Fluorouracil combined with Loxonin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tumour Ulceration Other Serious 8/8/2005 60 Female 130 lb 3/4/2006 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 4/27/2006 72 Female 5/30/2006 Consumer United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 4/27/2006 72 Female 6/5/2006 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 7/14/2006 Male 8/10/2006 Pharmacist Japan
Primary
Concomitant
Treatment Related Secondary Malignancy Death 12/1/2005 84 Male 9/12/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased 5/29/2006 Male 10/31/2006 Pharmacist Japan
Primary
Concomitant
Stomatitis Other Serious 8/2/2006 Male 150 lb 11/14/2006 Physician Japan
Primary
Secondary
Concomitant
Uterine Neoplasm Hospitalization 12/1/2006 72 Female 115 lb 2/15/2007 Physician Japan
Primary
Concomitant
Stomatitis Death 12/10/2006 73 Male 146 lb 3/19/2007 Other Health Professional Japan
Primary
Concomitant
Metabolic Acidosis Hospitalization 12/6/2006 Male 4/19/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Life Threatening 3/9/2007 88 Male 99 lb 5/22/2007 Physician Japan
Primary
Concomitant
Blood Creatinine Increased Hospitalization 5/22/2007 Male 6/6/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 5/22/2007 Male 6/11/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Platelet Count Decreased Life Threatening 3/9/2007 88 Male 99 lb 6/25/2007 Physician Japan
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 6/14/2007 Male 8/7/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Fall Hospitalization 8/20/2007 Male 10/10/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Abnormal Other Serious 8/27/2007 Male 10/11/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Anaphylactic Shock Life Threatening 10/16/2007 Male 11/9/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 5/22/2007 Male 12/13/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Sepsis Death 11/6/2007 Male 12/14/2007 Consumer United Kingdom
Primary
Concomitant
Shock Haemorrhagic Other Serious 10/8/2007 Male 12/14/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Anaphylactic Shock Life Threatening 10/15/2007 Male 12/19/2007 Consumer United Kingdom
Primary
Concomitant
Sepsis Death 11/6/2007 Male 12/21/2007 Consumer United Kingdom
Primary
Concomitant
Shock Haemorrhagic Other Serious 10/8/2007 Male 1/3/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 12/18/2007 Male 1/10/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Anaphylactic Shock Life Threatening 10/16/2007 Male 1/16/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Anaphylactic Shock Life Threatening 1/18/2008 Male 2/6/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Pathological Fracture Hospitalization 11/16/2007 Male 2/7/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 6/14/2007 Male 2/13/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Cerebral Haemorrhage Life Threatening 2/15/2008 Male 119 lb 2/27/2008 Physician Japan
Primary
Secondary
Concomitant
Fall Other Serious 8/20/2007 Male 3/14/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Fall Other Serious 8/20/2007 Male 3/15/2008 Physician Japan
Primary
Secondary
Concomitant
Anaphylactoid Shock Life Threatening 1/18/2008 Male 3/20/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Rash Generalised Other Serious 12/30/2007 Male 128 lb 3/21/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Anaphylactic Shock Life Threatening 1/18/2008 Male 3/27/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Vomiting Life Threatening 11/6/2007 Male 3/28/2008 Consumer United Kingdom
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 12/11/2007 Male 4/2/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Cerebral Haemorrhage Life Threatening 2/15/2008 Male 119 lb 4/7/2008 Physician Japan
Primary
Secondary
Concomitant
Cerebral Haemorrhage Life Threatening 2/15/2008 Male 119 lb 4/9/2008 Physician Japan
Primary
Secondary
Concomitant
Pathological Fracture Hospitalization 11/16/2007 Male 4/11/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Oral Herpes Hospitalization 9/7/2007 Female 4/9/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Cerebral Haemorrhage Life Threatening 2/15/2008 Male 119 lb 4/7/2008 Physician Japan
Primary
Secondary
Concomitant
Bronchospasm Life Threatening 3/26/2008 Male 5/29/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Visual Field Defect Other Serious 8/20/2007 Male 6/4/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Jaw Fracture Other Serious 8/20/2007 Male 6/6/2008 Physician Japan
Primary
Secondary
Concomitant
Anaphylactic Shock Life Threatening 10/16/2007 Male 6/11/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Purpura Hospitalization 5/10/2008 Male 155 lb 6/11/2008 Physician United Kingdom
Primary
Concomitant
Malnutrition Hospitalization 5/25/2008 Female 97 lb 6/13/2008 Physician Japan
Primary
Secondary
Concomitant
Hyperbilirubinaemia Other Serious 8/27/2007 Male 6/16/2008 Physician Japan
Primary
Secondary
Concomitant
Pelvic Abscess Other Serious 9/25/2007 Male 6/16/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Stomatitis Hospitalization 9/2/2007 Female 6/20/2008 Physician Japan
Primary
Secondary
Concomitant
Disease Progression Life Threatening 10/16/2007 Male 6/26/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Anaphylactic Shock Life Threatening 1/18/2008 Male 7/22/2008 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Life Threatening 1/1/2008 Male 132 lb 7/28/2008 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 4/1/2008 Female 188 lb 8/1/2008 Consumer United Kingdom
Primary
Concomitant
Large Intestine Perforation Hospitalization 10/18/2007 Male 8/6/2008 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Other Serious 7/31/2008 Male 139 lb 8/12/2008 Physician Japan
Primary
Secondary
Concomitant
Pelvic Abscess Other Serious 9/25/2007 Male 8/15/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Peritonitis Life Threatening 4/10/2007 Female 159 lb 8/21/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Visual Field Defect Other Serious 8/20/2007 Male 125 lb 8/22/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Tumour Haemorrhage Hospitalization 5/26/2008 28 Male 121 lb 8/25/2008 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Life Threatening 1/1/2008 Male 132 lb 9/4/2008 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Life Threatening 3/26/2008 Male 132 lb 9/9/2008 Consumer Japan
Primary
Secondary
Concomitant
Cardiac Failure Other Serious 7/31/2008 Male 139 lb 9/16/2008 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/1/2008 Female 188 lb 9/26/2008 Consumer United Kingdom
Primary
Concomitant
Ileus Life Threatening 1/18/2008 Male 220 lb 10/9/2008 Physician Japan
Primary
Secondary
Concomitant
Peritonitis Hospitalization 11/11/2008 Female 108 lb 11/25/2008 Physician United Kingdom
Primary
Concomitant
Varices Oesophageal Other Serious 8/20/2008 Male 12/16/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 8/20/2008 Male 110 lb 1/24/2009 Consumer Japan
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 12/5/2008 Male 139 lb 2/3/2009 Physician Japan
Primary
Concomitant
Hypertension Life Threatening 11/25/2008 Male 146 lb 2/4/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 11/12/2007 Male 146 lb 2/11/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 4/3/2008 Male 2/12/2009 Consumer Japan
Primary
Concomitant
Pneumothorax Hospitalization 1/24/2009 Male 3/4/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumothorax Hospitalization 1/24/2009 Male 117 lb 3/13/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 1/22/2009 Male 127 lb 3/17/2009 Consumer Japan
Primary
Secondary
Concomitant
Hypertension Life Threatening 11/25/2008 Male 146 lb 3/17/2009 Physician Japan
Primary
Secondary
Concomitant
Peritonitis Hospitalization 11/11/2008 Female 108 lb 3/25/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 1/22/2009 Male 127 lb 3/27/2009 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Perforation Life Threatening 8/27/2008 Female 100 lb 4/7/2009 Physician Japan
Primary
Secondary
Concomitant
Oesophageal Perforation Death 11/30/2008 Male 4/8/2009 Consumer United Kingdom
Primary
Concomitant
Gastrointestinal Perforation Life Threatening 3/23/2009 Male 123 lb 4/23/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Colitis Ischaemic Hospitalization 6/20/2009 Female 130 lb 7/8/2009 Physician Japan
Primary
Secondary
Concomitant
Disease Progression Death 6/9/2008 Male 147 lb 7/10/2009 Physician Japan
Primary
Secondary
Concomitant
Colitis Ischaemic Hospitalization 6/20/2009 Female 130 lb 7/17/2009 Physician Japan
Primary
Secondary
Concomitant
Drug Exposure During Pregnancy Other Serious 7/29/2009 Female 8/19/2009 Physician Japan
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 12/15/2008 68 8/25/2009 Physician Japan
Primary
Secondary
Concomitant
Drug Exposure During Pregnancy Other Serious 7/29/2009 Female 8/28/2009 Physician Japan
Primary
Secondary
Concomitant
Somnolence Other Serious 8/19/2009 Male 9/2/2009 Pharmacist Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2009 Male 9/10/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2009 Male 10/6/2009 Physician Japan
Primary
Secondary
Concomitant
Lung Infection Hospitalization 7/27/2009 68 10/28/2009 Physician Japan
Primary
Secondary
Concomitant
Venous Thrombosis Other Serious 10/20/2009 71 Female 126 lb 12/16/2009 Physician Germany
Primary
Concomitant
Septic Shock Other Serious 9/1/2009 Female 84 lb 3/18/2010 Physician Japan
Primary
Concomitant
Sepsis Life Threatening 12/12/2009 Male 121 lb 3/25/2010 Physician Japan
Primary
Concomitant
Septic Shock Other Serious 9/1/2009 66 Female 84 lb 4/2/2010 Physician Japan
Primary
Concomitant
Lung Infection Hospitalization 7/27/2009 68 Male 132 lb 4/9/2010 Physician Japan
Primary
Secondary
Concomitant
Venous Thrombosis Other Serious 10/20/2009 71 Female 126 lb 4/29/2010 Physician Germany
Primary
Concomitant
Gastrointestinal Necrosis Life Threatening 4/27/2010 61 Female 117 lb 5/19/2010 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Necrosis Death 4/27/2010 61 Female 117 lb 6/2/2010 Physician Japan
Primary
Secondary
Concomitant
Wound Dehiscence Other Serious 6/1/2009 67 Male 104 lb 6/24/2010 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 8/28/2009 74 Male 93 lb 7/6/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 8/28/2009 75 Male 7/8/2010 Physician Japan
Primary
Secondary
Concomitant
Large Intestine Perforation Hospitalization 6/8/2010 58 Female 130 lb 7/28/2010 Physician Japan
Primary
Secondary
Concomitant
Rash Hospitalization 11/11/2008 Male 8/3/2010 United States
Primary
Concomitant
Malaise Hospitalization 6/25/2010 65 Female 8/4/2010 Physician Japan
Primary
Secondary
Concomitant
Malaise Hospitalization 6/4/2010 65 Female 8/19/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 1/1/2010 53 Male 106 lb 8/26/2010 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/21/2009 65 Female 8/27/2010 Physician Japan
Primary
Secondary
Concomitant
Rectal Perforation Hospitalization 2/5/2010 60 Male 97 lb 9/4/2010 Physician Japan
Primary
Secondary
Concomitant
Oesophageal Carcinoma Other Serious 6/22/2010 76 Male 115 lb 9/15/2010 Physician Japan
Primary
Secondary
Concomitant
Rectal Perforation Hospitalization 2/5/2010 60 Male 9/17/2010 Physician Japan
Primary
Secondary
Concomitant
Vesical Fistula Other Serious 8/7/2010 60 Female 9/20/2010 Pharmacist Japan
Primary
Secondary
Concomitant
Malaise Hospitalization 6/4/2010 65 Female 9/21/2010 Physician Japan
Primary
Secondary
Concomitant
Peripheral Coldness Death 8/20/2010 66 Female 66 lb 9/21/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 6/23/2010 54 Male 106 lb 9/30/2010 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2009 54 Male 165 lb 10/6/2010 Physician Japan
Primary
Secondary
Concomitant
Peptic Ulcer Other Serious 7/31/2010 60 Female 88 lb 10/13/2010 Physician Japan
Primary
Secondary
Concomitant
Oesophageal Carcinoma Other Serious 6/22/2010 76 Male 115 lb 10/15/2010 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Hypertension Hospitalization 10/12/2010 73 Female 10/25/2010 Physician Japan
Primary
Secondary
Concomitant
Pyothorax Other Serious 6/18/2010 74 Female 121 lb 10/28/2010 Physician Japan
Primary
Concomitant
Hypomagnesaemia Other Serious 7/13/2010 10/29/2010 Other Health Professional Japan
Primary
Concomitant
Metastases To Central Nervous System Hospitalization 9/15/2010 10/29/2010 Physician Japan
Primary
Concomitant
Thrombosis Other Serious 4/27/2010 61 Female 117 lb 11/3/2010 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Hypertension Hospitalization 10/12/2010 73 Female 11/5/2010 Physician Japan
Primary
Secondary
Concomitant
Dermatitis Acneiform Other Serious 7/13/2010 11/9/2010 Physician Japan
Primary
Concomitant
Sepsis Other Serious 10/12/2010 60 Male 128 lb 11/19/2010 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Hypertension Hospitalization 10/12/2010 73 Female 11/29/2010 Physician Japan
Primary
Secondary
Concomitant
Dermatitis Acneiform Other Serious 7/13/2010 12/10/2010 Physician Japan
Primary
Concomitant
Thrombosis Other Serious 1/1/2010 60 Female 117 lb 12/14/2010 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Hospitalization 10/12/2010 73 Female 94 lb 12/14/2010 Physician Japan
Primary
Secondary
Concomitant
Sepsis Death 1/1/2008 77 Female 79 lb 12/16/2010 Physician Japan
Primary
Concomitant
Tachycardia Death 8/1/2009 52 Male 150 lb 12/17/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 12/3/2010 66 Female 101 lb 12/23/2010 Physician Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 10/12/2010 60 Male 128 lb 12/24/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 9/9/2010 12/30/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Constipation Death 8/1/2009 52 Male 1/3/2011 Consumer Japan
Primary
Secondary
Concomitant
Pyothorax Hospitalization 6/18/2010 74 Female 121 lb 1/3/2011 Other Health Professional Japan
Primary
Concomitant
Diarrhoea Hospitalization 10/12/2010 1/21/2011 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Hypertension Hospitalization 10/12/2010 73 Female 94 lb 1/21/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 12/7/2010 67 Male 110 lb 2/7/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Infusion Related Reaction Life Threatening 8/9/2010 56 Male 154 lb 2/10/2011 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 10/18/2010 58 Male 165 lb 2/15/2011 Japan
Primary
Secondary
Concomitant
Rash Other Serious 8/18/2010 57 Male 2/17/2011 Physician Japan
Primary
Concomitant
Intestinal Obstruction Other Serious 10/18/2007 38 Male 2/18/2011 Physician Japan
Primary
Secondary
Concomitant
Delirium Other Serious 8/1/2009 52 Male 150 lb 2/22/2011 Physician Japan
Primary
Secondary
Concomitant
Sepsis Death 10/12/2010 60 Male 128 lb 2/28/2011 Physician Japan
Primary
Secondary
Concomitant
Drug Ineffective Death 12/17/2009 60 Male 110 lb 2/28/2011 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Life Threatening 8/25/2010 47 Male 183 lb 3/21/2011 Physician Japan
Primary
Secondary
Concomitant
Haemorrhoidal Haemorrhage Disability 10/19/2010 66 Female 101 lb 3/22/2011 Physician Japan
Primary
Secondary
Concomitant

Drug Data