Estradiol combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Breast Cancer Female Life Threatening 10/15/2005 66 Female 1/19/2006 Other Health Professional France
Primary
Secondary
Concomitant
Tuberculosis Other Serious 8/1/2005 Female 139 lb 2/13/2006 Physician Belgium
Primary
Concomitant
Postoperative Infection Hospitalization 2/3/2006 Female 225 lb 3/14/2006 Consumer Canada
Primary
Concomitant
Postoperative Infection Hospitalization 2/3/2006 Female 225 lb 5/3/2006 Consumer Canada
Primary
Concomitant
Urethral Operation Other Serious 3/30/2006 Female 155 lb 5/5/2006 Consumer Canada
Primary
Concomitant
Postoperative Infection Hospitalization 2/3/2006 Female 225 lb 5/12/2006 Consumer Canada
Primary
Concomitant
Cardiac Disorder Hospitalization 9/1/2005 Female 112 lb 5/25/2006 Physician United States
Primary
Concomitant
Unevaluable Event Other Serious 1/1/2006 Female 136 lb 5/31/2006 Consumer United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2006 Female 154 lb 6/16/2006 Physician United States
Primary
Concomitant
Urethral Stenosis Other Serious 2/18/2005 Female 161 lb 7/25/2006 Other Health Professional United Kingdom
Primary
Concomitant
Urethral Operation Other Serious 3/30/2006 Female 155 lb 7/26/2006 Consumer Canada
Primary
Concomitant
Haemorrhage Hospitalization 5/30/2006 55 Female 116 lb 12/4/2006 United States
Primary
Concomitant
Pulmonary Embolism Life Threatening 2/13/2007 Female 161 lb 4/18/2007 Physician United States
Primary
Concomitant
Septic Shock Hospitalization 71 Female 9/20/2007 Physician Canada
Primary
Secondary
Concomitant
Vaginal Haemorrhage Other Serious 1/1/2003 67 Female 11/2/2007 Physician United States
Primary
Concomitant
Vaginal Haemorrhage Other Serious 1/1/2003 67 Female 11/5/2007 Physician United States
Primary
Concomitant
Vaginal Haemorrhage Other Serious 1/1/2002 67 Female 11/14/2007 Physician United States
Primary
Concomitant
Vaginal Haemorrhage Other Serious 1/1/2002 67 Female 11/21/2007 Physician United States
Primary
Concomitant
Ovarian Cancer Death 8/1/2005 Female 11/26/2007 Physician United States
Primary
Secondary
Concomitant
Vaginal Haemorrhage Other Serious 1/1/2002 67 Female 12/14/2007 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 5/1/2004 Female 11/1/2007 Physician United States
Primary
Secondary
Concomitant
Oral Candidiasis Female 160 lb 12/14/2007 United States
Primary
Concomitant
Sinusitis 10/17/2007 Female 366 lb 12/14/2007 Physician United States
Primary
Concomitant
Injection Site Pain Female 265 lb 12/14/2007 Consumer United States
Primary
Concomitant
Paranasal Sinus Hypersecretion 9/1/2007 Female 146 lb 12/14/2007 Consumer United States
Primary
Concomitant
Spinal Osteoarthritis 8/23/2007 Female 155 lb 12/15/2007 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 60 Female 1/25/2008 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 12/11/2007 46 Female 225 lb 1/31/2008 Consumer United Kingdom
Primary
Concomitant
Vaginal Haemorrhage Other Serious 1/1/2002 67 Female 2/22/2008 Physician United States
Primary
Concomitant
Ovarian Cancer Death 8/1/2005 Female 3/10/2008 Physician United States
Primary
Secondary
Concomitant
Injection Site Pain 11/22/2007 Female 190 lb 3/14/2008 Consumer United States
Primary
Concomitant
Nasopharyngitis Other Serious 5/1/2007 59 Female 192 lb 3/18/2008 Consumer United States
Primary
Secondary
Wrist Fracture Other Serious 1/1/2002 67 Female 3/18/2008 Physician United States
Primary
Concomitant
Nasopharyngitis Other Serious 6/1/2007 Female 192 lb 4/1/2008 Consumer United States
Primary
Secondary
Pain In Extremity Other Serious 5/1/2007 59 Female 192 lb 4/2/2008 Other Health Professional United States
Primary
Secondary
Nasopharyngitis Other Serious 5/1/2007 59 Female 192 lb 4/14/2008 United States
Primary
Secondary
Tremor Other Serious 12/1/2006 49 5/5/2008 Other Health Professional United Kingdom
Primary
Concomitant
Arthritis Disability 1/15/2008 70 Female 121 lb 5/9/2008 Other Health Professional United Kingdom
Primary
Concomitant
Rash Other Serious 3/1/2008 Female 160 lb 5/28/2008 United States
Primary
Concomitant
Injection Site Reaction 1/1/2008 Female 6/12/2008 United States
Primary
Concomitant
Injection Site Pain 12/1/2007 Female 240 lb 6/12/2008 United States
Primary
Concomitant
White Blood Cell Count Decreased 4/1/2006 Female 109 lb 6/12/2008 United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 11/20/2007 Female 120 lb 6/16/2008 Physician United States
Primary
Concomitant
Viral Infection Life Threatening 6/1/2008 Female 145 lb 6/18/2008 Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 5/15/2008 Female 6/24/2008 Physician United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 11/20/2007 Female 120 lb 6/27/2008 Physician United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 5/15/2008 Female 7/24/2008 Other Health Professional France
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 10/1/2007 Female 120 lb 9/2/2008 Physician United States
Primary
Concomitant
Fatigue 6/2/2008 Female 108 lb 9/12/2008 United States
Primary
Concomitant
Psoriasis 1/1/2008 Female 176 lb 9/13/2008 Physician United States
Primary
Concomitant
Pain Disability 8/1/2005 Female 11/25/2008 Consumer United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 5/15/2008 Female 11/26/2008 Other Health Professional France
Primary
Secondary
Concomitant
Vomiting Other Serious 11/22/2008 Female 12/10/2008 Consumer Guatemala
Primary
Concomitant
Rash 6/1/2008 Female 12/12/2008 Consumer United States
Primary
Concomitant
Neck Pain 1/1/2007 Female 133 lb 12/12/2008 Physician United States
Primary
Concomitant
Psoriasis 1/1/2008 Female 12/12/2008 Consumer United States
Primary
Concomitant
Incorrect Dose Administered 11/11/2008 116 lb 12/12/2008 Other Health Professional United States
Primary
Concomitant
Injection Site Irritation Female 12/15/2008 Pharmacist United States
Primary
Concomitant
Vomiting Other Serious 11/22/2008 Female 12/18/2008 Consumer Guatemala
Primary
Concomitant
Wrist Fracture Other Serious 1/1/2002 66 Female 12/22/2008 Physician United States
Primary
Concomitant
Stomatitis 56 Female 12/31/2008 Consumer United States
Primary
Concomitant
Muscle Spasms 1/1/2005 Female 209 lb 3/14/2009 Consumer United States
Primary
Concomitant
Injection Site Irritation 2/1/2009 Female 159 lb 3/14/2009 United States
Primary
Concomitant
Injection Site Pain Female 157 lb 3/14/2009 Consumer United States
Primary
Concomitant
Ligament Rupture Other Serious 3/1/2009 Female 140 lb 5/4/2009 United States
Primary
Concomitant
Speech Disorder Other Serious 1/1/2009 Female 161 lb 6/2/2009 Consumer United States
Primary
Concomitant
Pain 2/1/2009 Female 218 lb 6/11/2009 United States
Primary
Concomitant
Discomfort 7/1/2008 Female 140 lb 6/12/2009 United States
Primary
Concomitant
Upper Respiratory Tract Infection 12/1/2008 Female 250 lb 6/12/2009 United States
Primary
Concomitant
Skin Laceration 5/21/2009 Female 207 lb 6/12/2009
Primary
Concomitant
Weight Decreased Hospitalization 7/1/2003 73 Female 4/20/2009 Physician United States
Primary
Secondary
Concomitant
Skin Flap Necrosis Other Serious 5/24/2009 Female 130 lb 7/2/2009 United States
Primary
Concomitant
Stomatitis Other Serious 1/1/2004 Female 7/20/2009 Lawyer United States
Primary
Secondary
Concomitant
Skin Flap Necrosis Other Serious 5/24/2009 Female 130 lb 7/31/2009 United States
Primary
Concomitant
Streptococcal Infection Other Serious 5/24/2009 Female 130 lb 8/14/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 68 Female 8/13/2009 Consumer United States
Primary
Concomitant
Oedema Peripheral Female 8/21/2009 United States
Primary
Concomitant
Feeling Hot Female 147 lb 8/23/2009 United States
Primary
Concomitant
Vomiting Hospitalization 62 Female 8/25/2009 Lawyer United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 68 Female 8/23/2009 Lawyer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process 10/24/2006 Female 250 lb 9/11/2009 Consumer United States
Primary
Concomitant
Incorrect Dose Administered 11/2/2006 Female 180 lb 9/11/2009 Consumer United States
Primary
Concomitant
Incorrect Dose Administered 2/21/2007 Female 115 lb 9/11/2009 Consumer United States
Primary
Concomitant
Injection Site Pain 4/1/2007 Female 229 lb 9/11/2009 Consumer United States
Primary
Concomitant
Injection Site Pain 11/22/2007 Female 190 lb 9/12/2009 Consumer United States
Primary
Concomitant
Streptococcal Infection Other Serious 5/24/2009 Female 130 lb 9/18/2009 United States
Primary
Concomitant
Alopecia 1/1/2009 Female 145 lb 9/19/2009 Consumer United States
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 68 Female 9/17/2009 United States
Primary
Concomitant
Vomiting Hospitalization 56 Female 9/17/2009 United States
Primary
Concomitant
Vomiting Hospitalization 53 Female 9/24/2009 United States
Primary
Concomitant
Nausea Other Serious 1/1/2009 Female 144 lb 10/6/2009 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 7/23/2009 68 Female 226 lb 10/30/2009 Physician United States
Primary
Concomitant
Vomiting Hospitalization 53 Female 11/4/2009 United States
Primary
Concomitant
Bronchiectasis Other Serious 4/24/2009 Female 11/23/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Femur Fracture Other Serious 1/1/2007 61 Female 11/30/2009 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Injection Site Swelling 1/7/2009 Female 153 lb 12/4/2009 Other Health Professional United States
Primary
Concomitant
Pain In Extremity 7/1/2009 Female 12/9/2009 Physician United States
Primary
Concomitant
Tendon Rupture 10/1/2007 Female 12/10/2009 Physician United States
Primary
Concomitant
Bronchiectasis Other Serious 4/24/2009 Female 12/16/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Bronchiectasis Other Serious 4/24/2009 Female 12/22/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Bronchiectasis Other Serious 4/24/2009 Female 1/4/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Pneumonia Other Serious 4/24/2009 Female 1/27/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Pain 1/1/2007 Female 158 lb 1/29/2010 United States
Primary
Concomitant
Drug Dose Omission 9/15/2009 Female 170 lb 1/29/2010 United States
Primary
Concomitant
Injection Site Haematoma 10/1/2008 Female 121 lb 1/29/2010 Consumer United States
Primary
Concomitant
Wound Haemorrhage 12/15/2009 Female 200 lb 1/30/2010 United States
Primary
Concomitant
Visual Impairment Other Serious 1/1/2008 Female 2/10/2010 United States
Primary
Concomitant
Atrial Fibrillation Hospitalization 11/15/2009 Female 2/15/2010 Physician Denmark
Primary
Concomitant
Vomiting 51 Female 192 lb 2/22/2010 Consumer United States
Primary
Concomitant
Bronchiectasis Other Serious 4/24/2009 74 Female 4/2/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Meningioma Hospitalization 7/7/2009 55 Female 136 lb 4/1/2010 Other Health Professional Czech Republic
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 7/7/2009 55 Female 136 lb 4/14/2010 Pharmacist Czech Republic
Primary
Concomitant
Breast Cancer Other Serious 2/24/2010 62 Female 169 lb 4/22/2010 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 53 Female 4/15/2010 United States
Primary
Concomitant
Breast Cancer Other Serious 2/24/2010 62 Female 169 lb 4/27/2010 Physician United States
Primary
Concomitant
Injection Site Haematoma Female 120 lb 5/11/2010 Consumer United States
Primary
Concomitant
Tibia Fracture Required Intervention 48 Female 6/10/2010 Physician United States
Primary
Concomitant
Bronchiectasis Other Serious 4/24/2009 74 Female 6/16/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Malignant Melanoma Other Serious 1/1/2010 66 Female 140 lb 7/6/2010 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Other Serious 2/1/2009 59 Female 7/8/2010 Physician United States
Primary
Concomitant
No Adverse Event 1/21/2007 54 Female 137 lb 7/9/2010 Consumer United States
Primary
Concomitant
Polydipsia 3/1/2007 67 Female 145 lb 7/12/2010 Consumer United States
Primary
Concomitant
Dissociation Other Serious 7/1/2007 49 Female 166 lb 7/14/2010 Consumer United States
Primary
Concomitant
Wound Dehiscence Other Serious 7/1/2003 73 Female 4/13/2010 Physician United States
Primary
Secondary
Concomitant
Wound Dehiscence Other Serious 7/1/2003 73 Female 4/13/2010 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 12/10/2009 42 Female 174 lb 7/20/2010 Consumer United Kingdom
Primary
Concomitant
Synovial Cyst Other Serious 1/1/2006 48 Female 212 lb 7/23/2010 Consumer United States
Primary
Concomitant
Weight Decreased Other Serious 12/10/2009 42 Female 174 lb 7/30/2010 Physician United Kingdom
Primary
Concomitant
Injection Site Pain Female 120 lb 7/26/2010 Other Health Professional United States
Primary
Concomitant
Gastroenteritis Viral Hospitalization 9/1/2010 55 Female 186 lb 9/20/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 8/1/2009 49 Female 9/16/2010 United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 4/30/2010 74 Male 9/16/2010 Physician United States
Primary
Concomitant
Intervertebral Disc Protrusion Hospitalization 9/1/2010 55 Female 186 lb 9/23/2010 Physician United States
Primary
Concomitant
Red Blood Cell Sedimentation Rate Increased Other Serious 8/25/2010 50 Female 104 lb 10/1/2010 Physician United States
Primary
Concomitant
Product Quality Issue 8/16/2010 59 Female 11/16/2010 Consumer United States
Primary
Secondary
Concomitant
Nausea 2/1/2010 65 Female 11/29/2010 Consumer United States
Primary
Concomitant
Red Blood Cell Sedimentation Rate Increased Other Serious 8/25/2010 50 Female 104 lb 12/13/2010 Physician United States
Primary
Concomitant
Nasal Congestion 11/23/2009 12/15/2010 Consumer United States
Primary
Concomitant
Precancerous Skin Lesion Other Serious 6/1/2010 71 Female 142 lb 12/17/2010 Other Health Professional Canada
Primary
Concomitant
Paraesthesia 3/30/2010 12/19/2010 Consumer United States
Primary
Concomitant
White Blood Cell Count Abnormal 1/1/2007 12/20/2010 Physician United States
Primary
Concomitant
Injection Site Reaction 1/7/2010 12/22/2010 Consumer United States
Primary
Concomitant
Oedema Peripheral 7/1/2010 12/22/2010 Consumer United States
Primary
Concomitant
Nasopharyngitis 8/23/2010 12/23/2010 Consumer United States
Primary
Concomitant
Injection Site Swelling 12/23/2010 Consumer United States
Primary
Concomitant
Vision Blurred 6/1/2010 12/23/2010 Pharmacist United States
Primary
Concomitant
Wound Dehiscence Other Serious 7/1/2003 73 Female 10/28/2010 Physician United States
Primary
Secondary
Concomitant
Tooth Fracture Other Serious 9/28/2005 68 Female 123 lb 10/28/2010 Physician United States
Primary
Secondary
Concomitant
Pain Female 145 lb 1/28/2011 Consumer United States
Primary
Concomitant
Sinusitis Other Serious 1/1/2009 65 Female 200 lb 1/28/2011 United States
Primary
Concomitant

Drug Data