Folic Acid combined with Valproate Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Unintended Pregnancy Other Serious 8/30/2005 19 Female 2/1/2006 Physician Germany
Primary
Concomitant
Weight Decreased Hospitalization 11/4/2005 Female 2/9/2006 United Kingdom
Primary
Concomitant
Renal Failure Death 2/24/2006 55 Female 3/14/2006 United States
Primary
Concomitant
Somnolence Other Serious 1/1/1994 32 Female 121 lb 3/29/2006 Physician Germany
Primary
Secondary
Concomitant
Gastroschisis Death Male 4/6/2006 Physician Poland
Primary
Concomitant
Thrombotic Thrombocytopenic Purpura Hospitalization 2/3/2006 43 Female 183 lb 4/3/2006 United States
Primary
Concomitant
Breast Cancer Required Intervention 2/1/2005 55 Female 159 lb 2/27/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/7/2006 66 Male 5/18/2006 United States
Primary
Concomitant
Leukopenia Required Intervention 12/6/2005 53 Female 3/7/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/9/2005 46 Male 1/13/2006 United States
Primary
Concomitant
Ventricular Septal Defect Death 0 Female 13 lb 8/19/2006 United States
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 10/31/2005 28 Female 2/15/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/23/2005 55 Male 2/27/2006 Consumer United States
Primary
Concomitant
Ventricular Septal Defect Death 0 Female 13 lb 8/25/2006 United States
Primary
Secondary
Concomitant
Unintended Pregnancy Other Serious 8/30/2005 19 Female 8/21/2006 Physician Germany
Primary
Concomitant
Vomiting Other Serious 7/5/2006 54 Male 108 lb 8/24/2006 United Kingdom
Primary
Concomitant
Ventricular Septal Defect Death 0 Female 13 lb 8/19/2006 United States
Primary
Secondary
Concomitant
Drug Exposure During Pregnancy Congenital Anomaly 7/27/2006 NotSpecified 10/13/2006 Physician United States
Primary
Concomitant
Pregnancy Other Serious 2/13/2006 0 Male 12/23/2006 Physician Norway
Primary
Secondary
Concomitant
Drug Exposure During Pregnancy Congenital Anomaly 7/27/2006 Female 2/5/2007 Other Health Professional United States
Primary
Concomitant
Neutropenia Other Serious 12/14/2006 60 Female 128 lb 2/15/2007 Other Health Professional United Kingdom
Primary
Concomitant
Wrong Drug Administered 12/30/2005 66 Female 300 lb 2/28/2007 Pharmacist United States
Primary
Secondary
Concomitant
Drug Exposure During Pregnancy Congenital Anomaly 7/27/2006 Female 3/27/2007 Physician United States
Primary
Concomitant
Drug Exposure During Pregnancy Congenital Anomaly 7/27/2006 Female 4/5/2007 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/4/2007 55 Male 189 lb 5/29/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Premature Baby Congenital Anomaly 7/27/2006 Female 6 lb 6/29/2007 Physician United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 4/18/2004 31 Female 7/9/2007 United States
Primary
Concomitant
Vision Blurred Hospitalization 6/18/2007 23 Female 7/16/2007 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Rash Maculo-papular Other Serious 2/7/2007 28 Female 7/20/2007 Consumer United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 11/4/2005 Male 7/26/2007 Other Health Professional United Kingdom
Primary
Concomitant
Vision Blurred Hospitalization 6/18/2007 23 Female 7/30/2007 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Transplant Failure Required Intervention 2/7/2007 28 Female 8/20/2007 United Kingdom
Primary
Concomitant
Clavicle Fracture Hospitalization 12/21/2006 Male 130 lb 9/14/2007 United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 2/7/2007 28 Female 143 lb 9/21/2007 Consumer United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 11/4/2005 Male 10/29/2007 Other Health Professional United Kingdom
Primary
Concomitant
Cataract Other Serious 61 Female 11/30/2007 Consumer France
Primary
Concomitant
Injection Site Pruritus 9/17/2007 Male 208 lb 12/14/2007 United States
Primary
Concomitant
Ear Infection 10/27/2007 Male 188 lb 12/14/2007 United States
Primary
Concomitant
Muscular Weakness Congenital Anomaly 7/27/2006 Female 6 lb 1/2/2008 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 2/7/2007 28 Female 143 lb 2/29/2008 Consumer United Kingdom
Primary
Concomitant
Drug Administration Error 2/25/2008 50 Female 133 lb 3/15/2008 United States
Primary
Concomitant
Injection Site Irritation 2/11/2008 Female 185 lb 3/15/2008 United States
Primary
Concomitant
White Blood Cell Count Increased Required Intervention 2/7/2007 28 Female 143 lb 3/27/2008 United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 3/31/2008 57 Male 4/24/2008 Other Health Professional Ireland
Primary
Concomitant
Protein Urine Present Other Serious Female 5/2/2008 Other Health Professional France
Primary
Concomitant
Grand Mal Convulsion Other Serious 3/2/1998 Female 5/5/2008 Physician France
Primary
Concomitant
Thrombocytopenia Life Threatening 66 Female 5/30/2008 Other Health Professional France
Primary
Concomitant
Grand Mal Convulsion Other Serious 3/1/1984 Female 5/30/2008 Physician France
Primary
Secondary
Concomitant
Grand Mal Convulsion Other Serious Female 6/2/2008 Physician France
Primary
Secondary
Concomitant
Convulsion Other Serious Female 6/6/2008 Physician France
Primary
Concomitant
Psychotic Disorder Other Serious Male 6/16/2008 Other Health Professional United Kingdom
Primary
Concomitant
Hyponatraemia Hospitalization 6/16/2008 58 Female 7/11/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Other Serious 6/29/2008 64 Male 7/29/2008 Other Health Professional France
Primary
Secondary
Concomitant
Speech Disorder Developmental Congenital Anomaly Female 7 lb 9/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Strabismus Congenital Anomaly 12/28/1997 Male 9/26/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Paraesthesia Other Serious 4/1/2007 52 Male 12/4/2008 Physician Switzerland
Primary
Secondary
Concomitant
Vision Blurred 8/1/2007 Male 250 lb 12/12/2008 Consumer United States
Primary
Secondary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 12/3/2008 United States
Primary
Secondary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 12/3/2008 United States
Primary
Secondary
Concomitant
Shoulder Deformity Congenital Anomaly 0 2/2/2009 France
Primary
Concomitant
Muscular Weakness Congenital Anomaly 7/27/2006 Female 6 lb 1/23/2009 Physician United States
Primary
Concomitant
Ventricular Septal Defect Congenital Anomaly 0 Female 2/6/2009 France
Primary
Concomitant
Somnolence Hospitalization 1/1/2007 77 Female 2/9/2009 Other Health Professional France
Primary
Secondary
Concomitant
Ventricular Septal Defect Congenital Anomaly 0 Female 2/20/2009 France
Primary
Concomitant
Shoulder Deformity Congenital Anomaly 0 2/20/2009 France
Primary
Concomitant
Pain Other Serious 1/1/2006 Female 240 lb 3/14/2009 Consumer United States
Primary
Concomitant
Gastrointestinal Tube Insertion Hospitalization 2/11/2009 Female 4/9/2009 Pharmacist United Kingdom
Primary
Concomitant
Device Malfunction Other Serious 1/1/2008 4/9/2009 Pharmacist United Kingdom
Primary
Concomitant
Urinary Incontinence Life Threatening 12/1/2008 90 Female 4/22/2009 Other Health Professional France
Primary
Concomitant
Schizophrenia Other Serious 2/11/2009 5/4/2009 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/1997 23 Male 150 lb 5/21/2009 United States
Primary
Concomitant
Gingival Ulceration Other Serious Female 158 lb 6/3/2009 Canada
Primary
Concomitant
Tremor Disability 1/1/2009 70 6/4/2009 Other Health Professional France
Primary
Concomitant
Pyrexia Hospitalization 1/22/2009 69 Female 6/11/2009 Other Health Professional United Kingdom
Primary
Concomitant
Tooth Fracture Other Serious Female 158 lb 6/19/2009 Canada
Primary
Concomitant
Spina Bifida Required Intervention 6/18/2009 United Kingdom
Primary
Secondary
Meningomyelocele Congenital Anomaly 6/18/2009 United Kingdom
Primary
Secondary
Schizophrenia Other Serious 2/11/2009 7/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Ischaemia Death Male 130 lb 8/11/2009 United Kingdom
Primary
Concomitant
Malaise Death Male 8/20/2009 Other Health Professional Australia
Primary
Concomitant
Gastrointestinal Tube Insertion Hospitalization 2/11/2009 Female 9/22/2009 Pharmacist United Kingdom
Primary
Concomitant
Gastrointestinal Tube Insertion Hospitalization 2/11/2009 Female 10/12/2009 Pharmacist United Kingdom
Primary
Concomitant
Gastrointestinal Tube Insertion Hospitalization 2/11/2009 Female 10/14/2009 United Kingdom
Primary
Concomitant
Gastrointestinal Tube Insertion Hospitalization 2/11/2009 Female 11/24/2009 Pharmacist United Kingdom
Primary
Concomitant
Autism Other Serious 1/5/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Polydactyly Congenital Anomaly 0 2/10/2010 France
Primary
Secondary
Ventricular Septal Defect Congenital Anomaly 0 3/25/2010 France
Primary
Secondary
Treatment Noncompliance Hospitalization 38 Female 4/2/2010 Other Health Professional France
Primary
Secondary
Drug Abuse Hospitalization 38 Female 4/5/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 38 Female 4/20/2010 Other Health Professional France
Primary
Secondary
Concomitant
Premature Baby Hospitalization 2/15/2002 Female 6 lb 5/19/2010 Physician United Kingdom
Primary
Concomitant
Tumour Necrosis Hospitalization 12/17/2009 67 Female 7/1/2010 Japan
Primary
Concomitant
Constipation 9/1/2007 57 Male 294 lb 7/15/2010 Consumer United States
Primary
Concomitant
Renal Tuberculosis Hospitalization 12/17/2009 67 Female 7/13/2010 Japan
Primary
Concomitant
Fall Hospitalization 12/17/2009 67 Female 7/29/2010 Japan
Primary
Concomitant
Necrosis Hospitalization 12/17/2009 67 Female 8/6/2010 Other Health Professional Japan
Primary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/2007 65 Female 117 lb 8/27/2010 Other Health Professional United Kingdom
Primary
Concomitant
Somnolence 5/23/2010 33 Female 9/8/2010 Other Health Professional Ireland
Primary
Concomitant
Hyponatraemia Hospitalization 9/7/2010 44 Female 168 lb 9/24/2010 United Kingdom
Primary
Concomitant
Somnolence Other Serious 5/23/2010 33 Female 10/21/2010 Other Health Professional Ireland
Primary
Concomitant
Grand Mal Convulsion Other Serious Female 10/25/2010 Other Health Professional Germany
Primary
Concomitant
Confusional State Hospitalization 7/21/2009 65 Male 255 lb 11/12/2010 Consumer United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/2007 65 Female 117 lb 12/8/2010 Other Health Professional United Kingdom
Primary
Concomitant
Pancreatitis Necrotising Other Serious 6/1/2009 65 Female 12/28/2010 Physician Germany
Primary
Secondary
Concomitant
Wound Complication Hospitalization 12/17/2009 67 Female 12/16/2010 Other Health Professional Japan
Primary
Concomitant
Urinary Tract Infection Other Serious 5/21/2008 70 Female 157 lb 1/13/2011 Other Health Professional United Kingdom
Primary
Concomitant
Fall Hospitalization 12/17/2007 65 Female 1/18/2011 Other Health Professional Japan
Primary
Concomitant
Constipation Hospitalization 12/17/2009 67 Female 2/7/2011 Other Health Professional Japan
Primary
Concomitant
Gaze Palsy Hospitalization 8/10/2010 57 Female 146 lb 3/30/2011 Other Health Professional Japan
Primary
Concomitant
Cleft Palate Congenital Anomaly 24 4/13/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Back Pain Hospitalization 12/17/2009 67 Female 4/15/2011 Other Health Professional Japan
Primary
Concomitant
Malabsorption Hospitalization 8/10/2010 57 Female 146 lb 4/15/2011 Other Health Professional Japan
Primary
Concomitant
Drug Exposure During Pregnancy Congenital Anomaly 1/1/2004 5/9/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Exposure During Pregnancy Congenital Anomaly 1/1/2004 5/9/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ruptured Cerebral Aneurysm Hospitalization 8/10/2010 57 Female 146 lb 4/26/2011 Other Health Professional Japan
Primary
Concomitant
Aortic Aneurysm Hospitalization 8/10/2010 57 Female 146 lb 5/3/2011 Other Health Professional Japan
Primary
Concomitant
Abortion Induced Other Serious Female 5/23/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Drug Exposure During Pregnancy Other Serious Female 5/23/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Abortion Induced Other Serious Female 5/23/2011 Physician Germany
Primary
Secondary
Concomitant
Anticonvulsant Drug Level Decreased Other Serious 12/1/2010 Female 5/24/2011 Other Health Professional United Kingdom
Primary
Concomitant
Convulsion Hospitalization 8/10/2010 57 Female 146 lb 5/24/2011 Physician Japan
Primary
Concomitant
Red Blood Cell Count Increased Hospitalization 3/29/2011 30 Female 6/2/2011 Physician Japan
Primary
Concomitant
Toxicity To Various Agents Other Serious Male 6/4/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Contusion Hospitalization 12/17/2009 67 Female 6/10/2011 Physician Japan
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 1/1/2011 35 Female 6/16/2011 Physician France
Primary
Secondary
Concomitant
Ventricular Fibrillation Life Threatening 6/20/2011 60 Male 190 lb 7/5/2011 Physician Australia
Primary
Concomitant
Epilepsy Other Serious 51 Male 6/22/2011 Consumer United Kingdom
Primary
Concomitant
Developmental Delay Congenital Anomaly 11/1/2010 Male 9 lb 7/15/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
T-cell Lymphoma Other Serious 6/14/2011 71 Female 8/1/2011 Physician France
Primary
Concomitant
T-cell Lymphoma Other Serious 6/14/2011 71 Female 157 lb 8/12/2011 Physician France
Primary
Concomitant
Meningioma Hospitalization 12/17/2009 67 Female 9/13/2011 Physician Japan
Primary
Concomitant
Diabetes Mellitus Other Serious 3/24/2003 50 Female 9/14/2011 Consumer Canada
Primary
Concomitant
Insomnia Other Serious 51 Male 9/14/2011 United Kingdom
Primary
Concomitant
Flatulence Hospitalization 67 Female 10/7/2011 Other Health Professional New Zealand
Primary
Concomitant
Interacting
Meningioma Hospitalization 12/17/2009 68 Female 10/12/2011 Physician Japan
Primary
Concomitant
Meningioma Hospitalization 12/17/2009 68 Female 10/20/2011 Physician Japan
Primary
Concomitant
Squamous Cell Carcinoma Other Serious 7/14/2011 57 Female 10/27/2011 Physician United States
Primary
Secondary
Concomitant
Hypotonia Congenital Anomaly 11/1/2010 Male 9 lb 11/1/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Intracranial Aneurysm Hospitalization 12/17/2009 68 Female 11/7/2011 Physician Japan
Primary
Concomitant
Pruritus Hospitalization 10/1/2011 46 Female 11/21/2011 Other Health Professional Australia
Primary
Concomitant
Dysarthria Other Serious Male 11/22/2011 Other Health Professional Canada
Primary
Secondary
Concomitant
Hallucination Other Serious 10/18/2010 38 Female 12/7/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Confusional State Hospitalization 7/21/2009 65 Male 255 lb 12/29/2011 Physician United States
Primary
Secondary
Concomitant
Intracranial Aneurysm Hospitalization 12/17/2009 68 Female 1/9/2012 Physician Japan
Primary
Concomitant
Premature Baby Other Serious 11/28/2008 0 Male 8 lb 1/18/2012 Physician United States
Primary
Secondary
Concomitant
Mean Cell Haemoglobin Decreased Other Serious Female 152 lb 1/27/2012 Physician United Kingdom
Primary
Concomitant
Maternal Exposure During Pregnancy Other Serious 1/1/2007 22 Female 2/3/2012 Physician France
Primary
Secondary
Concomitant
Blood Pressure Increased Congenital Anomaly 1/1/2007 -1 Female 5 lb 2/3/2012 Physician France
Primary
Secondary
Concomitant
Lymphocyte Count Decreased Hospitalization 12/13/2011 2/7/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Other Serious 12/13/2011 52 Female 2/9/2012 Physician United Kingdom
Primary
Concomitant
Interacting

Drug Data