Folic Acid combined with Tocilizumab

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting Hospitalization 7/28/2006 64 Female 157 lb 8/18/2006 Physician Canada
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Hospitalization 5/7/2009 Male 274 lb 6/18/2009 Physician United States
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Hospitalization 5/7/2009 Male 274 lb 8/7/2009 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Death 11/21/2007 Female 9/11/2009 Germany
Primary
Concomitant
Respiratory Failure Death 11/21/2007 Female 9/14/2009 Germany
Primary
Concomitant
Respiratory Failure Death 11/21/2007 Female 143 lb 9/15/2009 Physician Germany
Primary
Concomitant
Respiratory Failure Hospitalization 11/21/2007 Female 10/13/2009 Germany
Primary
Concomitant
Alveolitis Other Serious 3/1/2009 Female 164 lb 10/27/2009 Physician United States
Primary
Secondary
Concomitant
Endometrial Cancer Metastatic Other Serious Female 261 lb 10/30/2009 Physician United States
Primary
Secondary
Concomitant
Malignant Pleural Effusion Hospitalization 10/20/2009 Female 150 lb 1/5/2010 Physician United States
Primary
Secondary
Concomitant
Osteomyelitis Hospitalization 12/15/2009 Female 158 lb 1/14/2010 Physician United States
Primary
Secondary
Concomitant
Quadriparesis Hospitalization 1/1/2010 Female 1/15/2010 Physician Japan
Primary
Secondary
Concomitant
Laboratory Test Abnormal Other Serious 1/6/2010 Female 148 lb 1/22/2010 Physician United States
Primary
Secondary
Concomitant
Subdural Haematoma Hospitalization 12/6/2009 Female 117 lb 1/25/2010 Physician Mexico
Primary
Secondary
Concomitant
Subdural Haematoma Hospitalization 12/6/2009 Female 117 lb 1/29/2010 Physician Mexico
Primary
Secondary
Concomitant
Subarachnoid Haemorrhage Death 10/23/2008 Female 132 lb 2/1/2010 Physician China
Primary
Secondary
Concomitant
Lung Neoplasm Life Threatening 10/16/2009 Female 150 lb 2/1/2010 Physician Brazil
Primary
Concomitant
Renal Neoplasm Other Serious 10/15/2009 Female 161 lb 2/2/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Lung Neoplasm Other Serious 11/25/2009 Male 196 lb 2/2/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumonia Hospitalization 3/12/2008 Female 194 lb 2/3/2010 Physician United States
Primary
Secondary
Concomitant
Aortic Aneurysm Hospitalization Female 200 lb 2/4/2010 Physician United States
Primary
Concomitant
Renal Neoplasm Other Serious 10/12/2009 Female 161 lb 2/5/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 11/21/2007 Female 2/5/2010 Germany
Primary
Concomitant
Cholelithiasis Hospitalization 12/17/2009 Male 224 lb 2/8/2010 Physician Canada
Primary
Concomitant
Pulmonary Embolism Hospitalization 11/21/2009 Female 481 lb 2/8/2010 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 11/21/2007 Female 2/8/2010 Germany
Primary
Concomitant
Bursitis Infective Hospitalization 8/1/2009 Female 148 lb 2/9/2010 Physician Netherlands
Primary
Concomitant
Respiratory Failure Hospitalization 11/21/2007 Female 2/9/2010 Germany
Primary
Concomitant
Gastric Ulcer Hospitalization 8/2/2006 Female 187 lb 2/10/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 1/22/2010 Male 187 lb 2/10/2010 Physician Mexico
Primary
Secondary
Concomitant
Prostate Cancer Life Threatening 12/9/2008 Male 212 lb 2/11/2010 Physician United States
Primary
Concomitant
Pneumonia Hospitalization 3/12/2008 Female 194 lb 2/12/2010 Physician United States
Primary
Secondary
Concomitant
Lung Neoplasm Other Serious 11/1/2009 Male 196 lb 2/12/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Procedural Pain Hospitalization 6/4/2009 Female 133 lb 2/12/2010 Physician United States
Primary
Secondary
Concomitant
Renal Mass Other Serious 10/12/2009 Female 161 lb 2/12/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Myasthenia Gravis Hospitalization 4/16/2009 Female 257 lb 2/16/2010 Physician South Africa
Primary
Secondary
Concomitant
Syncope Hospitalization 10/15/2009 Female 111 lb 2/16/2010 Physician United States
Primary
Concomitant
Respiratory Failure Life Threatening 1/22/2010 Male 187 lb 2/16/2010 Physician Mexico
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 1/18/2010 Male 216 lb 2/17/2010 Physician Canada
Primary
Secondary
Concomitant
Spindle Cell Sarcoma Life Threatening 3/13/2008 Female 328 lb 2/17/2010 Physician Australia
Primary
Secondary
Concomitant
Fasciitis Hospitalization 4/18/2007 Male 208 lb 2/18/2010 Physician Canada
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 1/18/2010 Male 216 lb 2/19/2010 Physician Canada
Primary
Secondary
Concomitant
Pulmonary Fibrosis Hospitalization 11/21/2007 74 Female 2/10/2010 Other Health Professional Germany
Primary
Concomitant
Aortic Aneurysm Hospitalization 9/18/2009 Female 200 lb 2/24/2010 Physician United States
Primary
Concomitant
Respiratory Failure Hospitalization 1/22/2010 Male 187 lb 2/24/2010 Physician Mexico
Primary
Secondary
Concomitant
Vasculitis Hospitalization 12/1/2009 Female 126 lb 2/25/2010 Physician Slovakia (Slovak Republic)
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 1/18/2010 Male 216 lb 2/26/2010 Physician Canada
Primary
Secondary
Concomitant
Erysipelas Hospitalization 10/16/2008 Male 3/1/2010 Physician France
Primary
Concomitant
Cellulitis Hospitalization 12/29/2007 Female 209 lb 3/2/2010 Physician United States
Primary
Secondary
Concomitant
Cholelithiasis Hospitalization 12/17/2009 Male 224 lb 3/3/2010 Physician Canada
Primary
Concomitant
Lung Neoplasm Other Serious 11/1/2009 Male 196 lb 3/3/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Gallbladder Perforation Hospitalization 9/21/2009 Female 172 lb 3/4/2010 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 1/22/2010 Male 187 lb 3/4/2010 Physician Mexico
Primary
Secondary
Concomitant
Malignant Muscle Neoplasm Other Serious 3/19/2009 Male 291 lb 3/5/2010 Physician Canada
Primary
Concomitant
Atrial Flutter Hospitalization 1/30/2010 Female 187 lb 3/8/2010 Physician Portugal
Primary
Concomitant
Vaginal Haemorrhage Hospitalization 9/10/2006 Female 118 lb 3/10/2010 Physician Mexico
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 1/22/2010 Male 187 lb 3/10/2010 Physician Mexico
Primary
Secondary
Concomitant
Pseudomonas Infection Life Threatening 9/10/2006 Female 118 lb 3/11/2010 Physician Mexico
Primary
Secondary
Concomitant
Subdural Haematoma Life Threatening 12/6/2009 Female 118 lb 3/11/2010 Physician Mexico
Primary
Secondary
Concomitant
Endometrial Cancer Stage Ii Life Threatening 4/29/2008 Female 199 lb 3/11/2010 Physician United States
Primary
Concomitant
Spindle Cell Sarcoma Life Threatening 3/13/2008 Female 328 lb 3/12/2010 Physician Australia
Primary
Secondary
Concomitant
Emphysema Hospitalization 4/18/2009 Male 132 lb 3/18/2010 Physician Mexico
Primary
Concomitant
Respiratory Tract Infection Viral Hospitalization 11/7/2007 Female 187 lb 3/19/2010 Physician Australia
Primary
Concomitant
Jaundice Cholestatic Death 12/5/2008 Female 150 lb 3/19/2010 Physician Japan
Primary
Secondary
Concomitant
Procedural Pain Hospitalization 6/4/2009 Female 131 lb 3/19/2010 Physician United States
Primary
Secondary
Concomitant
Thymoma Other Serious 1/18/2010 Male 216 lb 3/19/2010 Physician Canada
Primary
Secondary
Concomitant
Lung Neoplasm Other Serious 10/16/2009 Female 150 lb 3/19/2010 Physician Brazil
Primary
Concomitant
Uterine Leiomyoma Other Serious 8/7/2009 Female 3/19/2010 Physician Japan
Primary
Secondary
Concomitant
Thymoma Other Serious 1/18/2010 Male 216 lb 3/23/2010 Physician Canada
Primary
Secondary
Concomitant
Tonsillitis Other Serious 1/1/2009 Female 97 lb 3/23/2010 Other Health Professional Japan
Primary
Concomitant
Pneumonia Staphylococcal Death 10/19/2009 Male 3/24/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 8/14/2009 Female 3/24/2010 Physician Japan
Primary
Secondary
Concomitant
Malignant Muscle Neoplasm Other Serious 3/19/2009 Male 291 lb 3/24/2010 Physician Canada
Primary
Concomitant
Atrial Flutter Hospitalization 1/30/2010 Female 187 lb 3/24/2010 Physician Portugal
Primary
Concomitant
Death Death 3/12/2010 Female 192 lb 3/26/2010 Physician United States
Primary
Secondary
Concomitant
Venous Injury Life Threatening 12/6/2009 Female 118 lb 3/26/2010 Physician Mexico
Primary
Secondary
Concomitant
Pseudomonas Infection Life Threatening 9/10/2006 Female 118 lb 3/29/2010 Physician Mexico
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 12/29/2007 Female 209 lb 3/29/2010 Physician United States
Primary
Secondary
Concomitant
Deep Vein Thrombosis Life Threatening 9/21/2009 Female 172 lb 3/29/2010 Physician United States
Primary
Secondary
Concomitant
Death Death 3/12/2010 Female 192 lb 3/29/2010 Physician United States
Primary
Secondary
Concomitant
Sinusitis Hospitalization 2/24/2009 Female 3/29/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Hospitalization 9/22/2009 Female 99 lb 3/29/2010 Physician Japan
Primary
Secondary
Concomitant
Skin Ulcer Hospitalization 10/20/2008 Female 3/30/2010 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/28/2009 Female 3/30/2010 Physician Japan
Primary
Secondary
Concomitant
Cellulitis Staphylococcal Hospitalization 4/18/2007 Male 208 lb 3/31/2010 Physician Canada
Primary
Secondary
Concomitant
Breast Cancer Female Other Serious 12/24/2009 Female 174 lb 3/31/2010 Physician Israel
Primary
Secondary
Concomitant
Bladder Cancer Hospitalization 7/30/2009 Male 110 lb 3/31/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Disorder Other Serious 2/15/2010 72 Female 225 lb 4/1/2010 Physician Australia
Primary
Secondary
Concomitant
Cardiac Arrest Death 3/12/2010 73 Female 192 lb 4/1/2010 Physician United States
Primary
Secondary
Concomitant
Transitional Cell Carcinoma Hospitalization 12/3/2009 71 Male 176 lb 4/2/2010 Physician Italy
Primary
Secondary
Concomitant
Peritonitis Life Threatening 2/10/2010 54 Female 132 lb 4/5/2010 Physician Russian Federation
Primary
Concomitant
Subcutaneous Abscess Hospitalization 10/16/2009 67 Female 4/5/2010 Other Health Professional Japan
Primary
Concomitant
Lung Neoplasm Malignant Life Threatening 3/29/2010 52 Male 137 lb 4/5/2010 Physician China
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 10/2/2008 28 Female 112 lb 4/6/2010 Physician Japan
Primary
Secondary
Concomitant
Skin Ulcer Hospitalization 2/5/2010 46 Female 225 lb 4/6/2010 Physician Brazil
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 11/21/2009 69 Female 481 lb 4/6/2010 Physician United States
Primary
Secondary
Concomitant
Glomerulonephritis Acute Other Serious 3/16/2010 61 Female 126 lb 4/6/2010 Physician Japan
Primary
Concomitant
Renal Failure Acute Hospitalization 12/29/2007 73 Female 209 lb 4/8/2010 Physician United States
Primary
Secondary
Concomitant
Retroperitoneal Abscess Hospitalization 10/10/2009 78 Female 4/8/2010 Physician Japan
Primary
Concomitant
Aortic Rupture Death Female 4/8/2010 Physician Japan
Primary
Concomitant
Lung Squamous Cell Carcinoma Stage Iv Hospitalization 9/6/2007 73 Female 111 lb 4/9/2010 Physician United States
Primary
Concomitant
Surgical Failure Hospitalization 6/4/2009 49 Female 131 lb 4/12/2010 Physician United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 4/28/2008 67 Female 208 lb 4/12/2010 Physician United States
Primary
Concomitant
Platelet Count Decreased Hospitalization 3/9/2009 59 Female 113 lb 4/13/2010 Physician Japan
Primary
Secondary
Concomitant
Thymoma Other Serious 1/18/2010 60 Male 216 lb 4/13/2010 Physician Canada
Primary
Secondary
Concomitant
Dystonia Other Serious 10/1/2009 60 Male 216 lb 4/13/2010 Physician Canada
Primary
Concomitant
Breast Cancer Hospitalization 1/27/2010 61 Female 174 lb 4/14/2010 Physician Israel
Primary
Secondary
Concomitant
Metastases To Liver Other Serious 12/23/2009 64 Female 119 lb 4/14/2010 Physician Netherlands
Primary
Concomitant
Tonsillitis Other Serious 1/1/2009 67 Female 97 lb 4/14/2010 Other Health Professional Japan
Primary
Concomitant
Cervix Carcinoma Stage Iii Hospitalization 7/17/2007 47 Female 112 lb 4/16/2010 Physician Poland
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 12/29/2007 73 Female 209 lb 4/19/2010 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 4/3/2010 71 Male 149 lb 4/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Erysipelas Hospitalization 10/16/2008 65 Male 4/20/2010 Physician France
Primary
Concomitant
Cerebrovascular Accident Hospitalization 4/3/2010 71 Male 149 lb 4/20/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Life Threatening 12/29/2007 73 Female 209 lb 4/21/2010 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 7/25/2008 70 Female 99 lb 4/21/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/19/2008 76 Male 199 lb 4/21/2010 Physician United States
Primary
Secondary
Concomitant
Thymus Enlargement Other Serious 1/18/2010 60 Male 216 lb 4/22/2010 Physician Canada
Primary
Secondary
Concomitant
Skin Ulcer Hospitalization 2/5/2010 46 Female 225 lb 4/22/2010 Physician Brazil
Primary
Secondary
Concomitant
Cholelithiasis Hospitalization 12/17/2009 78 Male 224 lb 4/23/2010 Physician Canada
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/28/2009 75 Female 4/23/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Hospitalization 4/30/2009 45 Female 210 lb 4/26/2010 Physician United States
Primary
Concomitant
Colitis Ischaemic Hospitalization 4/1/2010 81 Female 127 lb 4/26/2010 Physician United States
Primary
Concomitant
Sepsis Life Threatening 12/29/2007 73 Female 209 lb 4/27/2010 Physician United States
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 1/18/2010 60 Male 216 lb 4/27/2010 Physician Canada
Primary
Secondary
Concomitant
Dystonia Other Serious 10/1/2009 60 Male 216 lb 4/27/2010 Physician Canada
Primary
Concomitant
Pulmonary Embolism Hospitalization 11/21/2009 69 Female 481 lb 4/28/2010 Physician United States
Primary
Secondary
Concomitant
Tibia Fracture Hospitalization 9/2/2009 76 Female 141 lb 4/29/2010 Physician Panama
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 4/3/2010 71 Male 149 lb 4/29/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Central Nervous System Mass Other Serious 4/13/2010 52 Male 192 lb 4/29/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Cerebral Infarction Hospitalization 4/4/2010 70 Female 132 lb 4/29/2010 Physician Japan
Primary
Concomitant
Sepsis Life Threatening 12/29/2007 73 Female 209 lb 4/30/2010 Physician United States
Primary
Secondary
Concomitant
Central Nervous System Mass Other Serious 4/13/2010 52 Male 198 lb 5/3/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Sepsis Hospitalization 7/13/2008 76 Male 199 lb 5/3/2010 Physician United States
Primary
Secondary
Concomitant
Rectal Cancer Life Threatening 1/7/2010 65 Female 220 lb 5/3/2010 Physician France
Primary
Secondary
Concomitant
Peritonitis Life Threatening 2/10/2010 54 Female 132 lb 5/4/2010 Physician Russian Federation
Primary
Concomitant
Surgical Failure Hospitalization 6/4/2009 49 Female 131 lb 5/4/2010 Physician United States
Primary
Secondary
Concomitant
Empyema Hospitalization 11/14/2007 53 Female 104 lb 5/5/2010 Physician Mexico
Primary
Concomitant
Peritonitis Life Threatening 2/10/2010 54 Female 132 lb 5/5/2010 Physician Russian Federation
Primary
Concomitant
Atrial Flutter Hospitalization 1/30/2010 74 Female 187 lb 5/5/2010 Physician Portugal
Primary
Concomitant
Renal Cyst Hospitalization 7/31/2008 70 Male 164 lb 5/5/2010 Physician United States
Primary
Secondary
Concomitant
Dystonia Other Serious 10/1/2009 60 Male 216 lb 5/6/2010 Physician Canada
Primary
Concomitant
Colitis Ischaemic Hospitalization 4/1/2010 81 Female 127 lb 5/7/2010 Physician United States
Primary
Concomitant
Pain In Extremity Life Threatening 7/1/2009 69 Female 112 lb 5/7/2010 Physician Japan
Primary
Concomitant
Pulmonary Embolism Hospitalization 9/10/2008 70 Female 160 lb 5/10/2010 Physician United States
Primary
Concomitant
Tonsillitis Other Serious 1/1/2009 67 Female 97 lb 5/10/2010 Other Health Professional Japan
Primary
Concomitant
Lung Squamous Cell Carcinoma Stage I Other Serious 1/18/2010 60 Male 196 lb 5/11/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Upper Respiratory Tract Inflammation Hospitalization 9/29/2008 12 Female 130 lb 5/12/2010 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 3/12/2008 67 Female 194 lb 5/12/2010 Physician United States
Primary
Secondary
Concomitant
Subcutaneous Abscess Hospitalization 4/22/2009 53 Female 139 lb 5/12/2010 Physician Japan
Primary
Concomitant

Drug Data