Fluorouracil combined with Irinotecan Hydrochloride

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting Hospitalization 4/11/2006 43 Female 148 lb 7/4/2006 Other Health Professional United Kingdom
Primary
Secondary
Depressed Level Of Consciousness Other Serious 8/6/2006 42 Male 9/20/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/7/2007 52 Female 150 lb 12/27/2007 Canada
Primary
Concomitant
Thrombosis Hospitalization 2/2/2008 Female 163 lb 2/28/2008 Physician Germany
Primary
Secondary
Concomitant
Intestinal Ulcer Hospitalization 10/1/2007 Female 3/6/2008 Physician United Kingdom
Primary
Concomitant
Platelet Count Decreased Life Threatening 10/2/2007 Female 3/10/2008 Physician Japan
Primary
Secondary
Concomitant
Necrotising Fasciitis Hospitalization 2/22/2008 Male 3/11/2008 Consumer United Kingdom
Primary
Concomitant
Sepsis Death 11/18/2007 Male 3/11/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Haemorrhage Death 9/28/2007 Male 3/11/2008 Physician Japan
Primary
Secondary
Concomitant
Hypersensitivity Hospitalization 1/16/2008 Male 3/13/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 3/22/2006 Male 181 lb 3/17/2008 United Kingdom
Primary
Secondary
Interacting
White Blood Cell Count Decreased Hospitalization 9/25/2007 Female 79 lb 3/18/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Fistula Other Serious 2/23/2008 62 Male 3/21/2008 Physician Germany
Primary
Secondary
Rash Generalised Other Serious 12/30/2007 Male 128 lb 3/21/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Delusion Other Serious 3/8/2008 63 Female 3/25/2008 Consumer United Kingdom
Primary
Concomitant
Convulsion Hospitalization 2/29/2008 Male 185 lb 3/27/2008 Physician Germany
Primary
Secondary
Concomitant
Convulsion Hospitalization 2/29/2008 Male 185 lb 3/31/2008 Consumer United States
Primary
Secondary
Concomitant
Necrotising Fasciitis Hospitalization 2/24/2008 Male 146 lb 4/4/2008 Consumer United Kingdom
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 1/23/2008 Female 121 lb 4/9/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombosis Hospitalization 9/13/2007 Female 179 lb 4/9/2008 Physician Germany
Primary
Secondary
Concomitant
Pathological Fracture Hospitalization 11/16/2007 Male 4/11/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Intestinal Obstruction Other Serious 8/17/2003 57 Male 4/9/2008 United States
Primary
Secondary
Oesophagitis Hospitalization 68 Male 4/18/2008 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 1/23/2008 Female 121 lb 4/21/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 1/23/2008 Male 150 lb 4/24/2008 Physician Germany
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 4/9/2008 Male 4/29/2008 Consumer United Kingdom
Primary
Concomitant
Reflux Oesophagitis Hospitalization 3/29/2008 Male 157 lb 4/30/2008 Physician United Kingdom
Primary
Concomitant
Abscess Intestinal Hospitalization 3/25/2008 Male 130 lb 5/1/2008 Physician France
Primary
Secondary
Fistula Hospitalization 3/27/2008 Female 5/1/2008 Physician Germany
Primary
Secondary
Urine Output Decreased Hospitalization 4/16/2008 Female 5/1/2008 Physician United Kingdom
Primary
Secondary
Colitis Hospitalization 8/31/2008 Male 170 lb 10/8/2008 Physician United States
Primary
Concomitant
Interstitial Lung Disease Other Serious 1/10/2007 Male 10/8/2008 Physician Australia
Primary
Concomitant
Pulmonary Embolism Life Threatening 65 Male 168 lb 10/8/2008 Other Health Professional United Kingdom
Primary
Concomitant
Vertigo Hospitalization 7/18/2008 70 Male 203 lb 10/10/2008 Consumer United States
Primary
Secondary
Concomitant
Convulsion Hospitalization 10/1/2008 Female 283 lb 10/10/2008 Consumer United States
Primary
Secondary
Rhabdomyolysis Hospitalization 9/1/2008 Male 10/10/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Keratoconjunctivitis Sicca Hospitalization 9/5/2008 68 Male 10/13/2008 Consumer Germany
Primary
Secondary
General Physical Health Deterioration Hospitalization 7/18/2007 Female 10/14/2008 Physician France
Primary
Secondary
Septic Shock Hospitalization 6/28/2007 Female 10/14/2008 Physician France
Primary
Secondary
Neutrophil Count Decreased Disability 11/22/2007 Female 98 lb 10/14/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 4/2/2008 Male 134 lb 10/15/2008 Physician Japan
Primary
Secondary
Concomitant
Sepsis Life Threatening 7/11/2008 Male 10/17/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Hypersensitivity Other Serious 6/16/2008 Female 183 lb 10/20/2008 Physician Germany
Primary
Secondary
Concomitant
Pulmonary Thrombosis Hospitalization 10/3/2008 Male 10/20/2008 Physician Sweden
Primary
Secondary
Concomitant
Laryngospasm Life Threatening 10/8/2008 Female 10/20/2008 Physician Austria
Primary
Secondary
Concomitant
Hypovolaemic Shock Life Threatening 10/5/2008 Female 10/21/2008 Physician Switzerland
Primary
Secondary
Hypovolaemic Shock Life Threatening 10/8/2008 Female 10/22/2008 Physician United Kingdom
Primary
Secondary
Restrictive Pulmonary Disease Other Serious 1/10/2007 Male 10/22/2008 Physician Australia
Primary
Concomitant
Anaphylactic Shock Other Serious 5/15/2008 Female 10/23/2008 Consumer Japan
Primary
Secondary
Concomitant
Pneumatosis Intestinalis Other Serious 6/26/2008 Female 10/23/2008 Physician Germany
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 8/9/2007 55 Male 10/24/2008 Consumer United States
Primary
Secondary
Vomiting Hospitalization 10/14/2008 70 Male 10/24/2008 Consumer Germany
Primary
Secondary
Weight Decreased Hospitalization 7/1/2008 Female 10/27/2008 Physician Germany
Primary
Secondary
Concomitant
Uterine Haemorrhage Other Serious 7/1/2008 40 Female 10/27/2008 Consumer Denmark
Primary
Secondary
Pulmonary Thrombosis Hospitalization 10/3/2008 Male 10/29/2008 Physician Sweden
Primary
Secondary
Concomitant
Abdominal Rigidity Other Serious 7/1/2008 Male 10/29/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 10/9/2008 35 Male 10/30/2008 Other Health Professional France
Primary
Secondary
Sinus Tachycardia Other Serious 9/1/2008 69 Male 10/31/2008 Physician Switzerland
Primary
Concomitant
Intestinal Obstruction Life Threatening 9/17/2008 Female 10/31/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Neutrophil Count Decreased Other Serious 1/11/2008 Male 106 lb 10/31/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypomagnesaemia Other Serious 5/13/2008 Male 185 lb 10/31/2008 Physician United States
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 10/4/2008 Female 90 lb 11/3/2008 Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/14/2008 70 Male 11/4/2008 Consumer Germany
Primary
Secondary
Death Death 1/25/2008 Male 11/4/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Drug Eruption Hospitalization 6/16/2008 Female 11/4/2008 Consumer Japan
Primary
Secondary
Concomitant
Flushing Hospitalization 10/23/2008 Male 123 lb 11/4/2008 Consumer Japan
Primary
Concomitant
Rectal Haemorrhage Other Serious 10/1/2008 45 Female 11/5/2008 Physician Russian Federation
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 10/4/2008 Female 90 lb 11/5/2008 Japan
Primary
Secondary
Concomitant
Lung Abscess Hospitalization 10/14/2008 Male 11/7/2008 Physician Singapore
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 10/5/2008 Male 11/7/2008 Physician Germany
Primary
Secondary
Diarrhoea Hospitalization 9/29/2008 68 Male 11/7/2008 Consumer Germany
Primary
Secondary
Neoplasm Progression Death 9/1/2008 Female 11/7/2008 Physician United Kingdom
Primary
Concomitant
Hypovolaemic Shock Life Threatening 10/5/2008 65 Female 11/3/2008 Physician Switzerland
Primary
Secondary
Myocardial Infarction Death 10/30/2008 Female 104 lb 11/7/2008 Japan
Primary
Secondary
Concomitant
Pelvic Venous Thrombosis Hospitalization 8/9/2007 Male 11/10/2008 Physician Germany
Primary
Secondary
Grand Mal Convulsion Hospitalization 9/10/2008 Female 11/10/2008 Physician United Kingdom
Primary
Concomitant
Disease Progression Death 5/8/2008 Female 157 lb 11/10/2008 Physician Japan
Primary
Secondary
Concomitant
Peptic Ulcer Disability 1/1/2008 Male 119 lb 11/10/2008 Consumer Japan
Primary
Secondary
Concomitant
Pulmonary Thrombosis Hospitalization 10/3/2008 Male 11/10/2008 Physician Sweden
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 4/2/2008 Male 115 lb 11/11/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypomagnesaemia Other Serious 5/13/2008 Male 185 lb 11/11/2008 Physician United States
Primary
Secondary
Concomitant
Keratoconjunctivitis Sicca Hospitalization 9/5/2008 68 Male 11/11/2008 Consumer United States
Primary
Secondary
Pulmonary Infarction Life Threatening 10/22/2008 Female 121 lb 11/11/2008 Consumer United Kingdom
Primary
Concomitant
Hypovolaemic Shock Life Threatening 10/8/2008 Female 11/11/2008 Physician United Kingdom
Primary
Secondary
Herpes Zoster Hospitalization 11/29/2007 Female 105 lb 11/12/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Skin Discolouration Other Serious 10/14/2008 Female 11/12/2008 Physician United Kingdom
Primary
Concomitant
Keratoconjunctivitis Sicca Hospitalization 9/10/2008 Male 11/12/2008 Physician Switzerland
Primary
Secondary
Pleural Effusion Death 10/30/2008 Female 104 lb 11/13/2008 Japan
Primary
Secondary
Concomitant
Abscess Intestinal Hospitalization 3/25/2008 Male 130 lb 11/14/2008 Physician France
Primary
Secondary
Nephrotic Syndrome Other Serious 1/10/2008 Male 11/14/2008 Physician Japan
Primary
Concomitant
Cardiomyopathy Hospitalization 4/1/2008 68 Female 11/17/2008 Physician Switzerland
Primary
Secondary
Concomitant
Hyperammonaemia Other Serious 66 Male 11/18/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hypersensitivity Other Serious 6/16/2008 Female 183 lb 11/18/2008 Physician Germany
Primary
Secondary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 9/26/2008 Female 11/18/2008 Physician United States
Primary
Concomitant
Cerebral Infarction Hospitalization 8/23/2008 11/18/2008 Consumer United Kingdom
Primary
Secondary
Renal Failure Death 63 Female 11/19/2008 Physician Norway
Primary
Secondary
Anaemia Other Serious 11/19/2008 Physician United Kingdom
Primary
Secondary
Perinephric Collection Hospitalization 9/25/2007 Male 11/19/2008 Physician Australia
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 8/11/2007 Male 11/19/2008 Physician United Kingdom
Primary
Secondary
Vomiting Other Serious 10/11/2008 70 Male 11/20/2008 Consumer Germany
Primary
Secondary
Respiratory Failure Death 58 Male 11/20/2008 Consumer Korea, Republic Of
Primary
Secondary
Concomitant
Anaphylactic Shock Hospitalization 9/1/2008 Female 11/20/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Grand Mal Convulsion Hospitalization 9/10/2008 Female 11/20/2008 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 8/11/2007 Male 11/20/2008 Physician United Kingdom
Primary
Secondary
Lymphocyte Count Decreased Hospitalization 10/30/2008 43 Female 103 lb 11/18/2008 Physician United States
Primary
Secondary
Cytomegalovirus Colitis Hospitalization 1/1/2008 77 Male 11/21/2008 Other Health Professional Japan
Primary
Secondary
Vitreous Haemorrhage Other Serious 8/4/2008 Male 11/21/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Myocardial Ischaemia Hospitalization 7/24/2008 69 Male 212 lb 11/21/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 10/5/2008 Female 11/24/2008 Physician Switzerland
Primary
Secondary
Pulmonary Embolism Life Threatening 10/8/2008 Female 11/25/2008 Physician United Kingdom
Primary
Secondary
Cardiomyopathy Hospitalization 4/1/2008 68 Female 11/25/2008 Physician Switzerland
Primary
Secondary
Concomitant
Epistaxis Hospitalization 9/18/2007 Male 11/25/2008 Consumer Japan
Primary
Secondary
Concomitant
Renal Failure Other Serious 10/14/2008 Male 11/25/2008 Physician United Kingdom
Primary
Secondary
Peritonitis Hospitalization 11/11/2008 Female 108 lb 11/25/2008 Physician United Kingdom
Primary
Concomitant
Anaemia Death 9/16/2008 Female 11/25/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Hypokalaemia Other Serious 4/8/2008 Male 88 lb 11/25/2008 India
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 9/29/2008 Male 11/26/2008 Physician Switzerland
Primary
Secondary
Disorientation Hospitalization 2/13/2008 Male 119 lb 11/26/2008 Physician United Kingdom
Primary
Secondary
Concomitant
C-reactive Protein Increased Hospitalization 9/29/2008 Male 11/26/2008 Consumer United States
Primary
Secondary
Pulmonary Thrombosis Hospitalization 10/4/2008 Male 11/26/2008 Physician Sweden
Primary
Secondary
Concomitant
Pyrexia Hospitalization 9/18/2008 Male 11/26/2008 Physician Austria
Primary
Concomitant
Myocardial Infarction Death 10/30/2008 Female 104 lb 11/28/2008 Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Life Threatening 3/30/2006 Female 137 lb 11/30/2008 United Kingdom
Primary
Secondary
Concomitant
Red Blood Cell Count Decreased Hospitalization 10/30/2008 43 Female 103 lb 11/21/2008 Physician United States
Primary
Secondary
Keratoconjunctivitis Sicca Hospitalization 9/10/2008 Male 12/2/2008 Physician Switzerland
Primary
Secondary
Renal Failure Acute Other Serious 10/5/2008 Female 12/2/2008 Physician Switzerland
Primary
Secondary
Death Death Male 12/5/2008 Physician United Kingdom
Primary
Concomitant
Pulmonary Embolism Other Serious 7/9/2008 Female 12/5/2008 Physician Germany
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 7/1/2008 Female 12/5/2008 Physician Germany
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 9/14/2008 Female 12/5/2008 Physician Germany
Primary
Concomitant
Death Death Male 12/5/2008 Physician United Kingdom
Primary
Concomitant
Death Death Male 12/5/2008 Consumer United Kingdom
Primary
Concomitant
Laryngospasm Life Threatening 10/8/2008 Female 12/5/2008 Physician Austria
Primary
Secondary
Concomitant
Death Death Female 12/5/2008 Consumer United Kingdom
Primary
Concomitant
Death Death Female 12/5/2008 Physician Belgium
Primary
Concomitant
Thrombocytopenia Life Threatening 11/3/2008 Male 12/8/2008 Physician France
Primary
Secondary
Concomitant
Death Death Male 12/8/2008 Consumer United Kingdom
Primary
Concomitant
Generalised Oedema Hospitalization 10/25/2007 Male 12/9/2008 Physician Italy
Primary
Secondary
Vomiting Other Serious 10/20/2008 69 Male 12/5/2008 Other Health Professional Italy
Primary
Secondary
Abdominal Rigidity Other Serious 7/1/2008 Male 12/10/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Platelet Count Decreased Hospitalization 11/25/2008 Male 146 lb 12/10/2008 Physician Japan
Primary
Secondary
Concomitant
Deep Vein Thrombosis Other Serious 5/15/2008 Male 243 lb 12/11/2008 Physician Germany
Primary
Concomitant
Keratoconjunctivitis Sicca Hospitalization 9/5/2008 68 Male 12/12/2008 Consumer United States
Primary
Secondary
Acute Myocardial Infarction Hospitalization 2/22/2008 Male 141 lb 12/15/2008 Physician
Primary
Secondary
Concomitant
Sudden Death Death 10/31/2008 67 Male 12/15/2008 Physician Japan
Primary
Secondary
Pulmonary Thrombosis Hospitalization 10/4/2008 Male 12/15/2008 Physician Sweden
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/6/2008 Male 12/15/2008 Physician Germany
Primary
Secondary
Diarrhoea Hospitalization 1/15/2008 Female 12/17/2008 Physician United Kingdom
Primary
Concomitant
Pancreatitis Acute Hospitalization 11/2/2008 Female 150 lb 12/17/2008 Physician Russian Federation
Primary
Secondary
Left Ventricular Dysfunction Life Threatening 11/26/2008 Male 12/19/2008 Physician France
Primary
Secondary
Concomitant

Drug Data