Fluorouracil combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Treatment Related Secondary Malignancy Other Serious 62 Female 1/5/2006 Other Health Professional Korea, Republic Of
Primary
Secondary
Treatment Related Secondary Malignancy Other Serious 62 Female 1/5/2006 Other Health Professional Korea, Republic Of
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious 1/4/2006 63 Male 1/16/2006 Physician Japan
Primary
Secondary
Viral Infection Hospitalization 9/9/2005 40 Female 119 lb 1/20/2006 Physician Germany
Primary
Secondary
Blood Alkaline Phosphatase Increased Other Serious 1/24/2006 Physician Jamaica
Primary
Secondary
Ejection Fraction Decreased Hospitalization 12/13/2005 58 Female 1/20/2006 France
Primary
Secondary
Pancytopenia Hospitalization 8/12/2005 67 Female 181 lb 2/6/2006 Physician Germany
Primary
Secondary
Neoplasm Malignant Death 1/1/2005 51 Female 2/8/2006 Other Health Professional Korea, Democratic People's Republic Of
Primary
Secondary
Dermatomyositis Hospitalization 3/15/2005 54 Female 2/16/2006 Physician France
Primary
Secondary
Concomitant
Tachycardia Hospitalization 10/6/2005 Female 129 lb 2/21/2006 Other Health Professional United Kingdom
Primary
Concomitant
Drug Toxicity Hospitalization 3/15/2005 54 Female 2/22/2006
Primary
Secondary
Concomitant
Pleural Effusion Life Threatening 1/30/2006 56 Female 146 lb 2/17/2006 Physician Serbia And Montenegro
Primary
Secondary
Concomitant
Pleural Effusion Death 2/12/2006 61 Female 2/23/2006 Physician Serbia And Montenegro
Primary
Secondary
Pleural Effusion Hospitalization 2/12/2006 61 Female 2/27/2006 Physician Serbia And Montenegro
Primary
Secondary
Concomitant
Pleural Effusion Life Threatening 1/30/2006 56 Female 146 lb 2/27/2006 Physician Yugoslavia
Primary
Secondary
Concomitant
Myocardial Infarction Death 5/24/2005 51 Female 3/14/2006 Brazil
Primary
Secondary
Concomitant
Metastases To Liver Death 2/18/2000 57 Female 3/24/2006 Other Health Professional Switzerland
Primary
Secondary
Vith Nerve Paralysis Other Serious 2/24/2006 Female 3/24/2006 Physician Japan
Primary
Concomitant
Abdominal Pain Upper 52 Female 1/25/2006 United States
Primary
Concomitant
Vomiting Hospitalization 5/4/2005 49 Female 3/24/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2/8/2006 68 Female 126 lb 4/6/2006 Consumer United States
Primary
Secondary
Concomitant
Vith Nerve Paralysis Other Serious 2/24/2006 59 Female 4/10/2006 Physician Japan
Primary
Concomitant
Productive Cough Hospitalization 2/8/2006 68 Female 126 lb 4/7/2006 United Kingdom
Primary
Secondary
Concomitant
Eosinophilic Pustular Folliculitis Other Serious 60 Female 4/20/2006 Other Health Professional Ireland
Primary
Secondary
Ventricular Tachycardia Other Serious 3/1/2004 38 Female 4/19/2006 Other Health Professional United Kingdom
Primary
Concomitant
Eye Movement Disorder 1/1/2006 47 Female 4/28/2006 Consumer United States
Primary
Concomitant
Toothache Other Serious 10/3/2005 39 Female 128 lb 5/1/2006 Physician United Kingdom
Primary
Concomitant
Skin Lesion Other Serious 60 Female 5/1/2006
Primary
Secondary
Petechiae Hospitalization 6/8/2002 63 Female 5/5/2006 Other Health Professional France
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 6/8/2002 63 Female 5/5/2006 Other Health Professional France
Primary
Secondary
Wound Treatment Other Serious 1/1/1997 59 Female 157 lb 5/6/2006 United States
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 11/17/2005 52 Female 272 lb 5/11/2006 Physician Spain
Primary
Secondary
Concomitant
Neutropenic Sepsis Hospitalization 4/1/2006 Female 181 lb 5/23/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Death Death 1/22/2006 Female 5/18/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Death Death 1/22/2006 Female 5/18/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Toothache Other Serious 63 Female 132 lb 5/24/2006 Portugal
Primary
Concomitant
Tooth Extraction Other Serious 10/3/2005 39 Female 128 lb 5/24/2006 Physician United Kingdom
Primary
Concomitant
Swelling Other Serious 4/13/2006 51 Female 5/24/2006 Physician Portugal
Primary
Concomitant
Wound Treatment Other Serious 1/1/1997 59 Female 157 lb 5/31/2006 United States
Primary
Secondary
Concomitant
Toothache Other Serious 8/1/2005 63 Female 132 lb 6/8/2006 Portugal
Primary
Concomitant
Treatment Related Secondary Malignancy Death 9/8/1998 58 Female 6/23/2006 Other Health Professional Finland
Primary
Secondary
Pain In Jaw Other Serious 2/21/2006 78 Female 6/26/2006 Physician United States
Primary
Concomitant
Aspartate Aminotransferase Increased Other Serious 4/13/2006 43 Female 6/29/2006 Consumer United States
Primary
Secondary
Aspartate Aminotransferase Increased Other Serious 4/13/2006 43 Female 7/6/2006 Consumer United States
Primary
Secondary
Vaginal Exfoliation Hospitalization 5/23/2006 Female 139 lb 7/13/2006 Physician United Kingdom
Primary
Concomitant
Neutropenic Sepsis Hospitalization 4/4/2006 74 Female 7/12/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia 8/1/2005 68 Female 5/31/2006 Consumer United States
Primary
Concomitant
Tooth Extraction Other Serious 2/24/2005 85 Female 7/26/2006 Physician United States
Primary
Concomitant
Pain In Jaw Other Serious 2/21/2006 78 Female 8/4/2006 Physician United States
Primary
Concomitant
Lung Infiltration Hospitalization 1/27/2006 Female 8/1/2006 Physician Netherlands
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 1/1/2006 Female 8/8/2006 Physician United States
Primary
Secondary
Pain In Extremity Female 178 lb 8/8/2006 Other Health Professional United States
Primary
Concomitant
Tooth Extraction Other Serious 2/24/2005 85 Female 8/14/2006 Physician United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 8/17/2006 Female 187 lb 8/25/2006 United States
Primary
Secondary
Pneumonia Life Threatening 11/30/2005 61 Female 6/6/2006 Physician United States
Primary
Concomitant
Pulse Absent Hospitalization 56 Female 9/15/2006 Other Health Professional United Kingdom
Primary
Secondary
Haemorrhage Intracranial Death 1/1/2002 43 Female 9/28/2006 India
Primary
Secondary
Concomitant
Mucosal Ulceration Other Serious 6/2/2006 66 Female 10/6/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Lobar Pneumonia Hospitalization 9/30/2006 Female 206 lb 10/3/2006 United States
Primary
Secondary
Osteonecrosis Hospitalization 12/21/2004 58 Female 173 lb 10/13/2006 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 10/17/2006 61 Female 11/2/2006 Consumer United States
Primary
Secondary
Concomitant
Proctitis Hospitalization 11/8/2006 Female 11/15/2006 Other Health Professional Italy
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/4/2002 56 Female 11/20/2006 Consumer United States
Primary
Secondary
Concomitant
Petechiae Hospitalization 6/8/2002 63 Female 12/5/2006 Other Health Professional France
Primary
Secondary
Tooth Extraction Other Serious 10/3/2005 39 Female 128 lb 12/12/2006 Physician United Kingdom
Primary
Concomitant
Mucosal Inflammation Other Serious 5/1/1999 55 Female 12/12/2006
Primary
Secondary
Lip And/or Oral Cavity Cancer Other Serious 5/1/1999 54 Female 12/15/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pharyngolaryngeal Pain Other Serious 55 Female 12/18/2006 Consumer Hong Kong
Primary
Secondary
Concomitant
Vaginal Inflammation Other Serious 55 Female 12/18/2006
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 47 Female 12/4/2006 Other Health Professional United States
Primary
Secondary
Interstitial Lung Disease Hospitalization 12/1/2006 73 Female 12/20/2006 Consumer United States
Primary
Secondary
Lip And/or Oral Cavity Cancer Other Serious 5/1/1999 54 Female 12/20/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 11/24/2006 73 Female 1/8/2007 Consumer United States
Primary
Secondary
Concomitant
Lip And/or Oral Cavity Cancer Other Serious 5/1/1999 55 Female 1/9/2007 United States
Primary
Secondary
Concomitant
Lip And/or Oral Cavity Cancer Other Serious 5/1/1999 Female 1/10/2007 United States
Primary
Secondary
T-cell Type Acute Leukaemia Death 1/1/2003 38 Female 1/10/2007 Physician Greece
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 59 Female 157 lb 1/23/2007 United States
Primary
Secondary
Concomitant
Sepsis Neonatal Other Serious Male 3 lb 1/19/2007 Physician Austria
Primary
Concomitant
Proctitis Hospitalization 11/8/2006 37 Female 2/1/2007 Other Health Professional Italy
Primary
Secondary
Concomitant
Cardiomyopathy Other Serious 1/1/2004 57 Female 3/1/2007 Other Health Professional Germany
Primary
Secondary
Pulmonary Embolism Death Female 2/24/2007 Consumer United Kingdom
Primary
Secondary
Malignant Neoplasm Progression Other Serious 66 Female 3/8/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 1/27/2007 Female 134 lb 3/14/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Myeloid Leukaemia Hospitalization 56 Female 6/6/2003 Physician United States
Primary
Secondary
Wound Treatment Other Serious 1/1/1997 59 Female 157 lb 3/17/2007 Physician United States
Primary
Secondary
Concomitant
Pyrexia Life Threatening 12/16/2006 Female 169 lb 3/19/2007 Physician United Kingdom
Primary
Secondary
Dyspnoea Other Serious 2/12/2007 Female 170 lb 3/23/2007 Physician United Kingdom
Primary
Secondary
Musculoskeletal Chest Pain 2/2/2006 Female 3/28/2007 Consumer United States
Primary
Concomitant
White Blood Cell Morphology Abnormal Other Serious 51 Female 3/29/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Pulmonary Sarcoidosis Other Serious 3/1/2004 47 Female 3/29/2007 Physician Poland
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 10/3/2005 39 Female 128 lb 5/12/2007 Physician United Kingdom
Primary
Concomitant
Stem Cell Transplant Other Serious 51 Female 5/8/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Pregnancy Other Serious Female 5/17/2007 Consumer United States
Primary
Secondary
Dyspnoea Other Serious 2/12/2007 55 Female 170 lb 5/21/2007 Consumer United States
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 55 Female 5/25/2007 Physician Canada
Primary
Secondary
Concomitant
Pulmonary Embolism Death Female 6/2/2007 Physician Germany
Primary
Secondary
Pyrexia Life Threatening 12/16/2006 59 Female 6/26/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Dyspnoea Other Serious 2/12/2007 Female 170 lb 6/26/2007 United Kingdom
Primary
Secondary
Squamous Cell Carcinoma Other Serious 5/1/1999 56 Female 7/9/2007 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 7/1/2006 60 Female 158 lb 7/13/2007 Consumer United States
Primary
Secondary
Concomitant
Vaginal Inflammation Other Serious 55 Female 7/12/2007 Hong Kong
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 74 Male 8/4/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Lung Cancer Metastatic Other Serious 39 Female 8/9/2007 Physician United States
Primary
Concomitant
Tooth Extraction Other Serious 6/1/2006 Female 8/10/2007 Switzerland
Primary
Concomitant
Tooth Extraction Other Serious 6/1/2006 Female 8/10/2007 Switzerland
Primary
Concomitant
Lung Neoplasm Malignant Life Threatening 11/1/2003 42 Female 8/13/2007 Other Health Professional Japan
Primary
Concomitant
Temporomandibular Joint Syndrome Other Serious 17 Male 8/16/2007 Physician United States
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 16 Male 8/16/2007 Physician United States
Primary
Secondary
Concomitant
Trismus Other Serious 14 Female 8/16/2007 Physician United States
Primary
Secondary
Concomitant
Tooth Disorder Other Serious 10 Female 8/16/2007 Physician United States
Primary
Secondary
Vocal Cord Disorder Other Serious 14 Male 8/16/2007 Physician United States
Primary
Secondary
Concomitant
Pain In Jaw Other Serious 6/19/2007 53 Female 8/22/2007 United States
Primary
Concomitant
Pain In Jaw Other Serious 6/19/2007 53 Female 8/22/2007 United States
Primary
Concomitant
Weight Decreased Other Serious 51 Female 9/7/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Peripheral Ischaemia Hospitalization 56 Female 9/15/2007 United Kingdom
Primary
Secondary
Sepsis Death 7/3/2007 Female 9/25/2007 Physician Greece
Primary
Secondary
Concomitant
Tooth Abscess Other Serious 1/1/2004 53 Female 9/29/2007 France
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 11/1/2005 Female 10/8/2007 Consumer United States
Primary
Secondary
Rash Pruritic Other Serious 74 Male 10/11/2007 United States
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 11/1/2005 Female 10/12/2007 United Kingdom
Primary
Secondary
Myelodysplastic Syndrome Other Serious 3/1/2003 Male 10/17/2007
Primary
Secondary
Rash Pruritic Other Serious 74 Male 10/19/2007 Other Health Professional United States
Primary
Secondary
Rash Pruritic Other Serious 74 Male 10/17/2007 United States
Primary
Secondary
Rash 4/24/2007 59 Female 11/13/2007 Consumer United States
Primary
Concomitant
Neutropenic Sepsis Hospitalization 69 Female 11/27/2007 Pharmacist United Kingdom
Primary
Concomitant
Myelodysplastic Syndrome Other Serious 1/1/2007 74 Male 12/5/2007 United States
Primary
Secondary
Concomitant
Lung Cancer Metastatic Other Serious 39 Female 12/11/2007 Physician United States
Primary
Concomitant
Hairy Cell Leukaemia Other Serious 3/1/2007 75 Female 1/23/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 7/1/2006 60 Female 159 lb 1/30/2008 United States
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 51 Female 2/1/2008 United Kingdom
Primary
Concomitant
Interacting
Osteonecrosis Other Serious 51 Female 2/5/2008 Physician United Kingdom
Primary
Secondary
Osteonecrosis Other Serious 51 Female 2/5/2008 United Kingdom
Primary
Interacting
Osteonecrosis Other Serious 51 Female 2/8/2008 United Kingdom
Primary
Concomitant
Interacting
Osteonecrosis Required Intervention 1/4/2006 44 Female 1/17/2008 Physician United States
Primary
Concomitant
Human Herpesvirus 6 Infection Other Serious 56 Male 3/4/2008 Japan
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 51 Female 3/5/2008 United Kingdom
Primary
Concomitant
Interacting
Osteonecrosis Other Serious 51 Female 3/6/2008 Other Health Professional United Kingdom
Primary
Interacting
Chronic Granulomatous Disease Hospitalization Female 3/9/2008 Japan
Primary
Secondary
Concomitant
Rash Other Serious 56 Male 3/9/2008 Japan
Primary
Secondary
Concomitant
Rash Other Serious 12/1/2006 56 Male 3/11/2008 Japan
Primary
Secondary
Concomitant
Oedema Mucosal Hospitalization 27 Female 3/12/2008 Japan
Primary
Secondary
Concomitant
Portal Vein Thrombosis Hospitalization 11/10/2006 69 Male 3/4/2008 Japan
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 51 Female 3/14/2008 United Kingdom
Primary
Concomitant
Interacting
Weight Decreased Other Serious 51 Female 3/18/2008 Other Health Professional United Kingdom
Primary
Interacting
Weight Decreased Other Serious 51 Female 3/21/2008 Other Health Professional United Kingdom
Primary
Interacting
Vertigo Other Serious 67 Male 3/28/2008
Primary
Secondary
Weight Decreased Other Serious 51 Female 4/4/2008 Other Health Professional United Kingdom
Primary
Interacting
Weight Decreased Other Serious 51 Female 4/8/2008 Consumer United States
Primary
Secondary
Non-hodgkin's Lymphoma Other Serious 71 Female 4/8/2008 Other Health Professional Italy
Primary
Secondary
Portal Vein Thrombosis Hospitalization 11/10/2006 69 Male 4/2/2008 Japan
Primary
Secondary
Concomitant

Drug Data