Fluorouracil combined with Lapatinib

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Renal Failure Hospitalization 10/29/2007 60 Male 181 lb 11/12/2007 Physician Belgium
Primary
Secondary
Renal Failure Hospitalization 10/16/2007 60 Male 181 lb 11/21/2007 Physician Belgium
Primary
Secondary
Concomitant
Renal Failure Hospitalization 11/12/2007 57 Male 212 lb 11/26/2007 Physician Belgium
Primary
Secondary
Renal Failure Hospitalization 10/16/2007 60 Male 181 lb 11/29/2007 Physician Belgium
Primary
Secondary
Concomitant
Renal Failure Hospitalization 10/29/2007 60 Male 174 lb 12/19/2007 Physician Belgium
Primary
Secondary
Concomitant
Renal Failure Hospitalization 11/12/2007 57 Male 212 lb 12/19/2007 Physician Belgium
Primary
Secondary
Renal Failure Hospitalization 10/29/2007 60 Male 174 lb 12/27/2007 Physician Belgium
Primary
Secondary
Concomitant
Hyperpyrexia Hospitalization 6/1/2008 41 Female 121 lb 6/9/2008 Physician Italy
Primary
Secondary
Diarrhoea Hospitalization 6/16/2008 58 Male 172 lb 7/8/2008 Physician Belgium
Primary
Secondary
Concomitant
Renal Failure Hospitalization 6/16/2008 58 Male 172 lb 7/17/2008 Physician Belgium
Primary
Secondary
Concomitant
Back Pain Hospitalization 7/15/2008 47 Male 122 lb 7/22/2008 Physician Belgium
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 6/16/2008 58 Male 172 lb 8/1/2008 Physician Belgium
Primary
Secondary
Concomitant
Back Pain Hospitalization 7/15/2008 47 Male 122 lb 8/1/2008 Physician Belgium
Primary
Secondary
Concomitant
Renal Failure Hospitalization 11/12/2007 57 Male 212 lb 8/12/2008 Physician Belgium
Primary
Secondary
Renal Failure Hospitalization 10/29/2007 60 Male 174 lb 8/14/2008 Physician Belgium
Primary
Secondary
Concomitant
Stomatitis Hospitalization 9/16/2008 50 Male 198 lb 9/18/2008 Physician Belgium
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 9/16/2008 50 Male 198 lb 9/29/2008 Physician Belgium
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 9/16/2008 50 Male 198 lb 10/6/2008 Physician Belgium
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 9/16/2008 50 Male 198 lb 10/14/2008 Physician Belgium
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/6/2008 Male 207 lb 10/23/2008 Physician Belgium
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/6/2008 79 Male 207 lb 10/31/2008 Physician Belgium
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 9/16/2008 50 Male 198 lb 11/3/2008 Physician Belgium
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 9/16/2008 50 Male 198 lb 11/12/2008 Physician Belgium
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 9/16/2008 50 Male 198 lb 11/14/2008 Physician Belgium
Primary
Secondary
Concomitant
Lymphoedema Hospitalization 9/1/2008 53 Female 130 lb 11/20/2008 Physician Belgium
Primary
Secondary
Pyrexia Hospitalization 10/6/2008 79 Male 207 lb 11/24/2008 Physician Belgium
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 9/16/2008 50 Male 198 lb 11/25/2008 Physician Belgium
Primary
Secondary
Concomitant
Hypercreatinaemia Hospitalization 12/5/2008 79 Male 207 lb 12/12/2008 Physician Belgium
Primary
Secondary
Concomitant
Swelling Face Other Serious 12/13/2008 48 Female 136 lb 12/23/2008 Physician United States
Primary
Secondary
Pyrexia Hospitalization 10/6/2008 79 Male 207 lb 12/23/2008 Physician Belgium
Primary
Secondary
Concomitant
Hypercreatinaemia Hospitalization 12/5/2008 79 Male 207 lb 12/29/2008 Physician Belgium
Primary
Secondary
Concomitant
Hypercreatinaemia Hospitalization 12/5/2008 79 Male 207 lb 2/5/2009 Physician Belgium
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2/14/2009 52 Female 125 lb 2/25/2009 Physician Taiwan, Province Of China
Primary
Secondary
Swelling Face Other Serious 12/13/2008 48 Female 136 lb 4/2/2009 Physician United States
Primary
Secondary
Thrombocytopenia Hospitalization 9/16/2008 Male 198 lb 4/2/2009 Physician Belgium
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 1/19/2009 28 Female 294 lb 5/12/2009 Physician United States
Primary
Secondary
Febrile Neutropenia Hospitalization 1/19/2009 28 Female 294 lb 7/14/2009 Physician United States
Primary
Secondary
Pyrexia Hospitalization 1/13/2009 Female 150 lb 10/15/2009 Physician Germany
Primary
Secondary
Neutropenia Hospitalization 9/1/2008 Female 130 lb 10/22/2009 Physician Belgium
Primary
Secondary
Neutropenia Other Serious 4/6/2009 10/28/2009 Physician France
Primary
Secondary
Concomitant
Neutropenia Hospitalization 9/1/2008 Female 130 lb 10/29/2009 Physician Belgium
Primary
Secondary
Pneumonia Hospitalization 11/24/2009 Female 101 lb 12/9/2009 Physician Belgium
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 12/6/2009 40 Female 193 lb 12/16/2009 Physician United States
Primary
Secondary
Diarrhoea Hospitalization 12/15/2009 37 Female 135 lb 12/21/2009 Physician United States
Primary
Secondary
Syncope Hospitalization 12/15/2009 Male 150 lb 1/13/2010 Physician Germany
Primary
Secondary
Pneumonia Hospitalization 11/24/2009 Female 101 lb 1/15/2010 Physician Belgium
Primary
Secondary
Concomitant
Diarrhoea Other Serious 12/29/2009 Female 132 lb 1/15/2010 Physician France
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 1/14/2010 34 Female 251 lb 1/25/2010 Physician United States
Primary
Secondary
Seroma Hospitalization 12/22/2009 Female 1/27/2010 Physician Germany
Primary
Secondary
Concomitant
Seroma Hospitalization 12/22/2009 Female 1/28/2010 Physician Germany
Primary
Secondary
Concomitant
Pyrexia Other Serious 9/30/2008 Female 196 lb 2/9/2010 Physician New Zealand
Primary
Secondary
Concomitant
Syncope Hospitalization 12/15/2009 Male 150 lb 2/11/2010 Physician Germany
Primary
Secondary
Neutropenia Other Serious 4/6/2009 Female 119 lb 2/19/2010 Physician France
Primary
Secondary
Concomitant
Myocardial Ischaemia Hospitalization 11/1/2009 Female 141 lb 2/26/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Myocardial Ischaemia Hospitalization 11/1/2009 Female 3/8/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Myocardial Ischaemia Hospitalization 11/1/2009 Female 141 lb 3/8/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Organising Pneumonia Hospitalization 11/24/2009 Female 101 lb 3/10/2010 Physician Belgium
Primary
Secondary
Concomitant
Myocardial Ischaemia Hospitalization 11/1/2009 Female 141 lb 3/11/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Myocardial Ischaemia Hospitalization 11/1/2009 Female 3/17/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 48 Female 3/16/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 3/10/2010 Female 137 lb 3/23/2010 Physician Germany
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 48 Female 3/23/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Myocardial Ischaemia Hospitalization 11/1/2009 Female 141 lb 3/26/2010 Physician Russian Federation
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 3/25/2010 64 Female 115 lb 3/31/2010 Physician Germany
Primary
Secondary
Concomitant
Gastroenteritis Hospitalization 12/14/2009 37 Female 134 lb 4/1/2010 Physician United States
Primary
Secondary
Neutropenia Other Serious 4/6/2009 59 Female 119 lb 4/9/2010 Physician France
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 3/10/2010 66 Female 137 lb 4/27/2010 Physician Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/15/2009 54 Male 150 lb 4/29/2010 Physician Germany
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 3/25/2010 64 Female 115 lb 4/29/2010 Physician Germany
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 1/14/2010 34 Female 251 lb 6/8/2010 Physician United States
Primary
Secondary
Pyrexia Hospitalization 1/13/2009 66 Female 150 lb 6/23/2010 Physician Germany
Primary
Secondary
Diarrhoea Hospitalization 12/6/2009 40 Female 193 lb 7/6/2010 Physician United States
Primary
Secondary
Hepatic Enzyme Increased Other Serious 12/29/2009 25 Female 132 lb 7/26/2010 Physician France
Primary
Secondary
Concomitant
Metastases To Liver Other Serious 9/18/2009 63 Female 174 lb 7/29/2010 Physician Italy
Primary
Secondary
Concomitant
Organising Pneumonia Hospitalization 11/24/2009 42 Female 101 lb 7/30/2010 Physician Belgium
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 12/29/2009 25 Female 132 lb 8/2/2010 Physician France
Primary
Secondary
Concomitant
Organising Pneumonia Hospitalization 11/24/2009 42 Female 8/6/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2/14/2009 52 Female 125 lb 8/30/2010 Physician Taiwan, Province Of China
Primary
Secondary
Metastases To Liver Other Serious 9/18/2009 63 Female 174 lb 9/1/2010 Physician Italy
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 8/11/2010 49 Female 139 lb 11/10/2010 Physician Italy
Primary
Secondary
Neutropenia Other Serious 9/8/2010 47 Female 123 lb 11/12/2010 Physician Italy
Primary
Secondary
Organising Pneumonia Hospitalization 11/24/2009 42 Female 101 lb 11/16/2010 Physician Belgium
Primary
Secondary
Concomitant
Organising Pneumonia Hospitalization 11/24/2009 42 Female 11/18/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Gastroenteritis Hospitalization 12/14/2009 37 Female 134 lb 11/18/2010 Physician United States
Primary
Secondary
Vomiting Hospitalization 11/12/2010 38 Female 11/19/2010 Physician South Africa
Primary
Secondary
Concomitant
Haemoglobin Decreased Hospitalization 11/9/2010 50 Female 128 lb 11/19/2010 Physician Germany
Primary
Secondary
Concomitant
Pyrexia Other Serious 8/11/2010 49 Female 139 lb 11/23/2010 Physician Italy
Primary
Secondary
Neutropenia Other Serious 9/8/2010 47 Female 123 lb 11/24/2010 Physician Italy
Primary
Secondary
Haemoglobin Decreased Hospitalization 11/9/2010 50 Female 128 lb 12/1/2010 Physician Germany
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Death Female 117 lb 12/3/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 11/12/2010 38 Female 12/9/2010 Physician South Africa
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/9/2010 38 Female 12/20/2010 Physician South Africa
Primary
Secondary
Concomitant
Neutropenia Other Serious 1/5/2008 62 1/3/2011 Physician Italy
Primary
Secondary
Neutropenia Other Serious 4/9/2009 44 1/18/2011 Physician Italy
Primary
Secondary
Haematemesis Hospitalization 1/9/2011 72 Male 226 lb 1/20/2011 Physician United States
Primary
Secondary
Concomitant
Neutropenia Other Serious 4/9/2009 44 1/25/2011 Physician Italy
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 11/1/2010 64 Female 2/4/2011 Other Health Professional Poland
Primary
Secondary
Concomitant
Pneumonia Hospitalization 2/1/2011 54 Female 187 lb 3/2/2011 Physician Belgium
Primary
Secondary
Concomitant
Pneumonia Hospitalization 2/1/2011 54 Female 187 lb 3/21/2011 Physician Belgium
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious 3/28/2011 61 Female 143 lb 5/10/2011 Physician Italy
Primary
Secondary
Febrile Neutropenia Other Serious 3/28/2011 61 Female 143 lb 5/25/2011 Physician Italy
Primary
Secondary
Febrile Neutropenia Other Serious 3/28/2011 61 Female 143 lb 6/9/2011 Physician Italy
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 59 Female 6/24/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Other Serious 59 Female 6/24/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Neutropenia Other Serious 9/17/2009 61 Female 7/15/2011 Physician Germany
Primary
Secondary
Concomitant
Neutropenia Other Serious 3/14/2011 48 Female 7/21/2011 Physician Italy
Primary
Secondary
Concomitant
Neutropenia Other Serious 9/17/2009 61 Female 7/26/2011 Physician Germany
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization 8/14/2011 73 Male 10/14/2011 Physician Germany
Primary
Secondary
Concomitant
Dyspnoea At Rest Hospitalization 11/1/2009 59 Female 141 lb 12/1/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Cardiac Failure Congestive Hospitalization 11/1/2009 59 Female 12/6/2011 Physician Russian Federation
Primary
Secondary
Concomitant
Neutropenia Hospitalization 6/17/2009 55 Female 128 lb 2/3/2012 Physician Germany
Primary
Secondary
Concomitant
Neutropenia Hospitalization 6/19/2009 55 Female 128 lb 2/17/2012 Physician Germany
Primary
Secondary
Concomitant
Disease Progression Other Serious Female 2/22/2012 Consumer India
Primary
Secondary
Concomitant
Dehydration Hospitalization 4/16/2012 63 Female 154 lb 4/26/2012 Physician Germany
Primary
Secondary
Muscular Weakness Death 3/1/2011 Female 5/10/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 3/11/2012 Female 5/10/2012 Other Health Professional Denmark
Primary
Secondary
Concomitant
Rash Pustular Death 1/1/2011 45 Female 5/16/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ingrowing Nail Hospitalization 1/1/2011 45 Female 5/18/2012 Other Health Professional Denmark
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Other Serious 5/21/2012 60 Female 154 lb 7/11/2012 Physician United States
Primary
Concomitant
Disease Recurrence Other Serious 1/1/2006 45 Female 8/3/2012 Physician Australia
Primary
Secondary
Concomitant
Hypersensitivity Other Serious 8/20/2012 Other Health Professional Italy
Primary
Secondary
Myocardial Infarction Hospitalization 11/2009 Female 141 lb 2/6/2013 Physician Ru
Primary
Secondary
Concomitant
Neutropenia Hospitalization 6/17/2009 56 Female 128 lb 9/11/2012 Physician De
Primary
Secondary
Concomitant
Vomiting Hospitalization NotSpecified 6/26/2013 Other Health Professional It
Primary
Secondary
Toxicity To Various Agents Other Serious 5/1/2011 46 Female 150 lb 11/26/2012 Physician Be
Primary
Secondary
Stomatitis Other Serious Male 1/3/2013 Other Health Professional Be
Primary
Secondary
Neutropenia Other Serious NotSpecified 1/3/2013 Other Health Professional Be
Primary
Secondary
Rash Other Serious Female 1/29/2013 Other Health Professional Dk
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 2/2008 Female 2/11/2013 Physician Dk
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Other Serious 8/2012 68 Female 116 lb 1/22/2013 Physician Be
Primary
Secondary
Concomitant
Rash Other Serious Female 1/25/2013 Physician Dk
Primary
Secondary
Rash Other Serious 2/2008 Female 3/14/2013 Physician Dk
Primary
Secondary
Concomitant
Rash Other Serious Female 1/22/2013 Physician Dk
Primary
Secondary
Metastatic Neoplasm Other Serious 2/2011 36 Female 6/17/2013 Physician Au
Primary
Secondary
Concomitant
Metastases To The Mediastinum Other Serious 7/29/2009 35 Female 137 lb 2/28/2013 Other Health Professional Dk
Primary
Secondary
Rash Other Serious Female 2/15/2013 Physician Dk
Primary
Secondary
Concomitant
Metastases To The Mediastinum Other Serious 7/29/2009 35 Female 2/11/2013 Physician Dk
Primary
Secondary
Metastases To The Mediastinum Other Serious 7/29/2009 35 Female 137 lb 2/26/2013 Physician Dk
Primary
Secondary
Disease Progression Other Serious NotSpecified 2/26/2013 Physician Au
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Death 8/12/2011 58 Female 4/24/2013 Physician Sk
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 8/12/2011 58 Female 4/30/2013 Physician Sk
Primary
Secondary
Concomitant
Metastases To Bone Other Serious Female 5/23/2013 Physician Au
Primary
Secondary
Concomitant
Disease Progression Other Serious Female 8/6/2013 Physician Dk
Primary
Secondary
Concomitant
Disease Progression Other Serious 62 Female 8/6/2013 Physician Dk
Primary
Secondary
Concomitant
Disease Progression Other Serious Female 8/2/2013 Physician Dk
Primary
Secondary
Concomitant
Disease Progression Other Serious Female 7/25/2013 Physician Dk
Primary
Secondary
Concomitant
Off Label Use Other Serious 62 Female 8/27/2013 Physician Dk
Primary
Secondary
Concomitant
Disease Progression Hospitalization Female 8/23/2013 Physician Dk
Primary
Secondary
Concomitant
Disease Progression Hospitalization 62 Female 8/7/2013 Dk
Primary
Secondary
Concomitant
Procedural Complication Death 6/2012 62 Female 8/14/2013 Physician Ru
Primary
Secondary
Concomitant

Drug Data