Etoposide combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Neurotoxicity Death 36 Female 1/4/2006 Consumer Japan
Primary
Secondary
Tongue Disorder Other Serious 12/5/2005 Male 216 lb 12/27/2005 United States
Primary
Secondary
Pancytopenia Other Serious 11/15/2004 36 Male 1/10/2006 Consumer United States
Primary
Secondary
Concomitant
Neurotoxicity Death 36 Female 1/5/2006 Physician Turkey
Primary
Secondary
Concomitant
Palpitations Hospitalization 8/4/2005 Female 1/20/2006 Other Health Professional Sweden
Primary
Concomitant
Myelodysplastic Syndrome Other Serious 11/15/2004 36 Male 1/24/2006 Consumer United States
Primary
Secondary
Concomitant
Leukoencephalopathy Death 36 Female 1/26/2006 Consumer Japan
Primary
Secondary
Drug Toxicity Death Unknown 1/25/2006 United States
Primary
Secondary
Drug Toxicity Death Unknown 1/25/2006 United States
Primary
Secondary
Drug Toxicity Death Unknown 1/25/2006 United States
Primary
Secondary
Drug Toxicity Death Unknown 1/25/2006 United States
Primary
Secondary
Weight Decreased Death 6 Male 1/27/2006 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 6 Female 1/28/2006 Physician United States
Primary
Secondary
Swelling Death 36 Female 1/31/2006 Physician Turkey
Primary
Secondary
Small Cell Lung Cancer Stage Unspecified Death Female 129 lb 2/3/2006 United States
Primary
Concomitant
Vasculitic Rash Other Serious 10/1/2005 Male 2/7/2006 Physician Australia
Primary
Concomitant
Swelling Death 36 Female 2/13/2006 Physician Turkey
Primary
Secondary
Therapy Non-responder Death 36 Female 2/14/2006 Physician Turkey
Primary
Secondary
Staphylococcal Infection Hospitalization 11/23/2005 Male 3/1/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 36 Male 161 lb 3/16/2006 Japan
Primary
Secondary
Concomitant
Vasculitic Rash Other Serious 10/1/2005 Male 168 lb 3/20/2006 Physician Australia
Primary
Concomitant
T-cell Lymphoma Hospitalization 36 Female 3/17/2006 Physician Turkey
Primary
Secondary
Urinary Incontinence Disability 18 Male 3/15/2006
Primary
Secondary
Concomitant
Rash Generalised Hospitalization 1/13/2006 59 Female 3/28/2006 Other Health Professional France
Primary
Secondary
Concomitant
Treatment Related Secondary Malignancy Death 3/1/2005 42 Female 3/28/2006 Consumer United States
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 8/27/2005 63 Female 3/22/2006 Physician France
Primary
Secondary
Concomitant
Stupor Death 36 Female 3/24/2006 Turkey
Primary
Secondary
Concomitant
Performance Status Decreased Other Serious 3/13/2006 Male 216 lb 3/29/2006 United States
Primary
Secondary
Platelet Count Decreased Hospitalization 1/13/2006 71 Male 137 lb 4/3/2006 Physician France
Primary
Secondary
Concomitant
Stem Cell Transplant Hospitalization 1/13/2006 59 Female 4/18/2006 Other Health Professional France
Primary
Secondary
Concomitant
Therapy Non-responder Other Serious 66 Male 4/18/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Therapy Non-responder Other Serious 66 Male 4/21/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sepsis Hospitalization 25 Female 5/10/2006 Consumer United States
Primary
Secondary
Therapy Non-responder Hospitalization 66 Male 5/5/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
T-cell Lymphoma Death 66 Male 5/12/2006 Consumer United States
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 2/13/2005 66 Female 5/15/2006 Physician Germany
Primary
Concomitant
Thrombocytopenia Other Serious 16 Male 6/6/2006 Physician United States
Primary
Concomitant
Sepsis Hospitalization 5/10/2006 49 Female 6/29/2006 France
Primary
Secondary
Pyrexia Death 5/10/2006 49 Female 212 lb 7/7/2006 Physician France
Primary
Secondary
Concomitant
Tongue Disorder Hospitalization 6/1/2006 Male 212 lb 7/18/2006 Physician Germany
Primary
Secondary
Concomitant
Peritonitis Hospitalization 1/1/2001 56 Male 7/25/2006 Consumer United States
Primary
Secondary
Concomitant
Stomatitis Other Serious 7/13/2006 Female 165 lb 8/1/2006 Physician Belgium
Primary
Concomitant
Metastasis Other Serious 3 Male 7/25/2006 Physician Turkey
Primary
Secondary
Mucoepidermoid Carcinoma Other Serious 13 Female 7/25/2006 Physician Turkey
Primary
Secondary
Primitive Neuroectodermal Tumour Death 10 Male 7/25/2006 Physician Turkey
Primary
Secondary
Therapeutic Response Decreased Other Serious 37 Female 7/25/2006 Physician Japan
Primary
Secondary
Convulsion Other Serious 7/26/2006 Physician United States
Primary
Concomitant
Soft Tissue Disorder Other Serious 7/26/2006 Physician United States
Primary
Concomitant
Soft Tissue Disorder Other Serious 7/26/2006 Physician United States
Primary
Concomitant
Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Staphylococcal Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Enterobacter Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Bacterial Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Soft Tissue Disorder Required Intervention Unknown 7/26/2006 Physician United States
Primary
Concomitant
Soft Tissue Disorder Required Intervention Unknown 7/26/2006 Physician United States
Primary
Concomitant
Convulsion Other Serious Unknown 7/26/2006 Physician United States
Primary
Concomitant
Convulsion Other Serious Unknown 7/26/2006 Physician United States
Primary
Concomitant
Convulsion Other Serious Unknown 7/26/2006 Physician United States
Primary
Concomitant
Treatment Related Secondary Malignancy Other Serious 3 Male 8/3/2006 Consumer United States
Primary
Secondary
Respiratory Failure Required Intervention 20 Female 7/24/2006 Other Health Professional Japan
Primary
Secondary
Treatment Related Secondary Malignancy Death 10 Male 8/3/2006 Consumer United States
Primary
Secondary
Treatment Related Secondary Malignancy Other Serious 13 Female 8/3/2006 Consumer United States
Primary
Secondary
Tumour Perforation Required Intervention 20 Female 8/1/2006 Other Health Professional Japan
Primary
Secondary
White Blood Cell Count Decreased Life Threatening 3/6/2006 64 Male 182 lb 8/3/2006 Other Health Professional United States
Primary
Concomitant
Weight Decreased Hospitalization 12/30/2004 75 Male 8/2/2006 Physician France
Primary
Secondary
Concomitant
Sepsis Death 45 Female 8/30/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 27 Female 8/30/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Sepsis Death 45 Female 9/22/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 27 Female 9/26/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Hyponatraemia Other Serious 7/8/2006 65 Female 9/26/2006 Consumer United States
Primary
Concomitant
Septic Shock Death 10/2/2006 Consumer France
Primary
Secondary
Concomitant
Neurotoxicity Other Serious 10/2/2006 Consumer France
Primary
Secondary
Concomitant
Lung Infection Pseudomonal Other Serious 50 Female 9/29/2006 Canada
Primary
Secondary
Concomitant
Stem Cell Transplant Death Unknown 9/29/2006 France
Primary
Secondary
Concomitant
Neurotoxicity Other Serious Unknown 9/29/2006 France
Primary
Secondary
Concomitant
Stomatitis Other Serious 7/1/2006 Female 165 lb 10/9/2006 Physician Belgium
Primary
Concomitant
Vomiting Hospitalization 17 Female 88 lb 10/10/2006 Consumer Brazil
Primary
Concomitant
Vomiting Hospitalization 17 Female 88 lb 10/10/2006 Consumer Brazil
Primary
Concomitant
Stomatitis Other Serious 37 Female 10/17/2006 Consumer United States
Primary
Secondary
Thrombocytopenia Required Intervention 40 Male 10/6/2006 United States
Primary
Secondary
Thrombocytopenia Other Serious 16 Female 10/18/2006 Physician France
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 10/1/2005 66 Male 10/18/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Required Intervention 31 Female 10/23/2006 Japan
Primary
Secondary
Concomitant
Sinus Tachycardia Hospitalization 8/31/2006 47 112 lb 10/23/2006 Physician Germany
Primary
Secondary
Neutropenic Sepsis Death Female 10/23/2006 Physician Egypt
Primary
Secondary
Neutropenic Sepsis Death Female 10/23/2006 Physician Egypt
Primary
Secondary
Respiratory Failure Required Intervention 6/25/2004 31 Female 11/3/2006 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 6/25/2004 31 Female 11/3/2006 Japan
Primary
Secondary
Concomitant
Tuberculosis Other Serious 6/1/1994 38 Male 11/15/2006 Other Health Professional Turkey
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 16 Female 11/27/2006
Primary
Secondary
Concomitant
Stomatitis Hospitalization 7/2/2006 Female 51 lb 11/30/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Stomatitis Other Serious 7/12/2006 Female 165 lb 12/12/2006 Physician Belgium
Primary
Concomitant
Mucosal Inflammation Hospitalization 11/30/2006 Male 254 lb 12/6/2006 United States
Primary
Secondary
Tremor Hospitalization 11/20/2006 Female 216 lb 12/6/2006 United States
Primary
Secondary
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 2 Male 1/4/2007 Other Health Professional Thailand
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 8 Male 1/16/2007 Other Health Professional Germany
Primary
Concomitant
Sepsis Death 1/14/2007 Female 14 lb 1/17/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Vith Nerve Paralysis Other Serious 10/22/2006 23 Male 172 lb 1/10/2007 Physician Finland
Primary
Secondary
Concomitant
Hepatic Failure Death 1/11/2007 72 Female 2/12/2007 Other Health Professional Italy
Primary
Secondary
Weight Decreased Other Serious 12/1/2004 49 Male 2/10/2007 Japan
Primary
Concomitant
Interstitial Lung Disease Hospitalization Female 2/14/2007 Consumer United States
Primary
Secondary
Retroperitoneal Fibrosis Hospitalization 66 Female 2/26/2007
Primary
Secondary
Concomitant
Ureteric Obstruction Hospitalization 66 Female 2/22/2007 Physician Italy
Primary
Secondary
Retroperitoneal Fibrosis Hospitalization 66 2/19/2007 Italy
Primary
Secondary
Lymphohistiocytosis Hospitalization 0 Female 3/1/2007 Physician United States
Primary
Secondary
Concomitant
Retroperitoneal Fibrosis Hospitalization 66 Female 3/1/2007 Italy
Primary
Secondary
Retroperitoneal Fibrosis Hospitalization 66 Female 3/2/2007 Other Health Professional Italy
Primary
Secondary
Retroperitoneal Fibrosis Hospitalization 66 Female 3/5/2007 Consumer Japan
Primary
Secondary
Metastasis Death 16 Female 3/5/2007
Primary
Secondary
Glioma Other Serious 16 Female 3/8/2007 Consumer Finland
Primary
Secondary
Nervous System Disorder Death 16 Female 3/2/2007 Physician Germany
Primary
Secondary
Retroperitoneal Fibrosis Hospitalization 66 Female 3/8/2007 Italy
Primary
Secondary
Uv Light Therapy Other Serious 49 Male 3/9/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Glioma Other Serious 7 Female 3/9/2007 Consumer Finland
Primary
Secondary
Treatment Related Secondary Malignancy Death 16 Female 3/1/2007 Germany
Primary
Secondary
Malignant Neoplasm Progression Other Serious 5/13/2005 63 Female 3/13/2007 Consumer United States
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 1/23/2006 64 Male 3/13/2007 Other Health Professional United States
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 1/23/2006 64 Male 3/13/2007 Other Health Professional United States
Primary
Secondary
Retroperitoneal Fibrosis Hospitalization 66 Female 3/13/2007 Consumer United States
Primary
Secondary
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 16 Female 3/14/2007 Other Health Professional France
Primary
Secondary
Recall Phenomenon 49 Male 3/15/2007 United States
Primary
Secondary
Concomitant
Visual Acuity Reduced Life Threatening 16 Female 110 lb 3/15/2007
Primary
Secondary
Malignant Neoplasm Progression Other Serious 5/13/2005 63 Female 3/16/2007 Consumer United States
Primary
Secondary
Stomatitis Life Threatening 1/29/2007 68 Male 159 lb 3/19/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Other Serious 1/23/2006 64 Male 3/19/2007 Other Health Professional United States
Primary
Secondary
Pruritus Hospitalization 10/1/2005 Female 183 lb 3/19/2007 Netherlands
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 49 Male 3/19/2007
Primary
Secondary
Vomiting Disability 1/30/2007 7 Female 3/13/2007 Japan
Primary
Concomitant
Recall Phenomenon Other Serious 49 Male 3/14/2007 Other Health Professional United States
Primary
Secondary
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 16 Female 110 lb 3/21/2007 Other Health Professional France
Primary
Secondary
Stomatitis Life Threatening 1/29/2007 68 Male 3/22/2007 United Kingdom
Primary
Secondary
Concomitant
Pancytopenia Other Serious 4/2/2007 Other Health Professional Italy
Primary
Secondary
White Blood Cell Count Decreased Other Serious 49 Male 3/27/2007 United States
Primary
Secondary
Acute Myeloid Leukaemia Death 11 Male 4/4/2007 Other Health Professional Japan
Primary
Secondary
Staphylococcal Sepsis Other Serious 31 Male 4/4/2007 Other Health Professional United States
Primary
Secondary
Pyrexia Other Serious 12/23/2006 Female 163 lb 4/4/2007 Physician Bahrain
Primary
Concomitant
Encephalopathy Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Monoplegia Other Serious NotSpecified 3/29/2007 Other Health Professional France
Primary
Secondary
Spinal Disorder Other Serious 3/29/2007 France
Primary
Secondary
Leukoencephalopathy Other Serious 3/29/2007 France
Primary
Secondary
Leukoencephalopathy Other Serious 3/29/2007 Consumer France
Primary
Secondary
Musculoskeletal Disorder Other Serious 3/29/2007 Consumer France
Primary
Secondary
Spinal Disorder Other Serious 3/29/2007 Consumer France
Primary
Secondary
Neuropathy Peripheral Other Serious 3/29/2007 Other Health Professional France
Primary
Secondary
Neuropathy Peripheral Other Serious 3/29/2007 Consumer France
Primary
Secondary
Encephalopathy Other Serious 3/29/2007 Consumer France
Primary
Secondary
Tachycardia Other Serious 2/16/2005 17 Male 4/18/2007 Other Health Professional Malaysia
Primary
Secondary
Retroperitoneal Fibrosis Hospitalization 1/1/2006 66 Female 4/11/2007 Other Health Professional Italy
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 45 Male 143 lb 4/13/2007 Physician Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious Unknown 4/16/2007 Germany
Primary
Secondary

Drug Data