physician De
Primary
Secondary
Thrombocytopenia Other Serious 61 Female 6/25/2013 Physician Us
Primary
Secondary
Gastrointestinal Perforation Life Threatening NotSpecified 5/30/2013 Physician Br
Primary
Secondary
Ileostomy Other Serious 5/2012 55 Male 165 lb 6/10/2013 Consumer Ca
Primary
Secondary

Drug Data