Fluconazole combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Blood Creatinine Increased Required Intervention 10/10/2005 32 Male 11/15/2005 Other Health Professional United States
Primary
Concomitant
Renal Failure Required Intervention 8/25/2005 61 Male 11/15/2005 Other Health Professional United States
Primary
Concomitant
Renal Failure Required Intervention 11/9/2005 46 Male 11/15/2005 United States
Primary
Concomitant
Renal Failure Acute Required Intervention 10/29/2005 40 Female 11/15/2005 Other Health Professional United States
Primary
Concomitant
Renal Impairment Required Intervention 11/5/2005 54 Female 11/15/2005 Other Health Professional United States
Primary
Concomitant
Renal Failure Hospitalization 8/25/2005 61 Male 2/8/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Blood Creatinine Increased Hospitalization 10/10/2005 32 Male 2/8/2006 Other Health Professional United States
Primary
Concomitant
Renal Impairment Hospitalization 11/5/2005 54 Female 2/8/2006 Other Health Professional United States
Primary
Concomitant
Tracheostomy Hospitalization 40 Male 2/15/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Post Procedural Complication Death 34 Male 2/7/2006 Physician Japan
Primary
Concomitant
Paraesthesia Hospitalization 12/4/2005 21 Male 159 lb 2/17/2006 United Kingdom
Primary
Concomitant
Hemiplegia Death 34 Male 2/16/2006 Physician Japan
Primary
Concomitant
Renal Impairment Hospitalization 11/5/2005 54 Female 2/21/2006 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Other Serious 2/1/2002 Female 226 lb 3/13/2006 Physician United States
Primary
Concomitant
Visual Disturbance Disability 7/1/2005 39 Female 3/22/2006 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 8/25/2005 61 Male 3/24/2006 Other Health Professional United States
Primary
Concomitant
Therapeutic Response Unexpected With Drug Substitution Other Serious 10/4/2005 44 Female 163 lb 3/29/2006 Other Health Professional United Kingdom
Primary
Concomitant
Thrombocytopenia Life Threatening 2/7/2006 40 Female 209 lb 3/28/2006 Physician France
Primary
Secondary
Concomitant
Septic Shock Life Threatening 2/4/2006 40 Female 209 lb 3/28/2006 Consumer France
Primary
Secondary
Concomitant
Tachyarrhythmia Hospitalization 1/1/2006 Male 150 lb 4/7/2006 Physician Germany
Primary
Concomitant
Platelet Count Decreased Hospitalization 1/13/2006 71 Male 137 lb 4/3/2006 Physician France
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 54 Male 4/5/2006 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 1/1/2006 Male 132 lb 4/18/2006 Physician Germany
Primary
Concomitant
Thrombocytopenia Life Threatening 2/4/2006 40 Female 209 lb 4/13/2006 Physician France
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 2/7/2006 40 Female 209 lb 4/14/2006 Physician France
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 62 Male 4/21/2006 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 69 Male 4/21/2006 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 47 Male 4/21/2006 Physician United States
Primary
Secondary
Concomitant
Hyperbilirubinaemia Other Serious 59 Male 4/21/2006 Physician United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 51 Male 4/21/2006 Physician United States
Primary
Secondary
Concomitant
Graft Versus Host Disease Other Serious 55 Male 4/21/2006 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Sepsis Hospitalization 1/1/2006 Male 150 lb 5/5/2006 Physician Germany
Primary
Concomitant
Weight Increased Hospitalization 1/1/2006 Male 132 lb 5/5/2006 Physician Germany
Primary
Concomitant
Respiratory Failure Death 2/26/2006 Female 101 lb 5/8/2006 Physician Germany
Primary
Concomitant
Weight Increased Hospitalization 1/1/2006 Male 132 lb 5/8/2006 Physician Germany
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 1/1/2006 Male 150 lb 5/8/2006 Physician Germany
Primary
Concomitant
Septic Shock Life Threatening 2/4/2006 40 Female 209 lb 5/8/2006 Physician France
Primary
Secondary
Concomitant
Septic Shock Life Threatening 2/7/2006 40 Female 209 lb 5/15/2006 Physician France
Primary
Secondary
Concomitant
Respiratory Failure Death 2/26/2006 Female 101 lb 5/23/2006 Physician Germany
Primary
Concomitant
Weight Decreased Other Serious 6/10/2004 Female 90 lb 6/2/2006 France
Primary
Concomitant
Right Ventricular Failure Death 2/26/2006 Female 101 lb 6/7/2006 Physician Germany
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 1/1/2006 Male 150 lb 6/7/2006 Physician Germany
Primary
Concomitant
Weight Increased Hospitalization 1/1/2006 Male 132 lb 6/7/2006 Physician Germany
Primary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 6/9/2006 Physician United States
Primary
Secondary
Concomitant
Human Herpesvirus 6 Infection Death 34 Male 5/23/2006 Physician Japan
Primary
Concomitant
Vaginal Exfoliation Hospitalization 5/23/2006 Female 139 lb 7/13/2006 Physician United Kingdom
Primary
Concomitant
Pneumonia Fungal Death 7/14/2006 Australia
Primary
Secondary
Concomitant
Bacterial Sepsis Death 7/14/2006 Australia
Primary
Secondary
Concomitant
Bacterial Sepsis Death 7/14/2006 Australia
Primary
Secondary
Concomitant
Bacterial Sepsis Death 7/14/2006 Australia
Primary
Secondary
Concomitant
Pancytopenia Other Serious 5/18/2006 49 Male 146 lb 7/28/2006 Physician France
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 4/7/2006 Female 116 lb 8/10/2006 Physician United States
Primary
Secondary
Concomitant
Chest Discomfort Disability 2/16/2006 43 Female 8/30/2006 Australia
Primary
Secondary
Concomitant
Hyponatraemia Other Serious 7/8/2006 65 Female 9/26/2006 Consumer United States
Primary
Concomitant
Musculoskeletal Chest Pain Hospitalization 11/9/2005 Male 164 lb 10/5/2006 Physician Australia
Primary
Concomitant
Venoocclusive Liver Disease Required Intervention 55 Female 10/5/2006 Germany
Primary
Secondary
Concomitant
Visual Disturbance Other Serious 3/1/2006 61 Male 196 lb 8/8/2006 Pharmacist United States
Primary
Concomitant
Weight Increased Required Intervention 9/18/2006 Male 36 lb 9/29/2006 Pharmacist United States
Primary
Concomitant
Skin Exfoliation Other Serious 31 Female 10/31/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 1/1/2005 72 Male 11/1/2006 Other Health Professional Japan
Primary
Concomitant
Weight Increased Hospitalization 6/13/2006 74 Male 198 lb 11/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/6/2006 77 Male 11/10/2006 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Sepsis Hospitalization Female 87 lb 11/9/2006 United States
Primary
Secondary
Concomitant
Thrombosis 9/29/2006 Pharmacist United States
Primary
Concomitant
Pyrexia Hospitalization 3/28/2006 Male 172 lb 11/28/2006 Physician United States
Primary
Concomitant
Prostate Cancer Other Serious 11/1/2006 Male 12/6/2006 Physician United States
Primary
Concomitant
Venoocclusive Disease Other Serious 10/14/2006 11 Female 60 lb 11/30/2006 Physician Canada
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 10/18/2006 Female 87 lb 12/13/2006 United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 11/9/2005 46 Male 10/7/2006 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Hospitalization 10/29/2005 40 Female 10/7/2006 Other Health Professional United States
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 10/14/2006 11 Female 60 lb 1/4/2007 Physician Canada
Primary
Concomitant
Vasculitis Death 15 Male 2/6/2007 Physician Canada
Primary
Secondary
Concomitant
Vasculitis Death 15 Male 2/12/2007 Physician Canada
Primary
Secondary
Concomitant
Skin Lesion Other Serious 0 Male 2/15/2007 Other Health Professional Turkey
Primary
Secondary
Concomitant
Heart Rate Abnormal Disability 2/16/2006 43 Female 2/17/2007 Australia
Primary
Secondary
Concomitant
Neutropenic Sepsis Death 2/20/2007 Consumer Australia
Primary
Secondary
Thrombocytopenia Other Serious 2/20/2007 Consumer Australia
Primary
Secondary
Thrombocytopenia Other Serious 2/22/2007 Australia
Primary
Secondary
Stem Cell Transplant Death Unknown 2/22/2007 Australia
Primary
Secondary
Neutropenic Sepsis Death 12/20/2006 18 Male 2/20/2007 United Kingdom
Primary
Secondary
Concomitant
Neutropenic Sepsis Death 12/20/2006 18 Male 2/24/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Convulsion Other Serious 11 Male 3/9/2007 Other Health Professional India
Primary
Secondary
Pancytopenia Death 3/10/2007 37 Female 165 lb 3/20/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Life Threatening 1/30/2007 6 Female 45 lb 4/4/2007 Physician United States
Primary
Secondary
Concomitant
Nephritis Interstitial Other Serious 56 5/1/2007 Consumer Australia
Primary
Concomitant
Transplant Rejection Death 5/16/2006 49 Female 109 lb 4/29/2007 Physician Japan
Primary
Concomitant
Venous Haemorrhage Death 42 Male 6/1/2007 Greece
Primary
Secondary
Concomitant
Peroneal Nerve Palsy Hospitalization 6/18/2005 15 Female 108 lb 6/8/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rash Other Serious 0 Male 6/5/2007 Physician Japan
Primary
Concomitant
Peroneal Nerve Palsy Hospitalization 6/18/2005 15 Female 108 lb 6/19/2007 United Kingdom
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 6/18/2005 15 Female 6/13/2007 United Kingdom
Primary
Secondary
Concomitant
Mucous Membrane Disorder Other Serious 57 Female 6/13/2007 Japan
Primary
Secondary
Concomitant
Prophylaxis Hospitalization 6/18/2005 15 Female 6/13/2007 United Kingdom
Primary
Secondary
Concomitant
Peroneal Nerve Palsy Hospitalization 6/18/2005 15 Female 108 lb 6/19/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Visual Disturbance Disability 7/1/2005 39 Female 6/26/2007 Consumer United States
Primary
Concomitant
Lung Neoplasm Malignant Other Serious 5/9/2007 54 Female 6/27/2007 Consumer Australia
Primary
Concomitant
Bursitis Hospitalization 5/14/2007 Female 121 lb 6/27/2007 Italy
Primary
Concomitant
Weight Decreased Other Serious 8/20/2006 70 Female 6/29/2007 Other Health Professional Sweden
Primary
Concomitant
Infection In An Immunocompromised Host Hospitalization 6/25/2003 1 Male 12 lb 6/22/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/3/2007 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/3/2007 Japan
Primary
Secondary
Concomitant
Zygomycosis Other Serious 63 Male 7/3/2007 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 7/10/2007 Other Health Professional Sweden
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/12/2007 Japan
Primary
Secondary
Concomitant
Bursitis Hospitalization 5/14/2007 Female 121 lb 7/12/2007 Italy
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 8/3/2007 Other Health Professional Sweden
Primary
Concomitant
Bursitis Infective Hospitalization 5/14/2007 Female 121 lb 8/10/2007 Italy
Primary
Concomitant
Weight Decreased Other Serious 8/20/2006 Female 8/14/2007 Other Health Professional Sweden
Primary
Concomitant
Lymphoproliferative Disorder Other Serious 1/1/2002 71 Male 9/4/2007
Primary
Concomitant
Leukoencephalopathy Hospitalization 12/5/2006 70 Female 9/6/2007 Physician Japan
Primary
Secondary
Concomitant
Splenomegaly Other Serious 46 Male 9/5/2007 Physician United States
Primary
Concomitant
Zygomycosis Other Serious 63 Male 9/5/2007 Physician United States
Primary
Concomitant
Thrombocytopenia Other Serious 20 Male 9/17/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Required Intervention 10 Male 9/17/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2005 Female 9/28/2007 Other Health Professional Sweden
Primary
Concomitant
Myelodysplastic Syndrome Death 54 9/27/2007 Physician United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Death 61 9/27/2007 Physician United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Death 79 9/27/2007 Physician United States
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 9/12/2007 70 Male 196 lb 10/1/2007 Physician United States
Primary
Secondary
Concomitant
Pericarditis Fungal Other Serious 11/11/2005 3 Female 10/23/2007
Primary
Secondary
Concomitant
Procedural Site Reaction Other Serious 20 Male 10/23/2007 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 11/1/2005 34 Female 10/31/2007
Primary
Secondary
Concomitant
Vasculitis Other Serious 15 Male 11/5/2007 Other Health Professional Canada
Primary
Secondary
Concomitant
Sciatica Other Serious 44 Female 163 lb 11/7/2007 Consumer United Kingdom
Primary
Concomitant
Platelet Count Decreased Hospitalization 20 Male 11/14/2007
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 10/14/2006 11 Female 60 lb 11/8/2007 Physician Canada
Primary
Secondary
Concomitant
Vulvovaginal Mycotic Infection Hospitalization 1/1/2006 Female 11/20/2007 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 10 Male 11/8/2007 Sweden
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 9 Male 11/21/2007 Sweden
Primary
Secondary
Concomitant
Sciatica Other Serious 44 Female 163 lb 11/29/2007 Consumer United Kingdom
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious 10 Male 12/14/2007 Sweden
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 37 Male 12/14/2007 Consumer Turkey
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 37 Male 12/20/2007 Physician Turkey
Primary
Concomitant
Hypertension Other Serious 12/12/2007 1 Female 12/27/2007 United States
Primary
Concomitant
Mucosal Inflammation Hospitalization 37 Male 12/28/2007 Physician Turkey
Primary
Concomitant
Pulmonary Fibrosis Hospitalization 12/1/2007 Female 1/4/2008 United States
Primary
Concomitant
Stomatitis Other Serious 36 Female 265 lb 1/8/2008
Primary
Secondary
Concomitant
Shock Hospitalization 11/15/2007 70 Male 1/7/2008 Physician Japan
Primary
Secondary
Concomitant
Subcutaneous Emphysema Other Serious 17 Male 1/19/2008 Other Health Professional Japan
Primary
Concomitant
Hospitalisation Hospitalization 1/1/2008 74 Female 1/22/2008 Consumer United States
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Death 9/24/2007 46 Female 146 lb 1/24/2008 United Kingdom
Primary
Concomitant
Laboratory Test Abnormal Hospitalization 4/26/2007 Male 139 lb 1/24/2008 United States
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 6/22/2005 31 Female 1/15/2008 Physician Japan
Primary
Concomitant
Graft Versus Host Disease Death 33 Male 2/15/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 53 Male 2/18/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Death 15 Male 2/18/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 27 Female 2/18/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
No Therapeutic Response Death 33 Male 2/19/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Death 15 Male 2/20/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 53 Male 2/20/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant

Drug Data