Etoposide combined with Melphalan Hydrochloride

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Thrombotic Microangiopathy Hospitalization 5/28/2009 Male 27 lb 6/5/2009 United States
Primary
Secondary
Leukopenia Death 67 Female 6/23/2009 Other Health Professional Germany
Primary
Secondary
Mucosal Inflammation Hospitalization 1/1/2007 35 Male 6/25/2009 Physician France
Primary
Secondary
Malignant Neoplasm Progression Other Serious 8/1/2006 51 Male 7/6/2009 Other Health Professional United Kingdom
Primary
Secondary
Mucosal Inflammation Other Serious 8/1/2006 51 Male 7/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Thrombotic Thrombocytopenic Purpura Death 5/25/2009 57 Male 219 lb 7/12/2009 Physician United States
Primary
Secondary
Thrombosis Death 7/5/2009 Female 8/17/2009 Pharmacist United Kingdom
Primary
Concomitant
Transplant Failure Other Serious 69 Male 8/17/2009 United States
Primary
Secondary
Thrombocytopenia Life Threatening 5/12/2007 Male 223 lb 8/17/2009 Consumer United States
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 5/12/2007 Male 223 lb 8/18/2009 Consumer United States
Primary
Secondary
Concomitant
Urinary Retention Hospitalization 34 8/21/2009 Consumer Czech Republic
Primary
Secondary
Thrombocytopenia Life Threatening 5/12/2007 Male 223 lb 8/25/2009 Consumer United States
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 0 Female 8/27/2009 Other Health Professional Italy
Primary
Secondary
Thrombocytopenia Life Threatening 5/12/2007 Male 223 lb 8/28/2009 Consumer United States
Primary
Secondary
Concomitant
Streptococcal Sepsis Hospitalization 4/5/2009 Male 9/10/2009 Physician United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious Unknown 10/2/2009 Korea, Republic Of
Primary
Secondary
Bacterial Infection Death Unknown 12/1/2009 Italy
Primary
Secondary
Concomitant
Drug Toxicity Other Serious 12/1/2009 Physician Italy
Primary
Secondary
Capillary Leak Syndrome Death Unknown 12/14/2009 Italy
Primary
Secondary
Pathogen Resistance Death Unknown 12/14/2009 Croatia (Local Name: Hrvatska)
Primary
Secondary
Multi-organ Failure Death Unknown 12/14/2009 Croatia (Local Name: Hrvatska)
Primary
Secondary
Thrombocytopenia Hospitalization 11/23/2009 48 Female 12/23/2009 Other Health Professional Spain
Primary
Concomitant
Weight Increased Hospitalization 12/23/2009 Male 30 lb 1/11/2010 United States
Primary
Secondary
Productive Cough Hospitalization 8/9/2009 61 Male 190 lb 1/26/2010 Physician United States
Primary
Secondary
Concomitant
Agranulocytosis Hospitalization 7/7/2009 Male 1/26/2010 Physician United Kingdom
Primary
Concomitant
Thrombocytopenia Hospitalization 3/24/2008 59 Female 1/25/2010 Other Health Professional France
Primary
Concomitant
Weight Decreased Other Serious 9/1/2000 Male 2/11/2010 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/25/2009 Male 22 lb 2/25/2010 United States
Primary
Secondary
Respiratory Distress Hospitalization 12/11/2009 Male 40 lb 3/3/2010 United States
Primary
Secondary
Thrombocytopenia Hospitalization 9/21/2007 59 Female 3/1/2010 Other Health Professional France
Primary
Concomitant
Weight Increased Hospitalization 7/21/2009 Male 48 lb 2/24/2010 United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization Male 26 lb 3/4/2010 United States
Primary
Secondary
Use Of Accessory Respiratory Muscles Hospitalization 2/12/2010 Male 26 lb 3/9/2010 United States
Primary
Secondary
Venoocclusive Liver Disease Required Intervention 4 Male 3/10/2010 Physician United States
Primary
Secondary
Concomitant
Encephalitis Viral Death 3/12/2010 Other Health Professional Italy
Primary
Concomitant
Thrombocytopenia Hospitalization 11/15/2008 Female 3/16/2010 Other Health Professional France
Primary
Concomitant
Therapeutic Agent Toxicity Death Unknown 3/16/2010 Brazil
Primary
Secondary
Concomitant
Cardiotoxicity Death Unknown 3/16/2010 Brazil
Primary
Secondary
Concomitant
Pulmonary Alveolar Haemorrhage Death Unknown 3/16/2010 Brazil
Primary
Secondary
Concomitant
Weight Decreased Other Serious 9/1/2000 Male 3/22/2010 Physician United States
Primary
Concomitant
Respiratory Disorder Other Serious 16 Male 3/23/2010 Physician Japan
Primary
Concomitant
Viral Test Positive Hospitalization 12/11/2009 Male 40 lb 3/17/2010 United States
Primary
Secondary
Concomitant
Respiratory Failure Death 4/1/2008 45 Male 3/25/2010 Other Health Professional Italy
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 3/30/2010 Consumer United States
Primary
Secondary
Renal Failure Other Serious 3/30/2010 Consumer United States
Primary
Secondary
Thrombotic Microangiopathy Other Serious 3/30/2010 Consumer United States
Primary
Secondary
Thrombotic Microangiopathy Other Serious 3/30/2010 Consumer United States
Primary
Secondary
Thrombotic Microangiopathy Other Serious 3/30/2010 Consumer United States
Primary
Secondary
Stem Cell Transplant Death 6 Female 3/25/2010 Germany
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 5 Male 3/25/2010 Germany
Primary
Secondary
Concomitant
Respiratory Disorder Other Serious 7/6/2009 16 Male 110 lb 4/5/2010 Physician Japan
Primary
Concomitant
Weight Decreased Other Serious 10/22/2008 64 Male 4/5/2010 Other Health Professional United States
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 40 Female 4/2/2010 Physician Japan
Primary
Concomitant
Tachypnoea Hospitalization 2/12/2010 2 Male 26 lb 4/8/2010 United States
Primary
Secondary
Thrombocytopenia Other Serious 22 Female 4/26/2010 Physician Germany
Primary
Concomitant
Thrombocytopenia Other Serious 16 Female 4/26/2010 Physician Germany
Primary
Concomitant
Non-small Cell Lung Cancer Death 6/29/2009 68 Male 4/30/2010 Physician United Kingdom
Primary
Secondary
Pyrexia Other Serious 9 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 5 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 9 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 11 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 11 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 5 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Venoocclusive Disease Death 13 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Venoocclusive Disease Death 1 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Sepsis Death 7 5/4/2010 United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 2 5/4/2010 Physician United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 5/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 5/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Other Serious 5/19/2010 Physician United States
Primary
Secondary
Concomitant
Sepsis Other Serious 5/19/2010 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 5/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 5/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Death Unknown 5/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Roseolovirus Test Positive Hospitalization 4/20/2010 1 Female 20 lb 5/20/2010 United States
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Other Serious Male 5/27/2010 Physician United Kingdom
Primary
Concomitant
Stem Cell Transplant Hospitalization 6 Male 5/25/2010 Japan
Primary
Secondary
Renal Failure Hospitalization 4/20/2010 1 Female 20 lb 5/28/2010 United States
Primary
Secondary
Sweat Gland Tumour Required Intervention 32 Male 6/2/2010 Physician United Kingdom
Primary
Secondary
Sweat Gland Tumour Other Serious 32 Male 6/11/2010 Other Health Professional United Kingdom
Primary
Secondary
Sweat Gland Tumour Other Serious 32 Female 6/15/2010 Physician United Kingdom
Primary
Secondary
Sweat Gland Tumour Other Serious 32 Male 6/18/2010 Other Health Professional United Kingdom
Primary
Secondary
Vomiting Other Serious 9/1/2009 4 Male 6/23/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Sweat Gland Tumour Other Serious 32 Male 6/23/2010 Other Health Professional United Kingdom
Primary
Secondary
Myelodysplastic Syndrome Other Serious 4/28/2010 57 Female 199 lb 6/23/2010 Physician United States
Primary
Secondary
Myelodysplastic Syndrome Other Serious 4/28/2010 57 Female 199 lb 6/25/2010 Physician United States
Primary
Secondary
Sweat Gland Tumour Required Intervention 28 Male 6/17/2010 Consumer United Kingdom
Primary
Secondary
Myelodysplastic Syndrome Other Serious 57 Female 199 lb 6/29/2010 Consumer United States
Primary
Secondary
Myelodysplastic Syndrome Other Serious 4/28/2010 57 Female 199 lb 6/30/2010 Consumer United States
Primary
Secondary
Urinary Tract Infection Other Serious 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Herpes Zoster Other Serious 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Death 7/1/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Sepsis Death 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Venoocclusive Disease Death 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Other Serious 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Venoocclusive Disease Death 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonia Klebsiella Other Serious 58 Female 7/12/2010 United Kingdom
Primary
Secondary
Anaemia Haemolytic Autoimmune Other Serious 66 Male 7/12/2010 United Kingdom
Primary
Secondary
Streptococcal Sepsis Other Serious 63 Female 7/12/2010 United Kingdom
Primary
Secondary
Epstein-barr Virus Associated Lymphoproliferative Disorder Death 50 Male 7/12/2010 United Kingdom
Primary
Secondary
Vomiting Hospitalization 7 Male 8/24/2010 India
Primary
Secondary
Venoocclusive Disease Other Serious 8/26/2010 Korea, Republic Of
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 8/26/2010 Korea, Republic Of
Primary
Secondary
Concomitant
Engraftment Syndrome Death Unknown 8/26/2010 Korea, Republic Of
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Other Serious 56 Male 9/10/2010 Consumer United Kingdom
Primary
Secondary
Renal Impairment 7 Male 9/13/2010 Physician India
Primary
Secondary
Sebaceous Carcinoma Other Serious 10/1/2009 46 Male 203 lb 9/15/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/1995 57 Male 9/17/2010 United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 49 Female 9/23/2010 Other Health Professional Switzerland
Primary
Concomitant
Pleural Effusion Other Serious 31 Female 10/15/2010 Other Health Professional United States
Primary
Secondary
Suicide Attempt Hospitalization 9/7/2010 65 Male 209 lb 10/15/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Organ Failure Death 10/7/2010 Canada
Primary
Secondary
Neuropathy Peripheral Hospitalization 9/13/2010 38 Male 10/13/2010 Physician Japan
Primary
Concomitant
Stem Cell Transplant Other Serious 15 Female 10/27/2010 Other Health Professional Japan
Primary
Concomitant
Venoocclusive Liver Disease Hospitalization 9/16/2010 59 Male 206 lb 10/28/2010 Physician United States
Primary
Secondary
Thrombotic Microangiopathy Death 9/21/2009 62 Female 126 lb 11/3/2010 Physician Japan
Primary
Concomitant
Staphylococcal Infection Hospitalization 8/30/2010 64 Female 163 lb 11/4/2010 Physician United States
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 10/28/2010 Physician Canada
Primary
Secondary
Concomitant
Organ Failure Death 10/28/2010 Physician Canada
Primary
Secondary
Stomatitis Other Serious 8/12/2009 50 Male 10/29/2010 Japan
Primary
Secondary
Concomitant
Colitis Other Serious 33 Female 11/16/2010 Other Health Professional Czech Republic
Primary
Concomitant
Pyrexia Life Threatening Male 112 lb 11/24/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Life Threatening Male 112 lb 11/24/2010 Physician Japan
Primary
Concomitant
Stem Cell Transplant Other Serious 15 Female 11/26/2010 Other Health Professional Japan
Primary
Concomitant
Staphylococcal Sepsis Other Serious 4/20/2010 1 Male 15 lb 12/10/2010 Physician Japan
Primary
Concomitant
Pleural Effusion Other Serious 31 Female 11/30/2010 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 7 Male 12/24/2010 Other Health Professional United States
Primary
Secondary
Disorientation Death 4/13/2009 52 Male 117 lb 1/10/2011 Physician Japan
Primary
Concomitant
Intestinal Obstruction Other Serious 22 Male 1/28/2011 Greece
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 39 Female 2/28/2011 Other Health Professional Australia
Primary
Secondary
Febrile Neutropenia Other Serious 22 Male 2/28/2011 Other Health Professional Greece
Primary
Secondary
Concomitant
Shock Death 49 Male 2/28/2011 Other Health Professional Spain
Primary
Secondary
Pulmonary Oedema Death 59 Female 2/28/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Geotrichum Infection Death 49 Male 3/17/2011 Other Health Professional Spain
Primary
Secondary
Cardiac Failure Acute Other Serious 1/1/2009 63 Female 3/18/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Engraftment Syndrome Other Serious 4/1/2011 Physician Spain
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 4/1/2011 Physician Spain
Primary
Secondary
Concomitant
Engraftment Syndrome Other Serious 4/1/2011 Physician Spain
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 4/1/2011 Physician Spain
Primary
Secondary
Concomitant
Infection Death Unknown 4/6/2011 Other Health Professional France
Primary
Secondary
Lymphopenia Death 10 Female 4/11/2011 Physician United States
Primary
Secondary
Concomitant
Device Breakage Hospitalization 3/23/2011 6 Male 66 lb 4/21/2011 Physician United States
Primary
Secondary
Bradycardia Hospitalization 59 Female 4/21/2011 Other Health Professional United States
Primary
Secondary
Cholestasis Death 7/23/2009 60 Female 208 lb 5/9/2011 Physician United States
Primary
Secondary
Concomitant
Syncope Hospitalization 5/3/2011 70 Female 5/20/2011 Physician United States
Primary
Secondary
Concomitant
Chest Pain Hospitalization Male 5/20/2011 Consumer United Kingdom
Primary
Concomitant
Vitreous Haemorrhage Other Serious 1 5/18/2011 Physician United States
Primary
Concomitant
Vitreous Haemorrhage Other Serious 2 5/18/2011 Other Health Professional United States
Primary
Concomitant
Neoplasm Progression Other Serious 3 5/18/2011 Other Health Professional United States
Primary
Concomitant

Drug Data