Fluconazole combined with Itraconazole

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Venoocclusive Disease Life Threatening 11/23/2005 63 Female 121 lb 1/12/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 1/18/2006 31 Female 108 lb 2/17/2006 Consumer United States
Primary
Secondary
Concomitant
Pancytopenia Death 1/1/2005 77 Female 148 lb 2/13/2006 Physician France
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 1/18/2006 Female 108 lb 2/22/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 1/18/2006 31 Female 108 lb 3/22/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Unintended Pregnancy Other Serious 11/8/2005 22 Female 3/16/2006 Pharmacist Netherlands
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 1/18/2006 Female 108 lb 3/24/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 1/18/2006 Female 108 lb 4/4/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Impairment Death 3/29/2006 64 Male 4/25/2006 Japan
Primary
Concomitant
Speech Disorder Hospitalization 8/24/2003 Female 5/26/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Impairment Death 3/29/2006 64 Male 6/30/2006 Japan
Primary
Concomitant
Febrile Neutropenia Other Serious 5/15/2006 83 Female 9/13/2006 United States
Primary
Secondary
Concomitant
Malaise Other Serious 5/1/2005 60 Female 126 lb 11/2/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Malaise Other Serious 5/1/2005 60 Female 126 lb 11/7/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Malaise Other Serious 5/1/2005 60 Female 11/1/2006 United Kingdom
Primary
Secondary
Concomitant
Visual Acuity Reduced Other Serious 62 Male 11/16/2006 Consumer Japan
Primary
Concomitant
Thrombocytopenia Death 5/14/2002 65 Female 11/8/2006 Italy
Primary
Secondary
Concomitant
Malaise Other Serious 5/1/2005 60 Female 126 lb 11/9/2006 United Kingdom
Primary
Secondary
Malaise Other Serious 5/1/2005 60 Female 126 lb 11/9/2006 United Kingdom
Primary
Secondary
Concomitant
Xanthopsia Other Serious 62 Male 12/21/2006
Primary
Concomitant
Xanthopsia Other Serious 62 Male 12/14/2006 Physician Japan
Primary
Concomitant
Neutropenia Other Serious 5/15/2006 83 Female 2/26/2007 Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 3/1/2004 34 Female 3/9/2007 Other Health Professional Japan
Primary
Concomitant
Pneumonia Hospitalization 3/1/2004 34 Female 3/15/2007 Other Health Professional Japan
Primary
Concomitant
Pneumonia Other Serious 5/15/2006 83 Female 3/19/2007 Japan
Primary
Secondary
Concomitant
Pneumonia Other Serious 5/15/2006 83 Female 4/13/2007 Japan
Primary
Secondary
Concomitant
Transplant Rejection Death 5/16/2006 49 Female 109 lb 4/29/2007 Physician Japan
Primary
Concomitant
Pneumonia Other Serious 5/15/2006 83 Female 6/21/2007 United States
Primary
Secondary
Concomitant
Pulmonary Alveolar Haemorrhage Other Serious 3/4/2007 66 Female 7/13/2007 Japan
Primary
Concomitant
Thrombocytopenia Life Threatening 6/11/2007 75 Male 194 lb 7/19/2007 Physician Greece
Primary
Concomitant
Leukoencephalopathy Hospitalization 12/5/2006 70 Female 9/6/2007 Physician Japan
Primary
Secondary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Life Threatening 6/14/2007 63 Male 9/21/2007 Physician Japan
Primary
Secondary
Concomitant
Venous Occlusion Hospitalization 52 Female 9/28/2007 United States
Primary
Concomitant
Thrombocytopenia Life Threatening 6/11/2007 75 Male 194 lb 10/4/2007 Physician Greece
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Life Threatening 6/14/2007 63 Male 11/26/2007 Physician Japan
Primary
Secondary
Concomitant
Tachycardia Life Threatening 9/28/2007 21 Female 150 lb 11/21/2007 Consumer United States
Primary
Secondary
Concomitant
Confusional State Hospitalization 10/25/2007 12/6/2007 Consumer United Kingdom
Primary
Concomitant
Unresponsive To Stimuli Life Threatening 9/28/2007 21 Female 150 lb 12/3/2007 Physician United States
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 33 Male 2/15/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 53 Male 2/18/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Death 15 Male 2/18/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 27 Female 2/18/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
No Therapeutic Response Death 33 Male 2/19/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Death 15 Male 2/20/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 53 Male 2/20/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 27 Female 2/20/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Chronic Myeloid Leukaemia Death 57 Male 2/20/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 1/3/2008 Male 165 lb 3/1/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 33 Male 3/10/2008 Mexico
Primary
Concomitant
Chronic Graft Versus Host Disease Death 15 Male 3/10/2008 Mexico
Primary
Concomitant
Graft Versus Host Disease Death 33 Male 3/12/2008 Mexico
Primary
Concomitant
Chronic Graft Versus Host Disease Death 15 Male 3/12/2008 Mexico
Primary
Concomitant
Febrile Neutropenia Hospitalization 1/3/2008 Male 165 lb 5/5/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Trichosporon Infection Death 73 Male 4/18/2008 Physician Japan
Primary
Concomitant
Drug Eruption Other Serious 52 Female 5/6/2008
Primary
Concomitant
Febrile Neutropenia Hospitalization 1/3/2008 Male 165 lb 5/8/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 3/7/2006 Male 5/28/2008 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/7/2006 Male 6/3/2008 Physician Japan
Primary
Secondary
Concomitant
Death Death 6/9/2008 Other Health Professional Brazil
Primary
Secondary
Aspergillosis Other Serious 43 Male 6/18/2008
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 48 Male 6/20/2008 Other Health Professional Spain
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/7/2006 Male 6/20/2008 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 4/2/2008 19 Male 110 lb 7/16/2008 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 6/24/2008 66 Male 7/24/2008 Physician China
Primary
Concomitant
Respiratory Failure Life Threatening 6/24/2008 66 Male 7/25/2008 Physician China
Primary
Concomitant
Respiratory Failure Life Threatening 6/24/2008 66 Male 7/28/2008 Physician China
Primary
Concomitant
Respiratory Failure Life Threatening 6/24/2008 66 Male 7/30/2008 Physician China
Primary
Secondary
Concomitant
Drug Ineffective Hospitalization 49 Female 8/4/2008 Physician Korea, Republic Of
Primary
Concomitant
Vomiting Hospitalization 3/7/2006 Male 8/5/2008 United States
Primary
Secondary
Concomitant
Drug Ineffective Hospitalization 49 Female 8/7/2008 Physician Korea, Republic Of
Primary
Concomitant
Sepsis Death Male 8/22/2008 Physician Switzerland
Primary
Concomitant
Supraventricular Tachycardia Hospitalization 9/15/2004 41 Male 121 lb 9/30/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/7/2006 Male 10/8/2008 United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 9/15/2004 41 Male 121 lb 10/1/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Other Serious 6/4/2008 61 Male 121 lb 10/13/2008 Physician Japan
Primary
Concomitant
Pneumonia Cryptococcal Hospitalization 24 Male 10/21/2008 Other Health Professional Japan
Primary
Secondary
Drug Resistance Other Serious 55 Male 10/21/2008 Other Health Professional United States
Primary
Concomitant
Vomiting Hospitalization 3/7/2006 Male 10/21/2008 United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 55 Male 10/22/2008 Other Health Professional United States
Primary
Concomitant
Pneumonia Cryptococcal Hospitalization 24 Male 10/30/2008 Other Health Professional Japan
Primary
Secondary
Pleurisy Other Serious 24 Male 11/3/2008 Japan
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 6/4/2008 61 Male 121 lb 11/24/2008 Physician Japan
Primary
Concomitant
Meningitis Cryptococcal Other Serious 6/1/2008 53 Male 12/9/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Meningitis Cryptococcal Other Serious 6/1/2008 53 Male 12/11/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Meningitis Cryptococcal Other Serious 6/1/2008 53 Male 12/12/2008 United States
Primary
Secondary
Concomitant
Meningitis Cryptococcal Death 6/1/2008 53 Male 12/15/2008 Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 24 Male 12/18/2008
Primary
Secondary
Concomitant
Meningitis Cryptococcal Other Serious 6/1/2008 53 Male 12/23/2008 United States
Primary
Secondary
Concomitant
Meningitis Cryptococcal Death 6/1/2008 53 Male 12/23/2008 Japan
Primary
Secondary
Concomitant
Meningitis Cryptococcal Other Serious 6/1/2008 53 Male 12/29/2008 United States
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 6/11/2007 75 Male 194 lb 2/13/2009 Physician Greece
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 8/28/2008 Male 2/26/2009 Pharmacist Portugal
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/2/2008 19 Male 110 lb 3/20/2009 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 6/1/2006 Female 98 lb 3/20/2009 Other Health Professional United States
Primary
Concomitant
Infection Other Serious 4/14/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Skin Test Positive Other Serious 42 Female 5/11/2009
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 6/1/2006 Female 98 lb 5/13/2009 United States
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Death 5/11/2009 India
Primary
Secondary
Concomitant
Pulmonary Embolism Death 5/11/2009 India
Primary
Secondary
Concomitant
Bronchopulmonary Aspergillosis Death 5/11/2009 India
Primary
Secondary
Concomitant
Haemorrhage Death Unknown 5/11/2009 India
Primary
Secondary
Concomitant
Haemorrhagic Diathesis Death Unknown 5/11/2009 India
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 6/24/2009 United States
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 6/25/2009 United States
Primary
Secondary
Concomitant
Renal Tubular Acidosis Hospitalization 4/14/2007 Female 7/1/2009 Physician United States
Primary
Concomitant
Meningitis Cryptococcal Other Serious 5/1/2007 53 Male 7/31/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 6/11/2008 22 Female 9/24/2009 Physician Japan
Primary
Secondary
Concomitant
Trichophytosis Hospitalization 7/17/2007 60 Female 11/19/2009 Physician Korea, Republic Of
Primary
Concomitant
Pleural Effusion Life Threatening 9/1/2009 Female 145 lb 1/19/2010 Consumer United States
Primary
Secondary
Concomitant
Treatment Failure Other Serious 44 2/16/2010 Other Health Professional United Kingdom
Primary
Concomitant
Pyrexia Other Serious 3/22/2009 15 Male 110 lb 2/26/2010 Physician Japan
Primary
Concomitant
Treatment Failure Other Serious 44 3/12/2010 Other Health Professional Canada
Primary
Concomitant
Transaminases Increased Other Serious 3/17/2010 United States
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 3/19/2010 United States
Primary
Secondary
Concomitant
Treatment Failure Other Serious 44 4/23/2010 Other Health Professional Canada
Primary
Concomitant
Drug Ineffective Death 16 Female 5/12/2010 Physician Japan
Primary
Secondary
Drug Ineffective Death 17 Male 5/12/2010 Physician Japan
Primary
Secondary
Drug Ineffective Death 3 Female 5/12/2010 Physician Japan
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 10/19/2009 54 Male 132 lb 6/21/2010 Other Health Professional Japan
Primary
Concomitant
Staphylococcal Infection Other Serious 4/14/2010 60 Male 110 lb 6/25/2010 Physician Japan
Primary
Concomitant
Weight Decreased 7/31/2008 59 Female 97 lb 8/6/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 1/9/2009 58 Female 97 lb 7/28/2010 Physician Japan
Primary
Concomitant
Respiratory Failure Death 1/1/2009 30 Male 8/26/2010 Other Health Professional Viet Nam
Primary
Concomitant
Staphylococcal Infection Other Serious 8/26/2010 63 Female 9/14/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Therapeutic Response Decreased Death 4/4/2009 55 Male 165 lb 11/29/2010 Physician Japan
Primary
Concomitant
Weight Increased Other Serious 1/1/2010 57 Female 143 lb 12/13/2010 Consumer United Kingdom
Primary
Concomitant
Drug Ineffective Death Female 12/21/2010 Other Health Professional China
Primary
Secondary
Concomitant
Hypertension Hospitalization 3/20/2010 71 Female 106 lb 12/30/2010 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Hospitalization 2/23/2010 69 Male 130 lb 12/30/2010 Physician Japan
Primary
Concomitant
Blood Bilirubin Increased Other Serious 5/7/2010 37 Male 152 lb 1/5/2011 Physician Japan
Primary
Concomitant
Keratitis Fungal Other Serious 75 Female 1/5/2011 Physician United Kingdom
Primary
Secondary
Keratitis Fungal Other Serious 75 Female 1/5/2011 Other Health Professional United Kingdom
Primary
Secondary
Interstitial Lung Disease Death 10/23/2009 62 Male 130 lb 1/6/2011 Physician Japan
Primary
Concomitant
Therapeutic Response Decreased Other Serious 7/1/2009 48 Female 115 lb 1/6/2011 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Death 10/23/2009 62 Male 130 lb 1/7/2011 Physician Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 10/29/2009 53 Female 159 lb 1/10/2011 Physician Japan
Primary
Concomitant
Cardiac Failure Death 8/6/2010 35 Female 71 lb 1/10/2011 Physician Japan
Primary
Concomitant
Blood Pressure Increased Other Serious 8/9/2009 48 Female 115 lb 1/10/2011 Physician Japan
Primary
Secondary
Concomitant
Keratitis Fungal Other Serious 75 Female 1/11/2011 Consumer United Kingdom
Primary
Secondary
Keratitis Fungal Other Serious 75 Female 1/13/2011 Other Health Professional United Kingdom
Primary
Secondary
Keratitis Fungal Other Serious 75 Female 1/14/2011 Other Health Professional United Kingdom
Primary
Secondary
Staphylococcal Infection Death 4/14/2010 60 Male 110 lb 1/20/2011 Physician Japan
Primary
Concomitant
Keratitis Fungal Other Serious 1/1/1998 75 Female 1/11/2011 United Kingdom
Primary
Secondary
Nasopharyngitis Other Serious 1/1/2010 57 Female 143 lb 1/28/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Keratitis Other Serious 75 Female 1/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Staphylococcal Infection Other Serious 8/26/2010 63 Female 1/28/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Death 1/19/2011 57 Male 2/10/2011 Physician Japan
Primary
Concomitant
Bone Marrow Failure Other Serious 8/26/2010 63 Female 2/10/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 80 Female 3/28/2011 Other Health Professional Japan
Primary
Secondary
Pulmonary Mycosis Death 80 Female 3/30/2011 Physician Japan
Primary
Secondary

Drug Data